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The map label for this gene is cusR [H]

Identifier: 116621283

GI number: 116621283

Start: 2769549

End: 2770265

Strand: Direct

Name: cusR [H]

Synonym: Acid_2164

Alternate gene names: 116621283

Gene position: 2769549-2770265 (Clockwise)

Preceding gene: 116621281

Following gene: 116621284

Centisome position: 27.79

GC content: 62.9

Gene sequence:

>717_bases
ATGCGAATTCTCGTGGTCGAGGACGAAAAACGAATTGCCGATTTTCTATGCCGCGGCTTGGAAGGCGCTGGCTACGCGGT
AGACGCCGCCCTCACCGGCGGCGCCGCGCTCGACCTGATTCACGACACCGACTACGACCTCGTCGTGCTGGATCGCATGT
TGCCCGATATGGACGGCCTGCAGGTCCTCGAAAAAATGCGCAGCCGTAAAGCGGGTCCACCCGTCCTGATCCTCAGCGCG
CGCGGCGCGCTTGACGATCGCGTCAAGGGACTCGAGCAGGGCGCCGACGATTACCTGGTCAAACCCTTCGCGTTCGTCGA
ACTCCTGGCGCGTGTGCGCGCCCTGTTGCGTCGCGGACAGCCCACGCCGGAGCGCCTCCAGGTCTCCGACCTCGCGCTCG
ATTGCATTCGCCGCAAGGTGACGCGCGGCGCCGAGACCATCGACCTGGCCCCCAAGGAATTCGGCATCCTGGAATATATG
ATGCGCAACAAGGGCCGCCCCTTGAGCCGTACCATGATCGTGGAGCATGTGTGGGACATGGACTACGACGGCCTCACCAA
TATCGTGGATGTCTACATCCGCCACCTGCGCAGCAAGATCGACGACCGCTTCCAACAGAAGCTGATTCAAACCGTGCGCG
GCATCGGATACATGATCGAAGCGCCCGACAAACCAGCCGACCGCTCTACCGAGCCGGCTGCCCTCCCGCAGGTCTGA

Upstream 100 bases:

>100_bases
CACCGCGAATCCGCACCCCAGACATCCTTATCCAAAAGGGCTGCCGTGGGTCGAAGGCGAAAACGCCCGCCCCACGGGGT
TTGCGATAAGCTGGAAGCAA

Downstream 100 bases:

>100_bases
TGTGAGCCGGAAACGCGATTTCCGCCGATTGGCCCGCGGACTCCGCTTCCGCTTGGCGTTGAGCTACGCGCTGTTATTCA
CGTTATTGCTGACCGGCATC

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MRILVVEDEKRIADFLCRGLEGAGYAVDAALTGGAALDLIHDTDYDLVVLDRMLPDMDGLQVLEKMRSRKAGPPVLILSA
RGALDDRVKGLEQGADDYLVKPFAFVELLARVRALLRRGQPTPERLQVSDLALDCIRRKVTRGAETIDLAPKEFGILEYM
MRNKGRPLSRTMIVEHVWDMDYDGLTNIVDVYIRHLRSKIDDRFQQKLIQTVRGIGYMIEAPDKPADRSTEPAALPQV

Sequences:

>Translated_238_residues
MRILVVEDEKRIADFLCRGLEGAGYAVDAALTGGAALDLIHDTDYDLVVLDRMLPDMDGLQVLEKMRSRKAGPPVLILSA
RGALDDRVKGLEQGADDYLVKPFAFVELLARVRALLRRGQPTPERLQVSDLALDCIRRKVTRGAETIDLAPKEFGILEYM
MRNKGRPLSRTMIVEHVWDMDYDGLTNIVDVYIRHLRSKIDDRFQQKLIQTVRGIGYMIEAPDKPADRSTEPAALPQV
>Mature_238_residues
MRILVVEDEKRIADFLCRGLEGAGYAVDAALTGGAALDLIHDTDYDLVVLDRMLPDMDGLQVLEKMRSRKAGPPVLILSA
RGALDDRVKGLEQGADDYLVKPFAFVELLARVRALLRRGQPTPERLQVSDLALDCIRRKVTRGAETIDLAPKEFGILEYM
MRNKGRPLSRTMIVEHVWDMDYDGLTNIVDVYIRHLRSKIDDRFQQKLIQTVRGIGYMIEAPDKPADRSTEPAALPQV

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=52, Blast_Score=240, Evalue=7e-65,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=45.9821428571429, Blast_Score=200, Evalue=7e-53,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=44.3438914027149, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=42.6666666666667, Blast_Score=166, Evalue=9e-43,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=38.6363636363636, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=33.9366515837104, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=36.4444444444444, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=37.8995433789954, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=35.0649350649351, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=34.2342342342342, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=36.3636363636364, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=30.7017543859649, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.9559471365639, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.7359307359307, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=36.4485981308411, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=35.9649122807018, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790299, Length=136, Percent_Identity=34.5588235294118, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI48994928, Length=118, Percent_Identity=38.135593220339, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1787487, Length=115, Percent_Identity=35.6521739130435, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26771; Mature: 26771

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVEDEKRIADFLCRGLEGAGYAVDAALTGGAALDLIHDTDYDLVVLDRMLPDMDGL
CEEEEECCHHHHHHHHHHCCCCCCEEEEHHHCCCCEEEEEECCCCCEEEHHHHCCCCCHH
QVLEKMRSRKAGPPVLILSARGALDDRVKGLEQGADDYLVKPFAFVELLARVRALLRRGQ
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PTPERLQVSDLALDCIRRKVTRGAETIDLAPKEFGILEYMMRNKGRPLSRTMIVEHVWDM
CCHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
DYDGLTNIVDVYIRHLRSKIDDRFQQKLIQTVRGIGYMIEAPDKPADRSTEPAALPQV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRILVVEDEKRIADFLCRGLEGAGYAVDAALTGGAALDLIHDTDYDLVVLDRMLPDMDGL
CEEEEECCHHHHHHHHHHCCCCCCEEEEHHHCCCCEEEEEECCCCCEEEHHHHCCCCCHH
QVLEKMRSRKAGPPVLILSARGALDDRVKGLEQGADDYLVKPFAFVELLARVRALLRRGQ
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PTPERLQVSDLALDCIRRKVTRGAETIDLAPKEFGILEYMMRNKGRPLSRTMIVEHVWDM
CCHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
DYDGLTNIVDVYIRHLRSKIDDRFQQKLIQTVRGIGYMIEAPDKPADRSTEPAALPQV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]