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The map label for this gene is atsA [H]

Identifier: 116620648

GI number: 116620648

Start: 1873505

End: 1875142

Strand: Direct

Name: atsA [H]

Synonym: Acid_1528

Alternate gene names: 116620648

Gene position: 1873505-1875142 (Clockwise)

Preceding gene: 116620647

Following gene: 116620650

Centisome position: 18.8

GC content: 65.32

Gene sequence:

>1638_bases
TTGATTCCACGCAGGGACTTCGTCAGAATTGCAGCTGCCGGCGCGGTCGGCGCCGGCAGTTTCCTCTCGGCGCCTCCACG
GCGGCCGAACGTCATCGTGATGATGGCGGACGATATGGGTTTCAGCGATCTCGGCTGCTACGGCAGCGAGATTCACACGC
CCAATATCGATAGCCTGGCGCAATCCGGCGTCCGGTTCACCCACTTTCGCAACACGGCGCGCTGCTGTCCCAGCCGCACC
AGCCTGCTCACGGGATTGTACGCGCACCAGGCGGGCGTCGGGCACATGGTCAATCCGCGGCCCACCCTGCCGGGATATCA
GGGCGACCTGAACCAAAGCTGCGTGACCATCGCCCAAGTCATGCGCGGGGCCGGATACCAGACCATGATGAGCGGCAAGT
GGCATGTGACGCCGAACAACGCTCGCAAGCACAACTGGCCGCTGCAACGCGGCTTTGACCGTTTCTACGGCATCATCGCG
GGCGCGGCCAGCTACTACCAGCCCTGGACGCTGACGCGCGACAACAACCCGATAGACCCCGAGGGCGCGGACTACTACCT
TACGGACGCGATCGGCCGCAACGCCGCTACGTACATTGAGGACGCCGCGGCCAAGCCAGACCCCTTCTTCCTTTACGTGG
GCTTCACCGCGCCGCACTGGCCGCTGCACGCCTTCGAAAGCGACATCGAACGCTACCGCGGCCGCTACCGCGATGGTTGG
GACGCGCTGCGCACCGAGCGCCACCAGCGCATGATCAGCATGGGGCTGGTCGATAAAAAGTGGGGACTGACACCGCGCGA
CGAAGAGGTCCCGGCATGGAAGGACGCGCCGGATCGCGAATGGCAGCAGCGCCGCATGGAGGTCTACGCGGCGCAGATCG
ACCGCATGGATCGCAATGTAGGAACGATTCTCGAGAGCCTGCGCAAGACCGGCAAGGAGCAGGAGACGTTGATTCTGTTT
CTGGCCGATAACGGCGGCTGCGCCGAAAACCTGCCCACCGGACGGATCAACAACAATAGCCCCAAGCAGGCGCGCGATGG
CCGCCCCATGCGCTCCGGCAACGCACCCTCCATCATGCCGGGCGGCGAAGACACGTTCGCGAGCTACGGCATCGCGTGGG
CGAATGCGTCCAATTCACCTTTCCGCAGATACAAGCACTGGGTGCACGAAGGCGGCATTGCCAGCCCGCTGATCGCGCGC
TGGCCGGGCGGAATAGGACGCGGCGGCGCCATCACGCACGAGCCGGGCCACGTCATCGACCTGATGGCGACATGCATTGA
CGTGGCCGGCACGCGCTACCCGGAGTTGCACAACGGGCAACACGTAACGCCGATGGAGGGCCGCAGTCTGGAGCCGGCAT
TCCATGGCAAGAAAGTCTCGCGCGGCGATGCGTTCTACTGGGAGCACGAGGGCAACCGGGCCGTGGTGGATGGCCGCTAC
AAGCTGGTCTCGCGCTTCCCGGATCGCTGGGAACTTTACGATCTGGAAGCCGACCGCTGCGAGATGCGCGACCTTTCCGG
CAGCGATGCGGCGCGCGTGGAGCGCATGGTGGGCCGTTACGACCGTTGGGCGGAGCGCTGCAACGTTCTCCCGTGGGACG
AGGTCCGCAAGATCCCCGCCGCGGACGCGGGCGGTTAG

Upstream 100 bases:

>100_bases
CGCAGCGTTGTTCATGGCCGGTCCGGCCCTGCTCGGGCTGGCAGCGTGGAAGCGGCGGCGGTAGTTTGCCGCGGGCCGCG
CTTCATGACAGAATGACTGC

Downstream 100 bases:

