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The map label for this gene is zraS [H]

Identifier: 116621040

GI number: 116621040

Start: 2383771

End: 2384931

Strand: Direct

Name: zraS [H]

Synonym: Acid_1921

Alternate gene names: 116621040

Gene position: 2383771-2384931 (Clockwise)

Preceding gene: 116621039

Following gene: 116621041

Centisome position: 23.92

GC content: 61.58

Gene sequence:

>1161_bases
ATGCTGGATGTGTTCGTGGTGGCGCCGCTGGTGGCGCTGGGCCTGGTGCAGGTGCTGGAGCCGAAGATCGAGGCGCTCTC
CACTACTAAATGGCGGGTGGCGTGGATCATCCTCAAGATGGCGATCATTTACCTGTTGATCGCTTACACCAACGGAATCG
AGAGCAATTTCTGGTTGCTGCTGTTGCTGCCGGTGGTGTCCGCGGCGACGGTTTCGGGGGTGATCGGAACGCTGGTGTTC
ACGACGCTGGCGGGCGCCGCGTATCTCTCTTTCCTATTGTTTCTGGATTGGAACAAGTTCGTGCTGGAACGGCCGGAGAT
CGAGGTGCTGGCGCAGCGCGTGATTTGCCTGTTCCTGGTGGGGAACCTGGCGAACCTGCTGGCGGAGGCGCTGCGGGTGC
AGAGTCAGAAATACCGGCGGGCAGCGGAGCACCTGGAGGATGCGAACCGGCAGGTGATGGAGGCGCAGGAAGCGGTGAGG
CGGTCTGACCGGCTGGCGGCGCTCGGGCAATTGACAGCCGGACTGGCGCATGAGCTGCGCAATCCGCTGGGGACGATCAA
GGCGTCGGCGGAGATGCTCAACCAGCAGCTGAGCAAGGAAAACGAAGTGGCGCGGGAAGTGGCCGGGTTCATTTCAACGG
AGGTGGACCGCACGAATTCGCTGGTGACGCGCTTTCTGCAATTCGCGCGGCCGCTGCATTTGCGGATGGACCGCGAGGAC
TTGACACAGACATTGGATCGCGCAATAACGCTGGCGGAACGGGAAGCACCGGGGATCGCGATCTACCGGAACTATGCGCC
GGAGATTCCGCCGTTCCCATTCGACCGGGAACTGTTGGAGCGCGTGTTTTACAACCTGGTGTTGAATGCGGCGCAGGCAA
CGGCGGCCGGCGGAGCGGTGACGGTGAAGACGCGGGCGCAGGGGCGGACGGTGGAGATCGCCGTGATCGACCGGGGGTCG
GGCATCGATGAAAAGACGATGAAGGATATCTTCAATCCGTTTTTCACCACGAAGAAAGAGGGTGTGGGCCTGGGCCTGGC
GATCGTTTCCAAGATCGTGGATGAACACGGCGGTAAGATAGCAGTGGAGAGCGAGCCGGGGAAAGGCAGCATTTTTTGCG
TGTCGCTGCCCACAAATCCGACGCCCCAACCCACCGCATGA

Upstream 100 bases:

>100_bases
TCGTTTGCCAGAAAGTCCACTTTCCCGTTGGATCCGACTGATCCGCCCACAGGATTTCGTCTGGATTCCTCTGTTCATTG
CGCTGGCCGCGACCAGTGAA

Downstream 100 bases:

>100_bases
AGAAACGCATTCTGGTCGTGGAAGACGAAGAGAAACTGCGGCGCGTGATCGAGCTGCAACTGTTGTCGGCCGGCTTCGAC
GTGGACAAGGCGGCTAGCGC

Product: signal transduction histidine kinase nitrogen specific NtrB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MLDVFVVAPLVALGLVQVLEPKIEALSTTKWRVAWIILKMAIIYLLIAYTNGIESNFWLLLLLPVVSAATVSGVIGTLVF
TTLAGAAYLSFLLFLDWNKFVLERPEIEVLAQRVICLFLVGNLANLLAEALRVQSQKYRRAAEHLEDANRQVMEAQEAVR
RSDRLAALGQLTAGLAHELRNPLGTIKASAEMLNQQLSKENEVAREVAGFISTEVDRTNSLVTRFLQFARPLHLRMDRED
LTQTLDRAITLAEREAPGIAIYRNYAPEIPPFPFDRELLERVFYNLVLNAAQATAAGGAVTVKTRAQGRTVEIAVIDRGS
GIDEKTMKDIFNPFFTTKKEGVGLGLAIVSKIVDEHGGKIAVESEPGKGSIFCVSLPTNPTPQPTA

Sequences:

>Translated_386_residues
MLDVFVVAPLVALGLVQVLEPKIEALSTTKWRVAWIILKMAIIYLLIAYTNGIESNFWLLLLLPVVSAATVSGVIGTLVF
TTLAGAAYLSFLLFLDWNKFVLERPEIEVLAQRVICLFLVGNLANLLAEALRVQSQKYRRAAEHLEDANRQVMEAQEAVR
RSDRLAALGQLTAGLAHELRNPLGTIKASAEMLNQQLSKENEVAREVAGFISTEVDRTNSLVTRFLQFARPLHLRMDRED
LTQTLDRAITLAEREAPGIAIYRNYAPEIPPFPFDRELLERVFYNLVLNAAQATAAGGAVTVKTRAQGRTVEIAVIDRGS
GIDEKTMKDIFNPFFTTKKEGVGLGLAIVSKIVDEHGGKIAVESEPGKGSIFCVSLPTNPTPQPTA
>Mature_386_residues
MLDVFVVAPLVALGLVQVLEPKIEALSTTKWRVAWIILKMAIIYLLIAYTNGIESNFWLLLLLPVVSAATVSGVIGTLVF
TTLAGAAYLSFLLFLDWNKFVLERPEIEVLAQRVICLFLVGNLANLLAEALRVQSQKYRRAAEHLEDANRQVMEAQEAVR
RSDRLAALGQLTAGLAHELRNPLGTIKASAEMLNQQLSKENEVAREVAGFISTEVDRTNSLVTRFLQFARPLHLRMDRED
LTQTLDRAITLAEREAPGIAIYRNYAPEIPPFPFDRELLERVFYNLVLNAAQATAAGGAVTVKTRAQGRTVEIAVIDRGS
GIDEKTMKDIFNPFFTTKKEGVGLGLAIVSKIVDEHGGKIAVESEPGKGSIFCVSLPTNPTPQPTA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=235, Percent_Identity=38.7234042553192, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788549, Length=237, Percent_Identity=36.2869198312236, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790300, Length=235, Percent_Identity=32.7659574468085, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=31.9327731092437, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693157, Length=252, Percent_Identity=28.1746031746032, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=28.7671232876712, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789149, Length=263, Percent_Identity=27.3764258555133, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789808, Length=210, Percent_Identity=30.4761904761905, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI48994928, Length=242, Percent_Identity=28.099173553719, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI87081816, Length=115, Percent_Identity=35.6521739130435, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790346, Length=221, Percent_Identity=26.2443438914027, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788393, Length=238, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=342, Percent_Identity=21.9298245614035, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790861, Length=231, Percent_Identity=26.8398268398268, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790551, Length=205, Percent_Identity=26.8292682926829, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082128, Length=235, Percent_Identity=23.8297872340426, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787894, Length=233, Percent_Identity=26.6094420600858, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42463; Mature: 42463

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVFVVAPLVALGLVQVLEPKIEALSTTKWRVAWIILKMAIIYLLIAYTNGIESNFWLL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LLLPVVSAATVSGVIGTLVFTTLAGAAYLSFLLFLDWNKFVLERPEIEVLAQRVICLFLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHH
GNLANLLAEALRVQSQKYRRAAEHLEDANRQVMEAQEAVRRSDRLAALGQLTAGLAHELR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NPLGTIKASAEMLNQQLSKENEVAREVAGFISTEVDRTNSLVTRFLQFARPLHLRMDRED
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHH
LTQTLDRAITLAEREAPGIAIYRNYAPEIPPFPFDRELLERVFYNLVLNAAQATAAGGAV
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEE
TVKTRAQGRTVEIAVIDRGSGIDEKTMKDIFNPFFTTKKEGVGLGLAIVSKIVDEHGGKI
EEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEE
AVESEPGKGSIFCVSLPTNPTPQPTA
EEECCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MLDVFVVAPLVALGLVQVLEPKIEALSTTKWRVAWIILKMAIIYLLIAYTNGIESNFWLL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LLLPVVSAATVSGVIGTLVFTTLAGAAYLSFLLFLDWNKFVLERPEIEVLAQRVICLFLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHH
GNLANLLAEALRVQSQKYRRAAEHLEDANRQVMEAQEAVRRSDRLAALGQLTAGLAHELR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NPLGTIKASAEMLNQQLSKENEVAREVAGFISTEVDRTNSLVTRFLQFARPLHLRMDRED
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHH
LTQTLDRAITLAEREAPGIAIYRNYAPEIPPFPFDRELLERVFYNLVLNAAQATAAGGAV
HHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEE
TVKTRAQGRTVEIAVIDRGSGIDEKTMKDIFNPFFTTKKEGVGLGLAIVSKIVDEHGGKI
EEEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEE
AVESEPGKGSIFCVSLPTNPTPQPTA
EEECCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]