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The map label for this gene is pntB [H]

Identifier: 116622475

GI number: 116622475

Start: 4274548

End: 4275936

Strand: Reverse

Name: pntB [H]

Synonym: Acid_3373

Alternate gene names: 116622475

Gene position: 4275936-4274548 (Counterclockwise)

Preceding gene: 116622476

Following gene: 116622474

Centisome position: 42.91

GC content: 61.56

Gene sequence:

>1389_bases
ATGAACTCGCTCGTCAGCTACATCTACATCATCTCGGGCGCGCTCTTCATTCTCTCTCTGAAATGGATGAACTCGCCGGT
GAGCGCGCGGCGCGGTGTCTTCGCGGGCGAGGCGGGCATGGTGATGGCGATCGGCGGCACGTTGATCGGGCATCACCAGA
ACTGGGAATGGATTCTGGCGGCCTTCTTCATCGGCACGGCAATCGGAGTGCCGATCGCGTACATCATGCCGATGACGGCG
GTGCCGCAGCGGACCGCGATGTCGCATGCCTGCGGCGCGCTGGCGGCGGCGCTGGTGGGCACTGCGGAGTTCTATCAGAG
GCAGCCGCAGGCCGACAGCGATCTGCACGGGTTCGTGATGGTGGCGCTGATCATCGAAACACTGCTCGGGTTCCTGACAT
TCACTGGAAGCCTGATGGCGATGGGCAAGCTGCAGGAGATTCTTCCCTCCCGGCCGATGACATTCAGGAATCAGAACCTG
ATCAACGGAGTGCTATTCACGATCGCGATCCTGCTGGGCGTGCGGCTGATCATGGTGCCGACGGATACCATGCTGTTCCC
GATTTTTGCAGGGCTTTCGCTGGTCTTCGGGGTGCTATTGATTCTGCCGATCGGCGGTGCGGACATGCCGACCGTGATTG
CGCTGTTGAATTCGTACGCGGGTCTTTCGGCATGCGCGATGGGATTCGTGTTGAACAATCACCTGCTGGTGATCGCGGGC
GCGCTGGATGGATCGAGCGGGCTGATTCTCTCGATCATCATGTGCAAGGCGATGAATCGGAGCTTCACGAATGTTCTGTT
CGGCGCCTTCGGACAGATTCAGGCCAGCGCGGTGAAGACGGAGCAGCGCGCCTATCGGAGCGCGAGCGCGGAAGAAGCCG
CGGCGGTGCTGGAGGCGGCCTCGAGTGTGATCATCGTGCCCGGATACGGACTCGCGGTCGCGCAGGCGCAGCACAAAATT
CGTGAATTGTTCGATTCGCTGATGAAGCGCGGCATCGACGTAAAGTTCGCGATCCATCCGGTGGCGGGCCGCATGCCGGG
GCACATGAACGTGCTGCTGGCCGAAGCCGACATCCCGTACGACCGGCTGGTGGAGATGGACGATATCAACGGCGAGTTCC
CGCAGTGCGATGTGGCGCTGGTGATCGGCGCGAACGATGTGACCAACCCGGCGGCGCGGACCGACAAGAACAGTCCGATC
TACGGGATGCCGATTCTGGACGTGGACCGCGCGCGCACCGTGATGGTGATCAAGCGCTCCATGAGCCCGGGCTTCGCGGG
GATCGACAACGACCTGTATTACATGGACAAGACGCTGATGCTGTTCGGCGACGCCAAGGCGTTCGTGGCTGAAATCGTGA
AAGAGCTGCCGGCACGCGTAGGTGCGTGA

Upstream 100 bases:

>100_bases
GCTTTATCGCGATCACGGCGGCTGTGACCAACATCGTGAGCGGATTTCTGATCACGGACCGCATGCTGAAGATGTTTAAG
AAGCGCGAGGAGAAGCGATA

Downstream 100 bases:

>100_bases
TGGACGAGCGGGTTGCGCACGGCATCGAGCTGTTCAACACCGGCCAGTTCTTCGTCTGCCACGAGGTGCTGGAAGAGGTC
TGGACTACGGAGCGCAATCC

Product: NAD(P) transhydrogenase subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MNSLVSYIYIISGALFILSLKWMNSPVSARRGVFAGEAGMVMAIGGTLIGHHQNWEWILAAFFIGTAIGVPIAYIMPMTA
VPQRTAMSHACGALAAALVGTAEFYQRQPQADSDLHGFVMVALIIETLLGFLTFTGSLMAMGKLQEILPSRPMTFRNQNL
INGVLFTIAILLGVRLIMVPTDTMLFPIFAGLSLVFGVLLILPIGGADMPTVIALLNSYAGLSACAMGFVLNNHLLVIAG
ALDGSSGLILSIIMCKAMNRSFTNVLFGAFGQIQASAVKTEQRAYRSASAEEAAAVLEAASSVIIVPGYGLAVAQAQHKI
RELFDSLMKRGIDVKFAIHPVAGRMPGHMNVLLAEADIPYDRLVEMDDINGEFPQCDVALVIGANDVTNPAARTDKNSPI
YGMPILDVDRARTVMVIKRSMSPGFAGIDNDLYYMDKTLMLFGDAKAFVAEIVKELPARVGA

Sequences:

