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The map label for this gene is aslA [H]

Identifier: 116621698

GI number: 116621698

Start: 3261602

End: 3263116

Strand: Direct

Name: aslA [H]

Synonym: Acid_2580

Alternate gene names: 116621698

Gene position: 3261602-3263116 (Clockwise)

Preceding gene: 116621686

Following gene: 116621700

Centisome position: 32.73

GC content: 65.02

Gene sequence:

>1515_bases
ATGAACCGACGCCAGTTTCTCTGTGCCCCGCTGCCCCTGCTCACCGCTTCGCGCGCATTTGCCGCCGCAAAGCCGCCGAA
CATCGTCTATATGTACGCCGACGACCTGGGCTATGGCGATACCAGCTGCTACGGCGCCACGCGGGTCAAGACGCCGAACC
TGGATCGCGCCGCAGCAGCCGGCATCCGCTTCACCAACGCGCATTCCTCGTCGGCCACCTGCACGCCGTCGCGCTATTCG
CTGCTGACCGGCGAATATGCCTGGCGCCACCAGGGCACGGGCGTGCTGCCGGGCGACGCGTCCCTGATCGTCCAGCCCGG
CCGCTACACGCTGCCCGCCATGCTTCAGCAGGCCGGCTACCGCACCGGCGCAGTCGGCAAATGGCACCTCGGCCTGGGCG
GACGCGACCTCGATTGGAACGGCGAGATCCGACCCGGCCCGCTCGAAGTCGGCTTCGACTACTCCTTCATTTTCCCTGCT
ACCGGGGATCGCGTGCCCTGCGTCTTCGTCGAGAATCGCAAGGTGGTCAATCTCGATCCCAACGACCCGCTCCGCGTGAG
GTACGACAAGCCATTCCCCGGCGAGCCCACCGGCGCAGCCAACCCCGAGCTGCTGAAGATGAAGCCGAGCCACGGCCACG
ACAACACCATCGTCAACGGCATCAGCCGCATCGGCTACATGGCCGGGGGAAAATCGGCGCGATGGGTGGACGAAGATATG
GCCGATACCATCACGGGCAAGGCCGTCTCTTTCCTGGAACAGAATCGCGCGCGTCCCTTCTTTCTCTATTTCGCGACCCA
CGATATCCATGTGCCGCGTGTTCCTCATCCGCGCTTCGTGGGCAAGACCGACATGGGACCGCGCGGCGACGCCATCGCCG
AGCTCGACTGGTCCATCGGCCGCATTCTCGATACACTCGATCGCCTCAAATTAACCCGCAACACGCTCTTCGTTTTCTCC
AGCGACAATGGCCCGGTGGTGGACGACGGCTATCGCGATCAGGCCGTCGAACGTCTCGGCGATCACCATCCCGCGGGCCC
GTTGCGCGGCGGCAAATATAGCGCCTACGATGGCGGCACGCGGATTCCGTTTGTGGTGCGCTGGCCGGGCACGGTCAAGC
CCGGCATCTCCGCCGCGCCCATCAGCCAGGTGGATCTGCTCGCCAGCTTCGCGGCGCTCACCGGCCGCAAACTGCCCGAA
ACTGCCGCGCCCGACAGCTTTAATGTGCTGCCCGCGCTACTCGGCAAGACGAAGCAAGGCAGGCCGCACATCGTGGAGCA
CGCGACCGCGCTCTCGCTGATCGCCGGCGATTGGAAGGTGATCCGGCCGCACACGGGTCCCCGTCGCAATCAGACCGGCA
ACGAGATCGGCAACGATCCGGAGCCGCAATTGTTCGACCTGGCTCACGATATCGGCGAACAGAATAACGTTGCGCCGCAG
CATCCGGAGAAGGTGCAGGAGTTGCTGGGGATGTTGGCGCAGATTGAGAAGTCGCCCCGTACGCGGCCCGAGTAG

Upstream 100 bases:

>100_bases
CAATGCACGAATTTCAGACATGGTCGTAGGATGCACCCTGGCGTTTCGCCGATTCAATCTCTCATTCTGCTATGGTGAAT
CGGAATCCGGTGACCACCCC

Downstream 100 bases:

>100_bases
CATGGGTCTCCGGCGTGCACCGACTTGCCAGGTGTTTCTTATTGGATCGGGTGTGCGTGGCAAGTCAGGAAGCCGGCTGA
AAGCCGGCTGCAGGCAAAAT

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MNRRQFLCAPLPLLTASRAFAAAKPPNIVYMYADDLGYGDTSCYGATRVKTPNLDRAAAAGIRFTNAHSSSATCTPSRYS
LLTGEYAWRHQGTGVLPGDASLIVQPGRYTLPAMLQQAGYRTGAVGKWHLGLGGRDLDWNGEIRPGPLEVGFDYSFIFPA
TGDRVPCVFVENRKVVNLDPNDPLRVRYDKPFPGEPTGAANPELLKMKPSHGHDNTIVNGISRIGYMAGGKSARWVDEDM
ADTITGKAVSFLEQNRARPFFLYFATHDIHVPRVPHPRFVGKTDMGPRGDAIAELDWSIGRILDTLDRLKLTRNTLFVFS
SDNGPVVDDGYRDQAVERLGDHHPAGPLRGGKYSAYDGGTRIPFVVRWPGTVKPGISAAPISQVDLLASFAALTGRKLPE
TAAPDSFNVLPALLGKTKQGRPHIVEHATALSLIAGDWKVIRPHTGPRRNQTGNEIGNDPEPQLFDLAHDIGEQNNVAPQ
HPEKVQELLGMLAQIEKSPRTRPE

Sequences:

>Translated_504_residues
MNRRQFLCAPLPLLTASRAFAAAKPPNIVYMYADDLGYGDTSCYGATRVKTPNLDRAAAAGIRFTNAHSSSATCTPSRYS
LLTGEYAWRHQGTGVLPGDASLIVQPGRYTLPAMLQQAGYRTGAVGKWHLGLGGRDLDWNGEIRPGPLEVGFDYSFIFPA
TGDRVPCVFVENRKVVNLDPNDPLRVRYDKPFPGEPTGAANPELLKMKPSHGHDNTIVNGISRIGYMAGGKSARWVDEDM
ADTITGKAVSFLEQNRARPFFLYFATHDIHVPRVPHPRFVGKTDMGPRGDAIAELDWSIGRILDTLDRLKLTRNTLFVFS
SDNGPVVDDGYRDQAVERLGDHHPAGPLRGGKYSAYDGGTRIPFVVRWPGTVKPGISAAPISQVDLLASFAALTGRKLPE
TAAPDSFNVLPALLGKTKQGRPHIVEHATALSLIAGDWKVIRPHTGPRRNQTGNEIGNDPEPQLFDLAHDIGEQNNVAPQ
HPEKVQELLGMLAQIEKSPRTRPE
>Mature_504_residues
MNRRQFLCAPLPLLTASRAFAAAKPPNIVYMYADDLGYGDTSCYGATRVKTPNLDRAAAAGIRFTNAHSSSATCTPSRYS
LLTGEYAWRHQGTGVLPGDASLIVQPGRYTLPAMLQQAGYRTGAVGKWHLGLGGRDLDWNGEIRPGPLEVGFDYSFIFPA
TGDRVPCVFVENRKVVNLDPNDPLRVRYDKPFPGEPTGAANPELLKMKPSHGHDNTIVNGISRIGYMAGGKSARWVDEDM
ADTITGKAVSFLEQNRARPFFLYFATHDIHVPRVPHPRFVGKTDMGPRGDAIAELDWSIGRILDTLDRLKLTRNTLFVFS
SDNGPVVDDGYRDQAVERLGDHHPAGPLRGGKYSAYDGGTRIPFVVRWPGTVKPGISAAPISQVDLLASFAALTGRKLPE
TAAPDSFNVLPALLGKTKQGRPHIVEHATALSLIAGDWKVIRPHTGPRRNQTGNEIGNDPEPQLFDLAHDIGEQNNVAPQ
HPEKVQELLGMLAQIEKSPRTRPE

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=477, Percent_Identity=31.8658280922432, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI146229329, Length=477, Percent_Identity=31.8658280922432, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI6005990, Length=477, Percent_Identity=31.8658280922432, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI146229324, Length=477, Percent_Identity=31.8658280922432, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI53831991, Length=540, Percent_Identity=28.1481481481481, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI157266309, Length=542, Percent_Identity=27.859778597786, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI58743319, Length=540, Percent_Identity=28.5185185185185, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4503899, Length=518, Percent_Identity=29.3436293436293, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI71852584, Length=520, Percent_Identity=28.0769230769231, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI45430057, Length=416, Percent_Identity=30.0480769230769, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI146229327, Length=384, Percent_Identity=28.6458333333333, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI71852586, Length=316, Percent_Identity=31.3291139240506, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI38569405, Length=529, Percent_Identity=23.8185255198488, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI38569407, Length=399, Percent_Identity=26.3157894736842, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI31742482, Length=165, Percent_Identity=36.3636363636364, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI59797060, Length=533, Percent_Identity=24.015009380863, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI109389362, Length=528, Percent_Identity=22.1590909090909, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4506919, Length=354, Percent_Identity=25.9887005649718, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790233, Length=422, Percent_Identity=28.436018957346, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1790112, Length=135, Percent_Identity=37.7777777777778, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI87081924, Length=193, Percent_Identity=27.979274611399, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533416, Length=510, Percent_Identity=25.0980392156863, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17559078, Length=278, Percent_Identity=28.7769784172662, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI115533418, Length=498, Percent_Identity=25.1004016064257, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24666175, Length=437, Percent_Identity=26.3157894736842, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI281366397, Length=463, Percent_Identity=25.9179265658747, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281366395, Length=463, Percent_Identity=25.9179265658747, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24666163, Length=463, Percent_Identity=25.9179265658747, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281363223, Length=462, Percent_Identity=24.8917748917749, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24666109, Length=140, Percent_Identity=38.5714285714286, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 55070; Mature: 55070

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRQFLCAPLPLLTASRAFAAAKPPNIVYMYADDLGYGDTSCYGATRVKTPNLDRAAAA
CCCCCEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCHHHHC
GIRFTNAHSSSATCTPSRYSLLTGEYAWRHQGTGVLPGDASLIVQPGRYTLPAMLQQAGY
CEEEECCCCCCCCCCCCCEEEEECCEEEECCCCEECCCCCEEEECCCCCCHHHHHHHCCC
RTGAVGKWHLGLGGRDLDWNGEIRPGPLEVGFDYSFIFPATGDRVPCVFVENRKVVNLDP
CCCCCEEEEECCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCEEEECCCEEEEECC
NDPLRVRYDKPFPGEPTGAANPELLKMKPSHGHDNTIVNGISRIGYMAGGKSARWVDEDM
CCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHH
ADTITGKAVSFLEQNRARPFFLYFATHDIHVPRVPHPRFVGKTDMGPRGDAIAELDWSIG
HHHHHHHHHHHHHHCCCCEEEEEEEECCEECCCCCCCCCCCCCCCCCCCCEEEECCHHHH
RILDTLDRLKLTRNTLFVFSSDNGPVVDDGYRDQAVERLGDHHPAGPLRGGKYSAYDGGT
HHHHHHHHHHEECCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCC
RIPFVVRWPGTVKPGISAAPISQVDLLASFAALTGRKLPETAAPDSFNVLPALLGKTKQG
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCC
RPHIVEHATALSLIAGDWKVIRPHTGPRRNQTGNEIGNDPEPQLFDLAHDIGEQNNVAPQ
CCHHHHHHHHHEEEECCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
HPEKVQELLGMLAQIEKSPRTRPE
CHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNRRQFLCAPLPLLTASRAFAAAKPPNIVYMYADDLGYGDTSCYGATRVKTPNLDRAAAA
CCCCCEEECCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCHHHHC
GIRFTNAHSSSATCTPSRYSLLTGEYAWRHQGTGVLPGDASLIVQPGRYTLPAMLQQAGY
CEEEECCCCCCCCCCCCCEEEEECCEEEECCCCEECCCCCEEEECCCCCCHHHHHHHCCC
RTGAVGKWHLGLGGRDLDWNGEIRPGPLEVGFDYSFIFPATGDRVPCVFVENRKVVNLDP
CCCCCEEEEECCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCCCEEEECCCEEEEECC
NDPLRVRYDKPFPGEPTGAANPELLKMKPSHGHDNTIVNGISRIGYMAGGKSARWVDEDM
CCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHH
ADTITGKAVSFLEQNRARPFFLYFATHDIHVPRVPHPRFVGKTDMGPRGDAIAELDWSIG
HHHHHHHHHHHHHHCCCCEEEEEEEECCEECCCCCCCCCCCCCCCCCCCCEEEECCHHHH
RILDTLDRLKLTRNTLFVFSSDNGPVVDDGYRDQAVERLGDHHPAGPLRGGKYSAYDGGT
HHHHHHHHHHEECCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCC
RIPFVVRWPGTVKPGISAAPISQVDLLASFAALTGRKLPETAAPDSFNVLPALLGKTKQG
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCC
RPHIVEHATALSLIAGDWKVIRPHTGPRRNQTGNEIGNDPEPQLFDLAHDIGEQNNVAPQ
CCHHHHHHHHHEEEECCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
HPEKVQELLGMLAQIEKSPRTRPE
CHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]