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The map label for this gene is atoC [H]

Identifier: 116620873

GI number: 116620873

Start: 2182802

End: 2184235

Strand: Direct

Name: atoC [H]

Synonym: Acid_1754

Alternate gene names: 116620873

Gene position: 2182802-2184235 (Clockwise)

Preceding gene: 116620871

Following gene: 116620875

Centisome position: 21.9

GC content: 61.92

Gene sequence:

>1434_bases
TTGAACCAACAAATCCGTGTTTTGATCGTTGACGATGAAGAGAGCCAGCGCGCCGGCTTGGCCGCCATGGTGTCCGCCTG
GGGAATGTTACCGAAGACTGCCGCGGACGGCAACGAGGCGCTGGAGACGCTTAATTCCTTTCCCGCCGATGTAATTTTGA
CCGATTTGAATATGCCGGGGCTCGACGGCTTCGGGTTCCTGCAGCGTTTGCGGGAAGCGGGCGACATGCCGCCGACGATC
GTGCTGACCGCCTATGGGAATATCGAGACGGCGGTCAAAACCGTGCACGAACTCGGCGCGTACTGGTTCCTGGAAAAGCC
GATTCAGGCGGGGACCCTTGAGGTCTTGGTCCGCCGTGCCGGCTCGCACGCGGAACTGAACCAGGAGAAGCGGGTGCTGG
AGCGGAACCTGGTATATAAGGGATCGCTGGGCGAAATGGTGGGCAAGTCGCCGCGCATGCAGGAGATCTTCGCCCTCTTG
CAGCAGGCGGGGCCGAGCCGGGCGGGCGTGCTGATCACGGGCGAGAGCGGGACCGGTAAGGAAATGGTGGCGCGCACGCT
GCACGCGCTGAGTCCGCGGAGGCAGGGGCCGTTCGTGGCGATCAACTGCGCGGCCTTGCCGGAATCGCTGATCGAAAGCG
AATTGTTTGGACACGAGAAGGGATCTTTCACGGGCGCCACGGAGCGGCGCGCCGGCTGTTTCGAACTGGCGCAGAACGGA
ACGCTGCTCTTGGACGAGATCGGCGAGATGCCGATGGCGACACAGGCGAAACTGCTGCGTATCCTGGAAGATTCCAAGGT
GCGCAGGCTGGGCGGCCGCACCGAGTTCGAGGTGGACGTGCGCGTGGTGGCGGCCACCAACAAAGTCCCCGAGGAAGCTG
TTCAAGGCGGACATTTGCGGGAGGATTTGTTCTACCGGTTGAATGTGTTTCATGTGCACCTGCCGCCGCTGCGCGATCGC
AAGGACGATATCCAGGCGATGGCGGACGCGTTGATCGCGGACCTCAATCGCAAGCACGAGTGCCGGGTTACGGAGATTGC
AGCCGCGGTGATGACGTGCCTGCAGCGCCACAACTGGCCGGGCAATGTCCGGGAACTGCGGAACGTGCTGGAACGCGCGG
TGATTCTGGCGGGTGAAGGGACGATCGAAGTGAAACACCTGCCGGTGTTTTTGCAGAACCGTCCGGCAACGGTGGTTGCG
AGCGATGAGCCGGCGGCGGTTGCGGCGACAGCTGCGGATGATCTGGAAACCGTGCGATTCTTGATCGGCACCACCGTGGA
AGAGGCGGAGAAAGGGTTGATTCTGCGGACGCTGGAACACACGAACAACAACAAGACGCGCGCGGCCGACATTCTCGGAA
TCAGCCTGAAGACGCTGCACAACAAGCTGAAGGAATACGGCGCAAAGGAAGTCGGAATCGGAGCGCAGGTCTAG

Upstream 100 bases:

>100_bases
AGCTTTCACCTCAATCTTAGCATCTCCCACAGGGTGGTCCGGAGAGCGTACGGAGGTAAAATAGTGATTAAGGCCATCCC
ATCCAAGGAAGGAACTCCGT

Downstream 100 bases:

>100_bases
CTATAGGGACGAAAGGGGGGAGCGTGTAGATCGCTCCCTCATCACGGTCGCGGCTCGTTAGCGGCCGGTGTGCAGGTTAT
TGTGAATCGCGTAGAGGGCG

Product: two component sigma54-specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNQQIRVLIVDDEESQRAGLAAMVSAWGMLPKTAADGNEALETLNSFPADVILTDLNMPGLDGFGFLQRLREAGDMPPTI
VLTAYGNIETAVKTVHELGAYWFLEKPIQAGTLEVLVRRAGSHAELNQEKRVLERNLVYKGSLGEMVGKSPRMQEIFALL
QQAGPSRAGVLITGESGTGKEMVARTLHALSPRRQGPFVAINCAALPESLIESELFGHEKGSFTGATERRAGCFELAQNG
TLLLDEIGEMPMATQAKLLRILEDSKVRRLGGRTEFEVDVRVVAATNKVPEEAVQGGHLREDLFYRLNVFHVHLPPLRDR
KDDIQAMADALIADLNRKHECRVTEIAAAVMTCLQRHNWPGNVRELRNVLERAVILAGEGTIEVKHLPVFLQNRPATVVA
SDEPAAVAATAADDLETVRFLIGTTVEEAEKGLILRTLEHTNNNKTRAADILGISLKTLHNKLKEYGAKEVGIGAQV

Sequences:

>Translated_477_residues
MNQQIRVLIVDDEESQRAGLAAMVSAWGMLPKTAADGNEALETLNSFPADVILTDLNMPGLDGFGFLQRLREAGDMPPTI
VLTAYGNIETAVKTVHELGAYWFLEKPIQAGTLEVLVRRAGSHAELNQEKRVLERNLVYKGSLGEMVGKSPRMQEIFALL
QQAGPSRAGVLITGESGTGKEMVARTLHALSPRRQGPFVAINCAALPESLIESELFGHEKGSFTGATERRAGCFELAQNG
TLLLDEIGEMPMATQAKLLRILEDSKVRRLGGRTEFEVDVRVVAATNKVPEEAVQGGHLREDLFYRLNVFHVHLPPLRDR
KDDIQAMADALIADLNRKHECRVTEIAAAVMTCLQRHNWPGNVRELRNVLERAVILAGEGTIEVKHLPVFLQNRPATVVA
SDEPAAVAATAADDLETVRFLIGTTVEEAEKGLILRTLEHTNNNKTRAADILGISLKTLHNKLKEYGAKEVGIGAQV
>Mature_477_residues
MNQQIRVLIVDDEESQRAGLAAMVSAWGMLPKTAADGNEALETLNSFPADVILTDLNMPGLDGFGFLQRLREAGDMPPTI
VLTAYGNIETAVKTVHELGAYWFLEKPIQAGTLEVLVRRAGSHAELNQEKRVLERNLVYKGSLGEMVGKSPRMQEIFALL
QQAGPSRAGVLITGESGTGKEMVARTLHALSPRRQGPFVAINCAALPESLIESELFGHEKGSFTGATERRAGCFELAQNG
TLLLDEIGEMPMATQAKLLRILEDSKVRRLGGRTEFEVDVRVVAATNKVPEEAVQGGHLREDLFYRLNVFHVHLPPLRDR
KDDIQAMADALIADLNRKHECRVTEIAAAVMTCLQRHNWPGNVRELRNVLERAVILAGEGTIEVKHLPVFLQNRPATVVA
SDEPAAVAATAADDLETVRFLIGTTVEEAEKGLILRTLEHTNNNKTRAADILGISLKTLHNKLKEYGAKEVGIGAQV

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=462, Percent_Identity=41.7748917748918, Blast_Score=353, Evalue=1e-98,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=39.8286937901499, Blast_Score=327, Evalue=8e-91,
Organism=Escherichia coli, GI1790437, Length=463, Percent_Identity=38.8768898488121, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI1788905, Length=399, Percent_Identity=37.34335839599, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI1789233, Length=324, Percent_Identity=42.2839506172839, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI87082117, Length=348, Percent_Identity=41.3793103448276, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI1789087, Length=364, Percent_Identity=39.8351648351648, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1786524, Length=336, Percent_Identity=41.9642857142857, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI87082152, Length=332, Percent_Identity=40.0602409638554, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1787583, Length=331, Percent_Identity=38.9728096676737, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI87081872, Length=330, Percent_Identity=37.8787878787879, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI87081858, Length=329, Percent_Identity=27.9635258358663, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789828, Length=254, Percent_Identity=35.4330708661417, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI145693157, Length=130, Percent_Identity=34.6153846153846, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787487, Length=104, Percent_Identity=35.5769230769231, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52186; Mature: 52186

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQQIRVLIVDDEESQRAGLAAMVSAWGMLPKTAADGNEALETLNSFPADVILTDLNMPG
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCC
LDGFGFLQRLREAGDMPPTIVLTAYGNIETAVKTVHELGAYWFLEKPIQAGTLEVLVRRA
CCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHC
GSHAELNQEKRVLERNLVYKGSLGEMVGKSPRMQEIFALLQQAGPSRAGVLITGESGTGK
CCCCCCCHHHHHHHHHCEECCCHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCH
EMVARTLHALSPRRQGPFVAINCAALPESLIESELFGHEKGSFTGATERRAGCFELAQNG
HHHHHHHHHHCCCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHCCC
TLLLDEIGEMPMATQAKLLRILEDSKVRRLGGRTEFEVDVRVVAATNKVPEEAVQGGHLR
CEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHHHCCCCHH
EDLFYRLNVFHVHLPPLRDRKDDIQAMADALIADLNRKHECRVTEIAAAVMTCLQRHNWP
HHHHEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
GNVRELRNVLERAVILAGEGTIEVKHLPVFLQNRPATVVASDEPAAVAATAADDLETVRF
CCHHHHHHHHHHHEEEECCCEEEEEEEEEEECCCCEEEEECCCCCEEEEECHHHHHHHHH
LIGTTVEEAEKGLILRTLEHTNNNKTRAADILGISLKTLHNKLKEYGAKEVGIGAQV
HHHCCHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNQQIRVLIVDDEESQRAGLAAMVSAWGMLPKTAADGNEALETLNSFPADVILTDLNMPG
CCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCC
LDGFGFLQRLREAGDMPPTIVLTAYGNIETAVKTVHELGAYWFLEKPIQAGTLEVLVRRA
CCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHC
GSHAELNQEKRVLERNLVYKGSLGEMVGKSPRMQEIFALLQQAGPSRAGVLITGESGTGK
CCCCCCCHHHHHHHHHCEECCCHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCH
EMVARTLHALSPRRQGPFVAINCAALPESLIESELFGHEKGSFTGATERRAGCFELAQNG
HHHHHHHHHHCCCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHCCC
TLLLDEIGEMPMATQAKLLRILEDSKVRRLGGRTEFEVDVRVVAATNKVPEEAVQGGHLR
CEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHHHCCCCHH
EDLFYRLNVFHVHLPPLRDRKDDIQAMADALIADLNRKHECRVTEIAAAVMTCLQRHNWP
HHHHEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
GNVRELRNVLERAVILAGEGTIEVKHLPVFLQNRPATVVASDEPAAVAATAADDLETVRF
CCHHHHHHHHHHHEEEECCCEEEEEEEEEEECCCCEEEEECCCCCEEEEECHHHHHHHHH
LIGTTVEEAEKGLILRTLEHTNNNKTRAADILGISLKTLHNKLKEYGAKEVGIGAQV
HHHCCHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]