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The map label for this gene is dapE [H]

Identifier: 116621330

GI number: 116621330

Start: 2832557

End: 2833885

Strand: Direct

Name: dapE [H]

Synonym: Acid_2211

Alternate gene names: 116621330

Gene position: 2832557-2833885 (Clockwise)

Preceding gene: 116621328

Following gene: 116621331

Centisome position: 28.42

GC content: 65.16

Gene sequence:

>1329_bases
ATGGCGTTTGGGCAGCAGGGTGAAACCGCAAGCGACCTGGCGGCGCGCTACTTGCCGGAGCTGATCCGGCTCGACAGCAC
CAATCCTCCGGGAAACGAATCGCGGGTGGCGCGGTATTTGAAACAGGTGGCGGACCGGGAAGGGATTCCGGCGGAGCTGC
TGGGCAACGATCCCGAGCGGTTGAATTTCGTGGCGCGACTGAAGGGCACGGGAAAGCAGCGGCCGCTGCTGCTAATCGCG
CACAGCGACGTGGTGCCGGCGGACCGCTCGCAATGGTCGGTGGACCCGCTGGCGGCAATCGAAAAGAACGGGTACATCTA
CGGGCGCGGAGCAGAGGACGACAAACAGCTACTCGCGGCGGAACTCGCGGTGATGGTGGACCTGCACCGCCGCAAGGTGG
TGCTGGATCGCGACATCATTCTGCTTTCGGAATCGGACGAAGAGGCGGGCTCGCTCGGCGCGCTGTGGATGGTGGAGCAC
GCGTGGACGAAGATCGACGCGGAGTTCGCGCTGAATGAGTACTCGTACATCCTGCCGACGTCGTCGGGCGTGCCGGTGTT
TCAGATTCAGACAGCGGAGAAGGTGCCGACGCGCTTTAAGATGACGGCGCGCGGGACGGCCGGGCATGGGTCGCTGCCGC
GCGAGGACAATCCGGTGGAGCACCTGGCGCGGGCGATTTACCGGTTGAGCCAGGCGGACGAGCCGGTGAAGCTGAATGCC
ACCACTCGCGCGTACCTGGCGGCGATGGGCAAATTGCCGGACTACGCCTGGGTGGCTCCGCTGGTGGCGAGGCTGGAAGA
TCCGGCGACGGCATCGCGCACGGCCGATGAAATTCGCAAGCGCGATCCCGAGATCCACGCCATGCTGCGGACCACGGTAT
CGGCGACGATGTTGAGCGCGGGGACGAAGATCAACGTGATTCCAAATGTCGCGGAGGCCCAGCTGGATGGGCGCCGGCTC
CCGACGGAGACTCGCGAGGAAGTCTTCGAACGCTTCCGCAAGATCATCGACGACCCGGCGGTGACAATCGAGGCGACCAG
CAGCCAGCAGCCCTCGACCGAGCCGAGCTCGTTGACGTCGCCGCTGTATCGGGCGATGGAGAAGGTCTTCCACGAAGCGG
CGCCTAACGCGGTGGTAGTCCCGTTCCTGATGCGCGGGACAACCGATGGGGCCTACCTGCGCGCCAAGGGGATGGCGGTC
TACGGCGTGCCTCTGTTCCGCAAGGATGGCGAGCTGCGGATGCACGGCAACGACGAGCGCATCTCGCTCGAGAACCTGCG
GGCGGGGACGGAGTTGCTGGGAAAGATCGTGATGGAGGTGGCGAAGTGA

Upstream 100 bases:

>100_bases
GTGAAGGCTTGTTACAACGTACCGGGCAGCACGCGCTGGGCCAGATGGTAAAGTCGGATCTATGAATCGTCTCGTTTTAG
CCGCGCTGGGGTGCGCGGCG

Downstream 100 bases:

>100_bases
AGTGTGGAGTGCTGCTGGCGGCAGCGGCGTTGTCCGCGGCCGCCCAAGCTCCGGGGCCGCGGACGCTGCGGCTGGATTAC
GTCCACACCGGAACTGCGGC

Product: peptidase M20

Products: NA

Alternate protein names: SDAP desuccinylase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MAFGQQGETASDLAARYLPELIRLDSTNPPGNESRVARYLKQVADREGIPAELLGNDPERLNFVARLKGTGKQRPLLLIA
HSDVVPADRSQWSVDPLAAIEKNGYIYGRGAEDDKQLLAAELAVMVDLHRRKVVLDRDIILLSESDEEAGSLGALWMVEH
AWTKIDAEFALNEYSYILPTSSGVPVFQIQTAEKVPTRFKMTARGTAGHGSLPREDNPVEHLARAIYRLSQADEPVKLNA
TTRAYLAAMGKLPDYAWVAPLVARLEDPATASRTADEIRKRDPEIHAMLRTTVSATMLSAGTKINVIPNVAEAQLDGRRL
PTETREEVFERFRKIIDDPAVTIEATSSQQPSTEPSSLTSPLYRAMEKVFHEAAPNAVVVPFLMRGTTDGAYLRAKGMAV
YGVPLFRKDGELRMHGNDERISLENLRAGTELLGKIVMEVAK

Sequences:

>Translated_442_residues
MAFGQQGETASDLAARYLPELIRLDSTNPPGNESRVARYLKQVADREGIPAELLGNDPERLNFVARLKGTGKQRPLLLIA
HSDVVPADRSQWSVDPLAAIEKNGYIYGRGAEDDKQLLAAELAVMVDLHRRKVVLDRDIILLSESDEEAGSLGALWMVEH
AWTKIDAEFALNEYSYILPTSSGVPVFQIQTAEKVPTRFKMTARGTAGHGSLPREDNPVEHLARAIYRLSQADEPVKLNA
TTRAYLAAMGKLPDYAWVAPLVARLEDPATASRTADEIRKRDPEIHAMLRTTVSATMLSAGTKINVIPNVAEAQLDGRRL
PTETREEVFERFRKIIDDPAVTIEATSSQQPSTEPSSLTSPLYRAMEKVFHEAAPNAVVVPFLMRGTTDGAYLRAKGMAV
YGVPLFRKDGELRMHGNDERISLENLRAGTELLGKIVMEVAK
>Mature_441_residues
AFGQQGETASDLAARYLPELIRLDSTNPPGNESRVARYLKQVADREGIPAELLGNDPERLNFVARLKGTGKQRPLLLIAH
SDVVPADRSQWSVDPLAAIEKNGYIYGRGAEDDKQLLAAELAVMVDLHRRKVVLDRDIILLSESDEEAGSLGALWMVEHA
WTKIDAEFALNEYSYILPTSSGVPVFQIQTAEKVPTRFKMTARGTAGHGSLPREDNPVEHLARAIYRLSQADEPVKLNAT
TRAYLAAMGKLPDYAWVAPLVARLEDPATASRTADEIRKRDPEIHAMLRTTVSATMLSAGTKINVIPNVAEAQLDGRRLP
TETREEVFERFRKIIDDPAVTIEATSSQQPSTEPSSLTSPLYRAMEKVFHEAAPNAVVVPFLMRGTTDGAYLRAKGMAVY
GVPLFRKDGELRMHGNDERISLENLRAGTELLGKIVMEVAK

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=374, Percent_Identity=27.807486631016, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI4501901, Length=435, Percent_Identity=25.5172413793103, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17538642, Length=434, Percent_Identity=22.5806451612903, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71982082, Length=441, Percent_Identity=22.6757369614512, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71982085, Length=455, Percent_Identity=22.1978021978022, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17538640, Length=443, Percent_Identity=23.2505643340858, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71982710, Length=403, Percent_Identity=23.8213399503722, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322289, Length=277, Percent_Identity=26.3537906137184, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649208, Length=434, Percent_Identity=24.8847926267281, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356353, Length=441, Percent_Identity=24.9433106575964, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24649210, Length=435, Percent_Identity=25.9770114942529, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24649212, Length=432, Percent_Identity=24.0740740740741, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 48774; Mature: 48643

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFGQQGETASDLAARYLPELIRLDSTNPPGNESRVARYLKQVADREGIPAELLGNDPER
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCHHH
LNFVARLKGTGKQRPLLLIAHSDVVPADRSQWSVDPLAAIEKNGYIYGRGAEDDKQLLAA
HEEHEEECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEECCCCHHHHHHHH
ELAVMVDLHRRKVVLDRDIILLSESDEEAGSLGALWMVEHAWTKIDAEFALNEYSYILPT
HHHHHHHHHHHEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEC
SSGVPVFQIQTAEKVPTRFKMTARGTAGHGSLPREDNPVEHLARAIYRLSQADEPVKLNA
CCCCCEEEEECHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECC
TTRAYLAAMGKLPDYAWVAPLVARLEDPATASRTADEIRKRDPEIHAMLRTTVSATMLSA
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GTKINVIPNVAEAQLDGRRLPTETREEVFERFRKIIDDPAVTIEATSSQQPSTEPSSLTS
CCEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHH
PLYRAMEKVFHEAAPNAVVVPFLMRGTTDGAYLRAKGMAVYGVPLFRKDGELRMHGNDER
HHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCEEEECCEEEEECEEEECCCCEEECCCCCE
ISLENLRAGTELLGKIVMEVAK
EEHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AFGQQGETASDLAARYLPELIRLDSTNPPGNESRVARYLKQVADREGIPAELLGNDPER
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCHHH
LNFVARLKGTGKQRPLLLIAHSDVVPADRSQWSVDPLAAIEKNGYIYGRGAEDDKQLLAA
HEEHEEECCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEECCCCHHHHHHHH
ELAVMVDLHRRKVVLDRDIILLSESDEEAGSLGALWMVEHAWTKIDAEFALNEYSYILPT
HHHHHHHHHHHEEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEC
SSGVPVFQIQTAEKVPTRFKMTARGTAGHGSLPREDNPVEHLARAIYRLSQADEPVKLNA
CCCCCEEEEECHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECC
TTRAYLAAMGKLPDYAWVAPLVARLEDPATASRTADEIRKRDPEIHAMLRTTVSATMLSA
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GTKINVIPNVAEAQLDGRRLPTETREEVFERFRKIIDDPAVTIEATSSQQPSTEPSSLTS
CCEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHH
PLYRAMEKVFHEAAPNAVVVPFLMRGTTDGAYLRAKGMAVYGVPLFRKDGELRMHGNDER
HHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCEEEECCEEEEECEEEECCCCEEECCCCCE
ISLENLRAGTELLGKIVMEVAK
EEHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]