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The map label for this gene is pccB [H]

Identifier: 116620613

GI number: 116620613

Start: 1829855

End: 1831396

Strand: Direct

Name: pccB [H]

Synonym: Acid_1492

Alternate gene names: 116620613

Gene position: 1829855-1831396 (Clockwise)

Preceding gene: 116620612

Following gene: 116620614

Centisome position: 18.36

GC content: 63.94

Gene sequence:

>1542_bases
ATGAATCGCCTCGAGGAATTACGGCGCCGGCACGCGGCTGCGGAGCAGGGCGGCGGGCCGGAGCGCAAGGCCCGGCAGCA
CAAGGAAGGCAAGCTCAGCGCGCGCGAGCGGATTGAGTTGCTGCTGGACGAAGGCTCCTTCGAAGAGCTCGATAAGCTGG
TGACGCATCGCTGCCTGGATTTCGGCATGGAGAAAGAGATCGTGCCGGGCGATGGATTCGTCACGGGATACGGGCGCATC
GAGGGGCGACTAGTCTACGTGTTCGCGCAGGACTTTACGGTCTTCGGCGGGTCGCTCTCGGAGACCAACGCGCTGAAGAT
CTGCAAGGTGATGGACCTGGCGTTGAAGACGGGCGCGCCGGTGATCGGACTCAACGATTCCGGCGGCGCGCGGATTCAGG
AAGGCGTAGTCTCGCTGGCGGGGTACGCGGATATTTTTCTGCGCAACACACTGGCAAGCGGGGTGGTGCCGCAGATCTCG
GCGATCATGGGGCCGTGCGCGGGCGGCGCGGTGTACTCGCCGGCGATCACGGATTTCGTGTTCATGGTGGACCACACGAG
CTACATGTTCGTGACCGGGCCGGACGTGATCAAGACGGTGACGCACGAGGACGTCACCAAGGAAACGCTGGGCGGGTCGA
TGACGCACAACTCGGTGAGCGGAGTGGGGCACTTCATCGCGGCGGATGACGCGGAGTGCTGCCGGATGATTCGCGAGCTG
ATGACGTACCTGCCGCAGAACAATCGCGAGGATCCGCCGCGGCGGGCGACCAACGACCCCATCGAGCGGATGGACGCGGC
GCTGGATACGATCGTACCCGCGGAATCGAACCTGCCGTACGACATTAAGGACGTGATTCACCGGGTGGTGGATGACGGGG
AATTTTTCGAGGTGCACGAGCATTTCGCGAAGAACCTGGTGGTGGGGTTCGCGCGAATGGACGGGCGGTCGATCGGGATC
GTGGGCAATCAGCCGGCGTTTCTGGCGGGGTGCCTGGATATCAACTCGTCGGTGAAGGGCGCGCGGTTCGTGCGGTTCTG
CGATGCATTCAATATCCCAATTCTGACGTTTGAGGATGTGCCGGGCTTTCTGCCGGGGACGGCGCAGGAGTTCGGCGGGA
TCATCCGGCACGGGGCGAAGCTGCTGTACGCGTACGCGGAGGCGACCGTCCCCAAGATTACGGTAATTACGCGGAAGGCA
TACGGGGGCGCGTATTGCGTGATGGGGTCGAAGCACATTCGGACGGACATCAACCTCGCGTGGCCGACGGCGGAGATTGC
GGTGATGGGTCCGGAGGGTGCGGTCAATATCGTGTACCGGCGCGAGTTGGCGGCGGCGAAGGACCAGGCGGCGGTGCGGC
GGGAGAAGACGGAGGAGTTCCGCGAGCGGTTCGCGAACCCGTTCATCGCGGCCGAGCGGGGGTATGTGGACGACGTGATC
GAGCCGCGGGAGACGCGGCCGCGAGTGATCCGCGCACTGCGCATGCTGGAGAACAAAGTGGACACGATGCCGCGCAAGAA
GCACGGCAACATACCGCTATGA

Upstream 100 bases:

>100_bases
GGGAATACGATTTTGTGGCGCGGGCGGAAGTATTATCTGCAGGCGGATGGGCGGTTCGAGCTGGTGAGGTAGAGAGGGGC
GCGCTGTACAATGGTCCACG

Downstream 100 bases:

>100_bases
AATTGATGGCGTGTTTGGCGATGCTGGCCGCCGGCGGGTTGGCGCAAGAGCGGTATCCGGTGGACTGGCGCAAGCTGGAG
CCGGAGGTCCTTGCCAACTT

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MNRLEELRRRHAAAEQGGGPERKARQHKEGKLSARERIELLLDEGSFEELDKLVTHRCLDFGMEKEIVPGDGFVTGYGRI
EGRLVYVFAQDFTVFGGSLSETNALKICKVMDLALKTGAPVIGLNDSGGARIQEGVVSLAGYADIFLRNTLASGVVPQIS
AIMGPCAGGAVYSPAITDFVFMVDHTSYMFVTGPDVIKTVTHEDVTKETLGGSMTHNSVSGVGHFIAADDAECCRMIREL
MTYLPQNNREDPPRRATNDPIERMDAALDTIVPAESNLPYDIKDVIHRVVDDGEFFEVHEHFAKNLVVGFARMDGRSIGI
VGNQPAFLAGCLDINSSVKGARFVRFCDAFNIPILTFEDVPGFLPGTAQEFGGIIRHGAKLLYAYAEATVPKITVITRKA
YGGAYCVMGSKHIRTDINLAWPTAEIAVMGPEGAVNIVYRRELAAAKDQAAVRREKTEEFRERFANPFIAAERGYVDDVI
EPRETRPRVIRALRMLENKVDTMPRKKHGNIPL

Sequences:

>Translated_513_residues
MNRLEELRRRHAAAEQGGGPERKARQHKEGKLSARERIELLLDEGSFEELDKLVTHRCLDFGMEKEIVPGDGFVTGYGRI
EGRLVYVFAQDFTVFGGSLSETNALKICKVMDLALKTGAPVIGLNDSGGARIQEGVVSLAGYADIFLRNTLASGVVPQIS
AIMGPCAGGAVYSPAITDFVFMVDHTSYMFVTGPDVIKTVTHEDVTKETLGGSMTHNSVSGVGHFIAADDAECCRMIREL
MTYLPQNNREDPPRRATNDPIERMDAALDTIVPAESNLPYDIKDVIHRVVDDGEFFEVHEHFAKNLVVGFARMDGRSIGI
VGNQPAFLAGCLDINSSVKGARFVRFCDAFNIPILTFEDVPGFLPGTAQEFGGIIRHGAKLLYAYAEATVPKITVITRKA
YGGAYCVMGSKHIRTDINLAWPTAEIAVMGPEGAVNIVYRRELAAAKDQAAVRREKTEEFRERFANPFIAAERGYVDDVI
EPRETRPRVIRALRMLENKVDTMPRKKHGNIPL
>Mature_513_residues
MNRLEELRRRHAAAEQGGGPERKARQHKEGKLSARERIELLLDEGSFEELDKLVTHRCLDFGMEKEIVPGDGFVTGYGRI
EGRLVYVFAQDFTVFGGSLSETNALKICKVMDLALKTGAPVIGLNDSGGARIQEGVVSLAGYADIFLRNTLASGVVPQIS
AIMGPCAGGAVYSPAITDFVFMVDHTSYMFVTGPDVIKTVTHEDVTKETLGGSMTHNSVSGVGHFIAADDAECCRMIREL
MTYLPQNNREDPPRRATNDPIERMDAALDTIVPAESNLPYDIKDVIHRVVDDGEFFEVHEHFAKNLVVGFARMDGRSIGI
VGNQPAFLAGCLDINSSVKGARFVRFCDAFNIPILTFEDVPGFLPGTAQEFGGIIRHGAKLLYAYAEATVPKITVITRKA
YGGAYCVMGSKHIRTDINLAWPTAEIAVMGPEGAVNIVYRRELAAAKDQAAVRREKTEEFRERFANPFIAAERGYVDDVI
EPRETRPRVIRALRMLENKVDTMPRKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=513, Percent_Identity=63.9376218323587, Blast_Score=658, Evalue=0.0,
Organism=Homo sapiens, GI295821216, Length=533, Percent_Identity=61.5384615384615, Blast_Score=647, Evalue=0.0,
Organism=Homo sapiens, GI11545863, Length=505, Percent_Identity=33.0693069306931, Blast_Score=229, Evalue=6e-60,
Organism=Homo sapiens, GI38679974, Length=443, Percent_Identity=23.9277652370203, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38679960, Length=443, Percent_Identity=23.9277652370203, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38679971, Length=443, Percent_Identity=23.9277652370203, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38679977, Length=443, Percent_Identity=23.9277652370203, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38679967, Length=443, Percent_Identity=23.9277652370203, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI134142062, Length=399, Percent_Identity=23.8095238095238, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788655, Length=189, Percent_Identity=29.1005291005291, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25147362, Length=512, Percent_Identity=63.8671875, Blast_Score=662, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=512, Percent_Identity=63.8671875, Blast_Score=662, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17552936, Length=497, Percent_Identity=33.4004024144869, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71997163, Length=379, Percent_Identity=24.2744063324538, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324343, Length=398, Percent_Identity=24.3718592964824, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24586065, Length=532, Percent_Identity=32.8947368421053, Blast_Score=236, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56490; Mature: 56490

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLEELRRRHAAAEQGGGPERKARQHKEGKLSARERIELLLDEGSFEELDKLVTHRCLD
CCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
FGMEKEIVPGDGFVTGYGRIEGRLVYVFAQDFTVFGGSLSETNALKICKVMDLALKTGAP
CCCCCCCCCCCCEEEECCCCCCEEEEEEECCEEEECCCCCCCCHHHHHHHHHHHHHCCCC
VIGLNDSGGARIQEGVVSLAGYADIFLRNTLASGVVPQISAIMGPCAGGAVYSPAITDFV
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHEE
FMVDHTSYMFVTGPDVIKTVTHEDVTKETLGGSMTHNSVSGVGHFIAADDAECCRMIREL
EEEECCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEECCCHHHHHHHHHH
MTYLPQNNREDPPRRATNDPIERMDAALDTIVPAESNLPYDIKDVIHRVVDDGEFFEVHE
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHH
HFAKNLVVGFARMDGRSIGIVGNQPAFLAGCLDINSSVKGARFVRFCDAFNIPILTFEDV
HHHHHHHEEHEECCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCC
PGFLPGTAQEFGGIIRHGAKLLYAYAEATVPKITVITRKAYGGAYCVMGSKHIRTDINLA
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCEEECCCEEE
WPTAEIAVMGPEGAVNIVYRRELAAAKDQAAVRREKTEEFRERFANPFIAAERGYVDDVI
CCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHC
EPRETRPRVIRALRMLENKVDTMPRKKHGNIPL
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNRLEELRRRHAAAEQGGGPERKARQHKEGKLSARERIELLLDEGSFEELDKLVTHRCLD
CCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
FGMEKEIVPGDGFVTGYGRIEGRLVYVFAQDFTVFGGSLSETNALKICKVMDLALKTGAP
CCCCCCCCCCCCEEEECCCCCCEEEEEEECCEEEECCCCCCCCHHHHHHHHHHHHHCCCC
VIGLNDSGGARIQEGVVSLAGYADIFLRNTLASGVVPQISAIMGPCAGGAVYSPAITDFV
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHEE
FMVDHTSYMFVTGPDVIKTVTHEDVTKETLGGSMTHNSVSGVGHFIAADDAECCRMIREL
EEEECCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEECCCHHHHHHHHHH
MTYLPQNNREDPPRRATNDPIERMDAALDTIVPAESNLPYDIKDVIHRVVDDGEFFEVHE
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHH
HFAKNLVVGFARMDGRSIGIVGNQPAFLAGCLDINSSVKGARFVRFCDAFNIPILTFEDV
HHHHHHHEEHEECCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCC
PGFLPGTAQEFGGIIRHGAKLLYAYAEATVPKITVITRKAYGGAYCVMGSKHIRTDINLA
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCEEECCCEEE
WPTAEIAVMGPEGAVNIVYRRELAAAKDQAAVRREKTEEFRERFANPFIAAERGYVDDVI
CCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHC
EPRETRPRVIRALRMLENKVDTMPRKKHGNIPL
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]