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The map label for this gene is argH

Identifier: 116621622

GI number: 116621622

Start: 3177509

End: 3178891

Strand: Reverse

Name: argH

Synonym: Acid_2504

Alternate gene names: 116621622

Gene position: 3178891-3177509 (Counterclockwise)

Preceding gene: 116621623

Following gene: 116621621

Centisome position: 31.9

GC content: 64.57

Gene sequence:

>1383_bases
ATGAAACTCTGGGGAGGCCGTTTTGAATCCGGACCCGGCGAGGTTTTCGAGCGCTTCAGCGGCTCGCTCGATTTCGACCG
CCGCCTGATCGATTGCGATATCCGCGGCTCGCAGGCCTTTGCCCGCGCCCTCGAAAATGTGGGCATACTCACCGCCACTG
AGCGCGCCCAGATCGTCGAGGCATTCGATTCCATCCGCGCCGAATCCCTCTCGCCGGCTTTCTACGAAGGCGCCACCGAC
GAGGACGTCCACACTCTCGTCATCCGCAAACTAAAGGAACGCGCCGGCGCCGTCGCCGATAAGATCCACACCGGCCGCAG
CCGCAACGAACAAGTCTCGCTCGATACCCGCATGTGGCTCCGCGAAGAGAGCACCGATCTGCAGGCCCAGCTCTTCGCGG
TCATGGGCCGCCTGCTCGACCTCGCGGAAATGTATCCGCACGCCATCATCCCCGGCTATACCCACATGCGCCGCGCGCAG
GCCGTCCTCTGGCCACACTACCTGCTCGCCTATTTCGAAATGTTCCTGCGCGATTGGCATCGCTTCGGCGACGCCCGCCG
CCGCGCCAACGTCCTGCCTCTCGGCTCCGGCGCCCTCGCCGGCTCCGGCTTCCCGCTCGATCGCGAGGCGATGGCCCAAA
ACCTGGGCTTCGAAGGCATCACGCAGAACAGCATGGATGTCTCCGGCGATCGTGATTTCGCCCTCGACTTCCTCTACGCC
TGCACCGTCACCATGATCCACCTCAGCCGCCTCGCCGAGGATTGGATCCTCTACTCCAGCGAGGAATTCGGCTGGCTGGA
ACTCGGCGATGGCGTCACCTCCGGCTCCAGCCTCATGCCGCAGAAGAAGAACCCCGATTCGCTCGAGCTCATACGCGGTA
AGAGCGGACGCGTGGTCGGCTGCCTGACCTCCCTGCTCGTCACCATGAAAGGTCTCCCCATGACCTATAACCGCGACATG
CAGGAGGATAAGATCCCCATCTTCGATGCCGCCGACCAGCTTTCCGGCTCGCTCCTCATGACCTCCGCCGTCATCGAATC
CACGCGCCTCAACCCCGCGCGTCCGGCGGCCGCCGCCGAGGAATCCTGGGTCGTCGCCACCGATCTTGCCGAGGCCCTCG
CACGCGCCGGGACGCCTTTCCACCAGGCCCACCAGATCGTCGGCCGCTTCGTCCTCGAAAGCGTGCGCGCCAACAAGAAG
CCTTCCGATTGGACCGCCGAAGAAATGCACGCCTTCGCCCCCGAGTTCACACCGGATTTCGCCGCCCTGCTCAATCCCGC
GGAAGGCATGAAGTCCCGCGAAATCCCCGGCGGCACCGGAACGGCCGCCGTCGCCGCCGCGCTCGCTCACGCCCGCCAAT
TACTTGGAAAGTTGATCGTATGA

Upstream 100 bases:

>100_bases
ACTCACCCCTGACGTGAGCGCCCGACAGCGAACCGCGACCGTAAAGGAACCGATCTAAGATTATGACTATTCCGAACTAC
GCCCGTGCGTGCGGCCTTCT

Downstream 100 bases:

>100_bases
CCAAAAGCTACCGTCAAGGCCAGATCCTCAAACTCATCCGCGGCAAGCGGATCGGAACCCAGGATGAGCTCGCCCAGGAG
CTCAAGAGTCAGGGCATCGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MKLWGGRFESGPGEVFERFSGSLDFDRRLIDCDIRGSQAFARALENVGILTATERAQIVEAFDSIRAESLSPAFYEGATD
EDVHTLVIRKLKERAGAVADKIHTGRSRNEQVSLDTRMWLREESTDLQAQLFAVMGRLLDLAEMYPHAIIPGYTHMRRAQ
AVLWPHYLLAYFEMFLRDWHRFGDARRRANVLPLGSGALAGSGFPLDREAMAQNLGFEGITQNSMDVSGDRDFALDFLYA
CTVTMIHLSRLAEDWILYSSEEFGWLELGDGVTSGSSLMPQKKNPDSLELIRGKSGRVVGCLTSLLVTMKGLPMTYNRDM
QEDKIPIFDAADQLSGSLLMTSAVIESTRLNPARPAAAAEESWVVATDLAEALARAGTPFHQAHQIVGRFVLESVRANKK
PSDWTAEEMHAFAPEFTPDFAALLNPAEGMKSREIPGGTGTAAVAAALAHARQLLGKLIV

Sequences:

>Translated_460_residues
MKLWGGRFESGPGEVFERFSGSLDFDRRLIDCDIRGSQAFARALENVGILTATERAQIVEAFDSIRAESLSPAFYEGATD
EDVHTLVIRKLKERAGAVADKIHTGRSRNEQVSLDTRMWLREESTDLQAQLFAVMGRLLDLAEMYPHAIIPGYTHMRRAQ
AVLWPHYLLAYFEMFLRDWHRFGDARRRANVLPLGSGALAGSGFPLDREAMAQNLGFEGITQNSMDVSGDRDFALDFLYA
CTVTMIHLSRLAEDWILYSSEEFGWLELGDGVTSGSSLMPQKKNPDSLELIRGKSGRVVGCLTSLLVTMKGLPMTYNRDM
QEDKIPIFDAADQLSGSLLMTSAVIESTRLNPARPAAAAEESWVVATDLAEALARAGTPFHQAHQIVGRFVLESVRANKK
PSDWTAEEMHAFAPEFTPDFAALLNPAEGMKSREIPGGTGTAAVAAALAHARQLLGKLIV
>Mature_460_residues
MKLWGGRFESGPGEVFERFSGSLDFDRRLIDCDIRGSQAFARALENVGILTATERAQIVEAFDSIRAESLSPAFYEGATD
EDVHTLVIRKLKERAGAVADKIHTGRSRNEQVSLDTRMWLREESTDLQAQLFAVMGRLLDLAEMYPHAIIPGYTHMRRAQ
AVLWPHYLLAYFEMFLRDWHRFGDARRRANVLPLGSGALAGSGFPLDREAMAQNLGFEGITQNSMDVSGDRDFALDFLYA
CTVTMIHLSRLAEDWILYSSEEFGWLELGDGVTSGSSLMPQKKNPDSLELIRGKSGRVVGCLTSLLVTMKGLPMTYNRDM
QEDKIPIFDAADQLSGSLLMTSAVIESTRLNPARPAAAAEESWVVATDLAEALARAGTPFHQAHQIVGRFVLESVRANKK
PSDWTAEEMHAFAPEFTPDFAALLNPAEGMKSREIPGGTGTAAVAAALAHARQLLGKLIV

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=454, Percent_Identity=41.6299559471366, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI68303542, Length=454, Percent_Identity=41.6299559471366, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI68303549, Length=454, Percent_Identity=39.2070484581498, Blast_Score=342, Evalue=5e-94,
Organism=Homo sapiens, GI68303547, Length=454, Percent_Identity=38.9867841409692, Blast_Score=338, Evalue=5e-93,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=43.7636761487965, Blast_Score=381, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6321806, Length=457, Percent_Identity=40.0437636761488, Blast_Score=339, Evalue=6e-94,
Organism=Drosophila melanogaster, GI221473854, Length=447, Percent_Identity=40.9395973154362, Blast_Score=359, Evalue=2e-99,
Organism=Drosophila melanogaster, GI78706858, Length=447, Percent_Identity=40.9395973154362, Blast_Score=359, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_SOLUE (Q024T3)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_823778.1
- ProteinModelPortal:   Q024T3
- SMR:   Q024T3
- STRING:   Q024T3
- GeneID:   4429313
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_2504
- NMPDR:   fig|234267.9.peg.2397
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   Q024T3
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50724; Mature: 50724

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWGGRFESGPGEVFERFSGSLDFDRRLIDCDIRGSQAFARALENVGILTATERAQIVE
CCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEHHHHHHHH
AFDSIRAESLSPAFYEGATDEDVHTLVIRKLKERAGAVADKIHTGRSRNEQVSLDTRMWL
HHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
REESTDLQAQLFAVMGRLLDLAEMYPHAIIPGYTHMRRAQAVLWPHYLLAYFEMFLRDWH
HCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGDARRRANVLPLGSGALAGSGFPLDREAMAQNLGFEGITQNSMDVSGDRDFALDFLYA
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
CTVTMIHLSRLAEDWILYSSEEFGWLELGDGVTSGSSLMPQKKNPDSLELIRGKSGRVVG
HHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCCCCCCCCCCCCCHHHEEECCCCCHHH
CLTSLLVTMKGLPMTYNRDMQEDKIPIFDAADQLSGSLLMTSAVIESTRLNPARPAAAAE
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCC
ESWVVATDLAEALARAGTPFHQAHQIVGRFVLESVRANKKPSDWTAEEMHAFAPEFTPDF
CCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHH
AALLNPAEGMKSREIPGGTGTAAVAAALAHARQLLGKLIV
HHHCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLWGGRFESGPGEVFERFSGSLDFDRRLIDCDIRGSQAFARALENVGILTATERAQIVE
CCCCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEHHHHHHHH
AFDSIRAESLSPAFYEGATDEDVHTLVIRKLKERAGAVADKIHTGRSRNEQVSLDTRMWL
HHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
REESTDLQAQLFAVMGRLLDLAEMYPHAIIPGYTHMRRAQAVLWPHYLLAYFEMFLRDWH
HCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFGDARRRANVLPLGSGALAGSGFPLDREAMAQNLGFEGITQNSMDVSGDRDFALDFLYA
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
CTVTMIHLSRLAEDWILYSSEEFGWLELGDGVTSGSSLMPQKKNPDSLELIRGKSGRVVG
HHHHHHHHHHHHHHHHEECCCCCCEEECCCCCCCCCCCCCCCCCCCHHHEEECCCCCHHH
CLTSLLVTMKGLPMTYNRDMQEDKIPIFDAADQLSGSLLMTSAVIESTRLNPARPAAAAE
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCC
ESWVVATDLAEALARAGTPFHQAHQIVGRFVLESVRANKKPSDWTAEEMHAFAPEFTPDF
CCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCHHH
AALLNPAEGMKSREIPGGTGTAAVAAALAHARQLLGKLIV
HHHCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA