| Definition | Candidatus Solibacter usitatus Ellin6076 chromosome, complete genome. |
|---|---|
| Accession | NC_008536 |
| Length | 9,965,640 |
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The map label for this gene is ppiA [H]
Identifier: 116620416
GI number: 116620416
Start: 1593452
End: 1594201
Strand: Reverse
Name: ppiA [H]
Synonym: Acid_1293
Alternate gene names: 116620416
Gene position: 1594201-1593452 (Counterclockwise)
Preceding gene: 116620418
Following gene: 116620413
Centisome position: 16.0
GC content: 63.73
Gene sequence:
>750_bases ATGAAACGGCTGTCTACTCTTTTCCTGATCGCTGCATGCGCGTTTGCGCAGACCACGCCCCCCGCCGCGGCACCCGCGAA AAAGGCGGCTCCCGCACCCGCTAAGAAAGAAGCCGCGCCACCGGCTCCGGAGCGCGACCCGGGGCTGTACATGATCATCA ACACGTCGCTGGGAACGATTACGGCGCAATTGTTCGAGAAGGAGGCGCCGGGAACGGTGGCCAACTTCGTGGCGCTCGCG CGCGGCACCAAGGCATACAAGAACAAGGCCGGCGCGATGGTGAAGGGACCGTATTTCAACAACCTGATTTTCCACCGCGT GATTCCGGGCTTCATGATTCAGACCGGCGACATCGCCGGCACCGGCTCCAGCGACTGCGGCTTCACGATCAAAGATGAGA TTGTGCCGACGCTGAAGTACGATAAGCCGGGACGTCTAGGCCTGGCCCGCTTGGATTCGCCGAACACTGGCGCATGCCAG TTCTTCATCACCGATGCGCCGTATCCATCGCTGAGCGGCCAGTACACGATCTTCGGACAGGTGGTGGAGGGACAGGACGT CGTCAGCAAGATCGCTGCCGTGCCGCGCGACAACATGGACAAGCCGCGCACGCCCGTGCGGCTGATCAGCATGACGATCA AGCGGTACGGGCCGCCGCCCGCGGGCACCGCACCGGTCCCTGCGAAGAAGGCCGCTCCGGCGCCCGGCACTACAGCGCCG AAGAAGGCAGCAACGCCAGCGAAGCAGTAG
Upstream 100 bases:
>100_bases GGGGCGCAGCAGGCCGGCGGACAACAGCAGGATCGGAAGCAGGCGGCGTATGGTATCCATCGCTGTCTATAGAATAGAAT GAGTCTTTACGGAGAATCAG
Downstream 100 bases:
>100_bases GACTACGTAAATTACTATCCGCTGATCCGCAGCGGGCTTCGCTCGACTGCGCGCAAGCTAAAGCGTGCGCCACCAAGGAG ACGCTGTTCAGTGGTGGGGC
Product: peptidylprolyl isomerase
Products: NA
Alternate protein names: PPIase A; Rotamase A [H]
Number of amino acids: Translated: 249; Mature: 249
Protein sequence:
>249_residues MKRLSTLFLIAACAFAQTTPPAAAPAKKAAPAPAKKEAAPPAPERDPGLYMIINTSLGTITAQLFEKEAPGTVANFVALA RGTKAYKNKAGAMVKGPYFNNLIFHRVIPGFMIQTGDIAGTGSSDCGFTIKDEIVPTLKYDKPGRLGLARLDSPNTGACQ FFITDAPYPSLSGQYTIFGQVVEGQDVVSKIAAVPRDNMDKPRTPVRLISMTIKRYGPPPAGTAPVPAKKAAPAPGTTAP KKAATPAKQ
Sequences:
>Translated_249_residues MKRLSTLFLIAACAFAQTTPPAAAPAKKAAPAPAKKEAAPPAPERDPGLYMIINTSLGTITAQLFEKEAPGTVANFVALA RGTKAYKNKAGAMVKGPYFNNLIFHRVIPGFMIQTGDIAGTGSSDCGFTIKDEIVPTLKYDKPGRLGLARLDSPNTGACQ FFITDAPYPSLSGQYTIFGQVVEGQDVVSKIAAVPRDNMDKPRTPVRLISMTIKRYGPPPAGTAPVPAKKAAPAPGTTAP KKAATPAKQ >Mature_249_residues MKRLSTLFLIAACAFAQTTPPAAAPAKKAAPAPAKKEAAPPAPERDPGLYMIINTSLGTITAQLFEKEAPGTVANFVALA RGTKAYKNKAGAMVKGPYFNNLIFHRVIPGFMIQTGDIAGTGSSDCGFTIKDEIVPTLKYDKPGRLGLARLDSPNTGACQ FFITDAPYPSLSGQYTIFGQVVEGQDVVSKIAAVPRDNMDKPRTPVRLISMTIKRYGPPPAGTAPVPAKKAAPAPGTTAP KKAATPAKQ
Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]
COG id: COG0652
COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PPIase cyclophilin-type domain [H]
Homologues:
Organism=Homo sapiens, GI24308049, Length=167, Percent_Identity=41.3173652694611, Blast_Score=118, Evalue=4e-27, Organism=Homo sapiens, GI7706339, Length=175, Percent_Identity=38.2857142857143, Blast_Score=109, Evalue=2e-24, Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=33.7349397590361, Blast_Score=95, Evalue=5e-20, Organism=Homo sapiens, GI4758950, Length=214, Percent_Identity=35.0467289719626, Blast_Score=95, Evalue=8e-20, Organism=Homo sapiens, GI64276486, Length=168, Percent_Identity=32.7380952380952, Blast_Score=91, Evalue=7e-19, Organism=Homo sapiens, GI4505991, Length=163, Percent_Identity=38.0368098159509, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI42560244, Length=164, Percent_Identity=34.7560975609756, Blast_Score=84, Evalue=1e-16, Organism=Homo sapiens, GI4826932, Length=153, Percent_Identity=36.6013071895425, Blast_Score=82, Evalue=6e-16, Organism=Homo sapiens, GI10863927, Length=146, Percent_Identity=36.986301369863, Blast_Score=80, Evalue=1e-15, Organism=Homo sapiens, GI310129267, Length=146, Percent_Identity=36.986301369863, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI310120620, Length=146, Percent_Identity=36.986301369863, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI5031987, Length=155, Percent_Identity=37.4193548387097, Blast_Score=79, Evalue=6e-15, Organism=Homo sapiens, GI310110104, Length=145, Percent_Identity=35.1724137931034, Blast_Score=78, Evalue=7e-15, Organism=Homo sapiens, GI6631100, Length=157, Percent_Identity=35.6687898089172, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI22547212, Length=168, Percent_Identity=33.9285714285714, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI7657473, Length=168, Percent_Identity=33.9285714285714, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI22547215, Length=168, Percent_Identity=33.9285714285714, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI169163387, Length=150, Percent_Identity=36, Blast_Score=76, Evalue=4e-14, Organism=Homo sapiens, GI169164185, Length=151, Percent_Identity=35.7615894039735, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI169163623, Length=151, Percent_Identity=35.7615894039735, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI303305009, Length=182, Percent_Identity=34.0659340659341, Blast_Score=75, Evalue=6e-14, Organism=Homo sapiens, GI310127646, Length=136, Percent_Identity=35.2941176470588, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI310114371, Length=136, Percent_Identity=35.2941176470588, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI310119221, Length=136, Percent_Identity=35.2941176470588, Blast_Score=75, Evalue=7e-14, Organism=Homo sapiens, GI27735045, Length=169, Percent_Identity=29.585798816568, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI5174637, Length=172, Percent_Identity=34.8837209302326, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI45439316, Length=170, Percent_Identity=34.7058823529412, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI20911035, Length=194, Percent_Identity=27.319587628866, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI5454154, Length=155, Percent_Identity=34.1935483870968, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI256017253, Length=137, Percent_Identity=37.2262773722628, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI221139811, Length=137, Percent_Identity=37.2262773722628, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI256017251, Length=137, Percent_Identity=37.2262773722628, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI150418007, Length=163, Percent_Identity=36.1963190184049, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI178057341, Length=137, Percent_Identity=36.4963503649635, Blast_Score=68, Evalue=7e-12, Organism=Homo sapiens, GI310132444, Length=142, Percent_Identity=35.2112676056338, Blast_Score=65, Evalue=4e-11, Organism=Homo sapiens, GI310113152, Length=142, Percent_Identity=35.2112676056338, Blast_Score=65, Evalue=4e-11, Organism=Escherichia coli, GI1786736, Length=174, Percent_Identity=35.0574712643678, Blast_Score=81, Evalue=6e-17, Organism=Escherichia coli, GI1789763, Length=195, Percent_Identity=32.8205128205128, Blast_Score=79, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17539496, Length=172, Percent_Identity=40.1162790697674, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17506311, Length=167, Percent_Identity=40.1197604790419, Blast_Score=116, Evalue=1e-26, Organism=Caenorhabditis elegans, GI71980594, Length=165, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=9e-20, Organism=Caenorhabditis elegans, GI17551284, Length=155, Percent_Identity=40, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17551282, Length=155, Percent_Identity=40, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17552784, Length=160, Percent_Identity=38.125, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI71980590, Length=153, Percent_Identity=34.640522875817, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17565860, Length=138, Percent_Identity=42.0289855072464, Blast_Score=87, Evalue=8e-18, Organism=Caenorhabditis elegans, GI17552780, Length=154, Percent_Identity=37.6623376623377, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17532643, Length=158, Percent_Identity=38.6075949367089, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17532641, Length=207, Percent_Identity=29.951690821256, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17566266, Length=140, Percent_Identity=37.8571428571429, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17559074, Length=140, Percent_Identity=37.1428571428571, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17506307, Length=154, Percent_Identity=37.012987012987, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17539498, Length=138, Percent_Identity=32.6086956521739, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI71997782, Length=134, Percent_Identity=33.5820895522388, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17552782, Length=140, Percent_Identity=36.4285714285714, Blast_Score=69, Evalue=2e-12, Organism=Saccharomyces cerevisiae, GI6320510, Length=204, Percent_Identity=37.2549019607843, Blast_Score=102, Evalue=5e-23, Organism=Saccharomyces cerevisiae, GI6321848, Length=157, Percent_Identity=41.4012738853503, Blast_Score=93, Evalue=3e-20, Organism=Saccharomyces cerevisiae, GI6322492, Length=194, Percent_Identity=34.5360824742268, Blast_Score=88, Evalue=1e-18, Organism=Saccharomyces cerevisiae, GI6323562, Length=143, Percent_Identity=38.4615384615385, Blast_Score=86, Evalue=8e-18, Organism=Saccharomyces cerevisiae, GI6320359, Length=142, Percent_Identity=38.7323943661972, Blast_Score=84, Evalue=2e-17, Organism=Saccharomyces cerevisiae, GI6323246, Length=163, Percent_Identity=35.5828220858896, Blast_Score=77, Evalue=3e-15, Organism=Drosophila melanogaster, GI17986117, Length=169, Percent_Identity=39.0532544378698, Blast_Score=117, Evalue=6e-27, Organism=Drosophila melanogaster, GI19922912, Length=169, Percent_Identity=38.4615384615385, Blast_Score=103, Evalue=7e-23, Organism=Drosophila melanogaster, GI19922376, Length=157, Percent_Identity=36.3057324840764, Blast_Score=97, Evalue=8e-21, Organism=Drosophila melanogaster, GI24650807, Length=150, Percent_Identity=38, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI17136360, Length=160, Percent_Identity=36.25, Blast_Score=85, Evalue=5e-17, Organism=Drosophila melanogaster, GI24586038, Length=165, Percent_Identity=36.3636363636364, Blast_Score=81, Evalue=6e-16, Organism=Drosophila melanogaster, GI24652460, Length=146, Percent_Identity=32.8767123287671, Blast_Score=81, Evalue=8e-16, Organism=Drosophila melanogaster, GI21357249, Length=168, Percent_Identity=30.3571428571429, Blast_Score=79, Evalue=2e-15, Organism=Drosophila melanogaster, GI45549139, Length=144, Percent_Identity=38.8888888888889, Blast_Score=74, Evalue=6e-14, Organism=Drosophila melanogaster, GI24664125, Length=141, Percent_Identity=37.5886524822695, Blast_Score=71, Evalue=9e-13, Organism=Drosophila melanogaster, GI21357783, Length=141, Percent_Identity=37.5886524822695, Blast_Score=71, Evalue=9e-13, Organism=Drosophila melanogaster, GI21355677, Length=178, Percent_Identity=28.6516853932584, Blast_Score=70, Evalue=1e-12,
Paralogues:
None
Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR015891 - InterPro: IPR020892 - InterPro: IPR002130 [H]
Pfam domain/function: PF00160 Pro_isomerase [H]
EC number: =5.2.1.8 [H]
Molecular weight: Translated: 26124; Mature: 26124
Theoretical pI: Translated: 10.42; Mature: 10.42
Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKRLSTLFLIAACAFAQTTPPAAAPAKKAAPAPAKKEAAPPAPERDPGLYMIINTSLGTI CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHH TAQLFEKEAPGTVANFVALARGTKAYKNKAGAMVKGPYFNNLIFHRVIPGFMIQTGDIAG HHHHHHCCCCCHHHHHHHHHHCCHHHHHCCCCEEECCCHHHHHHHHHCCCCEEECCCCCC TGSSDCGFTIKDEIVPTLKYDKPGRLGLARLDSPNTGACQFFITDAPYPSLSGQYTIFGQ CCCCCCCEEECCCCCCEECCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCEEEEEE VVEGQDVVSKIAAVPRDNMDKPRTPVRLISMTIKRYGPPPAGTAPVPAKKAAPAPGTTAP EECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC KKAATPAKQ CCCCCCCCC >Mature Secondary Structure MKRLSTLFLIAACAFAQTTPPAAAPAKKAAPAPAKKEAAPPAPERDPGLYMIINTSLGTI CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHH TAQLFEKEAPGTVANFVALARGTKAYKNKAGAMVKGPYFNNLIFHRVIPGFMIQTGDIAG HHHHHHCCCCCHHHHHHHHHHCCHHHHHCCCCEEECCCHHHHHHHHHCCCCEEECCCCCC TGSSDCGFTIKDEIVPTLKYDKPGRLGLARLDSPNTGACQFFITDAPYPSLSGQYTIFGQ CCCCCCCEEECCCCCCEECCCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCCCEEEEEE VVEGQDVVSKIAAVPRDNMDKPRTPVRLISMTIKRYGPPPAGTAPVPAKKAAPAPGTTAP EECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC KKAATPAKQ CCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 12788972 [H]