>Translated_462_residues
MNSLVSYIYIISGALFILSLKWMNSPVSARRGVFAGEAGMVMAIGGTLIGHHQNWEWILAAFFIGTAIGVPIAYIMPMTA
VPQRTAMSHACGALAAALVGTAEFYQRQPQADSDLHGFVMVALIIETLLGFLTFTGSLMAMGKLQEILPSRPMTFRNQNL
INGVLFTIAILLGVRLIMVPTDTMLFPIFAGLSLVFGVLLILPIGGADMPTVIALLNSYAGLSACAMGFVLNNHLLVIAG
ALDGSSGLILSIIMCKAMNRSFTNVLFGAFGQIQASAVKTEQRAYRSASAEEAAAVLEAASSVIIVPGYGLAVAQAQHKI
RELFDSLMKRGIDVKFAIHPVAGRMPGHMNVLLAEADIPYDRLVEMDDINGEFPQCDVALVIGANDVTNPAARTDKNSPI
YGMPILDVDRARTVMVIKRSMSPGFAGIDNDLYYMDKTLMLFGDAKAFVAEIVKELPARVGA
>Mature_462_residues
MNSLVSYIYIISGALFILSLKWMNSPVSARRGVFAGEAGMVMAIGGTLIGHHQNWEWILAAFFIGTAIGVPIAYIMPMTA
VPQRTAMSHACGALAAALVGTAEFYQRQPQADSDLHGFVMVALIIETLLGFLTFTGSLMAMGKLQEILPSRPMTFRNQNL
INGVLFTIAILLGVRLIMVPTDTMLFPIFAGLSLVFGVLLILPIGGADMPTVIALLNSYAGLSACAMGFVLNNHLLVIAG
ALDGSSGLILSIIMCKAMNRSFTNVLFGAFGQIQASAVKTEQRAYRSASAEEAAAVLEAASSVIIVPGYGLAVAQAQHKI
RELFDSLMKRGIDVKFAIHPVAGRMPGHMNVLLAEADIPYDRLVEMDDINGEFPQCDVALVIGANDVTNPAARTDKNSPI
YGMPILDVDRARTVMVIKRSMSPGFAGIDNDLYYMDKTLMLFGDAKAFVAEIVKELPARVGA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=449, Percent_Identity=41.8708240534521, Blast_Score=315, Evalue=8e-86,
Organism=Homo sapiens, GI122939153, Length=449, Percent_Identity=41.8708240534521, Blast_Score=315, Evalue=8e-86,
Organism=Escherichia coli, GI1787886, Length=461, Percent_Identity=46.2039045553145, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17550456, Length=405, Percent_Identity=45.9259259259259, Blast_Score=320, Evalue=9e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 49481; Mature: 49481

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSLVSYIYIISGALFILSLKWMNSPVSARRGVFAGEAGMVMAIGGTLIGHHQNWEWILA
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEECCCCEEEEECCEEEECCCCHHHHHH
AFFIGTAIGVPIAYIMPMTAVPQRTAMSHACGALAAALVGTAEFYQRQPQADSDLHGFVM
HHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VALIIETLLGFLTFTGSLMAMGKLQEILPSRPMTFRNQNLINGVLFTIAILLGVRLIMVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEC
TDTMLFPIFAGLSLVFGVLLILPIGGADMPTVIALLNSYAGLSACAMGFVLNNHLLVIAG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEE
ALDGSSGLILSIIMCKAMNRSFTNVLFGAFGQIQASAVKTEQRAYRSASAEEAAAVLEAA
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
SSVIIVPGYGLAVAQAQHKIRELFDSLMKRGIDVKFAIHPVAGRMPGHMNVLLAEADIPY
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCH
DRLVEMDDINGEFPQCDVALVIGANDVTNPAARTDKNSPIYGMPILDVDRARTVMVIKRS
HHCEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEECCCCEECCCCCEEEEEEEC
MSPGFAGIDNDLYYMDKTLMLFGDAKAFVAEIVKELPARVGA
CCCCCCCCCCCEEEECCEEEEECCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSLVSYIYIISGALFILSLKWMNSPVSARRGVFAGEAGMVMAIGGTLIGHHQNWEWILA
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCEECCCCEEEEECCEEEECCCCHHHHHH
AFFIGTAIGVPIAYIMPMTAVPQRTAMSHACGALAAALVGTAEFYQRQPQADSDLHGFVM
HHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VALIIETLLGFLTFTGSLMAMGKLQEILPSRPMTFRNQNLINGVLFTIAILLGVRLIMVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEC
TDTMLFPIFAGLSLVFGVLLILPIGGADMPTVIALLNSYAGLSACAMGFVLNNHLLVIAG
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEE
ALDGSSGLILSIIMCKAMNRSFTNVLFGAFGQIQASAVKTEQRAYRSASAEEAAAVLEAA
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
SSVIIVPGYGLAVAQAQHKIRELFDSLMKRGIDVKFAIHPVAGRMPGHMNVLLAEADIPY
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCH
DRLVEMDDINGEFPQCDVALVIGANDVTNPAARTDKNSPIYGMPILDVDRARTVMVIKRS
HHCEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEECCCCEECCCCCEEEEEEEC
MSPGFAGIDNDLYYMDKTLMLFGDAKAFVAEIVKELPARVGA
CCCCCCCCCCCEEEECCEEEEECCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]