Click here to switch to the map view.

The map label for this gene is dxs [H]

Identifier: 116620902

GI number: 116620902

Start: 2218376

End: 2220292

Strand: Direct

Name: dxs [H]

Synonym: Acid_1783

Alternate gene names: 116620902

Gene position: 2218376-2220292 (Clockwise)

Preceding gene: 116620901

Following gene: 116620905

Centisome position: 22.26

GC content: 62.23

Gene sequence:

>1917_bases
GTGCGGAGTCCCCGCACACCACATACTAATATGGCAACCATTCTCGAAGGTATTCAGTCTCCCGAGCAGGTGCAGAAGCT
TTCGCTTCCCGAGCTCGACCAACTCGCGGCGGAGATCCGCGAACGGCTGATCACCGTGCTCTCTAATAACGGCGGACACC
TGGGCCCCAATCTCGGCGTGGTGGAACTCACTCTGGCCCTGCACTACGTCTTTCAAACGCCCGCAGACAGCCTGCTCTTC
GACGTAAGTCATCAGGCCTATGTCCACAAGCTGCTCACCGGCCGCCAGGACCAGTTCCACACCATCCGCACTCCCGGCGG
ACTTAATGGCTTCATGTTGCGCACCGAAAGCCCGCACGATGCCTACGGCGCGGGACACGCCGGCACGGCGCTCTCGGCCG
CGCTCGGCATGGCCGTGGCGCGCGATAAAACCGGCGGCAAGGAGCACGTGATCGCCGTCGCCGGCGACGCCGCGTTTACC
TGCGGAATCACTTACGAGGCGCTGAATAACATTGCGCACCACACCAAGCGGATGATCGTGGTGCTCAACGATAACGAATG
GTCCATCGACAAGAACGTCGGCGCCATAGCCACTTATCTTAATAAGATCGTCACCAGCCCGCGCTTCGACTATCTTCATG
ATCGCGCCGGAAAACTGGTGGAGATGGTCGGCGGCGAAGCGGCCCTGCGCATGGCCCGCAGAGCCGAAGAGGTCGCCAAG
GGCATGCTGTGGCCCAGCGTCATCTTCGAAGAGCTTGGGCTCAAATATTTCGGCCCCATCGATGGCCATGATACCGCCAC
TCTAATCAAGACCTTTGAGTACCTCAAGAAGCAGGATCGTCCCGTGCTGCTCCACGTGCTCACCCAGAAGGGCAAGGGCT
TCGAGCCCGCCATGCAAAAGCAAAAGAAATTCCATGGCCTCGGACCCTACGATCCGGAGACCGGCGAAACCAAACCTCTC
GGCCGCCGCACCTACTCCGAGGTCTTCGCCGACACCATGGTGAAGCTCGCCGATTACGATCCCAAAGTGGTCGCCATCAC
CGCGGCCATGCCCAATGGCACCGGCCTCGACCGCTTCCAGCCGCACCACCCCGACAAGTATTTCGATGTCGGAATCGCCG
AAGAGCATGCCGTCCTGTTCGCCGCCGGCCTCGCCGCCAAGGGCTTCAAGCCCTTCTGCGCCATCTACTCCACCTTCCTG
CAGCGCGCATTTGACCCCATCGTGCACGACGTCTGTTTGCAGAACCTTCCCGTCGTCTTCTGCATGGATCGCGGCGGCCT
CTCCGCCGACGATGGTCCCACCCACCACGGCCTCTTCGACATCAGCTACCTGCGCTCCGTCCCCAACCTCGTTCACATGG
TTCCCAAGGATGAGGACGAACTCGCCGACATGCTCTTCACTGCCATGAAGTGGAACGGCCCAATCGCCGTCCGCTATCCG
CGCGGCCTCGGACCCGGCACTCCCGTGAAGGACGTTCCCCGCGCAATCGCCGTCGGCAAGGCCGAGCTCTTGCAGCACGG
CGAGAACGATCGCGTCGCCATCTTCGCCATCGGCGCCATGGTTCCGCTCGCCGAGGAGATTGCGCGCAAGCTTGAGGGCG
AGGGCATCGCCGCGGCTGTTGTCAACGCGCGCTTCACCAAGCCCATCGATGTCGCTATGCTGGAGTTTTTCGCCGGCACC
GCCGAAGTCATCCTTACGCTGGAAGACCACGTGCTCCGCGGCGGCTTTGGCAGCGCGGTGCTGGAGGAGTTGAGCAATCT
CGGTTTGAACACGCCCGTGGTGCGCATCGGTTGGCCCGACCACTTCATCGAGCACGGCAAGCAGGATGCCCTGCGCGCCA
AGTACGGCTTCACTCCGGAAGCCGCGCTCGAAAAGCTCCGCCCCTACTTGAGGCTTCGCCAGGCGCAGCCGGTCTGA

Upstream 100 bases:

>100_bases
CGTGGGGACGCTTACATGGCGGCCGTGGCTTCGTGCCAAAATAATAAAATAGGAAAAACTTGTCACATGCCGCTAAATGG
CGCGCGGTTGAGGGATGCTC

Downstream 100 bases:

>100_bases
CCGCTACCACTTGTCGATGTAGATCGGCCGCTCCGGCGGCCTCCCTTCGCACCAGTAGTGGTCGAAGTCGGTGATTCCCG
CGAGCGTTGTCAGCGCCTCC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MRSPRTPHTNMATILEGIQSPEQVQKLSLPELDQLAAEIRERLITVLSNNGGHLGPNLGVVELTLALHYVFQTPADSLLF
DVSHQAYVHKLLTGRQDQFHTIRTPGGLNGFMLRTESPHDAYGAGHAGTALSAALGMAVARDKTGGKEHVIAVAGDAAFT
CGITYEALNNIAHHTKRMIVVLNDNEWSIDKNVGAIATYLNKIVTSPRFDYLHDRAGKLVEMVGGEAALRMARRAEEVAK
GMLWPSVIFEELGLKYFGPIDGHDTATLIKTFEYLKKQDRPVLLHVLTQKGKGFEPAMQKQKKFHGLGPYDPETGETKPL
GRRTYSEVFADTMVKLADYDPKVVAITAAMPNGTGLDRFQPHHPDKYFDVGIAEEHAVLFAAGLAAKGFKPFCAIYSTFL
QRAFDPIVHDVCLQNLPVVFCMDRGGLSADDGPTHHGLFDISYLRSVPNLVHMVPKDEDELADMLFTAMKWNGPIAVRYP
RGLGPGTPVKDVPRAIAVGKAELLQHGENDRVAIFAIGAMVPLAEEIARKLEGEGIAAAVVNARFTKPIDVAMLEFFAGT
AEVILTLEDHVLRGGFGSAVLEELSNLGLNTPVVRIGWPDHFIEHGKQDALRAKYGFTPEAALEKLRPYLRLRQAQPV

Sequences:

>Translated_638_residues
MRSPRTPHTNMATILEGIQSPEQVQKLSLPELDQLAAEIRERLITVLSNNGGHLGPNLGVVELTLALHYVFQTPADSLLF
DVSHQAYVHKLLTGRQDQFHTIRTPGGLNGFMLRTESPHDAYGAGHAGTALSAALGMAVARDKTGGKEHVIAVAGDAAFT
CGITYEALNNIAHHTKRMIVVLNDNEWSIDKNVGAIATYLNKIVTSPRFDYLHDRAGKLVEMVGGEAALRMARRAEEVAK
GMLWPSVIFEELGLKYFGPIDGHDTATLIKTFEYLKKQDRPVLLHVLTQKGKGFEPAMQKQKKFHGLGPYDPETGETKPL
GRRTYSEVFADTMVKLADYDPKVVAITAAMPNGTGLDRFQPHHPDKYFDVGIAEEHAVLFAAGLAAKGFKPFCAIYSTFL
QRAFDPIVHDVCLQNLPVVFCMDRGGLSADDGPTHHGLFDISYLRSVPNLVHMVPKDEDELADMLFTAMKWNGPIAVRYP
RGLGPGTPVKDVPRAIAVGKAELLQHGENDRVAIFAIGAMVPLAEEIARKLEGEGIAAAVVNARFTKPIDVAMLEFFAGT
AEVILTLEDHVLRGGFGSAVLEELSNLGLNTPVVRIGWPDHFIEHGKQDALRAKYGFTPEAALEKLRPYLRLRQAQPV
>Mature_638_residues
MRSPRTPHTNMATILEGIQSPEQVQKLSLPELDQLAAEIRERLITVLSNNGGHLGPNLGVVELTLALHYVFQTPADSLLF
DVSHQAYVHKLLTGRQDQFHTIRTPGGLNGFMLRTESPHDAYGAGHAGTALSAALGMAVARDKTGGKEHVIAVAGDAAFT
CGITYEALNNIAHHTKRMIVVLNDNEWSIDKNVGAIATYLNKIVTSPRFDYLHDRAGKLVEMVGGEAALRMARRAEEVAK
GMLWPSVIFEELGLKYFGPIDGHDTATLIKTFEYLKKQDRPVLLHVLTQKGKGFEPAMQKQKKFHGLGPYDPETGETKPL
GRRTYSEVFADTMVKLADYDPKVVAITAAMPNGTGLDRFQPHHPDKYFDVGIAEEHAVLFAAGLAAKGFKPFCAIYSTFL
QRAFDPIVHDVCLQNLPVVFCMDRGGLSADDGPTHHGLFDISYLRSVPNLVHMVPKDEDELADMLFTAMKWNGPIAVRYP
RGLGPGTPVKDVPRAIAVGKAELLQHGENDRVAIFAIGAMVPLAEEIARKLEGEGIAAAVVNARFTKPIDVAMLEFFAGT
AEVILTLEDHVLRGGFGSAVLEELSNLGLNTPVVRIGWPDHFIEHGKQDALRAKYGFTPEAALEKLRPYLRLRQAQPV

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=262, Percent_Identity=28.2442748091603, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4507521, Length=262, Percent_Identity=28.2442748091603, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI133778974, Length=369, Percent_Identity=23.3062330623306, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI225637461, Length=294, Percent_Identity=27.891156462585, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI225637463, Length=294, Percent_Identity=27.891156462585, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI225637459, Length=294, Percent_Identity=27.891156462585, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1786622, Length=619, Percent_Identity=42.3263327948304, Blast_Score=496, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17539652, Length=395, Percent_Identity=24.5569620253165, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24666278, Length=264, Percent_Identity=29.1666666666667, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45551847, Length=374, Percent_Identity=26.2032085561497, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45550715, Length=374, Percent_Identity=26.2032085561497, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24645119, Length=374, Percent_Identity=26.2032085561497, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69897; Mature: 69897

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSPRTPHTNMATILEGIQSPEQVQKLSLPELDQLAAEIRERLITVLSNNGGHLGPNLGV
CCCCCCCCCHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
VELTLALHYVFQTPADSLLFDVSHQAYVHKLLTGRQDQFHTIRTPGGLNGFMLRTESPHD
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCC
AYGAGHAGTALSAALGMAVARDKTGGKEHVIAVAGDAAFTCGITYEALNNIAHHTKRMIV
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEECEEHHHHHHHHHHCCEEEE
VLNDNEWSIDKNVGAIATYLNKIVTSPRFDYLHDRAGKLVEMVGGEAALRMARRAEEVAK
EECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GMLWPSVIFEELGLKYFGPIDGHDTATLIKTFEYLKKQDRPVLLHVLTQKGKGFEPAMQK
HCCCHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHH
QKKFHGLGPYDPETGETKPLGRRTYSEVFADTMVKLADYDPKVVAITAAMPNGTGLDRFQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
PHHPDKYFDVGIAEEHAVLFAAGLAAKGFKPFCAIYSTFLQRAFDPIVHDVCLQNLPVVF
CCCCCCCEECCCCCCCHHHEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
CMDRGGLSADDGPTHHGLFDISYLRSVPNLVHMVPKDEDELADMLFTAMKWNGPIAVRYP
EECCCCCCCCCCCCCCCEEHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEC
RGLGPGTPVKDVPRAIAVGKAELLQHGENDRVAIFAIGAMVPLAEEIARKLEGEGIAAAV
CCCCCCCCHHHHHHHHHHCHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEE
VNARFTKPIDVAMLEFFAGTAEVILTLEDHVLRGGFGSAVLEELSNLGLNTPVVRIGWPD
ECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCH
HFIEHGKQDALRAKYGFTPEAALEKLRPYLRLRQAQPV
HHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRSPRTPHTNMATILEGIQSPEQVQKLSLPELDQLAAEIRERLITVLSNNGGHLGPNLGV
CCCCCCCCCHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
VELTLALHYVFQTPADSLLFDVSHQAYVHKLLTGRQDQFHTIRTPGGLNGFMLRTESPHD
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEECCCCC
AYGAGHAGTALSAALGMAVARDKTGGKEHVIAVAGDAAFTCGITYEALNNIAHHTKRMIV
CCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEECEEHHHHHHHHHHCCEEEE
VLNDNEWSIDKNVGAIATYLNKIVTSPRFDYLHDRAGKLVEMVGGEAALRMARRAEEVAK
EECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GMLWPSVIFEELGLKYFGPIDGHDTATLIKTFEYLKKQDRPVLLHVLTQKGKGFEPAMQK
HCCCHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHH
QKKFHGLGPYDPETGETKPLGRRTYSEVFADTMVKLADYDPKVVAITAAMPNGTGLDRFQ
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
PHHPDKYFDVGIAEEHAVLFAAGLAAKGFKPFCAIYSTFLQRAFDPIVHDVCLQNLPVVF
CCCCCCCEECCCCCCCHHHEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
CMDRGGLSADDGPTHHGLFDISYLRSVPNLVHMVPKDEDELADMLFTAMKWNGPIAVRYP
EECCCCCCCCCCCCCCCEEHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEC
RGLGPGTPVKDVPRAIAVGKAELLQHGENDRVAIFAIGAMVPLAEEIARKLEGEGIAAAV
CCCCCCCCHHHHHHHHHHCHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEE
VNARFTKPIDVAMLEFFAGTAEVILTLEDHVLRGGFGSAVLEELSNLGLNTPVVRIGWPD
ECCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCCH
HFIEHGKQDALRAKYGFTPEAALEKLRPYLRLRQAQPV
HHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA