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The map label for this gene is uxaA [H]

Identifier: 116620574

GI number: 116620574

Start: 1782949

End: 1784484

Strand: Direct

Name: uxaA [H]

Synonym: Acid_1453

Alternate gene names: 116620574

Gene position: 1782949-1784484 (Clockwise)

Preceding gene: 116620573

Following gene: 116620575

Centisome position: 17.89

GC content: 66.34

Gene sequence:

>1536_bases
ATGCTCGTCGAAATCACCAAAGTCCCCAACGCCGAGAACTCCGTCATCCACCTCCACCCCACCGACAACGTCGCCGTCGC
CCGCGTCCCCCTCCCCGCCGGCACCGAGCTCCGCGTCGATGGACTCCCGGTCACCGTCCGCGACGCCATCCCCGCCGGGC
ACAAGATCGCCCTCTGGGACATCGCCCCCGGTGAAACCGTGGAGCGCTACGGCCAGGTCATCGGCCGCGCCAAACTCCCC
ATCGATGCCGGACGCCACATCCACACCCACAACCTCGCCTACGAAGAGCTCGCGCTCGACTACGAATTCCCTACCACCGA
AACCGCAGTCCCCACGCCGCGCCCCGACGCCCCCACCTTCCTCGGCTATCCCCGCGAGGATGGCCGCGTCGGCACCCGCA
ACTACATCGCCGTCGTCGCCGCCAGCAACTGCGCCGCCCACGCCGCGGAACTCATCGCCCGCTCTTACGAAGGCGTGACT
CTCCCGCCCAACGTCGATGGCGTCGTCGCCTTCCCGCACGGCGAAGGCTGCGGCCACGCCTTCGGCCCCGATGTCGATCA
GCTCCGCCGCACCCTCGGCGGCGTCCTCGTTCACCCCAACGTCTCCGCCGCCCTCATCCTAGGCTTGGGCTGCGAGGTCA
ACCAGATCGATCACTACCTCGGCGCCGGCTCGCCCCGCACCAATCGTCTGGTCGGCATGACCCTGCAGACCAGCGGCGGC
ACCCCCGGAATCCTCGCCGCCGCGCGCCGCGAAATCGGCCGCTTCTTCGAACAGGCCGCCGCCGAAAACCGCGTCCCGGT
CCCCGCGTCCAAAATCATCCTCGGCCTCAACTGCGGCGGCTCGGATTCTTTCTCCGGCATCACCGCCAACCCTGCCCTCG
GCTTCTGCTCGGACCTGCTCGCCGAACTAGGCGCCGCCAGCGTACTCGCCGAAACTCCCGAAATCTTTGGCGCCGAACAC
CTGCTTGTGCGCCGCGCCCGCAATCGTGAGATCGCGGACAAATTGCTCGGCTGCATCTCGCGTTACAAGAAATACCTCTC
CCGCTTCGACGGCAGTTTCGACGACAACCCGTCGCCCGGCAATAAGGAAGGCGGCCTCAGCAACATCCTCGAAAAAAGCT
TGGGCGCCGTCGCCAAGGGCGGCACCAGCCCCCTCATCGATGTCTATGAGTACGCCGAAAAAATCACCGCGCCCGGTTTC
AGCTTCATGAACACCCCCGGTTATGACCCCGTCAGCCTCACCGGCCTCGCTGCCGGCGGCTGTAACCTGATCGCTTTCAC
CACCGGCCGCGGCAGCGCCATCGGCTTCCCCACCATCCCGGTCATCAAAATATCCACCAACACCCACACCTACCGCGCCA
TGCCCGACAACATGGACATCAACGCCGGCGCTATCGCGGATGGCGAGTCCACCATCCAGCAAACCGGCCGCGAGATCTTC
CACGCCCTCCTTGCTATCGCCTCCGGCCGCCCCACCTGCGCCGAACGCCTCGGCCACAAAGAATTCGTCCCCTGGCGTAT
CGGCCCTGTAATGTAG

Upstream 100 bases:

>100_bases
CGATGGCGATGGCATGTGGGTTCACCCCGCCGGCGACCGCCTGCACGTCCACCTCGAAGAACCCGCCGGAGAACTCAAGC
TCGAACGATAAAGGAACCCC

Downstream 100 bases:

>100_bases
TTTGTTTTGTTTTATCCGTGTCCATCAGCGTTCATCCGCGGCCCATTTGCTTTTCTGTTCTTCCATCCGTGGCGCGCCCT
GTACCCCCGGAAACCGCCAC

Product: Altronate dehydratase

Products: NA

Alternate protein names: Altronic acid hydratase [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MLVEITKVPNAENSVIHLHPTDNVAVARVPLPAGTELRVDGLPVTVRDAIPAGHKIALWDIAPGETVERYGQVIGRAKLP
IDAGRHIHTHNLAYEELALDYEFPTTETAVPTPRPDAPTFLGYPREDGRVGTRNYIAVVAASNCAAHAAELIARSYEGVT
LPPNVDGVVAFPHGEGCGHAFGPDVDQLRRTLGGVLVHPNVSAALILGLGCEVNQIDHYLGAGSPRTNRLVGMTLQTSGG
TPGILAAARREIGRFFEQAAAENRVPVPASKIILGLNCGGSDSFSGITANPALGFCSDLLAELGAASVLAETPEIFGAEH
LLVRRARNREIADKLLGCISRYKKYLSRFDGSFDDNPSPGNKEGGLSNILEKSLGAVAKGGTSPLIDVYEYAEKITAPGF
SFMNTPGYDPVSLTGLAAGGCNLIAFTTGRGSAIGFPTIPVIKISTNTHTYRAMPDNMDINAGAIADGESTIQQTGREIF
HALLAIASGRPTCAERLGHKEFVPWRIGPVM

Sequences:

>Translated_511_residues
MLVEITKVPNAENSVIHLHPTDNVAVARVPLPAGTELRVDGLPVTVRDAIPAGHKIALWDIAPGETVERYGQVIGRAKLP
IDAGRHIHTHNLAYEELALDYEFPTTETAVPTPRPDAPTFLGYPREDGRVGTRNYIAVVAASNCAAHAAELIARSYEGVT
LPPNVDGVVAFPHGEGCGHAFGPDVDQLRRTLGGVLVHPNVSAALILGLGCEVNQIDHYLGAGSPRTNRLVGMTLQTSGG
TPGILAAARREIGRFFEQAAAENRVPVPASKIILGLNCGGSDSFSGITANPALGFCSDLLAELGAASVLAETPEIFGAEH
LLVRRARNREIADKLLGCISRYKKYLSRFDGSFDDNPSPGNKEGGLSNILEKSLGAVAKGGTSPLIDVYEYAEKITAPGF
SFMNTPGYDPVSLTGLAAGGCNLIAFTTGRGSAIGFPTIPVIKISTNTHTYRAMPDNMDINAGAIADGESTIQQTGREIF
HALLAIASGRPTCAERLGHKEFVPWRIGPVM
>Mature_511_residues
MLVEITKVPNAENSVIHLHPTDNVAVARVPLPAGTELRVDGLPVTVRDAIPAGHKIALWDIAPGETVERYGQVIGRAKLP
IDAGRHIHTHNLAYEELALDYEFPTTETAVPTPRPDAPTFLGYPREDGRVGTRNYIAVVAASNCAAHAAELIARSYEGVT
LPPNVDGVVAFPHGEGCGHAFGPDVDQLRRTLGGVLVHPNVSAALILGLGCEVNQIDHYLGAGSPRTNRLVGMTLQTSGG
TPGILAAARREIGRFFEQAAAENRVPVPASKIILGLNCGGSDSFSGITANPALGFCSDLLAELGAASVLAETPEIFGAEH
LLVRRARNREIADKLLGCISRYKKYLSRFDGSFDDNPSPGNKEGGLSNILEKSLGAVAKGGTSPLIDVYEYAEKITAPGF
SFMNTPGYDPVSLTGLAAGGCNLIAFTTGRGSAIGFPTIPVIKISTNTHTYRAMPDNMDINAGAIADGESTIQQTGREIF
HALLAIASGRPTCAERLGHKEFVPWRIGPVM

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789475, Length=501, Percent_Identity=35.7285429141717, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1789516, Length=511, Percent_Identity=37.3776908023483, Blast_Score=290, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.7 [H]

Molecular weight: Translated: 54024; Mature: 54024

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVEITKVPNAENSVIHLHPTDNVAVARVPLPAGTELRVDGLPVTVRDAIPAGHKIALWD
CEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCCEEEECCCCEEEHHCCCCCCEEEEEE
IAPGETVERYGQVIGRAKLPIDAGRHIHTHNLAYEELALDYEFPTTETAVPTPRPDAPTF
CCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHEEECCCCCCCCCCCCCCCCCCCC
LGYPREDGRVGTRNYIAVVAASNCAAHAAELIARSYEGVTLPPNVDGVVAFPHGEGCGHA
CCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEECCCCCCEEEEECCCCCCCCC
FGPDVDQLRRTLGGVLVHPNVSAALILGLGCEVNQIDHYLGAGSPRTNRLVGMTLQTSGG
CCCCHHHHHHHHCCEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEEEECCCC
TPGILAAARREIGRFFEQAAAENRVPVPASKIILGLNCGGSDSFSGITANPALGFCSDLL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEECCCCCCCCCEECCCHHHHHHHHH
AELGAASVLAETPEIFGAEHLLVRRARNREIADKLLGCISRYKKYLSRFDGSFDDNPSPG
HHHCHHHHHHCCHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NKEGGLSNILEKSLGAVAKGGTSPLIDVYEYAEKITAPGFSFMNTPGYDPVSLTGLAAGG
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCC
CNLIAFTTGRGSAIGFPTIPVIKISTNTHTYRAMPDNMDINAGAIADGESTIQQTGREIF
CEEEEEECCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
HALLAIASGRPTCAERLGHKEFVPWRIGPVM
HHHHHHHCCCCHHHHHCCCCCCCCEECCCCC
>Mature Secondary Structure
MLVEITKVPNAENSVIHLHPTDNVAVARVPLPAGTELRVDGLPVTVRDAIPAGHKIALWD
CEEEEECCCCCCCCEEEEECCCCEEEEEECCCCCCEEEECCCCEEEHHCCCCCCEEEEEE
IAPGETVERYGQVIGRAKLPIDAGRHIHTHNLAYEELALDYEFPTTETAVPTPRPDAPTF
CCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHEEECCCCCCCCCCCCCCCCCCCC
LGYPREDGRVGTRNYIAVVAASNCAAHAAELIARSYEGVTLPPNVDGVVAFPHGEGCGHA
CCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEECCCCCCEEEEECCCCCCCCC
FGPDVDQLRRTLGGVLVHPNVSAALILGLGCEVNQIDHYLGAGSPRTNRLVGMTLQTSGG
CCCCHHHHHHHHCCEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEEEECCCC
TPGILAAARREIGRFFEQAAAENRVPVPASKIILGLNCGGSDSFSGITANPALGFCSDLL
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEECCCCCCCCCEECCCHHHHHHHHH
AELGAASVLAETPEIFGAEHLLVRRARNREIADKLLGCISRYKKYLSRFDGSFDDNPSPG
HHHCHHHHHHCCHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NKEGGLSNILEKSLGAVAKGGTSPLIDVYEYAEKITAPGFSFMNTPGYDPVSLTGLAAGG
CCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCC
CNLIAFTTGRGSAIGFPTIPVIKISTNTHTYRAMPDNMDINAGAIADGESTIQQTGREIF
CEEEEEECCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
HALLAIASGRPTCAERLGHKEFVPWRIGPVM
HHHHHHHCCCCHHHHHCCCCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]