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The map label for this gene is tktB [C]

Identifier: 116621055

GI number: 116621055

Start: 2410597

End: 2412735

Strand: Reverse

Name: tktB [C]

Synonym: Acid_1936

Alternate gene names: 116621055

Gene position: 2412735-2410597 (Counterclockwise)

Preceding gene: 116621056

Following gene: 116621054

Centisome position: 24.21

GC content: 61.94

Gene sequence:

>2139_bases
ATGGGAAGCCCCTCGGCGGTTTTTAACGGATTGCGAATCGCTCGCCCGCAGGCGATTCCACGGACCGATTACCTGCTGCG
GCAAGCAGTGCTGAAACTACTTGCCATCAAGGACTCGGACGTCCGCATCCTCACCCTGCAACAATGCCGCGACGCCGTGG
ATAAGGGCCTGCACGCGGGCGGCGCTTTCTCGGCCGTGATCCCGCTGACCGCACTGTACTACGGTGGGTTCATCGATATT
GACATCGCCGACCCGACCCGGCGCGGGCAGGATCTCTTCACGTTGAGCAAGGGCCATGCCGTCGCAGCCATGGCCGCAAT
CTACGCAGACCTCGGTTACTTCGGCCTTGAGGTCCTACGCAACTCGCGCTCCTATTCGAGCATCCTGAATGGCCACCCCG
GTCCGATCTTGCCGGGCGTCCACATCGCCACCGGTCCCATGGGCCAGGGCTTCGGCGTGGCGCAGGGACTGGCGATCGCC
GGCCGCGTCTCCCCGCGATTCGATTCATACTGCATGTGCGGCGATGGTGAACTCCAGGAAGGCCCCATCTGGGAAGCCGT
CATGTTCGCCGGCTCGAAGAAGCTGGACAATCTCTGCCTGATGGTGGACCGCAATCACGGTCAACTCGATATCTATAGCA
AGACAATCTTCCCCATGCCTGACCTTGCGCCCGTCTTCCGATCCTTCGGATGGCAGGCGTTCGACGTCGATGCGACCCAG
TACGACGGCATTTACACCGCACTCGAGGAGTTCCGTTACGGCGCGCGTAACGGGAAGCCCACCGCGATCATTTGCAGCAC
CACCAAGGGTCACGGCAGCCTGTCCGATTTCTTCAACCGGCACAAGGTTGCAGCAGCGGATTCGCTGCTGGAACAGGAAT
TGACGCTGCAAGGCGAGCAGCGGCACGATCGCGTTGCGGAATTCGCGCGCTTCTATCTCGACCTGGAATCGGCTGAAGGC
GGCCCGTCACTGCAGGATACGTTATCAAAGCTGGCGCGCGGCATGCACCTGAACCTGGAAGCCGGGCCGGATGATGTGAG
GTTATCTCCGTCGATGGGTCCGGTGGCGCTGACGCGCGTACCGCCGCGCAATAAGAAGATCCGCTACGATGCGTCGCTGC
TGCCGCGCATCGATCGCTCGAAGGAGCCCGCCGCCAGTGAGATCGTGAGCGCTGCCATGAAGGTCTTCGCGCGCGATCCG
GCAGTGGTCTCCATCGATTCTGACCTGGCCAGCACCAGCGGCCTCGAAGCCGGGGTGGCCGCAGTGGACCAGCGGCGCGC
GCTCAACGTCGGCGTCGCTGAAGCCAACATGATGCTGATCGGCGAGGCGTTTGCCGCTCTCGGCTCCAACGTTTGGATCA
GCACCTTTTGCCCGTTCTACGACTGGAAGGTCCTCCGGCGAGTCGCCGTCGGCTATCAGGAGCGCCTGGAGGCTATGGAG
GCCGCCGACGGCTGGTTGAGCGAAGGCCACGGGCTCGACATCACCATGTTGGCCACCGCGTCCAACTTCGAGACGCGCAC
CAACGGCGCGACCCACATGGCGAACGACGACAACCTGGTCTTCGACGCCATCGCCCATCTCAAGATCATCGATGTCTCGT
GTCCTCAACAGATGCTGGCGATCATGAAGTGGATCATGGAAGGCAACCGGGGACTGGTCTACGTTCGGGTGATGCGCACC
GGCTCGCCCGTGATCTACGGGCCGGATTACAGCTTCGAATTCGGCAAGGGGCACGTGATCCGCGAATCCGCCGGGTACTC
CGCCATCCTTGTCAGCAGCGGACGAGGCGTCCACGAGGCGATCACCGCCGCGGCGCTTTGCAGCAAGAACAGCGTCGGCG
TCACAGTAGTGGACATGCCGTCGATCGATGACGGGTTGTTGCTCCAGTTGTACGATTCGGGAAAACTATTGCTCTTCGCC
GAACAGAACAACGGGTACATCTGGCAGAACTTCCTCAAGGTCCTGTACCGCCACCGCAAGGCATCCGCGGATCTCGGGCG
CGTCGCCGCCATCAACACGCTGGACGCCCAGGGGCGTGCTCGCTTCATCCATTCCGGCACCTATGAGGAATTGGTGGAAG
CGTTCGGGCTAAGCGCGGCGCAGATCGCCGAATTTATTGAGAAACAGGTGAATCCATGA

Upstream 100 bases:

>100_bases
CCCGAACTGCACGCCGATCTGGGCAAACCGGCCGGATGTCGGGATCGCGAACTATGTCCGCCAACTGACTGCGGTTCGCG
AAGGGAACGCGCGATAATTT

Downstream 100 bases:

>100_bases
GTGTTGCTGTATTACACGAAGGCGACATCGAGGAGTTGGATCTGCCGGGCCGGCGGTTTCGCTGGCTCGTAGCAGATGGC
CGCATACCGTCCGACTACTG

Product: transketolase domain-containing protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 712; Mature: 711

Protein sequence:

>712_residues
MGSPSAVFNGLRIARPQAIPRTDYLLRQAVLKLLAIKDSDVRILTLQQCRDAVDKGLHAGGAFSAVIPLTALYYGGFIDI
DIADPTRRGQDLFTLSKGHAVAAMAAIYADLGYFGLEVLRNSRSYSSILNGHPGPILPGVHIATGPMGQGFGVAQGLAIA
GRVSPRFDSYCMCGDGELQEGPIWEAVMFAGSKKLDNLCLMVDRNHGQLDIYSKTIFPMPDLAPVFRSFGWQAFDVDATQ
YDGIYTALEEFRYGARNGKPTAIICSTTKGHGSLSDFFNRHKVAAADSLLEQELTLQGEQRHDRVAEFARFYLDLESAEG
GPSLQDTLSKLARGMHLNLEAGPDDVRLSPSMGPVALTRVPPRNKKIRYDASLLPRIDRSKEPAASEIVSAAMKVFARDP
AVVSIDSDLASTSGLEAGVAAVDQRRALNVGVAEANMMLIGEAFAALGSNVWISTFCPFYDWKVLRRVAVGYQERLEAME
AADGWLSEGHGLDITMLATASNFETRTNGATHMANDDNLVFDAIAHLKIIDVSCPQQMLAIMKWIMEGNRGLVYVRVMRT
GSPVIYGPDYSFEFGKGHVIRESAGYSAILVSSGRGVHEAITAAALCSKNSVGVTVVDMPSIDDGLLLQLYDSGKLLLFA
EQNNGYIWQNFLKVLYRHRKASADLGRVAAINTLDAQGRARFIHSGTYEELVEAFGLSAAQIAEFIEKQVNP

Sequences:

>Translated_712_residues
MGSPSAVFNGLRIARPQAIPRTDYLLRQAVLKLLAIKDSDVRILTLQQCRDAVDKGLHAGGAFSAVIPLTALYYGGFIDI
DIADPTRRGQDLFTLSKGHAVAAMAAIYADLGYFGLEVLRNSRSYSSILNGHPGPILPGVHIATGPMGQGFGVAQGLAIA
GRVSPRFDSYCMCGDGELQEGPIWEAVMFAGSKKLDNLCLMVDRNHGQLDIYSKTIFPMPDLAPVFRSFGWQAFDVDATQ
YDGIYTALEEFRYGARNGKPTAIICSTTKGHGSLSDFFNRHKVAAADSLLEQELTLQGEQRHDRVAEFARFYLDLESAEG
GPSLQDTLSKLARGMHLNLEAGPDDVRLSPSMGPVALTRVPPRNKKIRYDASLLPRIDRSKEPAASEIVSAAMKVFARDP
AVVSIDSDLASTSGLEAGVAAVDQRRALNVGVAEANMMLIGEAFAALGSNVWISTFCPFYDWKVLRRVAVGYQERLEAME
AADGWLSEGHGLDITMLATASNFETRTNGATHMANDDNLVFDAIAHLKIIDVSCPQQMLAIMKWIMEGNRGLVYVRVMRT
GSPVIYGPDYSFEFGKGHVIRESAGYSAILVSSGRGVHEAITAAALCSKNSVGVTVVDMPSIDDGLLLQLYDSGKLLLFA
EQNNGYIWQNFLKVLYRHRKASADLGRVAAINTLDAQGRARFIHSGTYEELVEAFGLSAAQIAEFIEKQVNP
>Mature_711_residues
GSPSAVFNGLRIARPQAIPRTDYLLRQAVLKLLAIKDSDVRILTLQQCRDAVDKGLHAGGAFSAVIPLTALYYGGFIDID
IADPTRRGQDLFTLSKGHAVAAMAAIYADLGYFGLEVLRNSRSYSSILNGHPGPILPGVHIATGPMGQGFGVAQGLAIAG
RVSPRFDSYCMCGDGELQEGPIWEAVMFAGSKKLDNLCLMVDRNHGQLDIYSKTIFPMPDLAPVFRSFGWQAFDVDATQY
DGIYTALEEFRYGARNGKPTAIICSTTKGHGSLSDFFNRHKVAAADSLLEQELTLQGEQRHDRVAEFARFYLDLESAEGG
PSLQDTLSKLARGMHLNLEAGPDDVRLSPSMGPVALTRVPPRNKKIRYDASLLPRIDRSKEPAASEIVSAAMKVFARDPA
VVSIDSDLASTSGLEAGVAAVDQRRALNVGVAEANMMLIGEAFAALGSNVWISTFCPFYDWKVLRRVAVGYQERLEAMEA
ADGWLSEGHGLDITMLATASNFETRTNGATHMANDDNLVFDAIAHLKIIDVSCPQQMLAIMKWIMEGNRGLVYVRVMRTG
SPVIYGPDYSFEFGKGHVIRESAGYSAILVSSGRGVHEAITAAALCSKNSVGVTVVDMPSIDDGLLLQLYDSGKLLLFAE
QNNGYIWQNFLKVLYRHRKASADLGRVAAINTLDAQGRARFIHSGTYEELVEAFGLSAAQIAEFIEKQVNP

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=254, Percent_Identity=35.4330708661417, Blast_Score=130, Evalue=6e-30,
Organism=Homo sapiens, GI4507521, Length=254, Percent_Identity=35.4330708661417, Blast_Score=130, Evalue=6e-30,
Organism=Homo sapiens, GI133778974, Length=213, Percent_Identity=34.7417840375587, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI225637461, Length=145, Percent_Identity=32.4137931034483, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI225637463, Length=145, Percent_Identity=32.4137931034483, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI225637459, Length=145, Percent_Identity=32.4137931034483, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1788808, Length=249, Percent_Identity=32.1285140562249, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI48994911, Length=302, Percent_Identity=28.8079470198675, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17539652, Length=220, Percent_Identity=35.4545454545455, Blast_Score=125, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6325331, Length=209, Percent_Identity=35.4066985645933, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6319593, Length=662, Percent_Identity=24.6223564954683, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24666278, Length=586, Percent_Identity=25.0853242320819, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24645119, Length=556, Percent_Identity=25.8992805755396, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45551847, Length=556, Percent_Identity=25.8992805755396, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45550715, Length=556, Percent_Identity=25.8992805755396, Blast_Score=144, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 77358; Mature: 77227

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSPSAVFNGLRIARPQAIPRTDYLLRQAVLKLLAIKDSDVRILTLQQCRDAVDKGLHAG
CCCCHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCC
GAFSAVIPLTALYYGGFIDIDIADPTRRGQDLFTLSKGHAVAAMAAIYADLGYFGLEVLR
CCHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
NSRSYSSILNGHPGPILPGVHIATGPMGQGFGVAQGLAIAGRVSPRFDSYCMCGDGELQE
CCCHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHCCEEECCCCCCCCCEEEECCCCCCC
GPIWEAVMFAGSKKLDNLCLMVDRNHGQLDIYSKTIFPMPDLAPVFRSFGWQAFDVDATQ
CCCHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCHHHHHHHCCCEEEECCCHH
YDGIYTALEEFRYGARNGKPTAIICSTTKGHGSLSDFFNRHKVAAADSLLEQELTLQGEQ
HCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
RHDRVAEFARFYLDLESAEGGPSLQDTLSKLARGMHLNLEAGPDDVRLSPSMGPVALTRV
HHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHCCEEEEEECCCCCEEECCCCCCEEEEEC
PPRNKKIRYDASLLPRIDRSKEPAASEIVSAAMKVFARDPAVVSIDSDLASTSGLEAGVA
CCCCCEEEECHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHH
AVDQRRALNVGVAEANMMLIGEAFAALGSNVWISTFCPFYDWKVLRRVAVGYQERLEAME
HHHHHHHEECEEECCCEEEHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCHHHHHHHHH
AADGWLSEGHGLDITMLATASNFETRTNGATHMANDDNLVFDAIAHLKIIDVSCPQQMLA
HHCCHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHEECCEEEEEECCCHHHHHH
IMKWIMEGNRGLVYVRVMRTGSPVIYGPDYSFEFGKGHVIRESAGYSAILVSSGRGVHEA
HHHHHHCCCCCEEEEEEEECCCCEEECCCCCEECCCCEEEEECCCCEEEEEECCCCHHHH
ITAAALCSKNSVGVTVVDMPSIDDGLLLQLYDSGKLLLFAEQNNGYIWQNFLKVLYRHRK
HHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCEEEEEECCCCEEHHHHHHHHHHHHH
ASADLGRVAAINTLDAQGRARFIHSGTYEELVEAFGLSAAQIAEFIEKQVNP
CCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
GSPSAVFNGLRIARPQAIPRTDYLLRQAVLKLLAIKDSDVRILTLQQCRDAVDKGLHAG
CCCHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCCC
GAFSAVIPLTALYYGGFIDIDIADPTRRGQDLFTLSKGHAVAAMAAIYADLGYFGLEVLR
CCHHHHHHHHHHHHCCEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHH
NSRSYSSILNGHPGPILPGVHIATGPMGQGFGVAQGLAIAGRVSPRFDSYCMCGDGELQE
CCCHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHCCEEECCCCCCCCCEEEECCCCCCC
GPIWEAVMFAGSKKLDNLCLMVDRNHGQLDIYSKTIFPMPDLAPVFRSFGWQAFDVDATQ
CCCHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCHHHHHHHCCCEEEECCCHH
YDGIYTALEEFRYGARNGKPTAIICSTTKGHGSLSDFFNRHKVAAADSLLEQELTLQGEQ
HCHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
RHDRVAEFARFYLDLESAEGGPSLQDTLSKLARGMHLNLEAGPDDVRLSPSMGPVALTRV
HHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHCCEEEEEECCCCCEEECCCCCCEEEEEC
PPRNKKIRYDASLLPRIDRSKEPAASEIVSAAMKVFARDPAVVSIDSDLASTSGLEAGVA
CCCCCEEEECHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHH
AVDQRRALNVGVAEANMMLIGEAFAALGSNVWISTFCPFYDWKVLRRVAVGYQERLEAME
HHHHHHHEECEEECCCEEEHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCHHHHHHHHH
AADGWLSEGHGLDITMLATASNFETRTNGATHMANDDNLVFDAIAHLKIIDVSCPQQMLA
HHCCHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHEECCEEEEEECCCHHHHHH
IMKWIMEGNRGLVYVRVMRTGSPVIYGPDYSFEFGKGHVIRESAGYSAILVSSGRGVHEA
HHHHHHCCCCCEEEEEEEECCCCEEECCCCCEECCCCEEEEECCCCEEEEEECCCCHHHH
ITAAALCSKNSVGVTVVDMPSIDDGLLLQLYDSGKLLLFAEQNNGYIWQNFLKVLYRHRK
HHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCEEEEEECCCCEEHHHHHHHHHHHHH
ASADLGRVAAINTLDAQGRARFIHSGTYEELVEAFGLSAAQIAEFIEKQVNP
CCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]