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The map label for this gene is 116621949

Identifier: 116621949

GI number: 116621949

Start: 3587687

End: 3589096

Strand: Direct

Name: 116621949

Synonym: Acid_2834

Alternate gene names: NA

Gene position: 3587687-3589096 (Clockwise)

Preceding gene: 116621948

Following gene: 116621950

Centisome position: 36.0

GC content: 61.49

Gene sequence:

>1410_bases
ATGAAGCTCACGTTCTGGGGCGCTGCCGGCACCGTCACCGGCTCCATGCACCTGGTAGAAACCGGCGGTAAACGATACCT
CTTGGATTGCGGATTGGCCCAGGGCCGCCGCAAGGAAGCCGACGCGAAGAATCGCAACCTGCCCTTCTCCGGCTCCTCCA
TTGACGCGGTCGTGCTCTCCCACGCCCATATCGATCACAGCGGCAATCTGCCCTCGCTCGTCAAACACGGCTTTTCCGGC
CCGATTTATTCCACCCCCGCATCCAACGACCTCTGCGGCTGGATGCTGCGCGACACCGCCCACATCCAGGAGAAGGACGC
GGAGTTCCTGAACAAGCGCCTCGAAAAACGGCACGCCGCCGGGCTCCCTAACGGCGTGGTGGAACCGCTGTACGACACCG
CCGACGTAGAGCGCACCCTCCCGCTTTTCGCGCCTGTGCCGTACCACACGCCCCTCGCCATATCGGACCACCTGAGTTAC
GAGTCTTATGACGCCGGCCACATTCTGGGTTCGTCCTGCGTGATCCTCCACGATACCGCGGGCAGCGTTCCAGTCCGCCT
CGCCTTCTCGGGTGATGTGGGCCGCCCCGGCCTGCCCATCATCCGCGACCCCGAAGTGATGCCCCCGGCCGACTACCTGA
TCATGGAGAGCACCTACGGCGGGCGTCTGCACAAGCAGTCAGGTCACGTCATCAACAAACTTGCCGATGTCGTAACGCGC
ACCGCCAAGCGCGGCGGACGCATCATCGTCCCTGCCTTCGCTGTGGGCCGTACCCAGCAACTCGTGCTGCTCCTGCATCA
GTTGTTCAACGAGAAGCGAATTCCCAACATCCCGATCTTCGTGGATAGCCCCCTGGCTTTAAATGTGACTGCCGTCCACC
GCGCTCATCCCGAATGCTTCGATGAGGATACCCGCCGTTACCTGACCGACGGCGAAGATCCCTTCGGATTCCGCCGCCTG
CAATACATCCGCGAGGCCTCCGAGTCGAAGAAGCTCAACGATTTGCACGGCCCCTTCGTGGTCGTCTCCTCCTCGGGAAT
GTGTGAAGCGGGTCGCATTCTGCACCACCTGCGTAACAATATTGAGGATCCGCGCAACACCATCCTCATCACAGGTTTCC
AGGCGCAGGATACTTTGGGCCGGAAACTGGTCGAAAAATGGCCGGAGGTGAAGATCTTCGGCGAGCCCATGCGCGTCCGT
GCCGAGATCTCCAGCCTCGATGAGCTCAGCGGCCACGCCGACCAGAACGAACTGTTAGAGTGGATTAGACCAATGGTTCC
CGCACTCCGCAAGGTCTTTCTGGTGCACGGGGAGGCGCAGCAATCGCAGACCCTCGCCAAACTCCTGCACGATCGCTACG
GCCTGGAAGCGGTATGCCCAACCCCCGGCCAGAGCTTTGAAGTGAGTTAA

Upstream 100 bases:

>100_bases
ACGCAAGCCGCCCGGAACAGGCAGCCCCGCGGCCGCGCAACCGTCCACGAGTTCCCCCGTCCCGCGTGAGTTCCTGCACG
ATGCGCTACCATGAGCGCTG

Downstream 100 bases:

>100_bases
GTGAAACCGAAAACACCCGAATCTCCATCTATACTGTAAGGAAACCAAAGGAGTACCGTTACGTGAGTCCTCAACCGATC
TATCAGCAGCCGTCCCCGCA

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MKLTFWGAAGTVTGSMHLVETGGKRYLLDCGLAQGRRKEADAKNRNLPFSGSSIDAVVLSHAHIDHSGNLPSLVKHGFSG
PIYSTPASNDLCGWMLRDTAHIQEKDAEFLNKRLEKRHAAGLPNGVVEPLYDTADVERTLPLFAPVPYHTPLAISDHLSY
ESYDAGHILGSSCVILHDTAGSVPVRLAFSGDVGRPGLPIIRDPEVMPPADYLIMESTYGGRLHKQSGHVINKLADVVTR
TAKRGGRIIVPAFAVGRTQQLVLLLHQLFNEKRIPNIPIFVDSPLALNVTAVHRAHPECFDEDTRRYLTDGEDPFGFRRL
QYIREASESKKLNDLHGPFVVVSSSGMCEAGRILHHLRNNIEDPRNTILITGFQAQDTLGRKLVEKWPEVKIFGEPMRVR
AEISSLDELSGHADQNELLEWIRPMVPALRKVFLVHGEAQQSQTLAKLLHDRYGLEAVCPTPGQSFEVS

Sequences:

>Translated_469_residues
MKLTFWGAAGTVTGSMHLVETGGKRYLLDCGLAQGRRKEADAKNRNLPFSGSSIDAVVLSHAHIDHSGNLPSLVKHGFSG
PIYSTPASNDLCGWMLRDTAHIQEKDAEFLNKRLEKRHAAGLPNGVVEPLYDTADVERTLPLFAPVPYHTPLAISDHLSY
ESYDAGHILGSSCVILHDTAGSVPVRLAFSGDVGRPGLPIIRDPEVMPPADYLIMESTYGGRLHKQSGHVINKLADVVTR
TAKRGGRIIVPAFAVGRTQQLVLLLHQLFNEKRIPNIPIFVDSPLALNVTAVHRAHPECFDEDTRRYLTDGEDPFGFRRL
QYIREASESKKLNDLHGPFVVVSSSGMCEAGRILHHLRNNIEDPRNTILITGFQAQDTLGRKLVEKWPEVKIFGEPMRVR
AEISSLDELSGHADQNELLEWIRPMVPALRKVFLVHGEAQQSQTLAKLLHDRYGLEAVCPTPGQSFEVS
>Mature_469_residues
MKLTFWGAAGTVTGSMHLVETGGKRYLLDCGLAQGRRKEADAKNRNLPFSGSSIDAVVLSHAHIDHSGNLPSLVKHGFSG
PIYSTPASNDLCGWMLRDTAHIQEKDAEFLNKRLEKRHAAGLPNGVVEPLYDTADVERTLPLFAPVPYHTPLAISDHLSY
ESYDAGHILGSSCVILHDTAGSVPVRLAFSGDVGRPGLPIIRDPEVMPPADYLIMESTYGGRLHKQSGHVINKLADVVTR
TAKRGGRIIVPAFAVGRTQQLVLLLHQLFNEKRIPNIPIFVDSPLALNVTAVHRAHPECFDEDTRRYLTDGEDPFGFRRL
QYIREASESKKLNDLHGPFVVVSSSGMCEAGRILHHLRNNIEDPRNTILITGFQAQDTLGRKLVEKWPEVKIFGEPMRVR
AEISSLDELSGHADQNELLEWIRPMVPALRKVFLVHGEAQQSQTLAKLLHDRYGLEAVCPTPGQSFEVS

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=457, Percent_Identity=27.5711159737418, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI33300633, Length=487, Percent_Identity=24.6406570841889, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI32564696, Length=478, Percent_Identity=24.6861924686192, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32566029, Length=453, Percent_Identity=26.2693156732892, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323307, Length=459, Percent_Identity=26.5795206971678, Blast_Score=156, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24648013, Length=460, Percent_Identity=28.0434782608696, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21358523, Length=488, Percent_Identity=25, Blast_Score=140, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 51871; Mature: 51871

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTFWGAAGTVTGSMHLVETGGKRYLLDCGLAQGRRKEADAKNRNLPFSGSSIDAVVLS
CEEEEEECCCCEECCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
HAHIDHSGNLPSLVKHGFSGPIYSTPASNDLCGWMLRDTAHIQEKDAEFLNKRLEKRHAA
HEECCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLPNGVVEPLYDTADVERTLPLFAPVPYHTPLAISDHLSYESYDAGHILGSSCVILHDTA
CCCCCCHHCCCCHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEECC
GSVPVRLAFSGDVGRPGLPIIRDPEVMPPADYLIMESTYGGRLHKQSGHVINKLADVVTR
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCHHHHHHHHHHHH
TAKRGGRIIVPAFAVGRTQQLVLLLHQLFNEKRIPNIPIFVDSPLALNVTAVHRAHPECF
HHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEHHHCCCHHC
DEDTRRYLTDGEDPFGFRRLQYIREASESKKLNDLHGPFVVVSSSGMCEAGRILHHLRNN
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCEEEEECCCCCHHHHHHHHHHHC
IEDPRNTILITGFQAQDTLGRKLVEKWPEVKIFGEPMRVRAEISSLDELSGHADQNELLE
CCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEECCCCEEHHHHHHHHHHCCCCCHHHHHH
WIRPMVPALRKVFLVHGEAQQSQTLAKLLHDRYGLEAVCPTPGQSFEVS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCC
>Mature Secondary Structure
MKLTFWGAAGTVTGSMHLVETGGKRYLLDCGLAQGRRKEADAKNRNLPFSGSSIDAVVLS
CEEEEEECCCCEECCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEE
HAHIDHSGNLPSLVKHGFSGPIYSTPASNDLCGWMLRDTAHIQEKDAEFLNKRLEKRHAA
HEECCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLPNGVVEPLYDTADVERTLPLFAPVPYHTPLAISDHLSYESYDAGHILGSSCVILHDTA
CCCCCCHHCCCCHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEECC
GSVPVRLAFSGDVGRPGLPIIRDPEVMPPADYLIMESTYGGRLHKQSGHVINKLADVVTR
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCHHHHHHHHHHHH
TAKRGGRIIVPAFAVGRTQQLVLLLHQLFNEKRIPNIPIFVDSPLALNVTAVHRAHPECF
HHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEHHHCCCHHC
DEDTRRYLTDGEDPFGFRRLQYIREASESKKLNDLHGPFVVVSSSGMCEAGRILHHLRNN
CHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCEEEEECCCCCHHHHHHHHHHHC
IEDPRNTILITGFQAQDTLGRKLVEKWPEVKIFGEPMRVRAEISSLDELSGHADQNELLE
CCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEECCCCEEHHHHHHHHHHCCCCCHHHHHH
WIRPMVPALRKVFLVHGEAQQSQTLAKLLHDRYGLEAVCPTPGQSFEVS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA