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The map label for this gene is desK [H]

Identifier: 116620396

GI number: 116620396

Start: 1571349

End: 1572404

Strand: Reverse

Name: desK [H]

Synonym: Acid_1273

Alternate gene names: 116620396

Gene position: 1572404-1571349 (Counterclockwise)

Preceding gene: 116620397

Following gene: 116620395

Centisome position: 15.78

GC content: 65.34

Gene sequence:

>1056_bases
ATGAAACTCCTCCCCAAAGATCAGGATTGGACGGCGTACACGTATCTCGTGTACCTGATCTACTTTCTGCTCTATCCATT
TCTCGCCGGGTCTCCCGCGTGGCAGGCCAACGCGGCCCTGGCCGCCACCGCCGTTAGCGTCCTGTTTTATTTCTGGTCCT
ACTGGCTCCACGGGTTGAACGTGCTGTGGATCGCCGCCGGATGGTTTGCCCTGGCCGCCTTCTTCCTGAACATCAACATG
GGCGCCAGCGTCTTCTTCGTCTACGCAGCCTGCCTCTACGGCAAAGTCTGGGAGCCGCCGGCCGCCTTTCGCGCCCTGGC
GTTACACCTCGCGCTCGTCACGCTGCTCTGCGCGGTGCTCCATGCGAACGTCTTGATGTGGATCTCCTCGATGGTCTTCA
GCGCGCTCGTCGGCGCCGTGGTGATCCAGTTCGCGCAGCGCAAGCGGCTCGCCGACCGGCTCGCCGAGGCACACGAACAG
ACCGAGCATCTCGCCAAGGTCGCCGAGCGTGAACGCATCGCGCGCGACTTGCACGACCTGCTGGGCCACACGCTCTCGCT
GATCGTCCTGAAATCCGAGCTCGCCTCGCGCCTCTCCACCACCCAGCCGGAGCGCGCGGCCGAAGAGATCCGCGACGTGG
AACGCATCTCGCGCGAAGCGCTTGCGCAGGTACGCGCCGCCGTCCGCGGCTATCGCTCCATGGGCCTTGAAGGCGAGCTC
AAGCAGGCTCGCGCCACGCTCGAGACCGCCGGCATCGCGGTTGAATCCTCGCTCGAGACACCCAGGCTCTCGCCCATGCA
GGAAAGCGTCTTCGCGCTTGCCCTTCGTGAAGCGGTCACTAACGTGGTGCGCCATGCCCAGGCAACCTGCTGCCGGCTCT
CGCTGCGCCGCAACGGCGCCTTTTGCGAACTCGAGGTTGCCGATAACGGACGCGGCGGAGGCGCTGAAGACGGCAGCGGC
CTCAGCGGCATGCGCGAACGCGTGGAGGCGCTCGGCGGAATCCTCGAACGCGATGGTTCGCGTGGCACGCTGCTGCGTAT
TCGGGTGCCTGTATGA

Upstream 100 bases:

>100_bases
CGTCGAGGCGCTGGCTGCCTTCGCCTGCCTCTTCCTCGGCACCGCCTGGATTGCGCAATCCCGTGAACGCGAGAAGATGT
ATGGTTAAAGGCGGCCGCTG

Downstream 100 bases:

>100_bases
TCCGCGTCCTCATCGCCGAAGATCAGGCCATGGTGCGCGGCGCGCTCGCTGCCCTGCTCACCACCGAGGGTGATTTCGAA
ATCGCGGGCGACGCACCCAA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKLLPKDQDWTAYTYLVYLIYFLLYPFLAGSPAWQANAALAATAVSVLFYFWSYWLHGLNVLWIAAGWFALAAFFLNINM
GASVFFVYAACLYGKVWEPPAAFRALALHLALVTLLCAVLHANVLMWISSMVFSALVGAVVIQFAQRKRLADRLAEAHEQ
TEHLAKVAERERIARDLHDLLGHTLSLIVLKSELASRLSTTQPERAAEEIRDVERISREALAQVRAAVRGYRSMGLEGEL
KQARATLETAGIAVESSLETPRLSPMQESVFALALREAVTNVVRHAQATCCRLSLRRNGAFCELEVADNGRGGGAEDGSG
LSGMRERVEALGGILERDGSRGTLLRIRVPV

Sequences:

>Translated_351_residues
MKLLPKDQDWTAYTYLVYLIYFLLYPFLAGSPAWQANAALAATAVSVLFYFWSYWLHGLNVLWIAAGWFALAAFFLNINM
GASVFFVYAACLYGKVWEPPAAFRALALHLALVTLLCAVLHANVLMWISSMVFSALVGAVVIQFAQRKRLADRLAEAHEQ
TEHLAKVAERERIARDLHDLLGHTLSLIVLKSELASRLSTTQPERAAEEIRDVERISREALAQVRAAVRGYRSMGLEGEL
KQARATLETAGIAVESSLETPRLSPMQESVFALALREAVTNVVRHAQATCCRLSLRRNGAFCELEVADNGRGGGAEDGSG
LSGMRERVEALGGILERDGSRGTLLRIRVPV
>Mature_351_residues
MKLLPKDQDWTAYTYLVYLIYFLLYPFLAGSPAWQANAALAATAVSVLFYFWSYWLHGLNVLWIAAGWFALAAFFLNINM
GASVFFVYAACLYGKVWEPPAAFRALALHLALVTLLCAVLHANVLMWISSMVFSALVGAVVIQFAQRKRLADRLAEAHEQ
TEHLAKVAERERIARDLHDLLGHTLSLIVLKSELASRLSTTQPERAAEEIRDVERISREALAQVRAAVRGYRSMGLEGEL
KQARATLETAGIAVESSLETPRLSPMQESVFALALREAVTNVVRHAQATCCRLSLRRNGAFCELEVADNGRGGGAEDGSG
LSGMRERVEALGGILERDGSRGTLLRIRVPV

Specific function: Member of the two-component regulatory system desR/desK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates desR by phosphorylation [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=220, Percent_Identity=27.7272727272727, Blast_Score=71, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38718; Mature: 38718

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLPKDQDWTAYTYLVYLIYFLLYPFLAGSPAWQANAALAATAVSVLFYFWSYWLHGLN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLWIAAGWFALAAFFLNINMGASVFFVYAACLYGKVWEPPAAFRALALHLALVTLLCAVL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
HANVLMWISSMVFSALVGAVVIQFAQRKRLADRLAEAHEQTEHLAKVAERERIARDLHDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGHTLSLIVLKSELASRLSTTQPERAAEEIRDVERISREALAQVRAAVRGYRSMGLEGEL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
KQARATLETAGIAVESSLETPRLSPMQESVFALALREAVTNVVRHAQATCCRLSLRRNGA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FCELEVADNGRGGGAEDGSGLSGMRERVEALGGILERDGSRGTLLRIRVPV
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC
>Mature Secondary Structure
MKLLPKDQDWTAYTYLVYLIYFLLYPFLAGSPAWQANAALAATAVSVLFYFWSYWLHGLN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLWIAAGWFALAAFFLNINMGASVFFVYAACLYGKVWEPPAAFRALALHLALVTLLCAVL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
HANVLMWISSMVFSALVGAVVIQFAQRKRLADRLAEAHEQTEHLAKVAERERIARDLHDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGHTLSLIVLKSELASRLSTTQPERAAEEIRDVERISREALAQVRAAVRGYRSMGLEGEL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
KQARATLETAGIAVESSLETPRLSPMQESVFALALREAVTNVVRHAQATCCRLSLRRNGA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FCELEVADNGRGGGAEDGSGLSGMRERVEALGGILERDGSRGTLLRIRVPV
EEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]