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The map label for this gene is lytS [H]

Identifier: 116621315

GI number: 116621315

Start: 2814111

End: 2815244

Strand: Reverse

Name: lytS [H]

Synonym: Acid_2196

Alternate gene names: 116621315

Gene position: 2815244-2814111 (Counterclockwise)

Preceding gene: 116621319

Following gene: 116621314

Centisome position: 28.25

GC content: 66.4

Gene sequence:

>1134_bases
ATGGCCGCGTTAGCGAGCGCACAACCGAACCGCCGGCGGACGCAACTGCCGGGCTTCGCGCTGATTCTTGCCGCGTGGCT
CGTGCCGGCCATGCTCTCGGCGTTCGACAGCTACATGCAGAGCCGGCTCGACAACCAGCAGCCGGATTGGCGCTGGGTGT
TTTTCTCGGGCTTCGATTGGCTGCTATATGCGGTGCTCACGCCCGCGGTCTTTCGCATCAGCCGCAGCTTTCCGCTGCAA
CGCGACGGGCTGGCTCGACGGATCGCGCTGCATATCGCCTGCGCGCTGGGCATGTGCGTGGTGTGGGCGACGCTTGGCCA
GTTCTTGAGACTGGCAATCTTCCACCCTCCCGCCGGTTTTACGATGACGAAGTTCGCGCGCGCACTGGAAGGCTGGATCT
TCACCACGCTGCCGTTCGGAACCGGCGTTTACTTCGCGCTGGTGGGAATCGAACACGCGCTGGCCTACATGGCTCAGGCT
CGCGAGCGCGAAACCCAGGCGGTTCGCCTCACTGCCCAGCTGGCGGAGGCGCGCCTCGGGGCGCTGCGGATGCAGCTCAA
TCCGCACTTTCTGTTTAACAGCCTCAACGCGATCACGGTGCTGGTGCGCGATCAGAATACCGCGGCCGCGGCGCGAATGC
TCGAATTGCTGAGCGATGTGCTCCGCAGCGTACTGCGCGCGGAGGGCGCGCACGTAACTCCGCTCTCCACGGAGCTGGAG
TTTCTCGAGCGCTACCTGGCGATCGAGCAGGTTCGCTTCTCCGACCGGTTGCGGCCGCGGATTGCTGTGGATCCATCGCT
TCGCCGCGCCGCAGTGCCGCAGTTCATCCTGCAGCCGCTCGTGGAAAACGCGCTGCGGCACGGGATATCGCGCCGCGCGG
ATGCCGGGCTGCTGGAGGTCACGGCGCAGCGCGACGGCGACATGCTCGTGCTCACTGTGCGGGATGACGGTCCAGGGCTC
AGTCCGGTTGAGCCATTGGGCACGGGTGTCGGCCTGGCGAACACACGCGCCCGGCTGGCTGCGCTGTACGGCGATCGCGC
CAGCCTCGAGATCGCGAGTGGCGCCGGAGCCGGAGTCCTGGCGACCATCCGGCTGCCGTATCATGAGGCAGAGAACCATG
GCGGGGCAGAGTGA

Upstream 100 bases:

>100_bases
CAGCGCTGCCGGATGCCAATAAACTGCAGCGGGCGGCGCGGCGGGTGCAGCCGGCGGTCATGGCTTGACGTCTCGCGCGG
TAGGCCCTATCCTCGCGGGA

Downstream 100 bases:

>100_bases
AATCCGGGTGCTGGTAGCCGATGATGAGCCGCTGGCGCGCCGCGGCGTGCGGCAGCTTCTGGCGCCGCACCGCGACATGA
CAGTAGTCGGCGAGGCCCGT

Product: signal transduction histidine kinase LytS

Products: NA

Alternate protein names: Autolysin sensor kinase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAALASAQPNRRRTQLPGFALILAAWLVPAMLSAFDSYMQSRLDNQQPDWRWVFFSGFDWLLYAVLTPAVFRISRSFPLQ
RDGLARRIALHIACALGMCVVWATLGQFLRLAIFHPPAGFTMTKFARALEGWIFTTLPFGTGVYFALVGIEHALAYMAQA
RERETQAVRLTAQLAEARLGALRMQLNPHFLFNSLNAITVLVRDQNTAAAARMLELLSDVLRSVLRAEGAHVTPLSTELE
FLERYLAIEQVRFSDRLRPRIAVDPSLRRAAVPQFILQPLVENALRHGISRRADAGLLEVTAQRDGDMLVLTVRDDGPGL
SPVEPLGTGVGLANTRARLAALYGDRASLEIASGAGAGVLATIRLPYHEAENHGGAE

Sequences:

>Translated_377_residues
MAALASAQPNRRRTQLPGFALILAAWLVPAMLSAFDSYMQSRLDNQQPDWRWVFFSGFDWLLYAVLTPAVFRISRSFPLQ
RDGLARRIALHIACALGMCVVWATLGQFLRLAIFHPPAGFTMTKFARALEGWIFTTLPFGTGVYFALVGIEHALAYMAQA
RERETQAVRLTAQLAEARLGALRMQLNPHFLFNSLNAITVLVRDQNTAAAARMLELLSDVLRSVLRAEGAHVTPLSTELE
FLERYLAIEQVRFSDRLRPRIAVDPSLRRAAVPQFILQPLVENALRHGISRRADAGLLEVTAQRDGDMLVLTVRDDGPGL
SPVEPLGTGVGLANTRARLAALYGDRASLEIASGAGAGVLATIRLPYHEAENHGGAE
>Mature_376_residues
AALASAQPNRRRTQLPGFALILAAWLVPAMLSAFDSYMQSRLDNQQPDWRWVFFSGFDWLLYAVLTPAVFRISRSFPLQR
DGLARRIALHIACALGMCVVWATLGQFLRLAIFHPPAGFTMTKFARALEGWIFTTLPFGTGVYFALVGIEHALAYMAQAR
ERETQAVRLTAQLAEARLGALRMQLNPHFLFNSLNAITVLVRDQNTAAAARMLELLSDVLRSVLRAEGAHVTPLSTELEF
LERYLAIEQVRFSDRLRPRIAVDPSLRRAAVPQFILQPLVENALRHGISRRADAGLLEVTAQRDGDMLVLTVRDDGPGLS
PVEPLGTGVGLANTRARLAALYGDRASLEIASGAGAGVLATIRLPYHEAENHGGAE

Specific function: Member of the two-component regulatory system lytR/lytS that probably regulates genes involved in cell wall metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788446, Length=283, Percent_Identity=30.3886925795053, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1788723, Length=189, Percent_Identity=33.8624338624339, Blast_Score=105, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 41491; Mature: 41359

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALASAQPNRRRTQLPGFALILAAWLVPAMLSAFDSYMQSRLDNQQPDWRWVFFSGFDW
CCCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHH
LLYAVLTPAVFRISRSFPLQRDGLARRIALHIACALGMCVVWATLGQFLRLAIFHPPAGF
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TMTKFARALEGWIFTTLPFGTGVYFALVGIEHALAYMAQARERETQAVRLTAQLAEARLG
HHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRMQLNPHFLFNSLNAITVLVRDQNTAAAARMLELLSDVLRSVLRAEGAHVTPLSTELE
HHHEECCHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
FLERYLAIEQVRFSDRLRPRIAVDPSLRRAAVPQFILQPLVENALRHGISRRADAGLLEV
HHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
TAQRDGDMLVLTVRDDGPGLSPVEPLGTGVGLANTRARLAALYGDRASLEIASGAGAGVL
EECCCCCEEEEEEECCCCCCCCCCHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCEE
ATIRLPYHEAENHGGAE
EEEEECCHHCCCCCCCC
>Mature Secondary Structure 
AALASAQPNRRRTQLPGFALILAAWLVPAMLSAFDSYMQSRLDNQQPDWRWVFFSGFDW
CCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHH
LLYAVLTPAVFRISRSFPLQRDGLARRIALHIACALGMCVVWATLGQFLRLAIFHPPAGF
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TMTKFARALEGWIFTTLPFGTGVYFALVGIEHALAYMAQARERETQAVRLTAQLAEARLG
HHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALRMQLNPHFLFNSLNAITVLVRDQNTAAAARMLELLSDVLRSVLRAEGAHVTPLSTELE
HHHEECCHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
FLERYLAIEQVRFSDRLRPRIAVDPSLRRAAVPQFILQPLVENALRHGISRRADAGLLEV
HHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
TAQRDGDMLVLTVRDDGPGLSPVEPLGTGVGLANTRARLAALYGDRASLEIASGAGAGVL
EECCCCCEEEEEEECCCCCCCCCCHHCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCEE
ATIRLPYHEAENHGGAE
EEEEECCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA