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The map label for this gene is gcd [H]

Identifier: 116621051

GI number: 116621051

Start: 2402181

End: 2404424

Strand: Reverse

Name: gcd [H]

Synonym: Acid_1932

Alternate gene names: 116621051

Gene position: 2404424-2402181 (Counterclockwise)

Preceding gene: 116621052

Following gene: 116621049

Centisome position: 24.13

GC content: 61.5

Gene sequence:

>2244_bases
ATGAAAGCCACTTCCGTATCACATTTCGCGATTGCGTTCGCGACCATCGCCCTTCCGCCTTCTGCTCTTAAGGCGCAGAA
TTGGAGCGAGTATCTCGGGGGACCCGACAGCGCGCACTATTCACCGCTGAAACAAATCAATTCGCGAAACGTGAATAAGC
TGGACGTCGCCTGGAGCTACGAAACGGGCGATGATCTCAGCTATACCTTCTGTCCGCTGGTCGTCGACAACATCGCCTAC
GTGGCGGCGAAGCAGGGCTCGCTGGTCGCGCTCGATGCATCCACCGGCAAGCAGCTCTGGGTTTACGCGTTCCCGAGCGG
AGGACGCTTCAGCGGCATCGCGGGCCAGCGCGGGGCGAATTATTGGGAAAGTAAGGATCGCACGGACCGCCGCATCTTAG
TAACTTCCAGTGGGATGCTGTACGCCATCGATGCGCGCACCGGCAAGCTGGTCGAGTCTTTTGCCGATCACGGGAAGCTC
GACCTGAAAACCGGCATTGATCGCGCCCGTATGCCGCTGGGATCAAGGACTCCGGGGCGCATCTTCGAAAACCTGATCAT
TCTGGGCAGCGCGACCGGGGAGGGTTACCTGGCGCCCCCAGGAGATATCCGCGCCTTTGACGTGCCCACCGGCAAGCTCG
TGTGGGTGTTCCATACGATTCCGCGACCCGGCGAACTTGGATACGACACTTGGCCGAAAGACGCATACACCTACATGGGC
GGGGTCGACGTCTGGGGCGAAATCACCGTGGATGCGAAGCGCGCAGTCGTATATCTCGCGACTGCGTCCGCGAAGTACGA
ACTCTATGGCGGCGACCGGCACGGAGACAATCTCTTCGCGAACTGCCTCATTGCGCTCGATGCGCGCACCGGCAAACGCC
TCTGGCACTTCCAGACCGTTCATCACGATCTTTGGGACACCGATCCGGCTGCCGCTCCACAACTGGCGACTGTGCGGCAC
GAAGGCAAGGCGGTCGATGTCGTCGCATTGGCGTCCAAGAACGGCTTCCTTTATGTATTCGAACGCGCTACCGGCAAACC
GCTGTGGCCCATCGAGGAGCGCCCGGTGCCGAAGTCCGATGTACCGGGAGAGTTGGCTTCGCCCACGCAGCCGTTCCCGA
CGATGCTGCCTCCCTTCAGTCGCCAGGGTATGACCGTGAAGGACATGTACGACGCCTTCATGACCGGCGAGGAAAAGGTG
TGGTGGAAGGACCGGCTTACGAAGGCGCGCACCGGGTTGTATACGCCTCCCGGGTTGGAGGACACGATCCTGATGCCCAG
CGTGAACGGCGGCGCATTGTTCTTCGGAAGCGGCGCGGATCCGACCAACGGGACTGTGTACGTGCTCGGCAAGGATATGC
CGTCCATCCTCAAACTCGTCCCCGCCGGCGAATCCACGTCGTCGAATGCGGGCGGTTTGATTCCCGACCGGCCGCGCGGC
GGACGCGGCGGAGCGCAGACCCTTCAGCTCACGGCGGAACGGCGCGGGCGCGCAGTCTATGAGCAAAGCTGCCAAATTTG
TCATGGTCCGGACCTGAAGGGCGACCGCGGGCCCCAAGTGGATAACGCGGTGAGCCGCCTCGGCGCCGCCGCGACGCGCA
ACATGGTCATGAAAGGCAAGGGCGCGATGCCGCCAATTCCCAATCTGCCCCCCGCGCTGCTCGAAGACCTGATTGCTTTT
CTGACGAAGCCGGAATCCGCGCCGCCGGGCACAGCCGCGCCTGCGGCCGTCCTGGCGATGGCAAGAATGGAGCCGGGTTA
TCCCGAGGATGTCCCGCCGCCTCCATCGCGTTACAAAACCGGCTATGGCAACGAGCCGTACGTGATTACGCCGCCGTGGA
GCCAGATCACAGCTTATGATCTGAACGCCGGCAAGATTAAATGGCAGACGCCTTATGGCGATCTCCCGCAGGCCGGGCCA
AGCAAGAAGCTGCGCGGCAACGTCTATCCAAAGAGCGGCTTCGTGGTCACTGCGGGCGGTTTGATTCTATTCGCCGGCAA
CGATTCGAAGCTCTATGCACTGGACAAAAACACAGGTGAGTTGATCTGCACGAAAGACCTGCCGAATGGCTCCCTGGGCG
TACCGGCGGTGTACGAAGCGAATGGCAAGCAGTTTATCCTGCTGGCTGTTTCCGGAGGCAATCCGTTTCCGGTGGGCGGA
CGGCTTGCTCCGGGCGGTGTGAATCCGCCGGCGATTTCGAAGAGCTACATCGCGTTTTCGCTTCCGGAACCAGCTGTACG
GTAA

Upstream 100 bases:

>100_bases
ACATCGTCATCTCCTGCGTGAAAGGCACATTTATCTTCTGGAATCAGATGCGCGTGCGGCCTCAGTCCGCGCGGAAAAAC
TAACACCTGAGAGACCAGCC

Downstream 100 bases:

>100_bases
CCGTCGAACGCCTCTCGCGTCCGCTGTCTGTTGACAAAAGCCCGTCATTGCGCAAAATCAGCAGCTTGCGATTTCGGAGC
GTCAGTCCAACGAAGCCGCG

Product: quinoprotein glucose dehydrogenase

Products: NA

Alternate protein names: Glucose dehydrogenase [pyrroloquinoline-quinone] [H]

Number of amino acids: Translated: 747; Mature: 747

Protein sequence:

>747_residues
MKATSVSHFAIAFATIALPPSALKAQNWSEYLGGPDSAHYSPLKQINSRNVNKLDVAWSYETGDDLSYTFCPLVVDNIAY
VAAKQGSLVALDASTGKQLWVYAFPSGGRFSGIAGQRGANYWESKDRTDRRILVTSSGMLYAIDARTGKLVESFADHGKL
DLKTGIDRARMPLGSRTPGRIFENLIILGSATGEGYLAPPGDIRAFDVPTGKLVWVFHTIPRPGELGYDTWPKDAYTYMG
GVDVWGEITVDAKRAVVYLATASAKYELYGGDRHGDNLFANCLIALDARTGKRLWHFQTVHHDLWDTDPAAAPQLATVRH
EGKAVDVVALASKNGFLYVFERATGKPLWPIEERPVPKSDVPGELASPTQPFPTMLPPFSRQGMTVKDMYDAFMTGEEKV
WWKDRLTKARTGLYTPPGLEDTILMPSVNGGALFFGSGADPTNGTVYVLGKDMPSILKLVPAGESTSSNAGGLIPDRPRG
GRGGAQTLQLTAERRGRAVYEQSCQICHGPDLKGDRGPQVDNAVSRLGAAATRNMVMKGKGAMPPIPNLPPALLEDLIAF
LTKPESAPPGTAAPAAVLAMARMEPGYPEDVPPPPSRYKTGYGNEPYVITPPWSQITAYDLNAGKIKWQTPYGDLPQAGP
SKKLRGNVYPKSGFVVTAGGLILFAGNDSKLYALDKNTGELICTKDLPNGSLGVPAVYEANGKQFILLAVSGGNPFPVGG
RLAPGGVNPPAISKSYIAFSLPEPAVR

Sequences:

>Translated_747_residues
MKATSVSHFAIAFATIALPPSALKAQNWSEYLGGPDSAHYSPLKQINSRNVNKLDVAWSYETGDDLSYTFCPLVVDNIAY
VAAKQGSLVALDASTGKQLWVYAFPSGGRFSGIAGQRGANYWESKDRTDRRILVTSSGMLYAIDARTGKLVESFADHGKL
DLKTGIDRARMPLGSRTPGRIFENLIILGSATGEGYLAPPGDIRAFDVPTGKLVWVFHTIPRPGELGYDTWPKDAYTYMG
GVDVWGEITVDAKRAVVYLATASAKYELYGGDRHGDNLFANCLIALDARTGKRLWHFQTVHHDLWDTDPAAAPQLATVRH
EGKAVDVVALASKNGFLYVFERATGKPLWPIEERPVPKSDVPGELASPTQPFPTMLPPFSRQGMTVKDMYDAFMTGEEKV
WWKDRLTKARTGLYTPPGLEDTILMPSVNGGALFFGSGADPTNGTVYVLGKDMPSILKLVPAGESTSSNAGGLIPDRPRG
GRGGAQTLQLTAERRGRAVYEQSCQICHGPDLKGDRGPQVDNAVSRLGAAATRNMVMKGKGAMPPIPNLPPALLEDLIAF
LTKPESAPPGTAAPAAVLAMARMEPGYPEDVPPPPSRYKTGYGNEPYVITPPWSQITAYDLNAGKIKWQTPYGDLPQAGP
SKKLRGNVYPKSGFVVTAGGLILFAGNDSKLYALDKNTGELICTKDLPNGSLGVPAVYEANGKQFILLAVSGGNPFPVGG
RLAPGGVNPPAISKSYIAFSLPEPAVR
>Mature_747_residues
MKATSVSHFAIAFATIALPPSALKAQNWSEYLGGPDSAHYSPLKQINSRNVNKLDVAWSYETGDDLSYTFCPLVVDNIAY
VAAKQGSLVALDASTGKQLWVYAFPSGGRFSGIAGQRGANYWESKDRTDRRILVTSSGMLYAIDARTGKLVESFADHGKL
DLKTGIDRARMPLGSRTPGRIFENLIILGSATGEGYLAPPGDIRAFDVPTGKLVWVFHTIPRPGELGYDTWPKDAYTYMG
GVDVWGEITVDAKRAVVYLATASAKYELYGGDRHGDNLFANCLIALDARTGKRLWHFQTVHHDLWDTDPAAAPQLATVRH
EGKAVDVVALASKNGFLYVFERATGKPLWPIEERPVPKSDVPGELASPTQPFPTMLPPFSRQGMTVKDMYDAFMTGEEKV
WWKDRLTKARTGLYTPPGLEDTILMPSVNGGALFFGSGADPTNGTVYVLGKDMPSILKLVPAGESTSSNAGGLIPDRPRG
GRGGAQTLQLTAERRGRAVYEQSCQICHGPDLKGDRGPQVDNAVSRLGAAATRNMVMKGKGAMPPIPNLPPALLEDLIAF
LTKPESAPPGTAAPAAVLAMARMEPGYPEDVPPPPSRYKTGYGNEPYVITPPWSQITAYDLNAGKIKWQTPYGDLPQAGP
SKKLRGNVYPKSGFVVTAGGLILFAGNDSKLYALDKNTGELICTKDLPNGSLGVPAVYEANGKQFILLAVSGGNPFPVGG
RLAPGGVNPPAISKSYIAFSLPEPAVR

Specific function: GDH is probably involved in energy conservation rather than in sugar metabolism [H]

COG id: COG4993

COG function: function code G; Glucose dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial PQQ dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786316, Length=478, Percent_Identity=31.7991631799163, Blast_Score=211, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017511
- InterPro:   IPR019556
- InterPro:   IPR019551
- InterPro:   IPR018391
- InterPro:   IPR002372
- InterPro:   IPR011047
- InterPro:   IPR001479 [H]

Pfam domain/function: PF01011 PQQ; PF10535 PQQ_C; PF10527 PQQ_N [H]

EC number: =1.1.5.2 [H]

Molecular weight: Translated: 80181; Mature: 80181

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS51007 CYTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKATSVSHFAIAFATIALPPSALKAQNWSEYLGGPDSAHYSPLKQINSRNVNKLDVAWSY
CCCCCCHHHEEEEEEEECCCHHHHCCCCHHHHCCCCCCCCCHHHHHCCCCCCEEEEEEEC
ETGDDLSYTFCPLVVDNIAYVAAKQGSLVALDASTGKQLWVYAFPSGGRFSGIAGQRGAN
CCCCCCCEEEHHHHHHCCCEEEECCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCC
YWESKDRTDRRILVTSSGMLYAIDARTGKLVESFADHGKLDLKTGIDRARMPLGSRTPGR
CCCCCCCCCCEEEEECCCEEEEEECCCHHHHHHHHHCCCEEEHHCCCHHHCCCCCCCHHH
IFENLIILGSATGEGYLAPPGDIRAFDVPTGKLVWVFHTIPRPGELGYDTWPKDAYTYMG
HHCEEEEEECCCCCCEECCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCHHEECC
GVDVWGEITVDAKRAVVYLATASAKYELYGGDRHGDNLFANCLIALDARTGKRLWHFQTV
CCCEEEEEEEECCEEEEEEEECCEEEEEECCCCCCCCCEEEEEEEEECCCCCEEEEEEHH
HHDLWDTDPAAAPQLATVRHEGKAVDVVALASKNGFLYVFERATGKPLWPIEERPVPKSD
HHHHCCCCCCCCCCEEEEECCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCC
VPGELASPTQPFPTMLPPFSRQGMTVKDMYDAFMTGEEKVWWKDRLTKARTGLYTPPGLE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCCCCC
DTILMPSVNGGALFFGSGADPTNGTVYVLGKDMPSILKLVPAGESTSSNAGGLIPDRPRG
CEEEEECCCCCEEEECCCCCCCCCEEEEEECCCCHHHHEECCCCCCCCCCCCCCCCCCCC
GRGGAQTLQLTAERRGRAVYEQSCQICHGPDLKGDRGPQVDNAVSRLGAAATRNMVMKGK
CCCCCEEEEEEHHHCCCCHHHHCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHCEEEECC
GAMPPIPNLPPALLEDLIAFLTKPESAPPGTAAPAAVLAMARMEPGYPEDVPPPPSRYKT
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHCCC
GYGNEPYVITPPWSQITAYDLNAGKIKWQTPYGDLPQAGPSKKLRGNVYPKSGFVVTAGG
CCCCCCEEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
LILFAGNDSKLYALDKNTGELICTKDLPNGSLGVPAVYEANGKQFILLAVSGGNPFPVGG
EEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCC
RLAPGGVNPPAISKSYIAFSLPEPAVR
EECCCCCCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MKATSVSHFAIAFATIALPPSALKAQNWSEYLGGPDSAHYSPLKQINSRNVNKLDVAWSY
CCCCCCHHHEEEEEEEECCCHHHHCCCCHHHHCCCCCCCCCHHHHHCCCCCCEEEEEEEC
ETGDDLSYTFCPLVVDNIAYVAAKQGSLVALDASTGKQLWVYAFPSGGRFSGIAGQRGAN
CCCCCCCEEEHHHHHHCCCEEEECCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCC
YWESKDRTDRRILVTSSGMLYAIDARTGKLVESFADHGKLDLKTGIDRARMPLGSRTPGR
CCCCCCCCCCEEEEECCCEEEEEECCCHHHHHHHHHCCCEEEHHCCCHHHCCCCCCCHHH
IFENLIILGSATGEGYLAPPGDIRAFDVPTGKLVWVFHTIPRPGELGYDTWPKDAYTYMG
HHCEEEEEECCCCCCEECCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCHHEECC
GVDVWGEITVDAKRAVVYLATASAKYELYGGDRHGDNLFANCLIALDARTGKRLWHFQTV
CCCEEEEEEEECCEEEEEEEECCEEEEEECCCCCCCCCEEEEEEEEECCCCCEEEEEEHH
HHDLWDTDPAAAPQLATVRHEGKAVDVVALASKNGFLYVFERATGKPLWPIEERPVPKSD
HHHHCCCCCCCCCCEEEEECCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCC
VPGELASPTQPFPTMLPPFSRQGMTVKDMYDAFMTGEEKVWWKDRLTKARTGLYTPPGLE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHCCCCCCCCCC
DTILMPSVNGGALFFGSGADPTNGTVYVLGKDMPSILKLVPAGESTSSNAGGLIPDRPRG
CEEEEECCCCCEEEECCCCCCCCCEEEEEECCCCHHHHEECCCCCCCCCCCCCCCCCCCC
GRGGAQTLQLTAERRGRAVYEQSCQICHGPDLKGDRGPQVDNAVSRLGAAATRNMVMKGK
CCCCCEEEEEEHHHCCCCHHHHCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHCEEEECC
GAMPPIPNLPPALLEDLIAFLTKPESAPPGTAAPAAVLAMARMEPGYPEDVPPPPSRYKT
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHCCC
GYGNEPYVITPPWSQITAYDLNAGKIKWQTPYGDLPQAGPSKKLRGNVYPKSGFVVTAGG
CCCCCCEEEECCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
LILFAGNDSKLYALDKNTGELICTKDLPNGSLGVPAVYEANGKQFILLAVSGGNPFPVGG
EEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCC
RLAPGGVNPPAISKSYIAFSLPEPAVR
EECCCCCCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2228962; 8419307; 8202364; 9278503; 8509415; 8554505 [H]