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The map label for this gene is fabF [H]

Identifier: 116621033

GI number: 116621033

Start: 2375503

End: 2376810

Strand: Reverse

Name: fabF [H]

Synonym: Acid_1914

Alternate gene names: 116621033

Gene position: 2376810-2375503 (Counterclockwise)

Preceding gene: 116621034

Following gene: 116621032

Centisome position: 23.85

GC content: 63.61

Gene sequence:

>1308_bases
ATGCTAGCATTCATAAGATTCAGCCTATACCGGCGACCAGAAAAAAGGCAAAGTAAATCCATGCGGCGTGTAGTCATCAC
GGGAATTGGGGCGGTCAGCCCGAATGGAATCGGGCGCGAGCGCTTTTGGGAGGCCACGCGGAACGGCGTGAGCGGCGTCC
GCCGCATCACGCGCTTCGATCCCTCGGCATATCAGGTGCAGGTGGCGGGCGAAGTGCCCGATGAGTTCGACGAGAATCGG
TACGTCGAAGTGAAGGACCGGCCGCACGTTTCGCGCGCCGTCCCGCTGGCCGCGGCCAGCGTCGCCGAGGCCGTGGCGGA
TGCCGGGCTCGACGTCAAAGCCATGGGCCGCGACGAACTGCGCGGCATCGGCGTCATCGTCGGCTCCGGCGGCGGCAGCC
AGGATTTCACCGAAGAACAGTATCGCCTCTACTACGCCGGCCTCATCAAGCAGTGCAGCGTGTATACCATTCCCACGGGC
ACCATCGGCACGCTCGCCAGTGAAGTCTCCATGCGCTTCGGCTTCCGCGGCCTCAGCCACATCGTCTCCACCGGCTGTAC
CTCCTCGACTGACGCCATCGGCTACGCCTTTCGCAATATTCAAGCCGGCGTACTCAGTACCGTGGTCGCAGGCGGCGTGG
ATTCGCCCATCGCGCCGCTCATCCTGCGCGGATTTCAGTTGATGCGCATTATGTCCACGCGCTGGAATCACGATCCCACG
CGCGCCTCCCGCCCCTTCTCCAAAGATCGCGACGGCTTCGTGATCGCCGAAGGCTCGTGGTTTTTCGTGCTCGAGGAAAT
GGAGCAGGCCAAGTCGCGCGGCGCGCACATCTATGGTGAGATCGCCGGCTACGGCTCCACCTGCGAGGCCTTCCATCGCG
TGCGCCTCGAGGAGTGCGGCGAAGAGCCCGCGCGCGCCATCGGCATGGCCGTCGAAGAGGCGGGCATCCAACCGTCCGAC
ATTCAGTACATCCACTATCACGGTACTTCCACCGAGCTCAACGATCGCATTGAGACGCGCGCCGTAAAGCTGGCTTTCAA
TGGCCACGCCGGAAAACTCGCGGGCTCGTCACTCAAGAGCATGATTGGTCATCCCCAAGGCGCCTGCGGAGCCGCCGGCA
TTGCCGCCACCCTCCTCGCCATGCGCGACGGCATCCTGCCGCCCACGATCAATGTCGATGAGCCCGACGAGAACTGCGAC
CTCGACTACATCACCGACATCGGCCGCAAAATGCACGTCGAACACGCCGTCGCCAACTGCATCGCCTTCGGCAGCAAGAA
CTCCGCCATGGTCCTCCGCCGCGCCTGA

Upstream 100 bases:

>100_bases
CGCGCTAACGCCCAGCCAGGCAAGCATCCAGAGCGCCGCGATCATTCCAGCCTGGAGTCCGGCCAAACATACGGCGAGTG
CGCTCACCGGCCGGTGCTCC

Downstream 100 bases:

>100_bases
GGTTGGGCGACAATAGGGCTCAGGAACAATTGCCGTGTCAACTGGAACCGTCGTGCCTCTCAGCGAATATCTGGCGACCA
GCTACCGTCCCGATTGCGAA

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLAFIRFSLYRRPEKRQSKSMRRVVITGIGAVSPNGIGRERFWEATRNGVSGVRRITRFDPSAYQVQVAGEVPDEFDENR
YVEVKDRPHVSRAVPLAAASVAEAVADAGLDVKAMGRDELRGIGVIVGSGGGSQDFTEEQYRLYYAGLIKQCSVYTIPTG
TIGTLASEVSMRFGFRGLSHIVSTGCTSSTDAIGYAFRNIQAGVLSTVVAGGVDSPIAPLILRGFQLMRIMSTRWNHDPT
RASRPFSKDRDGFVIAEGSWFFVLEEMEQAKSRGAHIYGEIAGYGSTCEAFHRVRLEECGEEPARAIGMAVEEAGIQPSD
IQYIHYHGTSTELNDRIETRAVKLAFNGHAGKLAGSSLKSMIGHPQGACGAAGIAATLLAMRDGILPPTINVDEPDENCD
LDYITDIGRKMHVEHAVANCIAFGSKNSAMVLRRA

Sequences:

>Translated_435_residues
MLAFIRFSLYRRPEKRQSKSMRRVVITGIGAVSPNGIGRERFWEATRNGVSGVRRITRFDPSAYQVQVAGEVPDEFDENR
YVEVKDRPHVSRAVPLAAASVAEAVADAGLDVKAMGRDELRGIGVIVGSGGGSQDFTEEQYRLYYAGLIKQCSVYTIPTG
TIGTLASEVSMRFGFRGLSHIVSTGCTSSTDAIGYAFRNIQAGVLSTVVAGGVDSPIAPLILRGFQLMRIMSTRWNHDPT
RASRPFSKDRDGFVIAEGSWFFVLEEMEQAKSRGAHIYGEIAGYGSTCEAFHRVRLEECGEEPARAIGMAVEEAGIQPSD
IQYIHYHGTSTELNDRIETRAVKLAFNGHAGKLAGSSLKSMIGHPQGACGAAGIAATLLAMRDGILPPTINVDEPDENCD
LDYITDIGRKMHVEHAVANCIAFGSKNSAMVLRRA
>Mature_435_residues
MLAFIRFSLYRRPEKRQSKSMRRVVITGIGAVSPNGIGRERFWEATRNGVSGVRRITRFDPSAYQVQVAGEVPDEFDENR
YVEVKDRPHVSRAVPLAAASVAEAVADAGLDVKAMGRDELRGIGVIVGSGGGSQDFTEEQYRLYYAGLIKQCSVYTIPTG
TIGTLASEVSMRFGFRGLSHIVSTGCTSSTDAIGYAFRNIQAGVLSTVVAGGVDSPIAPLILRGFQLMRIMSTRWNHDPT
RASRPFSKDRDGFVIAEGSWFFVLEEMEQAKSRGAHIYGEIAGYGSTCEAFHRVRLEECGEEPARAIGMAVEEAGIQPSD
IQYIHYHGTSTELNDRIETRAVKLAFNGHAGKLAGSSLKSMIGHPQGACGAAGIAATLLAMRDGILPPTINVDEPDENCD
LDYITDIGRKMHVEHAVANCIAFGSKNSAMVLRRA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=423, Percent_Identity=36.6430260047281, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI41872631, Length=434, Percent_Identity=25.8064516129032, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI223972627, Length=169, Percent_Identity=34.9112426035503, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1787337, Length=416, Percent_Identity=37.9807692307692, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1788663, Length=418, Percent_Identity=32.5358851674641, Blast_Score=184, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI71983541, Length=423, Percent_Identity=31.4420803782506, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=33.3333333333333, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI212642053, Length=384, Percent_Identity=24.21875, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17550940, Length=234, Percent_Identity=25.2136752136752, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=32.293986636971, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24644341, Length=434, Percent_Identity=33.6405529953917, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI19920632, Length=442, Percent_Identity=24.2081447963801, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI221330659, Length=441, Percent_Identity=24.0362811791383, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24581345, Length=439, Percent_Identity=23.0068337129841, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 47226; Mature: 47226

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAFIRFSLYRRPEKRQSKSMRRVVITGIGAVSPNGIGRERFWEATRNGVSGVRRITRFD
CEEEEEEHHHCCCHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PSAYQVQVAGEVPDEFDENRYVEVKDRPHVSRAVPLAAASVAEAVADAGLDVKAMGRDEL
CCCEEEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHC
RGIGVIVGSGGGSQDFTEEQYRLYYAGLIKQCSVYTIPTGTIGTLASEVSMRFGFRGLSH
CEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHH
IVSTGCTSSTDAIGYAFRNIQAGVLSTVVAGGVDSPIAPLILRGFQLMRIMSTRWNHDPT
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
RASRPFSKDRDGFVIAEGSWFFVLEEMEQAKSRGAHIYGEIAGYGSTCEAFHRVRLEECG
CCCCCCCCCCCCEEEECCCEEEEHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHC
EEPARAIGMAVEEAGIQPSDIQYIHYHGTSTELNDRIETRAVKLAFNGHAGKLAGSSLKS
CHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHEEEEEEEECCCCCCCCHHHHHH
MIGHPQGACGAAGIAATLLAMRDGILPPTINVDEPDENCDLDYITDIGRKMHVEHAVANC
HHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IAFGSKNSAMVLRRA
HHCCCCCCEEEEEEC
>Mature Secondary Structure
MLAFIRFSLYRRPEKRQSKSMRRVVITGIGAVSPNGIGRERFWEATRNGVSGVRRITRFD
CEEEEEEHHHCCCHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PSAYQVQVAGEVPDEFDENRYVEVKDRPHVSRAVPLAAASVAEAVADAGLDVKAMGRDEL
CCCEEEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCHHC
RGIGVIVGSGGGSQDFTEEQYRLYYAGLIKQCSVYTIPTGTIGTLASEVSMRFGFRGLSH
CEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHH
IVSTGCTSSTDAIGYAFRNIQAGVLSTVVAGGVDSPIAPLILRGFQLMRIMSTRWNHDPT
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
RASRPFSKDRDGFVIAEGSWFFVLEEMEQAKSRGAHIYGEIAGYGSTCEAFHRVRLEECG
CCCCCCCCCCCCEEEECCCEEEEHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHC
EEPARAIGMAVEEAGIQPSDIQYIHYHGTSTELNDRIETRAVKLAFNGHAGKLAGSSLKS
CHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHEEEEEEEECCCCCCCCHHHHHH
MIGHPQGACGAAGIAATLLAMRDGILPPTINVDEPDENCDLDYITDIGRKMHVEHAVANC
HHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IAFGSKNSAMVLRRA
HHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]