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The map label for this gene is ribBA [H]

Identifier: 116621027

GI number: 116621027

Start: 2369736

End: 2370854

Strand: Reverse

Name: ribBA [H]

Synonym: Acid_1908

Alternate gene names: 116621027

Gene position: 2370854-2369736 (Counterclockwise)

Preceding gene: 116621032

Following gene: 116621026

Centisome position: 23.79

GC content: 63.09

Gene sequence:

>1119_bases
ATGCCCATTGTTTCAGTGCCGGACGCGATCCAGGAAATCCGCGCCGGGCGCATCATCGTCGTGGTTGACGATGAAGACCG
GGAAAACGAGGGCGACCTCACCATTGCCGCGGAAAAAGTCACTCCCGAGATCATTAATTTTATGGCCGTTCAGGGCCGCG
GACTGATCTGCCTCGCGCTCACGGCCGAACGCTGCGACTACCTTCGCCTGCCGCTCATGAGCCCCACCAACACCTCCATG
TTCGGCACCGCGTTCACCGAGTCCATCGATGCCCTTCATGGCGTGACCACCGGCATTTCCGCCGCCGACCGCACCCGCAC
CATCCTCCAGGCCATCGACCCCGACTGCCGCCCCAGCGACCTGGCGCGCCCAGGCCACATGTTTCCCCTGCGCGCCCGGG
AGGGCGGCGTCCTGGTCCGTGCCGGACAGACCGAAGCCAGCGTCGATCTGGCCCGCCTGGCCGGCCTCACCCCCGCCGGA
GTCATCTGCGAAATCATGAATGATGATGGCACCATGGCTCGCGTGCCCCAGCTCATCGAGTTCTGCAAGCGCCACGACAT
GAAAATGCTCTCCGTGGCCGAGCTGATCCGGTACCGGATGAAAAACGAGAAGTTCATCCGCCGGGTGGCCGAAGGTATCA
TCCCTACCGAATTCGGCGATTTCCGCACCATTGCCTACGCCAGCGATCTCAACCCCGAATACCATCTGGCCCTGGTGCGC
GGCGATGTCTCGGGCAAGGAAAGCGTACTGGTTCGCATGCATTCACGCTGTGTCTTCGGGGACGTCTTCCGCTCCAGCCA
GTGCGAGTGCGGCCAACTGGTGCAGAATTCGCTGCGCGCCATCGCCAAAGAGGGGCAGGGCGTGCTCGTCTACCTGCACG
AAACCGGCCCCGGCTTTCGCGTAGACAGTGGACAGCTGGTCAGCCACGGCCGCGATTTTATGCACCTCAAGGGTGAGGAC
GGGCAGCGCCAGCTCCAGCACGAGCACGGCCTGGGCGCCCAGATTCTCTCCGATCTCGGCCTCCACACCATTCGCCTGCT
CACCAACCATCCCCGCAAAATCGTTGCCTTGGAAGGCTTTGGCATCGAAGTTGAGGCCCAGATCCCGGTTGGCCACTGA

Upstream 100 bases:

>100_bases
ACGGGATGAATCGCGCTAGCCGGTGCAGCATGGTCCGAACCCCATCTTAACTCGTTGAACTGGAGTGCGGCGGGCTTAGC
CCCAATGGATACAATGAATT

Downstream 100 bases:

>100_bases
GGCCGTTAATATTGCGATTTCACCTACGTCATGAATAGTATGAAGGCACAAATTCTCACCGCGACGCTGCTCACGGCATT
TTCCGGCGCCCTTTCAGCAG

Product: GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MPIVSVPDAIQEIRAGRIIVVVDDEDRENEGDLTIAAEKVTPEIINFMAVQGRGLICLALTAERCDYLRLPLMSPTNTSM
FGTAFTESIDALHGVTTGISAADRTRTILQAIDPDCRPSDLARPGHMFPLRAREGGVLVRAGQTEASVDLARLAGLTPAG
VICEIMNDDGTMARVPQLIEFCKRHDMKMLSVAELIRYRMKNEKFIRRVAEGIIPTEFGDFRTIAYASDLNPEYHLALVR
GDVSGKESVLVRMHSRCVFGDVFRSSQCECGQLVQNSLRAIAKEGQGVLVYLHETGPGFRVDSGQLVSHGRDFMHLKGED
GQRQLQHEHGLGAQILSDLGLHTIRLLTNHPRKIVALEGFGIEVEAQIPVGH

Sequences:

>Translated_372_residues
MPIVSVPDAIQEIRAGRIIVVVDDEDRENEGDLTIAAEKVTPEIINFMAVQGRGLICLALTAERCDYLRLPLMSPTNTSM
FGTAFTESIDALHGVTTGISAADRTRTILQAIDPDCRPSDLARPGHMFPLRAREGGVLVRAGQTEASVDLARLAGLTPAG
VICEIMNDDGTMARVPQLIEFCKRHDMKMLSVAELIRYRMKNEKFIRRVAEGIIPTEFGDFRTIAYASDLNPEYHLALVR
GDVSGKESVLVRMHSRCVFGDVFRSSQCECGQLVQNSLRAIAKEGQGVLVYLHETGPGFRVDSGQLVSHGRDFMHLKGED
GQRQLQHEHGLGAQILSDLGLHTIRLLTNHPRKIVALEGFGIEVEAQIPVGH
>Mature_371_residues
PIVSVPDAIQEIRAGRIIVVVDDEDRENEGDLTIAAEKVTPEIINFMAVQGRGLICLALTAERCDYLRLPLMSPTNTSMF
GTAFTESIDALHGVTTGISAADRTRTILQAIDPDCRPSDLARPGHMFPLRAREGGVLVRAGQTEASVDLARLAGLTPAGV
ICEIMNDDGTMARVPQLIEFCKRHDMKMLSVAELIRYRMKNEKFIRRVAEGIIPTEFGDFRTIAYASDLNPEYHLALVRG
DVSGKESVLVRMHSRCVFGDVFRSSQCECGQLVQNSLRAIAKEGQGVLVYLHETGPGFRVDSGQLVSHGRDFMHLKGEDG
QRQLQHEHGLGAQILSDLGLHTIRLLTNHPRKIVALEGFGIEVEAQIPVGH

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=203, Percent_Identity=51.2315270935961, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1787533, Length=169, Percent_Identity=33.7278106508876, Blast_Score=104, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=41.1764705882353, Blast_Score=157, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 40883; Mature: 40751

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVSVPDAIQEIRAGRIIVVVDDEDRENEGDLTIAAEKVTPEIINFMAVQGRGLICLAL
CCCCCCCHHHHHHHCCEEEEEECCCCCCCCCCEEEEEHHCCHHHHHHHEECCCCEEEEEE
TAERCDYLRLPLMSPTNTSMFGTAFTESIDALHGVTTGISAADRTRTILQAIDPDCRPSD
ECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHH
LARPGHMFPLRAREGGVLVRAGQTEASVDLARLAGLTPAGVICEIMNDDGTMARVPQLIE
CCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHH
FCKRHDMKMLSVAELIRYRMKNEKFIRRVAEGIIPTEFGDFRTIAYASDLNPEYHLALVR
HHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEEEE
GDVSGKESVLVRMHSRCVFGDVFRSSQCECGQLVQNSLRAIAKEGQGVLVYLHETGPGFR
ECCCCCHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCEE
VDSGQLVSHGRDFMHLKGEDGQRQLQHEHGLGAQILSDLGLHTIRLLTNHPRKIVALEGF
ECCCHHHHCCCCEEEEECCCHHHHHHHHCCCHHHHHHHCCHHEEEHHHCCCCEEEEEECC
GIEVEAQIPVGH
CEEEEEECCCCC
>Mature Secondary Structure 
PIVSVPDAIQEIRAGRIIVVVDDEDRENEGDLTIAAEKVTPEIINFMAVQGRGLICLAL
CCCCCCHHHHHHHCCEEEEEECCCCCCCCCCEEEEEHHCCHHHHHHHEECCCCEEEEEE
TAERCDYLRLPLMSPTNTSMFGTAFTESIDALHGVTTGISAADRTRTILQAIDPDCRPSD
ECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHH
LARPGHMFPLRAREGGVLVRAGQTEASVDLARLAGLTPAGVICEIMNDDGTMARVPQLIE
CCCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHH
FCKRHDMKMLSVAELIRYRMKNEKFIRRVAEGIIPTEFGDFRTIAYASDLNPEYHLALVR
HHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEEEE
GDVSGKESVLVRMHSRCVFGDVFRSSQCECGQLVQNSLRAIAKEGQGVLVYLHETGPGFR
ECCCCCHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCEE
VDSGQLVSHGRDFMHLKGEDGQRQLQHEHGLGAQILSDLGLHTIRLLTNHPRKIVALEGF
ECCCHHHHCCCCEEEEECCCHHHHHHHHCCCHHHHHHHCCHHEEEHHHCCCCEEEEEECC
GIEVEAQIPVGH
CEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]