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The map label for this gene is mdtA [H]

Identifier: 116621768

GI number: 116621768

Start: 3355253

End: 3356470

Strand: Reverse

Name: mdtA [H]

Synonym: Acid_2650

Alternate gene names: 116621768

Gene position: 3356470-3355253 (Counterclockwise)

Preceding gene: 116621770

Following gene: 116621767

Centisome position: 33.68

GC content: 65.44

Gene sequence:

>1218_bases
GTGCCGGGTATCAATCGTTGTACCGCGACTCTGTTGTCCGTAGTCTGCCTTTTTACGCTTGCGGCGTGTAAGCCGGCGCA
GCAGGCCAAGGGGCCGGCGGCTCCGGCTGTGGTCCCTGTCTCCGTTGCGAAGGCGACCCAGGAATCCGTGCCGACCGAGC
TTCGCGTGGTCGGCACCGTGGAAGCCTCCGCCATTGTGCAGGTCAAATCGCAGATCGCCGGCCAGCTCTTGAAGGCGGCG
TTCACCGAAGGCCAGAACGTAAAGAAGGACGACCTGCTCTTCGAGATCGATCCGCGTCCGTACGAGGAAGCGCTGCACCA
GGCCGAGGCCAACGTCTCGCGCGACCAGGCGCAGATCGCCCAACTGGAAGCGACCCTGGCACGCGACGCAGCGCAGTCCC
GGTTCAACGAGGGCGACGCCGCGCGCTACGCCGAACTCGCCAAGGCCGGCGTGGTCTCGAAGTCGCAGTCGGACCAGGCG
CGCACCAGCGCCGATGTCGCGCGCGAATCAGCCCGCGCGACACAGGCCGGCATCAACAGCGCTAAGGCCGCGCTCGAGAG
CGATGTCTCCGCGGTCGCCTCTGCCAAGCTGAATCTAGCCTACTGCACCATTCGTTCGCCGCTCAGCGGGCGCACCGGCA
ACCTGCTCATCCACGCCGGCAATCTGGTCAAGGCCAACGACGTTCCGCTGGTAGTTATCCACCAGGTGTCGCCGGTCTTC
GTGAACTTCAACGTGCCCGAGCAGCATCTGGCCGCGGTGCGCCGCCTCAGCGCCAACCGCAAGCTGGCCGTCCGGGTCTT
CGCGCAGGACGACCCGAACCGCACCGCGTCCGGCGAGCTCTCCGTGATTGATAACACCGTGGATGCATCCACCGGCACGA
TTCATCTCAAGGCGACCTTCCCCAACACCGACGGCATTCTCTGGCCCGGCCAGTTCGTGACTTCCGTGCTCACGCTCGAC
ACTCTGCAAGGCGCTACCGTGGTTCCGGCGGAGGCGGTGCAGCCCGGCCAGCAGGGGCAGTTCGTGTATGTGGTGAAGGC
GGACAACACCGTGGAGTCTCGGATCGTCACTCCCGGCCGCGCCTTCGGCAAGAAGATGGTGATCGAGAAGGGACTCGCTC
CCGGCGATACCGTGGTCACCGATGGCCAACTGCGCCTCTTCCCGGGCGCGCAAGTGCAGCTCGTCGATCCCTCGAAGATC
GACATGGGGAAGTCATGA

Upstream 100 bases:

>100_bases
CGCCGGCGCGCGTCTAATCCTGAATACCAGTAGCTCCGACTATCTGATAGACTGCGAAGAATAGGCGAAAGTCTCAATCT
GTAACCGGGAGTCATTCATC

Downstream 100 bases:

>100_bases
ACCTCTCGCGCATCTTCATCGAGCGCCCGGTGATGACGGCGCTCATCTGCTTCGCCATTCTGCTGTTCGGCACCATCGCC
TTCCGCGCGCTGCCGGTGGC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MPGINRCTATLLSVVCLFTLAACKPAQQAKGPAAPAVVPVSVAKATQESVPTELRVVGTVEASAIVQVKSQIAGQLLKAA
FTEGQNVKKDDLLFEIDPRPYEEALHQAEANVSRDQAQIAQLEATLARDAAQSRFNEGDAARYAELAKAGVVSKSQSDQA
RTSADVARESARATQAGINSAKAALESDVSAVASAKLNLAYCTIRSPLSGRTGNLLIHAGNLVKANDVPLVVIHQVSPVF
VNFNVPEQHLAAVRRLSANRKLAVRVFAQDDPNRTASGELSVIDNTVDASTGTIHLKATFPNTDGILWPGQFVTSVLTLD
TLQGATVVPAEAVQPGQQGQFVYVVKADNTVESRIVTPGRAFGKKMVIEKGLAPGDTVVTDGQLRLFPGAQVQLVDPSKI
DMGKS

Sequences:

>Translated_405_residues
MPGINRCTATLLSVVCLFTLAACKPAQQAKGPAAPAVVPVSVAKATQESVPTELRVVGTVEASAIVQVKSQIAGQLLKAA
FTEGQNVKKDDLLFEIDPRPYEEALHQAEANVSRDQAQIAQLEATLARDAAQSRFNEGDAARYAELAKAGVVSKSQSDQA
RTSADVARESARATQAGINSAKAALESDVSAVASAKLNLAYCTIRSPLSGRTGNLLIHAGNLVKANDVPLVVIHQVSPVF
VNFNVPEQHLAAVRRLSANRKLAVRVFAQDDPNRTASGELSVIDNTVDASTGTIHLKATFPNTDGILWPGQFVTSVLTLD
TLQGATVVPAEAVQPGQQGQFVYVVKADNTVESRIVTPGRAFGKKMVIEKGLAPGDTVVTDGQLRLFPGAQVQLVDPSKI
DMGKS
>Mature_404_residues
PGINRCTATLLSVVCLFTLAACKPAQQAKGPAAPAVVPVSVAKATQESVPTELRVVGTVEASAIVQVKSQIAGQLLKAAF
TEGQNVKKDDLLFEIDPRPYEEALHQAEANVSRDQAQIAQLEATLARDAAQSRFNEGDAARYAELAKAGVVSKSQSDQAR
TSADVARESARATQAGINSAKAALESDVSAVASAKLNLAYCTIRSPLSGRTGNLLIHAGNLVKANDVPLVVIHQVSPVFV
NFNVPEQHLAAVRRLSANRKLAVRVFAQDDPNRTASGELSVIDNTVDASTGTIHLKATFPNTDGILWPGQFVTSVLTLDT
LQGATVVPAEAVQPGQQGQFVYVVKADNTVESRIVTPGRAFGKKMVIEKGLAPGDTVVTDGQLRLFPGAQVQLVDPSKID
MGKS

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=383, Percent_Identity=36.8146214099217, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1789929, Length=409, Percent_Identity=28.1173594132029, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1786668, Length=399, Percent_Identity=32.0802005012531, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1789665, Length=383, Percent_Identity=28.4595300261097, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1790519, Length=216, Percent_Identity=29.1666666666667, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI87081796, Length=327, Percent_Identity=26.605504587156, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42672; Mature: 42541

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGINRCTATLLSVVCLFTLAACKPAQQAKGPAAPAVVPVSVAKATQESVPTELRVVGTV
CCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEHHHHHHHHHHCCCEEEEEEEC
EASAIVQVKSQIAGQLLKAAFTEGQNVKKDDLLFEIDPRPYEEALHQAEANVSRDQAQIA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHH
QLEATLARDAAQSRFNEGDAARYAELAKAGVVSKSQSDQARTSADVARESARATQAGINS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHH
AKAALESDVSAVASAKLNLAYCTIRSPLSGRTGNLLIHAGNLVKANDVPLVVIHQVSPVF
HHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCEEEEECCEEEECCCCEEEEECCCEEE
VNFNVPEQHLAAVRRLSANRKLAVRVFAQDDPNRTASGELSVIDNTVDASTGTIHLKATF
EECCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCEEEEEEEC
PNTDGILWPGQFVTSVLTLDTLQGATVVPAEAVQPGQQGQFVYVVKADNTVESRIVTPGR
CCCCCEEECHHHHHHHHHHHHCCCCEECCHHHCCCCCCCCEEEEEECCCCCHHEECCCCH
AFGKKMVIEKGLAPGDTVVTDGQLRLFPGAQVQLVDPSKIDMGKS
HHHHHHHHHCCCCCCCCEEECCEEEECCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
PGINRCTATLLSVVCLFTLAACKPAQQAKGPAAPAVVPVSVAKATQESVPTELRVVGTV
CCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEHHHHHHHHHHCCCEEEEEEEC
EASAIVQVKSQIAGQLLKAAFTEGQNVKKDDLLFEIDPRPYEEALHQAEANVSRDQAQIA
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHH
QLEATLARDAAQSRFNEGDAARYAELAKAGVVSKSQSDQARTSADVARESARATQAGINS
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHH
AKAALESDVSAVASAKLNLAYCTIRSPLSGRTGNLLIHAGNLVKANDVPLVVIHQVSPVF
HHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCCEEEEECCEEEECCCCEEEEECCCEEE
VNFNVPEQHLAAVRRLSANRKLAVRVFAQDDPNRTASGELSVIDNTVDASTGTIHLKATF
EECCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEEECCCCCCCCEEEEEEEC
PNTDGILWPGQFVTSVLTLDTLQGATVVPAEAVQPGQQGQFVYVVKADNTVESRIVTPGR
CCCCCEEECHHHHHHHHHHHHCCCCEECCHHHCCCCCCCCEEEEEECCCCCHHEECCCCH
AFGKKMVIEKGLAPGDTVVTDGQLRLFPGAQVQLVDPSKIDMGKS
HHHHHHHHHCCCCCCCCEEECCEEEECCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA