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The map label for this gene is mtnA

Identifier: 116620607

GI number: 116620607

Start: 1823605

End: 1824636

Strand: Direct

Name: mtnA

Synonym: Acid_1486

Alternate gene names: 116620607

Gene position: 1823605-1824636 (Clockwise)

Preceding gene: 116620606

Following gene: 116620608

Centisome position: 18.3

GC content: 64.15

Gene sequence:

>1032_bases
ATGGTAGAAACAATCGAATGGACACCGGGCGGCGTTGTCATGATCGACCAGACGCGCCTGCCGCTGCATGAAGAATACGT
GACCTGCCGGAATTACGAGGAGGTCGCGACCGCAATCCGGGACATGATTATCCGCGGGGCTCCGGCGATCGGAGTTGCGG
CGGCCATGGGGGTTGCGATCGGCGTGCAGCACGCGGGGGACGGCGATCTCGACGGACAGGTGGACCTGATCTGCGAGACG
CTGGCCAAGACGCGACCGACGGCGGTCAATCTGTTTTGGGCGATCGACCGGATGAAGCGGCTGTACGGGTCGATGCGCGG
GCGGCCGTTGGAGGAGATCCGGTCGCGGCTGATTGCCGAGGCGCAGATTGTTCGCGAGGAGGATATCGCGATCAACCGGG
CGATCGGACGCAATGGCGCGGCGCTGGTGCCTGACGGCAAAACAGTGCTGACGCACTGCAACGCGGGTGCGCTGGCGACG
GCCGGTTACGGCACGGCGCTGGGCGTGATTCGCGCGGCGATCGAGAGCGGGAAAAAGATCGACGTGTTCGCGGACGAGAC
GCGGCCCTTCCTGCAGGGCGCGCGGCTGACGGTGTGGGAACTGCAGCAGGATTCGATCCCCACGACGCTGATCACCGACA
ACATGGCGGGGCACTTCATGAAAGCGGGCCGGATCGGGTGCGTGGTGGTGGGGGCGGACCGGATCGCGGCCAACGGCGAC
GTGGCGAATAAGGTGGGTACGTATTCCGTGGCTGTGCTGGCGAAGGAGAACGGAGTGCCGTTTTATGTGGCTGCGCCGAT
TTCCACGCTGGATCTGACGTTGAGCTCCGGGGAGCAGATTCCGATTGAGGAACGCTCGGCGGCGGAGGTCACGCACGTGT
TCGGGCACGCGGTAGCGCCGGCGGGAACGGCGGTAAAGAACCCTGCGTTCGACGTTACGCCCGCGCGATACGTCACGGGG
ATTATCACGGAGAAGGGCGTGGCGCACGCGCCATACGAAGAATCTTTGAAGAAACTGGTGACAACGAAATGA

Upstream 100 bases:

>100_bases
GACCGCTCCCTGACGGTCACGGCTCGGATCCATTCTCATGCCTTGTTGCGGGGCACGAAAGCGCGTTCGAGCTGGTGTAG
GCTGAAAGTACAGCCTTCAC

Downstream 100 bases:

>100_bases
AGAAACTTGCGATTGCATTATTGTGCGCGATGGCGCTGACGGGCGCGGACGCACCGAGGCGCGCGCCCGGGTTCTGCCTG
CCGGATCAGACCATGCAGTG

Product: translation initiation factor 2B subunit I

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MVETIEWTPGGVVMIDQTRLPLHEEYVTCRNYEEVATAIRDMIIRGAPAIGVAAAMGVAIGVQHAGDGDLDGQVDLICET
LAKTRPTAVNLFWAIDRMKRLYGSMRGRPLEEIRSRLIAEAQIVREEDIAINRAIGRNGAALVPDGKTVLTHCNAGALAT
AGYGTALGVIRAAIESGKKIDVFADETRPFLQGARLTVWELQQDSIPTTLITDNMAGHFMKAGRIGCVVVGADRIAANGD
VANKVGTYSVAVLAKENGVPFYVAAPISTLDLTLSSGEQIPIEERSAAEVTHVFGHAVAPAGTAVKNPAFDVTPARYVTG
IITEKGVAHAPYEESLKKLVTTK

Sequences:

>Translated_343_residues
MVETIEWTPGGVVMIDQTRLPLHEEYVTCRNYEEVATAIRDMIIRGAPAIGVAAAMGVAIGVQHAGDGDLDGQVDLICET
LAKTRPTAVNLFWAIDRMKRLYGSMRGRPLEEIRSRLIAEAQIVREEDIAINRAIGRNGAALVPDGKTVLTHCNAGALAT
AGYGTALGVIRAAIESGKKIDVFADETRPFLQGARLTVWELQQDSIPTTLITDNMAGHFMKAGRIGCVVVGADRIAANGD
VANKVGTYSVAVLAKENGVPFYVAAPISTLDLTLSSGEQIPIEERSAAEVTHVFGHAVAPAGTAVKNPAFDVTPARYVTG
IITEKGVAHAPYEESLKKLVTTK
>Mature_343_residues
MVETIEWTPGGVVMIDQTRLPLHEEYVTCRNYEEVATAIRDMIIRGAPAIGVAAAMGVAIGVQHAGDGDLDGQVDLICET
LAKTRPTAVNLFWAIDRMKRLYGSMRGRPLEEIRSRLIAEAQIVREEDIAINRAIGRNGAALVPDGKTVLTHCNAGALAT
AGYGTALGVIRAAIESGKKIDVFADETRPFLQGARLTVWELQQDSIPTTLITDNMAGHFMKAGRIGCVVVGADRIAANGD
VANKVGTYSVAVLAKENGVPFYVAAPISTLDLTLSSGEQIPIEERSAAEVTHVFGHAVAPAGTAVKNPAFDVTPARYVTG
IITEKGVAHAPYEESLKKLVTTK

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=356, Percent_Identity=44.6629213483146, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI23943880, Length=350, Percent_Identity=37.7142857142857, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI4503503, Length=202, Percent_Identity=29.2079207920792, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17557462, Length=334, Percent_Identity=37.4251497005988, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17557123, Length=283, Percent_Identity=25.7950530035336, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325375, Length=382, Percent_Identity=35.0785340314136, Blast_Score=192, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6322878, Length=266, Percent_Identity=28.1954887218045, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357667, Length=362, Percent_Identity=41.9889502762431, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24651647, Length=362, Percent_Identity=41.9889502762431, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI21358605, Length=224, Percent_Identity=23.2142857142857, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_SOLUE (Q028S4)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_822763.1
- ProteinModelPortal:   Q028S4
- SMR:   Q028S4
- STRING:   Q028S4
- GeneID:   4430324
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_1486
- NMPDR:   fig|234267.9.peg.1416
- eggNOG:   COG0182
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- PhylomeDB:   Q028S4
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 36526; Mature: 36526

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: ACT_SITE 233-233 BINDING 85-85 BINDING 192-192

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVETIEWTPGGVVMIDQTRLPLHEEYVTCRNYEEVATAIRDMIIRGAPAIGVAAAMGVAI
CCCEEEECCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GVQHAGDGDLDGQVDLICETLAKTRPTAVNLFWAIDRMKRLYGSMRGRPLEEIRSRLIAE
EEEECCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AQIVREEDIAINRAIGRNGAALVPDGKTVLTHCNAGALATAGYGTALGVIRAAIESGKKI
HHHHHHHHHEEEHHHCCCCCEECCCCCEEEEECCCCCEEECCCHHHHHHHHHHHHCCCEE
DVFADETRPFLQGARLTVWELQQDSIPTTLITDNMAGHFMKAGRIGCVVVGADRIAANGD
EEEECCCCHHHCCCEEEEEEECCCCCCEEEEECCHHHHHHHCCCEEEEEEECCEEECCCC
VANKVGTYSVAVLAKENGVPFYVAAPISTLDLTLSSGEQIPIEERSAAEVTHVFGHAVAP
CCCCCCCEEEEEEEECCCCCEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCC
AGTAVKNPAFDVTPARYVTGIITEKGVAHAPYEESLKKLVTTK
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MVETIEWTPGGVVMIDQTRLPLHEEYVTCRNYEEVATAIRDMIIRGAPAIGVAAAMGVAI
CCCEEEECCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
GVQHAGDGDLDGQVDLICETLAKTRPTAVNLFWAIDRMKRLYGSMRGRPLEEIRSRLIAE
EEEECCCCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AQIVREEDIAINRAIGRNGAALVPDGKTVLTHCNAGALATAGYGTALGVIRAAIESGKKI
HHHHHHHHHEEEHHHCCCCCEECCCCCEEEEECCCCCEEECCCHHHHHHHHHHHHCCCEE
DVFADETRPFLQGARLTVWELQQDSIPTTLITDNMAGHFMKAGRIGCVVVGADRIAANGD
EEEECCCCHHHCCCEEEEEEECCCCCCEEEEECCHHHHHHHCCCEEEEEEECCEEECCCC
VANKVGTYSVAVLAKENGVPFYVAAPISTLDLTLSSGEQIPIEERSAAEVTHVFGHAVAP
CCCCCCCEEEEEEEECCCCCEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCC
AGTAVKNPAFDVTPARYVTGIITEKGVAHAPYEESLKKLVTTK
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA