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The map label for this gene is pepA

Identifier: 116620411

GI number: 116620411

Start: 1586462

End: 1587904

Strand: Direct

Name: pepA

Synonym: Acid_1288

Alternate gene names: 116620411

Gene position: 1586462-1587904 (Clockwise)

Preceding gene: 116620409

Following gene: 116620412

Centisome position: 15.92

GC content: 65.0

Gene sequence:

>1443_bases
ATGCAGATAACGATCGAACGCAAGCCTTTGGGCCAGATTGAGGCGGATGCCCTCATCGTGCCGGTCTTCGAGGGGAGGAG
AGATGCCCGATTCGGAGCCGAGGACCTTTTTGCCTCCGGCGAGGTCGCCGGGAAAGCCCTGGAGATGACTCTGCTCCACC
ACGCGCCAGGAGTTCGGGCCACCAGGGTCCTGCTGGTGGGAGCCGGTGCGGCCGGGAAGTTCGACGCCGCCGGGATGCGG
CGCCTCTCCGGCGCGGCCGTACGCTTCCTGAAAGCCAAATCGGTGAAGAAGATCGCATTGGTGCTGGATTCGGAATTCTC
CGGCAGCAACTTCGCCTCCGCTGCGGTCGAGGGCGCGCTGCTCGGCAACTTCGAGCCCGATCGGTATAAAACGGGTAACG
AGAAGAAATCCCTCGACACCTTCATCGTCGCCGGGGACACACCGGAGTTGGAGTCCGCGGTGGCGCGCGGCCGCATCCTG
GCCGAAGCGCAGAATTTCTCGCGCGACCTGGTGAACGAACCCGCGAACCTGCTCACGCCCCTCGGCATGGCGGACGCGGC
GCGCAAGATGGCCGCGGAGTTCGGCCTCGAGTGCGAAGTGCTGGATCGCGACGCAATGCAGAAACTCGGCATGGGCTCGC
TGCTCGGAGTGGCCATCGGCAGCGCCGAGCCTCCGGTGTTGATCGTGCTGCGCTACCGCCCCGCGAAATCGGAAGGCGCC
GCTCATCTTGGACTGGTGGGTAAGGGCGTGACCTTCGACACCGGCGGCATCTCGATCAAACCGGCCGACGGCATGGAGAA
GATGAAGTACGACATGGCCGGCGGCGCCGCGATGATCGGCGCGATGCGGGCCATCGCGCAACTGAAGCCCGCGATTCCGG
TGAGCGCGTACATCCCCGCCGTGGAGAATATGCCCGGCAGCCGTGCGCAGCGTCCCGGCGATATCGTCACCGCGATGAAC
GGCAAAACCATCGAGGTGATCAATACCGACGCCGAAGGCCGCCTGATTCTGGCCGACGCGCTCACCTACGCGCGTCGTCA
GGGCTGTACGCATCTGGTGGACGCCGCAACCTTGACCGGCGCGGTGGTCGTGGCGCTTGGGCATCTCAACGTCGGACTCT
TCGCCAATGACGATGCCATGCGCGATCGCGTGCTGGCCGCGGCGAAGGATGAGGGCGAGCGCATGTGGTCGCTCCCGCTC
GAGGACGATTACAAGGAGTATCTCAAGAGCGGATTCGCCGACATCGCCAATGTCGGCGGGCGCTGGGGCGGTGCGATCAC
GGCAGCCATCTTCCTGAAGGAATTCGCGGAGGAGACGCCGTGGGTGCATCTCGATATCGCCGGCACCGCGTGGCTCGACG
AAAATAAGCCCTACCTCGCCAAAGGTCCCACCGGCCTCCCGGTACGTACGCTGGCGCGGCTTGCGATGGACTGGAAAGCA
TGA

Upstream 100 bases:

>100_bases
AGAAGATGCGCCCGCATTCGCCGGGATTCAAAAGTTCCAGAATTTGGAATATTTTCGATTTTCACCCCTGAGCCCTGCAT
CGTGGCAAAATCGGAGGGTG

Downstream 100 bases:

>100_bases
AACCTCTCGCCCTGGTTGCACTCATCGCGATCGCCGCGCCCGTGGCCCGGCCCGCCGATACCGATTCCGTGGATAGCGTA
GTGCGCGCCGTGTACGACGT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MQITIERKPLGQIEADALIVPVFEGRRDARFGAEDLFASGEVAGKALEMTLLHHAPGVRATRVLLVGAGAAGKFDAAGMR
RLSGAAVRFLKAKSVKKIALVLDSEFSGSNFASAAVEGALLGNFEPDRYKTGNEKKSLDTFIVAGDTPELESAVARGRIL
AEAQNFSRDLVNEPANLLTPLGMADAARKMAAEFGLECEVLDRDAMQKLGMGSLLGVAIGSAEPPVLIVLRYRPAKSEGA
AHLGLVGKGVTFDTGGISIKPADGMEKMKYDMAGGAAMIGAMRAIAQLKPAIPVSAYIPAVENMPGSRAQRPGDIVTAMN
GKTIEVINTDAEGRLILADALTYARRQGCTHLVDAATLTGAVVVALGHLNVGLFANDDAMRDRVLAAAKDEGERMWSLPL
EDDYKEYLKSGFADIANVGGRWGGAITAAIFLKEFAEETPWVHLDIAGTAWLDENKPYLAKGPTGLPVRTLARLAMDWKA

Sequences:

>Translated_480_residues
MQITIERKPLGQIEADALIVPVFEGRRDARFGAEDLFASGEVAGKALEMTLLHHAPGVRATRVLLVGAGAAGKFDAAGMR
RLSGAAVRFLKAKSVKKIALVLDSEFSGSNFASAAVEGALLGNFEPDRYKTGNEKKSLDTFIVAGDTPELESAVARGRIL
AEAQNFSRDLVNEPANLLTPLGMADAARKMAAEFGLECEVLDRDAMQKLGMGSLLGVAIGSAEPPVLIVLRYRPAKSEGA
AHLGLVGKGVTFDTGGISIKPADGMEKMKYDMAGGAAMIGAMRAIAQLKPAIPVSAYIPAVENMPGSRAQRPGDIVTAMN
GKTIEVINTDAEGRLILADALTYARRQGCTHLVDAATLTGAVVVALGHLNVGLFANDDAMRDRVLAAAKDEGERMWSLPL
EDDYKEYLKSGFADIANVGGRWGGAITAAIFLKEFAEETPWVHLDIAGTAWLDENKPYLAKGPTGLPVRTLARLAMDWKA
>Mature_480_residues
MQITIERKPLGQIEADALIVPVFEGRRDARFGAEDLFASGEVAGKALEMTLLHHAPGVRATRVLLVGAGAAGKFDAAGMR
RLSGAAVRFLKAKSVKKIALVLDSEFSGSNFASAAVEGALLGNFEPDRYKTGNEKKSLDTFIVAGDTPELESAVARGRIL
AEAQNFSRDLVNEPANLLTPLGMADAARKMAAEFGLECEVLDRDAMQKLGMGSLLGVAIGSAEPPVLIVLRYRPAKSEGA
AHLGLVGKGVTFDTGGISIKPADGMEKMKYDMAGGAAMIGAMRAIAQLKPAIPVSAYIPAVENMPGSRAQRPGDIVTAMN
GKTIEVINTDAEGRLILADALTYARRQGCTHLVDAATLTGAVVVALGHLNVGLFANDDAMRDRVLAAAKDEGERMWSLPL
EDDYKEYLKSGFADIANVGGRWGGAITAAIFLKEFAEETPWVHLDIAGTAWLDENKPYLAKGPTGLPVRTLARLAMDWKA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=364, Percent_Identity=42.032967032967, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI47155554, Length=329, Percent_Identity=32.8267477203647, Blast_Score=135, Evalue=9e-32,
Organism=Escherichia coli, GI1790710, Length=499, Percent_Identity=38.877755511022, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI87082123, Length=318, Percent_Identity=38.6792452830189, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=300, Percent_Identity=36, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17565172, Length=129, Percent_Identity=41.8604651162791, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355725, Length=401, Percent_Identity=33.4164588528678, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24661038, Length=400, Percent_Identity=33, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24662227, Length=394, Percent_Identity=34.010152284264, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI20129969, Length=404, Percent_Identity=32.9207920792079, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21355645, Length=390, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24662223, Length=390, Percent_Identity=33.3333333333333, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI161077148, Length=377, Percent_Identity=32.8912466843501, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI20130057, Length=377, Percent_Identity=32.8912466843501, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI20129963, Length=375, Percent_Identity=33.3333333333333, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI19922386, Length=420, Percent_Identity=30.952380952381, Blast_Score=169, Evalue=6e-42,
Organism=Drosophila melanogaster, GI21357381, Length=287, Percent_Identity=32.404181184669, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI221379063, Length=287, Percent_Identity=32.404181184669, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI221379062, Length=287, Percent_Identity=32.404181184669, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24646701, Length=300, Percent_Identity=30, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24646703, Length=300, Percent_Identity=30, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21358201, Length=300, Percent_Identity=30, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_SOLUE (Q029J4)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_822567.1
- ProteinModelPortal:   Q029J4
- SMR:   Q029J4
- STRING:   Q029J4
- MEROPS:   M17.010
- GeneID:   4430555
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_1288
- NMPDR:   fig|234267.9.peg.1228
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   TKQVTDC
- PhylomeDB:   Q029J4
- ProtClustDB:   PRK00913
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 50869; Mature: 50869

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 260-260 ACT_SITE 334-334

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQITIERKPLGQIEADALIVPVFEGRRDARFGAEDLFASGEVAGKALEMTLLHHAPGVRA
CEEEEECCCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCHHHEEEHHHCCCCCCE
TRVLLVGAGAAGKFDAAGMRRLSGAAVRFLKAKSVKKIALVLDSEFSGSNFASAAVEGAL
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHCCCE
LGNFEPDRYKTGNEKKSLDTFIVAGDTPELESAVARGRILAEAQNFSRDLVNEPANLLTP
ECCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHCC
LGMADAARKMAAEFGLECEVLDRDAMQKLGMGSLLGVAIGSAEPPVLIVLRYRPAKSEGA
CCHHHHHHHHHHHHCCEEEEECHHHHHHCCCCCEEHEEECCCCCCEEEEEEECCCCCCCC
AHLGLVGKGVTFDTGGISIKPADGMEKMKYDMAGGAAMIGAMRAIAQLKPAIPVSAYIPA
EEEEEEECCCEEECCCEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHCCH
VENMPGSRAQRPGDIVTAMNGKTIEVINTDAEGRLILADALTYARRQGCTHLVDAATLTG
HHCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHH
AVVVALGHLNVGLFANDDAMRDRVLAAAKDEGERMWSLPLEDDYKEYLKSGFADIANVGG
HHHEEEECCEEEEEECCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCC
RWGGAITAAIFLKEFAEETPWVHLDIAGTAWLDENKPYLAKGPTGLPVRTLARLAMDWKA
CCCHHHHHHHHHHHHHHHCCEEEEEECEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MQITIERKPLGQIEADALIVPVFEGRRDARFGAEDLFASGEVAGKALEMTLLHHAPGVRA
CEEEEECCCCCCCCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCHHHEEEHHHCCCCCCE
TRVLLVGAGAAGKFDAAGMRRLSGAAVRFLKAKSVKKIALVLDSEFSGSNFASAAVEGAL
EEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHCCCE
LGNFEPDRYKTGNEKKSLDTFIVAGDTPELESAVARGRILAEAQNFSRDLVNEPANLLTP
ECCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHCC
LGMADAARKMAAEFGLECEVLDRDAMQKLGMGSLLGVAIGSAEPPVLIVLRYRPAKSEGA
CCHHHHHHHHHHHHCCEEEEECHHHHHHCCCCCEEHEEECCCCCCEEEEEEECCCCCCCC
AHLGLVGKGVTFDTGGISIKPADGMEKMKYDMAGGAAMIGAMRAIAQLKPAIPVSAYIPA
EEEEEEECCCEEECCCEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHCCH
VENMPGSRAQRPGDIVTAMNGKTIEVINTDAEGRLILADALTYARRQGCTHLVDAATLTG
HHCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHH
AVVVALGHLNVGLFANDDAMRDRVLAAAKDEGERMWSLPLEDDYKEYLKSGFADIANVGG
HHHEEEECCEEEEEECCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCC
RWGGAITAAIFLKEFAEETPWVHLDIAGTAWLDENKPYLAKGPTGLPVRTLARLAMDWKA
CCCHHHHHHHHHHHHHHHCCEEEEEECEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA