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The map label for this gene is fucP [H]

Identifier: 116620497

GI number: 116620497

Start: 1693542

End: 1694984

Strand: Reverse

Name: fucP [H]

Synonym: Acid_1375

Alternate gene names: 116620497

Gene position: 1694984-1693542 (Counterclockwise)

Preceding gene: 116620498

Following gene: 116620493

Centisome position: 17.01

GC content: 58.63

Gene sequence:

>1443_bases
ATGAGCACAACTTCGCAGGCGATGAACCCCCCGAAGAGGAGCATCTTTACCACGGACGATGGGCAGAACCTCATGTTCAC
CTTTATCCTGGTGAGTTCACTCTTCCTTCTGTGGGGCTTCTGCAACGGCATGATCGACGTGATGGACAAGCACTTTCAGG
AGGAATTGGGGCTGAGCAAGTCGCAATCTGCCTGGGTGCAGTTCGCGCACTACCTGGGATATTTTCTGATGTCGCTGCCG
GCCGGAGTACTCGCCAGCAAGCTCGGCTACAAGGGCGGAATCGTCGCCGGCTTGCTGATCGTCGCAGTCGGCGGCTTCTG
GTTTATCCCCGCGACGCACATCAACGCCATGGTGCATGAGGGCGCGGTTTCCGCCACCACTGCCTTTGTCGCGTTCCTGG
TCGGCGTTTGCGCGATCGCTACCGGGCTCACGTTCCTCGAGACGATCGCGAACCCGTACACCACGGTGCTTGGCGACCCG
CGCTTCGCAGCCACGCGCATCAACCTGGCGCAATCCTGCAACGGGATCGGCTGGATCTTCGGCCCCATCGTCGGCAGCAT
GTTCTTCTATGGCAAGGACGCGCAGGGCGCCAGCACCGGCAGTCAGACGCTCTACATCCCGTATGTCGGCGTCGCGGTGG
TGGTGATTGTGCTCGCGGTGGTCTTCTACTTCTCGCGCATTCCGGACATCAAGGCGCCGGACGATTATCATCTCGACGAT
GCCGTACCCGGCGTCGTCAAGTCCATCTGGGCTCATCCGCATTTCGTGCTCGCTGTGGCCGCGCAGTTTTTCTACGTCGC
TGCGCAAGCGGGCATTTTCAGTTTCTTCATCAACTACATGACCTCAGAGCTTCCCGCAATCCCGAAATCCTGGGAATCAG
GTCTGGCAAGTTTCGCGGGAAGCTCCGGCATGATCCACAACTGGCTGCAGGGATGGTTCGAGGTCAACAAGGCCGGCATT
TTGACGATGAGCAACAAGGGCGCGTCCAATCTCGCGTCGCTTGGTTCCATATGCTTCCTCATCGGCCGCTTCTCCGGCGC
CGGAATCCTGAAAAAGTTCTCCGCGCACAAAGTGGTCGGACTGTATGCGCTGATGAACGTATTCGCCACGCTGTTGATCG
CGTTGAAGCTCGGATGGCTCAGCGTGATTTGCGTGTTCGCCACGTATTTCTTTATGTCGATCATGTTCCCGACGATCTTC
GCGCTCGGCATCTTCGGCCTTGGTGCACGGGCAAAGAAGGCGTCGGCCTTCATCGTGATGGCGATCATGGGCGGCGCGAT
TCTGCCCAAGCTGATGGGCTACGTCGCTGATGAATACGACATGTCGCGCGGCTTCCTCGTCCCCATGTTCTGCTTCGCCT
TCGTCGCCTTCTACGGCTTCAACTGGCCCAAGTTCAGCAAGTCCGATTCCCTTCACGGAGTGAAGGCAATCAGTGGCCAC
TAG

Upstream 100 bases:

>100_bases
GAAGATCGAATTCTGACCTGCACGGCTGTTTAACGTTAAAGGGGGCAGCCTCCCCGTGCCCCCACAGCGCCCTTCCTGCT
GTTAGAATCATGGGCAAACC

Downstream 100 bases:

>100_bases
GTCCGCCGGGTGATTACATACCGGCTGCCGTGCACATTCCGGCTATTGCGCAGTCCTGCCATCGCGGAGTCCGCTGGGCC
GAATTCCGCAGGGTGCGGAA

Product: major facilitator transporter

Products: Proton [Cytoplasm]; L-fucose [Cytoplasm] [C]

Alternate protein names: 6-deoxy-L-galactose permease; L-fucose permease [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MSTTSQAMNPPKRSIFTTDDGQNLMFTFILVSSLFLLWGFCNGMIDVMDKHFQEELGLSKSQSAWVQFAHYLGYFLMSLP
AGVLASKLGYKGGIVAGLLIVAVGGFWFIPATHINAMVHEGAVSATTAFVAFLVGVCAIATGLTFLETIANPYTTVLGDP
RFAATRINLAQSCNGIGWIFGPIVGSMFFYGKDAQGASTGSQTLYIPYVGVAVVVIVLAVVFYFSRIPDIKAPDDYHLDD
AVPGVVKSIWAHPHFVLAVAAQFFYVAAQAGIFSFFINYMTSELPAIPKSWESGLASFAGSSGMIHNWLQGWFEVNKAGI
LTMSNKGASNLASLGSICFLIGRFSGAGILKKFSAHKVVGLYALMNVFATLLIALKLGWLSVICVFATYFFMSIMFPTIF
ALGIFGLGARAKKASAFIVMAIMGGAILPKLMGYVADEYDMSRGFLVPMFCFAFVAFYGFNWPKFSKSDSLHGVKAISGH

Sequences:

>Translated_480_residues
MSTTSQAMNPPKRSIFTTDDGQNLMFTFILVSSLFLLWGFCNGMIDVMDKHFQEELGLSKSQSAWVQFAHYLGYFLMSLP
AGVLASKLGYKGGIVAGLLIVAVGGFWFIPATHINAMVHEGAVSATTAFVAFLVGVCAIATGLTFLETIANPYTTVLGDP
RFAATRINLAQSCNGIGWIFGPIVGSMFFYGKDAQGASTGSQTLYIPYVGVAVVVIVLAVVFYFSRIPDIKAPDDYHLDD
AVPGVVKSIWAHPHFVLAVAAQFFYVAAQAGIFSFFINYMTSELPAIPKSWESGLASFAGSSGMIHNWLQGWFEVNKAGI
LTMSNKGASNLASLGSICFLIGRFSGAGILKKFSAHKVVGLYALMNVFATLLIALKLGWLSVICVFATYFFMSIMFPTIF
ALGIFGLGARAKKASAFIVMAIMGGAILPKLMGYVADEYDMSRGFLVPMFCFAFVAFYGFNWPKFSKSDSLHGVKAISGH
>Mature_479_residues
STTSQAMNPPKRSIFTTDDGQNLMFTFILVSSLFLLWGFCNGMIDVMDKHFQEELGLSKSQSAWVQFAHYLGYFLMSLPA
GVLASKLGYKGGIVAGLLIVAVGGFWFIPATHINAMVHEGAVSATTAFVAFLVGVCAIATGLTFLETIANPYTTVLGDPR
FAATRINLAQSCNGIGWIFGPIVGSMFFYGKDAQGASTGSQTLYIPYVGVAVVVIVLAVVFYFSRIPDIKAPDDYHLDDA
VPGVVKSIWAHPHFVLAVAAQFFYVAAQAGIFSFFINYMTSELPAIPKSWESGLASFAGSSGMIHNWLQGWFEVNKAGIL
TMSNKGASNLASLGSICFLIGRFSGAGILKKFSAHKVVGLYALMNVFATLLIALKLGWLSVICVFATYFFMSIMFPTIFA
LGIFGLGARAKKASAFIVMAIMGGAILPKLMGYVADEYDMSRGFLVPMFCFAFVAFYGFNWPKFSKSDSLHGVKAISGH

Specific function: Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-

COG id: COG0738

COG function: function code G; Fucose permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family [H]

Homologues:

Organism=Escherichia coli, GI1789166, Length=460, Percent_Identity=32.6086956521739, Blast_Score=211, Evalue=8e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005275
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51804; Mature: 51673

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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>Mature Secondary Structure 
STTSQAMNPPKRSIFTTDDGQNLMFTFILVSSLFLLWGFCNGMIDVMDKHFQEELGLSK
CCCCHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC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PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-fucose [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-fucose [Periplasm] = Proton [Cytoplasm] + L-fucose [Cytoplasm] [C]

General reaction: Permease [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2664711; 9278503; 2553671; 8052131; 2829831; 7783647 [H]