>100_bases
AGTTTACTTCAGCGCCGAAATGGGAACGGAGTACTTCTCGTAGTGCTTGCCATCGGTGTATCGCGGTCCGTTCGGGTCTT
CGACCAGCACCGTGGCGCGT

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MIPRRDFVRIAAAGAVGAGSFLSAPPRRPNVIVMMADDMGFSDLGCYGSEIHTPNIDSLAQSGVRFTHFRNTARCCPSRT
SLLTGLYAHQAGVGHMVNPRPTLPGYQGDLNQSCVTIAQVMRGAGYQTMMSGKWHVTPNNARKHNWPLQRGFDRFYGIIA
GAASYYQPWTLTRDNNPIDPEGADYYLTDAIGRNAATYIEDAAAKPDPFFLYVGFTAPHWPLHAFESDIERYRGRYRDGW
DALRTERHQRMISMGLVDKKWGLTPRDEEVPAWKDAPDREWQQRRMEVYAAQIDRMDRNVGTILESLRKTGKEQETLILF
LADNGGCAENLPTGRINNNSPKQARDGRPMRSGNAPSIMPGGEDTFASYGIAWANASNSPFRRYKHWVHEGGIASPLIAR
WPGGIGRGGAITHEPGHVIDLMATCIDVAGTRYPELHNGQHVTPMEGRSLEPAFHGKKVSRGDAFYWEHEGNRAVVDGRY
KLVSRFPDRWELYDLEADRCEMRDLSGSDAARVERMVGRYDRWAERCNVLPWDEVRKIPAADAGG

Sequences:

>Translated_545_residues
MIPRRDFVRIAAAGAVGAGSFLSAPPRRPNVIVMMADDMGFSDLGCYGSEIHTPNIDSLAQSGVRFTHFRNTARCCPSRT
SLLTGLYAHQAGVGHMVNPRPTLPGYQGDLNQSCVTIAQVMRGAGYQTMMSGKWHVTPNNARKHNWPLQRGFDRFYGIIA
GAASYYQPWTLTRDNNPIDPEGADYYLTDAIGRNAATYIEDAAAKPDPFFLYVGFTAPHWPLHAFESDIERYRGRYRDGW
DALRTERHQRMISMGLVDKKWGLTPRDEEVPAWKDAPDREWQQRRMEVYAAQIDRMDRNVGTILESLRKTGKEQETLILF
LADNGGCAENLPTGRINNNSPKQARDGRPMRSGNAPSIMPGGEDTFASYGIAWANASNSPFRRYKHWVHEGGIASPLIAR
WPGGIGRGGAITHEPGHVIDLMATCIDVAGTRYPELHNGQHVTPMEGRSLEPAFHGKKVSRGDAFYWEHEGNRAVVDGRY
KLVSRFPDRWELYDLEADRCEMRDLSGSDAARVERMVGRYDRWAERCNVLPWDEVRKIPAADAGG
>Mature_545_residues
MIPRRDFVRIAAAGAVGAGSFLSAPPRRPNVIVMMADDMGFSDLGCYGSEIHTPNIDSLAQSGVRFTHFRNTARCCPSRT
SLLTGLYAHQAGVGHMVNPRPTLPGYQGDLNQSCVTIAQVMRGAGYQTMMSGKWHVTPNNARKHNWPLQRGFDRFYGIIA
GAASYYQPWTLTRDNNPIDPEGADYYLTDAIGRNAATYIEDAAAKPDPFFLYVGFTAPHWPLHAFESDIERYRGRYRDGW
DALRTERHQRMISMGLVDKKWGLTPRDEEVPAWKDAPDREWQQRRMEVYAAQIDRMDRNVGTILESLRKTGKEQETLILF
LADNGGCAENLPTGRINNNSPKQARDGRPMRSGNAPSIMPGGEDTFASYGIAWANASNSPFRRYKHWVHEGGIASPLIAR
WPGGIGRGGAITHEPGHVIDLMATCIDVAGTRYPELHNGQHVTPMEGRSLEPAFHGKKVSRGDAFYWEHEGNRAVVDGRY
KLVSRFPDRWELYDLEADRCEMRDLSGSDAARVERMVGRYDRWAERCNVLPWDEVRKIPAADAGG

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=489, Percent_Identity=28.4253578732106, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI146229329, Length=489, Percent_Identity=28.4253578732106, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI6005990, Length=489, Percent_Identity=28.4253578732106, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI146229324, Length=489, Percent_Identity=28.4253578732106, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4503899, Length=534, Percent_Identity=23.5955056179775, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI38569405, Length=319, Percent_Identity=27.2727272727273, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI38569407, Length=338, Percent_Identity=27.5147928994083, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI109389362, Length=310, Percent_Identity=29.6774193548387, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI59797060, Length=310, Percent_Identity=30, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI53831991, Length=469, Percent_Identity=27.0788912579957, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI157266309, Length=199, Percent_Identity=34.1708542713568, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI71852586, Length=171, Percent_Identity=38.0116959064327, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI58743319, Length=343, Percent_Identity=28.2798833819242, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI71852584, Length=166, Percent_Identity=38.5542168674699, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI31742482, Length=172, Percent_Identity=34.8837209302326, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI45430057, Length=231, Percent_Identity=30.3030303030303, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI240255483, Length=304, Percent_Identity=25.3289473684211, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI29789100, Length=304, Percent_Identity=25.3289473684211, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI240255478, Length=304, Percent_Identity=25.3289473684211, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87081924, Length=350, Percent_Identity=22.2857142857143, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790233, Length=443, Percent_Identity=24.1534988713318, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1790112, Length=496, Percent_Identity=22.1774193548387, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115533416, Length=537, Percent_Identity=23.6499068901304, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI115533418, Length=529, Percent_Identity=23.4404536862004, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17559078, Length=247, Percent_Identity=28.3400809716599, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281366397, Length=438, Percent_Identity=27.8538812785388, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI281366395, Length=438, Percent_Identity=27.8538812785388, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24666163, Length=438, Percent_Identity=27.8538812785388, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24666109, Length=421, Percent_Identity=27.3159144893112, Blast_Score=127, Evalue=3e-29,
Organism=Drosophila melanogaster, GI281363223, Length=480, Percent_Identity=26.4583333333333, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24666175, Length=470, Percent_Identity=24.6808510638298, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653364, Length=308, Percent_Identity=27.5974025974026, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19922168, Length=308, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24647401, Length=312, Percent_Identity=25.3205128205128, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 61084; Mature: 61084

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPRRDFVRIAAAGAVGAGSFLSAPPRRPNVIVMMADDMGFSDLGCYGSEIHTPNIDSLA
CCCCHHHHEEEECCCCCCCHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHH
QSGVRFTHFRNTARCCPSRTSLLTGLYAHQAGVGHMVNPRPTLPGYQGDLNQSCVTIAQV
HCCCEEEECCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
MRGAGYQTMMSGKWHVTPNNARKHNWPLQRGFDRFYGIIAGAASYYQPWTLTRDNNPIDP
HHCCCCEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
EGADYYLTDAIGRNAATYIEDAAAKPDPFFLYVGFTAPHWPLHAFESDIERYRGRYRDGW
CCCCEEEEHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCH
DALRTERHQRMISMGLVDKKWGLTPRDEEVPAWKDAPDREWQQRRMEVYAAQIDRMDRNV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHH
GTILESLRKTGKEQETLILFLADNGGCAENLPTGRINNNSPKQARDGRPMRSGNAPSIMP
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
GGEDTFASYGIAWANASNSPFRRYKHWVHEGGIASPLIARWPGGIGRGGAITHEPGHVID
CCCCHHHHCCEEEECCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHH
LMATCIDVAGTRYPELHNGQHVTPMEGRSLEPAFHGKKVSRGDAFYWEHEGNRAVVDGRY
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEEEEECCCEEEECCHH
KLVSRFPDRWELYDLEADRCEMRDLSGSDAARVERMVGRYDRWAERCNVLPWDEVRKIPA
HHHHHCCCCCEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCC
ADAGG
CCCCC
>Mature Secondary Structure
MIPRRDFVRIAAAGAVGAGSFLSAPPRRPNVIVMMADDMGFSDLGCYGSEIHTPNIDSLA
CCCCHHHHEEEECCCCCCCHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHH
QSGVRFTHFRNTARCCPSRTSLLTGLYAHQAGVGHMVNPRPTLPGYQGDLNQSCVTIAQV
HCCCEEEECCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
MRGAGYQTMMSGKWHVTPNNARKHNWPLQRGFDRFYGIIAGAASYYQPWTLTRDNNPIDP
HHCCCCEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCC
EGADYYLTDAIGRNAATYIEDAAAKPDPFFLYVGFTAPHWPLHAFESDIERYRGRYRDGW
CCCCEEEEHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCH
DALRTERHQRMISMGLVDKKWGLTPRDEEVPAWKDAPDREWQQRRMEVYAAQIDRMDRNV
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHH
GTILESLRKTGKEQETLILFLADNGGCAENLPTGRINNNSPKQARDGRPMRSGNAPSIMP
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
GGEDTFASYGIAWANASNSPFRRYKHWVHEGGIASPLIARWPGGIGRGGAITHEPGHVID
CCCCHHHHCCEEEECCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHH
LMATCIDVAGTRYPELHNGQHVTPMEGRSLEPAFHGKKVSRGDAFYWEHEGNRAVVDGRY
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCEEEEECCCEEEECCHH
KLVSRFPDRWELYDLEADRCEMRDLSGSDAARVERMVGRYDRWAERCNVLPWDEVRKIPA
HHHHHCCCCCEEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCC
ADAGG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7744061; 10984043 [H]