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The map label for this gene is fabG [C]

Identifier: 116621097

GI number: 116621097

Start: 2497917

End: 2498852

Strand: Direct

Name: fabG [C]

Synonym: Acid_1978

Alternate gene names: 116621097

Gene position: 2497917-2498852 (Clockwise)

Preceding gene: 116621096

Following gene: 116621098

Centisome position: 25.07

GC content: 58.65

Gene sequence:

>936_bases
ATGCTGACCAACTCAAGCCAGATCGTATTGATTACCGGCGGTACCGGCGGCATCGGGCAGGCAATCGCGGTTCGAATGGC
AAAACTGGGTGCAACTACCATTGTGGTCGGCCGTGATCAGGCCCGCGGTGAGGCCGCCAAAGCAGAGATCCGGACTCAGA
GCGGCAACCGCTCCGTAGAACTGATGCTCGCCGATCTCTCCTCCCAGGGCGACATCCGCAGGCTTGCCGGCGAGTTCATG
GCGCGGTACGGCCGCCTGGATGTCCTGGTCAACAACGTGGGCGGGCTCTATGGGAAGCGTTGGGAAACCGTGGATGGCAT
TGAATGCACTCTGGCGCTCAATCATCTGTGCCCCTTTCTCTTGACGCATTTGCTGCTGCCCGTGCTTCGGGCCGGTGCTC
CGTCCCGGATCGTGAACATTAATTCAGAAGGTCACCGGGCTGCGAAGAGCGTCAACTTTGGGGATTTCGATGCCGCGCGA
TGGAAGCGCGGCTTCCTGATCTATAGCCAGTCGAAGCTCGCCAATCTATTGTTCACTTTCGAAATGGCACGGCGCCTGAG
TCCGTCGGAGATTACCGTGAACGCAGTGCATCCGGGCATCGTGGACACCCAGTTGTTCCGGCGATTCATCGAGGAGAGGT
TCACCTTGATTGGCGGCGTTCTATCCAAGGCAGCGGCCTTCGTGGCGAGAAAGGTGGCCTATCGGATTTCGCATTTTGAC
ACCGTGGAAACCGCGGCCGAGTGCCCGGTCTATCTCGCTTCCTCCAGTGAAGTGGCCGGCATAACGGGAAAATATTTCGG
TCTGAACAAGAAGATCGTCGAGACATCGGCGGCGTCCCTCGACGCAGACTTGTCCCGGGAAGTCTGGCGCATGAGCGCCG
AAATGGTGGGCTTGAGCGGAAATGAAGCGTCTCAGGTACAGAGACGGTTTGCGTAA

Upstream 100 bases:

>100_bases
TTTGGTGGGCTCACCGCATACAGCCGGCGCTTCTGGCCCCGCTTGAGTCCTGGTTTGTCAGAACACTTCGCGCGGCGCGC
ACGGAAAGTTGAGGTAGACG

Downstream 100 bases:

>100_bases
CGGTGAAAGGACAAAGGTGATGGGAAAAAGCATTCTGGTAACCGGCGCTTCCACGGGACTCGGCAAAGAAATGGCCCTGT
ATCTCGCCGAGCGCGGCTTT

Product: Fis family transcriptional regulator

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MLTNSSQIVLITGGTGGIGQAIAVRMAKLGATTIVVGRDQARGEAAKAEIRTQSGNRSVELMLADLSSQGDIRRLAGEFM
ARYGRLDVLVNNVGGLYGKRWETVDGIECTLALNHLCPFLLTHLLLPVLRAGAPSRIVNINSEGHRAAKSVNFGDFDAAR
WKRGFLIYSQSKLANLLFTFEMARRLSPSEITVNAVHPGIVDTQLFRRFIEERFTLIGGVLSKAAAFVARKVAYRISHFD
TVETAAECPVYLASSSEVAGITGKYFGLNKKIVETSAASLDADLSREVWRMSAEMVGLSGNEASQVQRRFA

Sequences:

>Translated_311_residues
MLTNSSQIVLITGGTGGIGQAIAVRMAKLGATTIVVGRDQARGEAAKAEIRTQSGNRSVELMLADLSSQGDIRRLAGEFM
ARYGRLDVLVNNVGGLYGKRWETVDGIECTLALNHLCPFLLTHLLLPVLRAGAPSRIVNINSEGHRAAKSVNFGDFDAAR
WKRGFLIYSQSKLANLLFTFEMARRLSPSEITVNAVHPGIVDTQLFRRFIEERFTLIGGVLSKAAAFVARKVAYRISHFD
TVETAAECPVYLASSSEVAGITGKYFGLNKKIVETSAASLDADLSREVWRMSAEMVGLSGNEASQVQRRFA
>Mature_311_residues
MLTNSSQIVLITGGTGGIGQAIAVRMAKLGATTIVVGRDQARGEAAKAEIRTQSGNRSVELMLADLSSQGDIRRLAGEFM
ARYGRLDVLVNNVGGLYGKRWETVDGIECTLALNHLCPFLLTHLLLPVLRAGAPSRIVNINSEGHRAAKSVNFGDFDAAR
WKRGFLIYSQSKLANLLFTFEMARRLSPSEITVNAVHPGIVDTQLFRRFIEERFTLIGGVLSKAAAFVARKVAYRISHFD
TVETAAECPVYLASSSEVAGITGKYFGLNKKIVETSAASLDADLSREVWRMSAEMVGLSGNEASQVQRRFA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI10190746, Length=310, Percent_Identity=37.0967741935484, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI225579078, Length=312, Percent_Identity=37.1794871794872, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI166795268, Length=293, Percent_Identity=34.1296928327645, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI186928839, Length=293, Percent_Identity=35.1535836177474, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI146231950, Length=301, Percent_Identity=33.2225913621262, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI19923931, Length=262, Percent_Identity=38.1679389312977, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI193804850, Length=301, Percent_Identity=31.2292358803987, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI7706523, Length=302, Percent_Identity=30.4635761589404, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI13375997, Length=165, Percent_Identity=29.6969696969697, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI32483357, Length=206, Percent_Identity=28.6407766990291, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI72534732, Length=160, Percent_Identity=30.625, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17558006, Length=297, Percent_Identity=28.6195286195286, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17532805, Length=311, Percent_Identity=29.5819935691318, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI193207620, Length=306, Percent_Identity=28.7581699346405, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17532791, Length=304, Percent_Identity=27.9605263157895, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71992402, Length=301, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI72001364, Length=208, Percent_Identity=36.0576923076923, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17505416, Length=331, Percent_Identity=26.2839879154079, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17535059, Length=297, Percent_Identity=26.9360269360269, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32565532, Length=208, Percent_Identity=28.8461538461538, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI115533172, Length=298, Percent_Identity=26.510067114094, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115533174, Length=298, Percent_Identity=26.510067114094, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=209, Percent_Identity=29.6650717703349, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=206, Percent_Identity=28.1553398058252, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=216, Percent_Identity=27.3148148148148, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560332, Length=220, Percent_Identity=30.9090909090909, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=206, Percent_Identity=27.6699029126214, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6324148, Length=236, Percent_Identity=27.5423728813559, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324820, Length=316, Percent_Identity=24.6835443037975, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45553409, Length=297, Percent_Identity=34.6801346801347, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24647948, Length=297, Percent_Identity=34.6801346801347, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24647946, Length=297, Percent_Identity=34.6801346801347, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI22024069, Length=301, Percent_Identity=35.2159468438538, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24586328, Length=290, Percent_Identity=35.1724137931034, Blast_Score=151, Evalue=5e-37,
Organism=Drosophila melanogaster, GI19921754, Length=297, Percent_Identity=34.006734006734, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI28573296, Length=297, Percent_Identity=33.6700336700337, Blast_Score=141, Evalue=6e-34,
Organism=Drosophila melanogaster, GI161076371, Length=262, Percent_Identity=33.587786259542, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45554248, Length=261, Percent_Identity=34.8659003831418, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24640117, Length=261, Percent_Identity=34.8659003831418, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24647931, Length=306, Percent_Identity=32.0261437908497, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20129347, Length=297, Percent_Identity=28.6195286195286, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24656154, Length=218, Percent_Identity=36.697247706422, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19922628, Length=218, Percent_Identity=36.697247706422, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571526, Length=210, Percent_Identity=30, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21357041, Length=210, Percent_Identity=30.4761904761905, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI23397609, Length=273, Percent_Identity=31.1355311355311, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24644339, Length=221, Percent_Identity=28.9592760180996, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355319, Length=214, Percent_Identity=29.4392523364486, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 33797; Mature: 33797

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNSSQIVLITGGTGGIGQAIAVRMAKLGATTIVVGRDQARGEAAKAEIRTQSGNRSVE
CCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHEEECCCCCEEE
LMLADLSSQGDIRRLAGEFMARYGRLDVLVNNVGGLYGKRWETVDGIECTLALNHLCPFL
EEEEECCCCCHHHHHHHHHHHHHCCHHEEEEHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
LTHLLLPVLRAGAPSRIVNINSEGHRAAKSVNFGDFDAARWKRGFLIYSQSKLANLLFTF
HHHHHHHHHHCCCCCEEEEECCCCCHHHHCCCCCCCCHHHHHCCEEEEEHHHHHHHHHHH
EMARRLSPSEITVNAVHPGIVDTQLFRRFIEERFTLIGGVLSKAAAFVARKVAYRISHFD
HHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVETAAECPVYLASSSEVAGITGKYFGLNKKIVETSAASLDADLSREVWRMSAEMVGLSG
HHHHHHHCCEEEECCCCCCCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC
NEASQVQRRFA
CHHHHHHHHCC
>Mature Secondary Structure
MLTNSSQIVLITGGTGGIGQAIAVRMAKLGATTIVVGRDQARGEAAKAEIRTQSGNRSVE
CCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHEEECCCCCEEE
LMLADLSSQGDIRRLAGEFMARYGRLDVLVNNVGGLYGKRWETVDGIECTLALNHLCPFL
EEEEECCCCCHHHHHHHHHHHHHCCHHEEEEHHCCCCCCCCCCCCCCCHHHHHHHHHHHH
LTHLLLPVLRAGAPSRIVNINSEGHRAAKSVNFGDFDAARWKRGFLIYSQSKLANLLFTF
HHHHHHHHHHCCCCCEEEEECCCCCHHHHCCCCCCCCHHHHHCCEEEEEHHHHHHHHHHH
EMARRLSPSEITVNAVHPGIVDTQLFRRFIEERFTLIGGVLSKAAAFVARKVAYRISHFD
HHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVETAAECPVYLASSSEVAGITGKYFGLNKKIVETSAASLDADLSREVWRMSAEMVGLSG
HHHHHHHCCEEEECCCCCCCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC
NEASQVQRRFA
CHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]