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The map label for this gene is relA [H]

Identifier: 116620408

GI number: 116620408

Start: 1582578

End: 1584806

Strand: Direct

Name: relA [H]

Synonym: Acid_1285

Alternate gene names: 116620408

Gene position: 1582578-1584806 (Clockwise)

Preceding gene: 116620407

Following gene: 116620409

Centisome position: 15.88

GC content: 62.45

Gene sequence:

>2229_bases
GTGCCTTCCGAGTCGACCAGCCTCTCCGATGCCGCGCCCGTACTGCCTCCCACCGATCCCGTGGAACAGTTGTATCGCGA
GTTAGAGGCCAAGATCCGCGAGTACCGTCCTAAGGACGATCTGACTGCGCTCGAAAAGGCCTTCCGGTTCGCCAGTAAAT
ATCACGAAGGGCAGACGCGCGATTCGGGCGAGCCGTATATGGCGCATCCCGTCATGGTGGCCCATATTCTCGCCGACATG
CGGATGGACGTGGTCGCGATGGAGACCGGTCTGCTGCACGACGTGGTGGAAGATACCAGCGTCACCGTGGAGCAGGTCCG
CAAGGAGTTCGGCCCCGACGTGGCGCGCTGCGTGGACGGGGTCACCAAACTCACCAAGCTCGATGTCTTCTCCGCCGAAG
ACCGTCAGGCGGAGAGCGTCCGCAAGATGCTGCTCGCCATGGTGGAGGACATCCGCGTCATTCTGGTCAAACTGGCGGAC
CGCATTCACAACATGCGCACGCTCGGTTACCTGAACCCCGAGCGGCGCGAGCGGATTGCGCGCGAGACCATCGAAATCTA
TGCGCCGATCGCGCACCGCCTCGGCATGGGAAAGGTGCGCGGCGAGTTGGAAGACCTCGCCTTCCAGCACCTGGAGCCGG
ACGCATATCAGGAGATTCTCAGCGCGATCGAATCCAAGCGCCACTCCAACGAAGAGTTTCTGAACGAGATTCGCCACACG
GTGGAAAGCGAACTCCGCCGCGAAGGAATTCCGGCGCGCATCGATGGCCGGGTGAAGCGGCCGTACTCCGTGTTCCAGAA
GATGCGCCGGCAGAAGATCTCGCTGGATCAGGTCTACGACCTGATGGCGCTGCGCATTCTCACCGATTCGGTCAAGAATT
GCTACGCCGCCCTGGGCGTGATCCATAACAAATGGCGGCCGATTCCCGGCCGCATTAAGGACTTCATCGCGATCCCGCGG
CCCAATCTCTACCAGTCGCTGCACACGAGCGTGGTCGGGCCGCACGGGCAGACCTTCGAAGTCCAGATCCGGACCGAAGA
GATGCACCGCATCGCCGAGGAAGGCATCGCGGCGCACTGGAAATACAAGGAAGGCCGCAAGGGTCCGGCGGTGGACGACC
AACGCATCGCATGGCTGCGCCACCTGGTGGAATGGCAGCGCGACGTGCAGGATCCGGGCGAGTTCATGTCCACGTTGAAG
GTGGATCTCTATCCTGAAGAGGCCTACACCTTCACTCCGCGCGGCAAGGTGATCGTGCTGCCGCGCGACGCCACGCCGAT
CGATTTCGCCTACGCGATTCACTCCGATGTCGGCAGCACCTGCGTCGGCGCCAAGGTGAACGGGCGCATCGTGCCGCTGC
GCTCCACTCTCCGCAACGGCGACATTGTGGAGATCATGACGCAGCCCGGCCACGAGCCGAGCAAGGATTGGCTGGCCTTC
GTCAAGACCTCGCGCGCGCGCAATAAAATCAAGCACCTGATCAATGCGAGCGAGCGCATCAAGGCCGTCGAAATCGGCCA
GAAGTATTTGGAGAAGGAAGCGCGGCGGCTGGGCGTCTCGCTCGGCAAGGTCACCAAGAGCGAGATGGAAAAGGTGGCGT
CGGAGTACGGGTATAGCAAGATGGAAGACCTGTACGCGGCGCTTGGCTACGGCAAGTTTTCGGCCCGGCAGGTGTTGGTA
AAGATTGCGCCGGGAGTGGTCAAGGAAGAGACCGTCGAAGCCAAGCCGGCGGCGGAAGCCGCGCCCCAGCCGGCGCCGGG
CGCGCGTAAGGGCGAAGGCGATGGCGTCATCAAGGTGCGCGGCATCGACGACCTGATGGTGTATCGCGCCAAGTGCTGCA
ACCCGATTCGCGGCGAGGCAATCGTCGGCTATGTCACGCGCGGCAAGGGAGTCGCGGTGCATTCCAGGGCCTGCCCCAAC
GTGCAGAGCCTGATGTACGACGTGGAACGCAAGATCGAAGTTGAATGGGCGCGGGCAGCCGAAGACTCCTTCCCGGTGCG
CATCGTGGTTCACACCGACGACCGGCCCGGCATGCTGAACCAGCTCACAGGCGTGCTCTCCGACGAGAATACGAACATCC
GCAGTCTGGAAGCCAAGACCGAAACCGACCACGACGGCGGCGTCGTGGAAATGACGGTCGATGTGCGCGATAAGAAGCAG
TTGGAGAAACTGGTGGCTGCCATGCGCCGCATCTCCGGCGTCCGCGACGTAGAGAGACTATTTACCTGA

Upstream 100 bases:

>100_bases
GTCCACGAATAAAGAAGAACCTTTGACGCTTGTGGTTTTTATTCGCGTATATTCGTGTCCATTCGTGACCCAATAATTCC
CCTGCTACAATCGAGATAGA

Downstream 100 bases:

>100_bases
AATGACTCCATCCACCGACCCCGAGCACATCGCAATCTCCAAATCCAAAGGAATCAAGATCGACTGGAAGGACGGCCATC
ACAGCGATTACGGCCTGACA

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 742; Mature: 741

Protein sequence:

>742_residues
MPSESTSLSDAAPVLPPTDPVEQLYRELEAKIREYRPKDDLTALEKAFRFASKYHEGQTRDSGEPYMAHPVMVAHILADM
RMDVVAMETGLLHDVVEDTSVTVEQVRKEFGPDVARCVDGVTKLTKLDVFSAEDRQAESVRKMLLAMVEDIRVILVKLAD
RIHNMRTLGYLNPERRERIARETIEIYAPIAHRLGMGKVRGELEDLAFQHLEPDAYQEILSAIESKRHSNEEFLNEIRHT
VESELRREGIPARIDGRVKRPYSVFQKMRRQKISLDQVYDLMALRILTDSVKNCYAALGVIHNKWRPIPGRIKDFIAIPR
PNLYQSLHTSVVGPHGQTFEVQIRTEEMHRIAEEGIAAHWKYKEGRKGPAVDDQRIAWLRHLVEWQRDVQDPGEFMSTLK
VDLYPEEAYTFTPRGKVIVLPRDATPIDFAYAIHSDVGSTCVGAKVNGRIVPLRSTLRNGDIVEIMTQPGHEPSKDWLAF
VKTSRARNKIKHLINASERIKAVEIGQKYLEKEARRLGVSLGKVTKSEMEKVASEYGYSKMEDLYAALGYGKFSARQVLV
KIAPGVVKEETVEAKPAAEAAPQPAPGARKGEGDGVIKVRGIDDLMVYRAKCCNPIRGEAIVGYVTRGKGVAVHSRACPN
VQSLMYDVERKIEVEWARAAEDSFPVRIVVHTDDRPGMLNQLTGVLSDENTNIRSLEAKTETDHDGGVVEMTVDVRDKKQ
LEKLVAAMRRISGVRDVERLFT

Sequences:

>Translated_742_residues
MPSESTSLSDAAPVLPPTDPVEQLYRELEAKIREYRPKDDLTALEKAFRFASKYHEGQTRDSGEPYMAHPVMVAHILADM
RMDVVAMETGLLHDVVEDTSVTVEQVRKEFGPDVARCVDGVTKLTKLDVFSAEDRQAESVRKMLLAMVEDIRVILVKLAD
RIHNMRTLGYLNPERRERIARETIEIYAPIAHRLGMGKVRGELEDLAFQHLEPDAYQEILSAIESKRHSNEEFLNEIRHT
VESELRREGIPARIDGRVKRPYSVFQKMRRQKISLDQVYDLMALRILTDSVKNCYAALGVIHNKWRPIPGRIKDFIAIPR
PNLYQSLHTSVVGPHGQTFEVQIRTEEMHRIAEEGIAAHWKYKEGRKGPAVDDQRIAWLRHLVEWQRDVQDPGEFMSTLK
VDLYPEEAYTFTPRGKVIVLPRDATPIDFAYAIHSDVGSTCVGAKVNGRIVPLRSTLRNGDIVEIMTQPGHEPSKDWLAF
VKTSRARNKIKHLINASERIKAVEIGQKYLEKEARRLGVSLGKVTKSEMEKVASEYGYSKMEDLYAALGYGKFSARQVLV
KIAPGVVKEETVEAKPAAEAAPQPAPGARKGEGDGVIKVRGIDDLMVYRAKCCNPIRGEAIVGYVTRGKGVAVHSRACPN
VQSLMYDVERKIEVEWARAAEDSFPVRIVVHTDDRPGMLNQLTGVLSDENTNIRSLEAKTETDHDGGVVEMTVDVRDKKQ
LEKLVAAMRRISGVRDVERLFT
>Mature_741_residues
PSESTSLSDAAPVLPPTDPVEQLYRELEAKIREYRPKDDLTALEKAFRFASKYHEGQTRDSGEPYMAHPVMVAHILADMR
MDVVAMETGLLHDVVEDTSVTVEQVRKEFGPDVARCVDGVTKLTKLDVFSAEDRQAESVRKMLLAMVEDIRVILVKLADR
IHNMRTLGYLNPERRERIARETIEIYAPIAHRLGMGKVRGELEDLAFQHLEPDAYQEILSAIESKRHSNEEFLNEIRHTV
ESELRREGIPARIDGRVKRPYSVFQKMRRQKISLDQVYDLMALRILTDSVKNCYAALGVIHNKWRPIPGRIKDFIAIPRP
NLYQSLHTSVVGPHGQTFEVQIRTEEMHRIAEEGIAAHWKYKEGRKGPAVDDQRIAWLRHLVEWQRDVQDPGEFMSTLKV
DLYPEEAYTFTPRGKVIVLPRDATPIDFAYAIHSDVGSTCVGAKVNGRIVPLRSTLRNGDIVEIMTQPGHEPSKDWLAFV
KTSRARNKIKHLINASERIKAVEIGQKYLEKEARRLGVSLGKVTKSEMEKVASEYGYSKMEDLYAALGYGKFSARQVLVK
IAPGVVKEETVEAKPAAEAAPQPAPGARKGEGDGVIKVRGIDDLMVYRAKCCNPIRGEAIVGYVTRGKGVAVHSRACPNV
QSLMYDVERKIEVEWARAAEDSFPVRIVVHTDDRPGMLNQLTGVLSDENTNIRSLEAKTETDHDGGVVEMTVDVRDKKQL
EKLVAAMRRISGVRDVERLFT

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=135, Percent_Identity=37.037037037037, Blast_Score=72, Evalue=3e-12,
Organism=Escherichia coli, GI1790082, Length=721, Percent_Identity=39.6671289875173, Blast_Score=549, Evalue=1e-157,
Organism=Escherichia coli, GI1789147, Length=691, Percent_Identity=34.876989869754, Blast_Score=466, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI25143118, Length=132, Percent_Identity=34.8484848484849, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83775; Mature: 83644

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSESTSLSDAAPVLPPTDPVEQLYRELEAKIREYRPKDDLTALEKAFRFASKYHEGQTR
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCC
DSGEPYMAHPVMVAHILADMRMDVVAMETGLLHDVVEDTSVTVEQVRKEFGPDVARCVDG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
VTKLTKLDVFSAEDRQAESVRKMLLAMVEDIRVILVKLADRIHNMRTLGYLNPERRERIA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
RETIEIYAPIAHRLGMGKVRGELEDLAFQHLEPDAYQEILSAIESKRHSNEEFLNEIRHT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
VESELRREGIPARIDGRVKRPYSVFQKMRRQKISLDQVYDLMALRILTDSVKNCYAALGV
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IHNKWRPIPGRIKDFIAIPRPNLYQSLHTSVVGPHGQTFEVQIRTEEMHRIAEEGIAAHW
HHHCCCCCCCHHHHHEECCCCHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHCHHEEC
KYKEGRKGPAVDDQRIAWLRHLVEWQRDVQDPGEFMSTLKVDLYPEEAYTFTPRGKVIVL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHEEEECCCCEEECCCCEEEEE
PRDATPIDFAYAIHSDVGSTCVGAKVNGRIVPLRSTLRNGDIVEIMTQPGHEPSKDWLAF
ECCCCCCHHHHHHHHCCCCCEECCCCCCEEEECHHHCCCCCEEEEEECCCCCCCHHHHHH
VKTSRARNKIKHLINASERIKAVEIGQKYLEKEARRLGVSLGKVTKSEMEKVASEYGYSK
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHCHHH
MEDLYAALGYGKFSARQVLVKIAPGVVKEETVEAKPAAEAAPQPAPGARKGEGDGVIKVR
HHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHCCCCCCHHCCCCCCCCCCCCCCCCEEEEE
GIDDLMVYRAKCCNPIRGEAIVGYVTRGKGVAVHSRACPNVQSLMYDVERKIEVEWARAA
CCHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHC
EDSFPVRIVVHTDDRPGMLNQLTGVLSDENTNIRSLEAKTETDHDGGVVEMTVDVRDKKQ
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEECCCCHHH
LEKLVAAMRRISGVRDVERLFT
HHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure 
PSESTSLSDAAPVLPPTDPVEQLYRELEAKIREYRPKDDLTALEKAFRFASKYHEGQTR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCC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HHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA