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The map label for this gene is atoC [H]

Identifier: 116620764

GI number: 116620764

Start: 2036068

End: 2037516

Strand: Reverse

Name: atoC [H]

Synonym: Acid_1645

Alternate gene names: 116620764

Gene position: 2037516-2036068 (Counterclockwise)

Preceding gene: 116620765

Following gene: 116620763

Centisome position: 20.45

GC content: 61.28

Gene sequence:

>1449_bases
ATGAACGACTCCCAGACCTCTTCCGCCGGCCCAAAGGGCAAGATCCTCGTCATCGACGATGAGCTGGATATCCGCGAAGG
TTTGCACGACCTTTTGACCCTGGAAGGCGGCTACATCGTCGAGCTGGCACACAACGGCGGCGAGGGACTGCAGAAGCTCG
AAGGCGCCTCCTACGACCTGGTCCTGCTCGACCTCATGATGCCCGATATGTCGGGCATGGACGTTCTGCAGCAGGTGCGC
ACGCGGGATCGCGAGACGCCGATCTTCATGATCACCGCCTATGGCTCCGTGGAAGCCGCGGTCGATGCGTTGAAGCTCGG
CGCCAACGATTATTTCTCGAAGCCTTGGGACAATGAAAAGCTGCTGATCGAGATCGACCGCATGATCGCGCGTCGCCTCC
TCGAATACGAGAACACCCACCTCAAGCGCGCCCTGAAACAGCGCTACAGCTTCCCCAACATCATCGGCAAGAGCGAGCGT
ATGGTGCGACTGCTAGACCTGGTCGGCCAGGTCGCCAGCAGCCGCTCCACCATCCTGATCACGGGCGAAACCGGCACCGG
CAAGGAACTTGTCGCGAAAGCGATCCACGCCAACTCGCCGCGGGCCGACCAGATGTTCGTCGCTGTCAACTCCGGCTCGC
TGCCGCCGGAGCTTCTGGAATCCACTCTGTTCGGCCACGTGCGCGGCGCCTTTACGAGCGCCATCCAGACCAAGAAGGGC
TACTTCGAAGTCGCCGATCGCGGGACCATCTTTTTCGATGAAATCGGCACGCTGGGTCCGGAGACGCAGATCAAACTGCT
GCGCGTCATCCAGGAGAAGGAGTTCACCCCGCTCGGCTCCACCGACCCGATCCGAGTGGACGTGCGCATCGTCGCCGCGA
CCAATGCCGATCTCGCCCAGCTGGTCAAGGAGGGCAAGTTCCGCGAGGACCTCTACTACCGCCTTAACGTCATCAATATC
GCGCTGCCCGCGCTGCGCGATCGCAAGGAAGATATCCCGTTGCTCGCCGGCCATTTCTTCACCTACTATTGCCGCGAGAA
CGATAAGTTCCTGGACCCCACCGGCAAGTCCATCCTCCACTTTCAGCCCGAAGCCCTCCAGGTGCTGATGGAGCACAGCT
GGCCGGGCAATGTCCGCGAGCTCGAAAACGTGGTCGAGCGTGCCGTGGTCCTCGCCAGCGAACCTTCCGTGCCGGTGGAC
GTCCTGCCGGATGCGCTCCTCCAGGCAAACGGCATCCGTCTCAACCGCGCGGAAGGCAGCCCCCTTCCCGCCGACGCGTC
CCTCTTCGAAATCGTCAACGAATTCGAGCGCCGCACCATCATCGACCGCCTGGAAAAATGCAGCTGGAGCCAGACCGAGG
CCGCCGAAAGCCTGCACGTCCCTCTCTCCACGCTGAACCAGAAAATCAAACGCCTGGACATCAAAATTCGAAAAAAATCC
GAAGGCTGA

Upstream 100 bases:

>100_bases
CGGCGCAACGTTCCGCGTGGAACTTCCTCTCGCCGTGCCTGGCTCCGCCAGGAAGCCGGTAACCGCCGCCTGACCGATAC
CCGGTCGGTAAACGTGATCA

Downstream 100 bases:

>100_bases
AACTCGCATCCTGGTTTGATAGCCTTAAATATTGCCTCGAATTCTAGCATTCCTCCTCCTCTCGCCGGCTCTCTTCGCCC
AGACCGCGACACTACGCGGC

Product: two component sigma54-specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MNDSQTSSAGPKGKILVIDDELDIREGLHDLLTLEGGYIVELAHNGGEGLQKLEGASYDLVLLDLMMPDMSGMDVLQQVR
TRDRETPIFMITAYGSVEAAVDALKLGANDYFSKPWDNEKLLIEIDRMIARRLLEYENTHLKRALKQRYSFPNIIGKSER
MVRLLDLVGQVASSRSTILITGETGTGKELVAKAIHANSPRADQMFVAVNSGSLPPELLESTLFGHVRGAFTSAIQTKKG
YFEVADRGTIFFDEIGTLGPETQIKLLRVIQEKEFTPLGSTDPIRVDVRIVAATNADLAQLVKEGKFREDLYYRLNVINI
ALPALRDRKEDIPLLAGHFFTYYCRENDKFLDPTGKSILHFQPEALQVLMEHSWPGNVRELENVVERAVVLASEPSVPVD
VLPDALLQANGIRLNRAEGSPLPADASLFEIVNEFERRTIIDRLEKCSWSQTEAAESLHVPLSTLNQKIKRLDIKIRKKS
EG

Sequences:

>Translated_482_residues
MNDSQTSSAGPKGKILVIDDELDIREGLHDLLTLEGGYIVELAHNGGEGLQKLEGASYDLVLLDLMMPDMSGMDVLQQVR
TRDRETPIFMITAYGSVEAAVDALKLGANDYFSKPWDNEKLLIEIDRMIARRLLEYENTHLKRALKQRYSFPNIIGKSER
MVRLLDLVGQVASSRSTILITGETGTGKELVAKAIHANSPRADQMFVAVNSGSLPPELLESTLFGHVRGAFTSAIQTKKG
YFEVADRGTIFFDEIGTLGPETQIKLLRVIQEKEFTPLGSTDPIRVDVRIVAATNADLAQLVKEGKFREDLYYRLNVINI
ALPALRDRKEDIPLLAGHFFTYYCRENDKFLDPTGKSILHFQPEALQVLMEHSWPGNVRELENVVERAVVLASEPSVPVD
VLPDALLQANGIRLNRAEGSPLPADASLFEIVNEFERRTIIDRLEKCSWSQTEAAESLHVPLSTLNQKIKRLDIKIRKKS
EG
>Mature_482_residues
MNDSQTSSAGPKGKILVIDDELDIREGLHDLLTLEGGYIVELAHNGGEGLQKLEGASYDLVLLDLMMPDMSGMDVLQQVR
TRDRETPIFMITAYGSVEAAVDALKLGANDYFSKPWDNEKLLIEIDRMIARRLLEYENTHLKRALKQRYSFPNIIGKSER
MVRLLDLVGQVASSRSTILITGETGTGKELVAKAIHANSPRADQMFVAVNSGSLPPELLESTLFGHVRGAFTSAIQTKKG
YFEVADRGTIFFDEIGTLGPETQIKLLRVIQEKEFTPLGSTDPIRVDVRIVAATNADLAQLVKEGKFREDLYYRLNVINI
ALPALRDRKEDIPLLAGHFFTYYCRENDKFLDPTGKSILHFQPEALQVLMEHSWPGNVRELENVVERAVVLASEPSVPVD
VLPDALLQANGIRLNRAEGSPLPADASLFEIVNEFERRTIIDRLEKCSWSQTEAAESLHVPLSTLNQKIKRLDIKIRKKS
EG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=463, Percent_Identity=41.2526997840173, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1790437, Length=460, Percent_Identity=42.1739130434783, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI1790299, Length=479, Percent_Identity=36.9519832985386, Blast_Score=297, Evalue=8e-82,
Organism=Escherichia coli, GI1788905, Length=443, Percent_Identity=39.5033860045147, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI87082117, Length=260, Percent_Identity=53.4615384615385, Blast_Score=258, Evalue=9e-70,
Organism=Escherichia coli, GI1789087, Length=436, Percent_Identity=39.4495412844037, Blast_Score=245, Evalue=5e-66,
Organism=Escherichia coli, GI1789233, Length=374, Percent_Identity=37.9679144385027, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI87082152, Length=325, Percent_Identity=42.4615384615385, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI87081872, Length=327, Percent_Identity=37.9204892966361, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1787583, Length=334, Percent_Identity=35.9281437125749, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1786524, Length=346, Percent_Identity=36.7052023121387, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789828, Length=279, Percent_Identity=37.9928315412186, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87081858, Length=331, Percent_Identity=29.607250755287, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786784, Length=119, Percent_Identity=39.4957983193277, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082012, Length=112, Percent_Identity=37.5, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789402, Length=103, Percent_Identity=35.9223300970874, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789809, Length=119, Percent_Identity=36.1344537815126, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786599, Length=120, Percent_Identity=34.1666666666667, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI2367329, Length=119, Percent_Identity=42.8571428571429, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=34.3137254901961, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53849; Mature: 53849

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDSQTSSAGPKGKILVIDDELDIREGLHDLLTLEGGYIVELAHNGGEGLQKLEGASYDL
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCCCE
VLLDLMMPDMSGMDVLQQVRTRDRETPIFMITAYGSVEAAVDALKLGANDYFSKPWDNEK
EEEEHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCE
LLIEIDRMIARRLLEYENTHLKRALKQRYSFPNIIGKSERMVRLLDLVGQVASSRSTILI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEE
TGETGTGKELVAKAIHANSPRADQMFVAVNSGSLPPELLESTLFGHVRGAFTSAIQTKKG
ECCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
YFEVADRGTIFFDEIGTLGPETQIKLLRVIQEKEFTPLGSTDPIRVDVRIVAATNADLAQ
CEEECCCCCEEEHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCHHHHH
LVKEGKFREDLYYRLNVINIALPALRDRKEDIPLLAGHFFTYYCRENDKFLDPTGKSILH
HHHCCCCHHHHHEEEEHHEEEHHHHHCCCCCCCEEECCEEEEEECCCCCEECCCCCCEEE
FQPEALQVLMEHSWPGNVRELENVVERAVVLASEPSVPVDVLPDALLQANGIRLNRAEGS
ECHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCCCHHHCCHHHHHCCCEEEECCCCC
PLPADASLFEIVNEFERRTIIDRLEKCSWSQTEAAESLHVPLSTLNQKIKRLDIKIRKKS
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHCEEEEECC
EG
CC
>Mature Secondary Structure
MNDSQTSSAGPKGKILVIDDELDIREGLHDLLTLEGGYIVELAHNGGEGLQKLEGASYDL
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCCCE
VLLDLMMPDMSGMDVLQQVRTRDRETPIFMITAYGSVEAAVDALKLGANDYFSKPWDNEK
EEEEHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCE
LLIEIDRMIARRLLEYENTHLKRALKQRYSFPNIIGKSERMVRLLDLVGQVASSRSTILI
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEE
TGETGTGKELVAKAIHANSPRADQMFVAVNSGSLPPELLESTLFGHVRGAFTSAIQTKKG
ECCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
YFEVADRGTIFFDEIGTLGPETQIKLLRVIQEKEFTPLGSTDPIRVDVRIVAATNADLAQ
CEEECCCCCEEEHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCHHHHH
LVKEGKFREDLYYRLNVINIALPALRDRKEDIPLLAGHFFTYYCRENDKFLDPTGKSILH
HHHCCCCHHHHHEEEEHHEEEHHHHHCCCCCCCEEECCEEEEEECCCCCEECCCCCCEEE
FQPEALQVLMEHSWPGNVRELENVVERAVVLASEPSVPVDVLPDALLQANGIRLNRAEGS
ECHHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCCCHHHCCHHHHHCCCEEEECCCCC
PLPADASLFEIVNEFERRTIIDRLEKCSWSQTEAAESLHVPLSTLNQKIKRLDIKIRKKS
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHCEEEEECC
EG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]