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The map label for this gene is hemE [H]

Identifier: 116621786

GI number: 116621786

Start: 3381999

End: 3383072

Strand: Direct

Name: hemE [H]

Synonym: Acid_2668

Alternate gene names: 116621786

Gene position: 3381999-3383072 (Clockwise)

Preceding gene: 116621779

Following gene: 116621787

Centisome position: 33.94

GC content: 58.85

Gene sequence:

>1074_bases
ATGCTGCCCGATCAATGGGAAACGTTTAAACGCGCCGCGCGCCGCGAGAAGATGGACCGGATACCGATGGCGCTCATCGT
GGACAGTCCCTGGATTCCAGGTTATCTGGGCATTAAGCATATGGACTATTATCTCGACCCCGAGTTGTGGTTCGAGTCCA
ACCTCAAGATCATGCGCGAGTTCCCCGATATCATTTTCATTCCGTCGTGGTGGATGGAGTACGGGATGGCGGCCGAGCCT
TCCATCCTCGGGGCCAAGATCAAGTTCTGGCAGGATAATACTCCGAGCGAGTATCACACGCTGTATCGACTGGAAGATAT
CGACAATTTCCCGGAGTATGAGGTGGACGCCGATGCCTTCGCGGCGCTGACGCTGCATCGGATCAAGATGATTAAGCCGC
GCATCGAAGATCTAGGCTATATCCTGCCGATGGTCACGGCGCGGGGACCGCTGTGCACGGCGGGCTTTGTGCGCGGCACC
ACGCACTTCATGATCGACATCGTGGAAGATCCGAAGGGCGCGCACCGACTGATCGACCTGTGCACGCGCGTGGTCATCGA
CTGGTTGAAGGCGCAGCAGGCGGTGATGGGCGACAAGGTGGAAGGCATCTTCATTCTGGACGACATTGTCGGCTTTATCA
ACGAAGAGCATTACCTGGAGTTCGCGCATCCTTACCTGAAGCGCATCTGCGATGCCTTCCCCGACAATTGGGTCAAGCTT
TATCACAACGATGCCGAGGTGGATGCGTGCCTGGATCACCTTCCGGACGCCGGCTTCAACGTGCTGAATTGGGGCAAGCA
GCGGCACATCACCGAAGTCAAGCGGCGCGTCGGGGATCGGATGTGCCTGATGGGGAACGTCAATCCGCTCGAGATCGCGG
TTCGCGGCACGCCCGAGGAAGTGAAGGATGAGACGTTGGAAGTGCTCGAAGGGGCGGGCGGCGAAGGCATCATTCTTTCC
GTGGGCGGCGGCGTCAGCCCCGGAATGCCGCGCGAGAATATACTGGCGATGCTGGAAGCGCTCCAGGAGTTCAACTCCAA
GCGTGCGGCCGCCATGGCTGCGAGCGTCCGGTAA

Upstream 100 bases:

>100_bases
CGGGACCGTGACCGTGGTCGCGCGAATATCCCGGATTTTCATAATTTGTTTCATGGTACAACAATATTCAGTTAGAGCCT
TTGAAACGGAAAGGAACCTT

Downstream 100 bases:

>100_bases
CGGGAGACTGGCATGGTGGATTACGCGCTGATGAACCAATACCTCTACGAGGGGAACGCCGCCGAAGTAGAGAAGATGAC
GCGCGACGCGTTGGTGGAGG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MLPDQWETFKRAARREKMDRIPMALIVDSPWIPGYLGIKHMDYYLDPELWFESNLKIMREFPDIIFIPSWWMEYGMAAEP
SILGAKIKFWQDNTPSEYHTLYRLEDIDNFPEYEVDADAFAALTLHRIKMIKPRIEDLGYILPMVTARGPLCTAGFVRGT
THFMIDIVEDPKGAHRLIDLCTRVVIDWLKAQQAVMGDKVEGIFILDDIVGFINEEHYLEFAHPYLKRICDAFPDNWVKL
YHNDAEVDACLDHLPDAGFNVLNWGKQRHITEVKRRVGDRMCLMGNVNPLEIAVRGTPEEVKDETLEVLEGAGGEGIILS
VGGGVSPGMPRENILAMLEALQEFNSKRAAAMAASVR

Sequences:

>Translated_357_residues
MLPDQWETFKRAARREKMDRIPMALIVDSPWIPGYLGIKHMDYYLDPELWFESNLKIMREFPDIIFIPSWWMEYGMAAEP
SILGAKIKFWQDNTPSEYHTLYRLEDIDNFPEYEVDADAFAALTLHRIKMIKPRIEDLGYILPMVTARGPLCTAGFVRGT
THFMIDIVEDPKGAHRLIDLCTRVVIDWLKAQQAVMGDKVEGIFILDDIVGFINEEHYLEFAHPYLKRICDAFPDNWVKL
YHNDAEVDACLDHLPDAGFNVLNWGKQRHITEVKRRVGDRMCLMGNVNPLEIAVRGTPEEVKDETLEVLEGAGGEGIILS
VGGGVSPGMPRENILAMLEALQEFNSKRAAAMAASVR
>Mature_357_residues
MLPDQWETFKRAARREKMDRIPMALIVDSPWIPGYLGIKHMDYYLDPELWFESNLKIMREFPDIIFIPSWWMEYGMAAEP
SILGAKIKFWQDNTPSEYHTLYRLEDIDNFPEYEVDADAFAALTLHRIKMIKPRIEDLGYILPMVTARGPLCTAGFVRGT
THFMIDIVEDPKGAHRLIDLCTRVVIDWLKAQQAVMGDKVEGIFILDDIVGFINEEHYLEFAHPYLKRICDAFPDNWVKL
YHNDAEVDACLDHLPDAGFNVLNWGKQRHITEVKRRVGDRMCLMGNVNPLEIAVRGTPEEVKDETLEVLEGAGGEGIILS
VGGGVSPGMPRENILAMLEALQEFNSKRAAAMAASVR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Escherichia coli, GI2367337, Length=362, Percent_Identity=21.2707182320442, Blast_Score=68, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19921920, Length=353, Percent_Identity=22.3796033994334, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI221330099, Length=353, Percent_Identity=22.3796033994334, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 40740; Mature: 40740

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPDQWETFKRAARREKMDRIPMALIVDSPWIPGYLGIKHMDYYLDPELWFESNLKIMRE
CCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHCHHHHHEEECCHHHHCCCHHHHHH
FPDIIFIPSWWMEYGMAAEPSILGAKIKFWQDNTPSEYHTLYRLEDIDNFPEYEVDADAF
CCCEEEECCHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHEEECCCCCCCCCCCCHHHH
AALTLHRIKMIKPRIEDLGYILPMVTARGPLCTAGFVRGTTHFMIDIVEDPKGAHRLIDL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCEEEEEEEECCCCHHHHHHHH
CTRVVIDWLKAQQAVMGDKVEGIFILDDIVGFINEEHYLEFAHPYLKRICDAFPDNWVKL
HHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEE
YHNDAEVDACLDHLPDAGFNVLNWGKQRHITEVKRRVGDRMCLMGNVNPLEIAVRGTPEE
ECCCCHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCHH
VKDETLEVLEGAGGEGIILSVGGGVSPGMPRENILAMLEALQEFNSKRAAAMAASVR
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MLPDQWETFKRAARREKMDRIPMALIVDSPWIPGYLGIKHMDYYLDPELWFESNLKIMRE
CCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHCHHHHHEEECCHHHHCCCHHHHHH
FPDIIFIPSWWMEYGMAAEPSILGAKIKFWQDNTPSEYHTLYRLEDIDNFPEYEVDADAF
CCCEEEECCHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHEEECCCCCCCCCCCCHHHH
AALTLHRIKMIKPRIEDLGYILPMVTARGPLCTAGFVRGTTHFMIDIVEDPKGAHRLIDL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCEEEEEEEECCCCHHHHHHHH
CTRVVIDWLKAQQAVMGDKVEGIFILDDIVGFINEEHYLEFAHPYLKRICDAFPDNWVKL
HHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEE
YHNDAEVDACLDHLPDAGFNVLNWGKQRHITEVKRRVGDRMCLMGNVNPLEIAVRGTPEE
ECCCCHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCHH
VKDETLEVLEGAGGEGIILSVGGGVSPGMPRENILAMLEALQEFNSKRAAAMAASVR
HHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA