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The map label for this gene is mro [H]

Identifier: 116620579

GI number: 116620579

Start: 1788348

End: 1789499

Strand: Direct

Name: mro [H]

Synonym: Acid_1458

Alternate gene names: 116620579

Gene position: 1788348-1789499 (Clockwise)

Preceding gene: 116620578

Following gene: 116620581

Centisome position: 17.95

GC content: 61.72

Gene sequence:

>1152_bases
ATGAGTTACACTCGCTGGTCCATGTGCGCCCTGCTGGGCGTGATCACTCTGGCCTGCTTTACCCAGGCCTGCTCCAGGAA
GGAAACCTCCGCCGTGAATGCAGAAACCAAGCCGCCGCAGCCCTACGGCAAGATGCCCGATGGCACCCCCGTCGAGCTCT
ACACGCTCACCAACGCCAACGGCATGCAGGCCGGCATCATCACCTATGGCGGCATCCTGACCTCGCTCACTGCCCCCGAT
AAGACCGGCAAGTTCGCCGACGTCGTTCTCGGCATGGACGACCTGCCCGGCTACCTCAAAGAGAAGGATTACTTCGGAGC
CCTGATCGGCCGCTATGGCAATCGCATCGGCCACGCCCAGTTCACTCTCGACGGCCAGACCTACAAGCTCCCCGACAACA
ATAACGGCGCCACTCTCCACGGCGGCATCAAGGGCTTCGACAAGCACGTCTGGACCGCCAAACCCGTTTCCAGTCCCGAT
GGCCAGGCCGTCGAACTTACCTACGTCAGCAAGGATGGTGAAGAAGGCTTCCCCGGAACCCTCACCGCCAAAGTCGTCTA
CACCCTCACTCCCAGGAACGAGCTCAACATCGATTACACCGCCACCACCGACAAGCCCACCGTCGTCAACCTGACCAACC
ACTCATACTTCAATCTCGCCGGCCCCGGCTCCGGCGACATCCTCTCCCACGAAGTCATGATCGCCGCCGACAAGTTCACC
CCCGTCGATGCGATCCTCATCCCCACCGGCGAGCTCAAGGACGTCAAGGGCACCCCCTTCGACTTCACCACCATGACCGC
CATTGGCGCGCGCATCAATCAGCCCGATGAGCAGCTCAAATTCGGCCGCGGCTACGATCACAATTGGGTCCTCAACAAAG
GCGCCGGCGGTATGACCAAGGCCGCCGAAGTCCACGAGCCCGTCACCGGCCGCACCATGGAAGTCTGGACCACCGAGCCC
GGCCTGCAGTTCTATACCGGCAACTTCCTCGATGGCACCAACAAGGCTAAAGGCAAGAGTTTCGACCTGCGCGGCGCCTT
CTGCATGGAGACCCAGCACTATCCCGATTCGCCCAACAAACCGGCCTTCCCCTCCACCGAGTTGAAGCCCGGCGCCACCT
ACCACACCACCACCAGCTACCGCTTCCGGTAA

Upstream 100 bases:

>100_bases
CTCGTCTACCTCGTCATCGCCGTGATCGTCGATGTCGGCGGCCTGGGCGGCGGAGAATCCCATCGCCGCAGCCGCTTGTA
ATCGCATACCATACCTAATG

Downstream 100 bases:

>100_bases
TGCCAGATCAGGCGCTCGCCGCCTTCCCGAGTACGGCCCTCGCGTATTCGTCGATGCCGGTCAGCTTGATCCCGAACGCA
TCCACCACGGGTGCCATATC

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MSYTRWSMCALLGVITLACFTQACSRKETSAVNAETKPPQPYGKMPDGTPVELYTLTNANGMQAGIITYGGILTSLTAPD
KTGKFADVVLGMDDLPGYLKEKDYFGALIGRYGNRIGHAQFTLDGQTYKLPDNNNGATLHGGIKGFDKHVWTAKPVSSPD
GQAVELTYVSKDGEEGFPGTLTAKVVYTLTPRNELNIDYTATTDKPTVVNLTNHSYFNLAGPGSGDILSHEVMIAADKFT
PVDAILIPTGELKDVKGTPFDFTTMTAIGARINQPDEQLKFGRGYDHNWVLNKGAGGMTKAAEVHEPVTGRTMEVWTTEP
GLQFYTGNFLDGTNKAKGKSFDLRGAFCMETQHYPDSPNKPAFPSTELKPGATYHTTTSYRFR

Sequences:

>Translated_383_residues
MSYTRWSMCALLGVITLACFTQACSRKETSAVNAETKPPQPYGKMPDGTPVELYTLTNANGMQAGIITYGGILTSLTAPD
KTGKFADVVLGMDDLPGYLKEKDYFGALIGRYGNRIGHAQFTLDGQTYKLPDNNNGATLHGGIKGFDKHVWTAKPVSSPD
GQAVELTYVSKDGEEGFPGTLTAKVVYTLTPRNELNIDYTATTDKPTVVNLTNHSYFNLAGPGSGDILSHEVMIAADKFT
PVDAILIPTGELKDVKGTPFDFTTMTAIGARINQPDEQLKFGRGYDHNWVLNKGAGGMTKAAEVHEPVTGRTMEVWTTEP
GLQFYTGNFLDGTNKAKGKSFDLRGAFCMETQHYPDSPNKPAFPSTELKPGATYHTTTSYRFR
>Mature_382_residues
SYTRWSMCALLGVITLACFTQACSRKETSAVNAETKPPQPYGKMPDGTPVELYTLTNANGMQAGIITYGGILTSLTAPDK
TGKFADVVLGMDDLPGYLKEKDYFGALIGRYGNRIGHAQFTLDGQTYKLPDNNNGATLHGGIKGFDKHVWTAKPVSSPDG
QAVELTYVSKDGEEGFPGTLTAKVVYTLTPRNELNIDYTATTDKPTVVNLTNHSYFNLAGPGSGDILSHEVMIAADKFTP
VDAILIPTGELKDVKGTPFDFTTMTAIGARINQPDEQLKFGRGYDHNWVLNKGAGGMTKAAEVHEPVTGRTMEVWTTEPG
LQFYTGNFLDGTNKAKGKSFDLRGAFCMETQHYPDSPNKPAFPSTELKPGATYHTTTSYRFR

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=343, Percent_Identity=45.4810495626822, Blast_Score=286, Evalue=2e-77,
Organism=Escherichia coli, GI1786971, Length=339, Percent_Identity=39.5280235988201, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17557428, Length=329, Percent_Identity=31.306990881459, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI115533334, Length=329, Percent_Identity=31.306990881459, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319493, Length=302, Percent_Identity=32.4503311258278, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322004, Length=356, Percent_Identity=30.6179775280899, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6324399, Length=341, Percent_Identity=29.0322580645161, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24659048, Length=354, Percent_Identity=41.2429378531073, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24668278, Length=350, Percent_Identity=38.8571428571429, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24668282, Length=343, Percent_Identity=39.9416909620991, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24583720, Length=339, Percent_Identity=38.9380530973451, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24641876, Length=346, Percent_Identity=32.9479768786127, Blast_Score=178, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 41630; Mature: 41499

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTRWSMCALLGVITLACFTQACSRKETSAVNAETKPPQPYGKMPDGTPVELYTLTNAN
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
GMQAGIITYGGILTSLTAPDKTGKFADVVLGMDDLPGYLKEKDYFGALIGRYGNRIGHAQ
CCEEEEEEECCEEEECCCCCCCCCEEEEEEECCCCCCHHHCCHHHHHHHHHHCCCCCCEE
FTLDGQTYKLPDNNNGATLHGGIKGFDKHVWTAKPVSSPDGQAVELTYVSKDGEEGFPGT
EEECCEEEECCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCCCE
LTAKVVYTLTPRNELNIDYTATTDKPTVVNLTNHSYFNLAGPGSGDILSHEVMIAADKFT
EEEEEEEEECCCCCCEEEEEECCCCCEEEEECCCCEEEECCCCCCCEEEEEEEEEECCCC
PVDAILIPTGELKDVKGTPFDFTTMTAIGARINQPDEQLKFGRGYDHNWVLNKGAGGMTK
CCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCC
AAEVHEPVTGRTMEVWTTEPGLQFYTGNFLDGTNKAKGKSFDLRGAFCMETQHYPDSPNK
HHHHCCCCCCCEEEEEECCCCCEEEECCEECCCCCCCCCCEECCCEEEECCCCCCCCCCC
PAFPSTELKPGATYHTTTSYRFR
CCCCCCCCCCCCEEEECEEEEEC
>Mature Secondary Structure 
SYTRWSMCALLGVITLACFTQACSRKETSAVNAETKPPQPYGKMPDGTPVELYTLTNAN
CCCHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
GMQAGIITYGGILTSLTAPDKTGKFADVVLGMDDLPGYLKEKDYFGALIGRYGNRIGHAQ
CCEEEEEEECCEEEECCCCCCCCCEEEEEEECCCCCCHHHCCHHHHHHHHHHCCCCCCEE
FTLDGQTYKLPDNNNGATLHGGIKGFDKHVWTAKPVSSPDGQAVELTYVSKDGEEGFPGT
EEECCEEEECCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCCCCCCE
LTAKVVYTLTPRNELNIDYTATTDKPTVVNLTNHSYFNLAGPGSGDILSHEVMIAADKFT
EEEEEEEEECCCCCCEEEEEECCCCCEEEEECCCCEEEECCCCCCCEEEEEEEEEECCCC
PVDAILIPTGELKDVKGTPFDFTTMTAIGARINQPDEQLKFGRGYDHNWVLNKGAGGMTK
CCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCC
AAEVHEPVTGRTMEVWTTEPGLQFYTGNFLDGTNKAKGKSFDLRGAFCMETQHYPDSPNK
HHHHCCCCCCCEEEEEECCCCCEEEECCEECCCCCCCCCCEECCCEEEECCCCCCCCCCC
PAFPSTELKPGATYHTTTSYRFR
CCCCCCCCCCCCEEEECEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]