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The map label for this gene is yrbE [H]

Identifier: 116620606

GI number: 116620606

Start: 1822237

End: 1823271

Strand: Direct

Name: yrbE [H]

Synonym: Acid_1485

Alternate gene names: 116620606

Gene position: 1822237-1823271 (Clockwise)

Preceding gene: 116620605

Following gene: 116620607

Centisome position: 18.29

GC content: 64.64

Gene sequence:

>1035_bases
GTGAGCACAAGACAGTTGAATGTAGGAATCATCGGCGCGGGACGGATCGGAAAAGTGCATGCGGAAACGCTGGCCTTCCG
GTTGCCGGAGGCCCGGACAGCGGCGATCGCGGACGTGAACCGCGAGGCCGCGCAGGCGGTGGCGGCGCGCTGCGGAATTC
CCACCGTGAGCGGATCGAGCGATGAGATTCTGGCGAACCGGGAGATCGAGGCGGTATTGATCTGCTCGTCCACGAATACG
CACGCGGACCTGATCGTGCAGGCGGCGCAGGCGGGCAAACATATTTTCTGCGAGAAGCCGATCGCGCACAGCGTGGCTGA
GATCGACCGGGCGCTGGCGGCGGTGGCGCGAGCGGGGGTGAAACTGCAGATCGGATTCAACCGCCGTTTCGACGCCAATT
TCGCGCGGGTACGGCAGGCGGTGACGAGCGGCGAGATCGGCACTCCGCGGCTGATGCACATTATCAGCCGCGACCCGGCG
CCGCCGCCGCCGGCATATGTGCGGGTCTCCGGGGGCATGTTCCTGGACATGACGATTCACGATTTCGACATGGCGCGCTT
TTTGATTGGCGACGAAGTGGAGGAGATCTACACGGCGGGCGGCGTGATGGTGGATCCGGAGATCGGCGCCGCGGGGGATC
TGGATACAGCGGTGATCACGCTGCGCTTCCGCAACGGTGTGATCGGCACAATCGACAACTGCCGGCAGGCGGCGTACGGG
TACGATCAGCGCGTGGAGATCCTGGGGAGCAAGGGCAGCATCGCTACGGGAAACAATTATCCCAATCAGGCGGTGGTGAG
TACGGGGCAGGAAGTGCGCAAGGATCTGCCGCTGAATTTCTTCATGGAGCGCTACACGGAGAGTTTTGCCAGTGAAATCC
GGGAGTTCGTGGCAGCGATTCGCGAGGACCGGCCGACCCCGGTGACGGGGAACGACGGACTGGTGGCGGTGCTGATGGGG
ATCGCGGCGCGCCGGTCGTACGATGAGCGGCGGGCGGTGCGGATGGACGAGCTGGCGGTAGGGGCTGCAGGGTAG

Upstream 100 bases:

>100_bases
GCAGGATGTGCTGCCCGGGATGGGCAGTCCGAAAGAGAGCGCGCGTCGAAATCGCGACTACCTGCGGTCGATCGAATCGA
ATTTTGCCTGAGAGGAAAAC

Downstream 100 bases:

>100_bases
AGAATTCGTCACTATCTTGTAAAACAACTATCGGACAATCTGTTTGAAAGCTGGGAGGTGTCACGTGCTCAGTAGGATTC
GAACGGTTGCCGACGTGCTG

Product: inositol 2-dehydrogenase

Products: 2,4,6/3,5-pentahydroxycyclohexanone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MSTRQLNVGIIGAGRIGKVHAETLAFRLPEARTAAIADVNREAAQAVAARCGIPTVSGSSDEILANREIEAVLICSSTNT
HADLIVQAAQAGKHIFCEKPIAHSVAEIDRALAAVARAGVKLQIGFNRRFDANFARVRQAVTSGEIGTPRLMHIISRDPA
PPPPAYVRVSGGMFLDMTIHDFDMARFLIGDEVEEIYTAGGVMVDPEIGAAGDLDTAVITLRFRNGVIGTIDNCRQAAYG
YDQRVEILGSKGSIATGNNYPNQAVVSTGQEVRKDLPLNFFMERYTESFASEIREFVAAIREDRPTPVTGNDGLVAVLMG
IAARRSYDERRAVRMDELAVGAAG

Sequences:

>Translated_344_residues
MSTRQLNVGIIGAGRIGKVHAETLAFRLPEARTAAIADVNREAAQAVAARCGIPTVSGSSDEILANREIEAVLICSSTNT
HADLIVQAAQAGKHIFCEKPIAHSVAEIDRALAAVARAGVKLQIGFNRRFDANFARVRQAVTSGEIGTPRLMHIISRDPA
PPPPAYVRVSGGMFLDMTIHDFDMARFLIGDEVEEIYTAGGVMVDPEIGAAGDLDTAVITLRFRNGVIGTIDNCRQAAYG
YDQRVEILGSKGSIATGNNYPNQAVVSTGQEVRKDLPLNFFMERYTESFASEIREFVAAIREDRPTPVTGNDGLVAVLMG
IAARRSYDERRAVRMDELAVGAAG
>Mature_343_residues
STRQLNVGIIGAGRIGKVHAETLAFRLPEARTAAIADVNREAAQAVAARCGIPTVSGSSDEILANREIEAVLICSSTNTH
ADLIVQAAQAGKHIFCEKPIAHSVAEIDRALAAVARAGVKLQIGFNRRFDANFARVRQAVTSGEIGTPRLMHIISRDPAP
PPPAYVRVSGGMFLDMTIHDFDMARFLIGDEVEEIYTAGGVMVDPEIGAAGDLDTAVITLRFRNGVIGTIDNCRQAAYGY
DQRVEILGSKGSIATGNNYPNQAVVSTGQEVRKDLPLNFFMERYTESFASEIREFVAAIREDRPTPVTGNDGLVAVLMGI
AARRSYDERRAVRMDELAVGAAG

Specific function: Unknown

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI87082405, Length=254, Percent_Identity=24.4094488188976, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787574, Length=241, Percent_Identity=26.5560165975104, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24581117, Length=306, Percent_Identity=24.1830065359477, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: 1.1.1.18

Molecular weight: Translated: 36969; Mature: 36837

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRQLNVGIIGAGRIGKVHAETLAFRLPEARTAAIADVNREAAQAVAARCGIPTVSGSS
CCCCEEEEEEEECCCCCHHHHHHHHEECCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
DEILANREIEAVLICSSTNTHADLIVQAAQAGKHIFCEKPIAHSVAEIDRALAAVARAGV
CCEEECCCEEEEEEECCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCE
KLQIGFNRRFDANFARVRQAVTSGEIGTPRLMHIISRDPAPPPPAYVRVSGGMFLDMTIH
EEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEECCCEEEEEEEE
DFDMARFLIGDEVEEIYTAGGVMVDPEIGAAGDLDTAVITLRFRNGVIGTIDNCRQAAYG
HHHHHHHHHCCHHHHHHHCCCEEECCCCCCCCCCCEEEEEEEECCCCEECHHHHHHHHCC
YDQRVEILGSKGSIATGNNYPNQAVVSTGQEVRKDLPLNFFMERYTESFASEIREFVAAI
CCCEEEEECCCCCEECCCCCCCHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
REDRPTPVTGNDGLVAVLMGIAARRSYDERRAVRMDELAVGAAG
HCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STRQLNVGIIGAGRIGKVHAETLAFRLPEARTAAIADVNREAAQAVAARCGIPTVSGSS
CCCEEEEEEEECCCCCHHHHHHHHEECCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
DEILANREIEAVLICSSTNTHADLIVQAAQAGKHIFCEKPIAHSVAEIDRALAAVARAGV
CCEEECCCEEEEEEECCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCE
KLQIGFNRRFDANFARVRQAVTSGEIGTPRLMHIISRDPAPPPPAYVRVSGGMFLDMTIH
EEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEEECCCEEEEEEEE
DFDMARFLIGDEVEEIYTAGGVMVDPEIGAAGDLDTAVITLRFRNGVIGTIDNCRQAAYG
HHHHHHHHHCCHHHHHHHCCCEEECCCCCCCCCCCEEEEEEEECCCCEECHHHHHHHHCC
YDQRVEILGSKGSIATGNNYPNQAVVSTGQEVRKDLPLNFFMERYTESFASEIREFVAAI
CCCEEEEECCCCCEECCCCCCCHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
REDRPTPVTGNDGLVAVLMGIAARRSYDERRAVRMDELAVGAAG
HCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: myo-inositol; NAD+

Specific reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9025289 [H]