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The map label for this gene is lytH [H]

Identifier: 116621254

GI number: 116621254

Start: 2734128

End: 2734763

Strand: Reverse

Name: lytH [H]

Synonym: Acid_2135

Alternate gene names: 116621254

Gene position: 2734763-2734128 (Counterclockwise)

Preceding gene: 116621255

Following gene: 116621252

Centisome position: 27.44

GC content: 62.42

Gene sequence:

>636_bases
ATGCGAGCACGAATGGCTGCCGTATTCGCGTTGGGATTCGCGGCCGGAATGGTTGTGCTGGCGGTTGCGTTGTGGAGCAC
TGGACATTTGACAGGCTACCGGCAAGAGGTCGCGCTGGCCGCGCCGGCAACGCCGCCGACGGCATTTACGCCGACACCCG
TGCCGGCGCCGGCCGGAGCGGAGCCGGTGCTGCCGGAACTGCATGTGAACAACGAGGGAACGCTGGCGATGCCGCTCGCC
AACCTCGATCCGCGGAAACTGGAGAGCACTTTTCACCAGAAGCGCGGGACACATGAACACGAAGCGCTCGATATTATGGC
GCCGCGCGGCACGCCGGTGATGGCGGTGGCGGAGGGCAACGTGGCGAAGTTGTTCACCAGCAAGCAGGGCGGATTGACAG
TGTACCAGTTCGACGACTCGCGCACATGGTGTTATTACTATGCCCACCTGGACCGGTACCAGGAGGGCTTGAAGGAAGGC
GTGCTGCTGCGAAAGGGAGAGGTGCTCGGGTATGTTGGGTCAACCGGTGACGCTTCCCCCGATGCACCCCACCTGCACTT
CGCAGTATTTCGCTTAGGGCCGGAGAAGCAGTGGTGGAAGGGAACGGCGATCGACCCACTGCCACTATTGAAATAG

Upstream 100 bases:

>100_bases
CACGGAATCGCACGGGTGTATCCGGTTGACCAACTGGGATGCCTTGGAACTGGCAGCGATGGTGCGGCCAGGGACTCCCG
CAAGTCTGAAGGAGTAAAGC

Downstream 100 bases:

>100_bases
AGATGGCTTTCTCACGGTCGCGATTCACTGCGATATCAGCGCATCTTCTTGAGTTCGTTATCGACCTTCTTGAACCCGGC
CGGGACCTCGAACTGCGAAG

Product: peptidase M23B

Products: NA

Alternate protein names: Peptidoglycan hydrolase; Sporulation-specific endopeptidase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MRARMAAVFALGFAAGMVVLAVALWSTGHLTGYRQEVALAAPATPPTAFTPTPVPAPAGAEPVLPELHVNNEGTLAMPLA
NLDPRKLESTFHQKRGTHEHEALDIMAPRGTPVMAVAEGNVAKLFTSKQGGLTVYQFDDSRTWCYYYAHLDRYQEGLKEG
VLLRKGEVLGYVGSTGDASPDAPHLHFAVFRLGPEKQWWKGTAIDPLPLLK

Sequences:

>Translated_211_residues
MRARMAAVFALGFAAGMVVLAVALWSTGHLTGYRQEVALAAPATPPTAFTPTPVPAPAGAEPVLPELHVNNEGTLAMPLA
NLDPRKLESTFHQKRGTHEHEALDIMAPRGTPVMAVAEGNVAKLFTSKQGGLTVYQFDDSRTWCYYYAHLDRYQEGLKEG
VLLRKGEVLGYVGSTGDASPDAPHLHFAVFRLGPEKQWWKGTAIDPLPLLK
>Mature_211_residues
MRARMAAVFALGFAAGMVVLAVALWSTGHLTGYRQEVALAAPATPPTAFTPTPVPAPAGAEPVLPELHVNNEGTLAMPLA
NLDPRKLESTFHQKRGTHEHEALDIMAPRGTPVMAVAEGNVAKLFTSKQGGLTVYQFDDSRTWCYYYAHLDRYQEGLKEG
VLLRKGEVLGYVGSTGDASPDAPHLHFAVFRLGPEKQWWKGTAIDPLPLLK

Specific function: L-Ala--D-Glu endopeptidase involved in production of single L-alanine side chains from tetrapeptides in the spore cortex peptidoglycan. Therefore, is required for the endospore cortex maturation [H]

COG id: COG0739

COG function: function code M; Membrane proteins related to metalloendopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M23B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011055
- InterPro:   IPR016047 [H]

Pfam domain/function: PF01551 Peptidase_M23 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 22870; Mature: 22870

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARMAAVFALGFAAGMVVLAVALWSTGHLTGYRQEVALAAPATPPTAFTPTPVPAPAGA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
EPVLPELHVNNEGTLAMPLANLDPRKLESTFHQKRGTHEHEALDIMAPRGTPVMAVAEGN
CCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCC
VAKLFTSKQGGLTVYQFDDSRTWCYYYAHLDRYQEGLKEGVLLRKGEVLGYVGSTGDASP
EEEEEECCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHCCEEEECCCEEEEECCCCCCCC
DAPHLHFAVFRLGPEKQWWKGTAIDPLPLLK
CCCCEEEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRARMAAVFALGFAAGMVVLAVALWSTGHLTGYRQEVALAAPATPPTAFTPTPVPAPAGA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
EPVLPELHVNNEGTLAMPLANLDPRKLESTFHQKRGTHEHEALDIMAPRGTPVMAVAEGN
CCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCC
VAKLFTSKQGGLTVYQFDDSRTWCYYYAHLDRYQEGLKEGVLLRKGEVLGYVGSTGDASP
EEEEEECCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHCCEEEECCCEEEEECCCCCCCC
DAPHLHFAVFRLGPEKQWWKGTAIDPLPLLK
CCCCEEEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 12813075 [H]