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The map label for this gene is rffG [H]

Identifier: 116620378

GI number: 116620378

Start: 1552880

End: 1553878

Strand: Direct

Name: rffG [H]

Synonym: Acid_1255

Alternate gene names: 116620378

Gene position: 1552880-1553878 (Clockwise)

Preceding gene: 116620377

Following gene: 116620379

Centisome position: 15.58

GC content: 60.66

Gene sequence:

>999_bases
ATGAAAGTTTTGGTTATCGGGGGAACTCTCTTCATCGGAAAAGCGCTGGTGGAGGAGTTGCTGAAGGAAGGGCACGAGGT
TGCGGTGCTGCACCGCAAGCCCAAGCACGACTTCGGCAGACGTGTCGAGAACATCATGGCCGACCGCAACAACGGCGACG
CTATGCGCGAAGCCTTGGCCGGACGGCGGTTCGATGTGGTATTCGATAACGTATACGATTGGGAACGCGGGACGACGGCG
GCGCAGGTGGAGGCCACCATTCGAGCCTGCGGAGACCGTCTCTCCCGTTATATTTTTATGTCTAGTGTCGCCGCGTATGG
CGACGGCTTGAATCACAAGGAAAGCGATCCGTTGGCGCCGGATTACCATCCGATTCCGTATACCAGCCACAAGGCGACCA
CGGAGCGGATGCTGTTCCGGATGCACGCCACGAGCGGACTGCCGGTGGTCACCTTCCGGCCGCCCTTTGTCTACGGTCCG
CGCACGAATTATTATCGCGAGCAGTTCTTCTGGGACCGGCTGCGGGCCGGCCGGCCGATCATCATCCCCGGTGACGGGCA
CCGGCTGATGCAGTTTGTCTATGTGAACGACCTGGTGACCGCAATGGTGAAGGCGATGGACGAGCCGCGCGCGGTGGGCG
AGGCGTTCAACATCGGCGATCCGAAGCCGGTGACGCAGGTGGAACTGGTGGAGAAGCTGGCGAAAGTCGCGAATGTGGAG
CCGGCTCTGGTCCGCGTTCCTCGCGATGTGATTACGCAGGCCGGCGGCAACGTCTTCAACGAGCCGCTGTATTTTGGGGA
GTATTACGACCTGCCGCCGATTACCGAGAATATCGGCAAGGTGACCCGCGTGCTGAAGATGAAGCTGACGCCGTTCGAGA
CCGGGTTGAAGGAAACCTACAAATGGTACGTCCGCAATCACAAGGCGCGGACCGCCGGCTTCGAGTTTGACGATAAGGTC
CTGGCGCTTGCCCGCGCGGGATCCCCGGCCAGCGTATAG

Upstream 100 bases:

>100_bases
ATTAGTAGCGGTATTGTTTGAAGACGCGGGGGCACGGAACGGAATCGGTTTCCGCGCCGTCGCGTCTTAGTGTCTGTAGT
GGCAGTCTTAGGGAGCTCCT

Downstream 100 bases:

>100_bases
GGGCGCCGGGGGCGACGCGCAACGGCCGTGACGCCCAGCCCTCCCCCGGCCTTACTCTTCTTTGCCTTCCTCTTCTTTGC
GTTACTCTGCGTCTCTGCGA

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKVLVIGGTLFIGKALVEELLKEGHEVAVLHRKPKHDFGRRVENIMADRNNGDAMREALAGRRFDVVFDNVYDWERGTTA
AQVEATIRACGDRLSRYIFMSSVAAYGDGLNHKESDPLAPDYHPIPYTSHKATTERMLFRMHATSGLPVVTFRPPFVYGP
RTNYYREQFFWDRLRAGRPIIIPGDGHRLMQFVYVNDLVTAMVKAMDEPRAVGEAFNIGDPKPVTQVELVEKLAKVANVE
PALVRVPRDVITQAGGNVFNEPLYFGEYYDLPPITENIGKVTRVLKMKLTPFETGLKETYKWYVRNHKARTAGFEFDDKV
LALARAGSPASV

Sequences:

>Translated_332_residues
MKVLVIGGTLFIGKALVEELLKEGHEVAVLHRKPKHDFGRRVENIMADRNNGDAMREALAGRRFDVVFDNVYDWERGTTA
AQVEATIRACGDRLSRYIFMSSVAAYGDGLNHKESDPLAPDYHPIPYTSHKATTERMLFRMHATSGLPVVTFRPPFVYGP
RTNYYREQFFWDRLRAGRPIIIPGDGHRLMQFVYVNDLVTAMVKAMDEPRAVGEAFNIGDPKPVTQVELVEKLAKVANVE
PALVRVPRDVITQAGGNVFNEPLYFGEYYDLPPITENIGKVTRVLKMKLTPFETGLKETYKWYVRNHKARTAGFEFDDKV
LALARAGSPASV
>Mature_332_residues
MKVLVIGGTLFIGKALVEELLKEGHEVAVLHRKPKHDFGRRVENIMADRNNGDAMREALAGRRFDVVFDNVYDWERGTTA
AQVEATIRACGDRLSRYIFMSSVAAYGDGLNHKESDPLAPDYHPIPYTSHKATTERMLFRMHATSGLPVVTFRPPFVYGP
RTNYYREQFFWDRLRAGRPIIIPGDGHRLMQFVYVNDLVTAMVKAMDEPRAVGEAFNIGDPKPVTQVELVEKLAKVANVE
PALVRVPRDVITQAGGNVFNEPLYFGEYYDLPPITENIGKVTRVLKMKLTPFETGLKETYKWYVRNHKARTAGFEFDDKV
LALARAGSPASV

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=251, Percent_Identity=27.8884462151394, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 37476; Mature: 37476

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVIGGTLFIGKALVEELLKEGHEVAVLHRKPKHDFGRRVENIMADRNNGDAMREALA
CEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHC
GRRFDVVFDNVYDWERGTTAAQVEATIRACGDRLSRYIFMSSVAAYGDGLNHKESDPLAP
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DYHPIPYTSHKATTERMLFRMHATSGLPVVTFRPPFVYGPRTNYYREQFFWDRLRAGRPI
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHCCCCE
IIPGDGHRLMQFVYVNDLVTAMVKAMDEPRAVGEAFNIGDPKPVTQVELVEKLAKVANVE
EEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC
PALVRVPRDVITQAGGNVFNEPLYFGEYYDLPPITENIGKVTRVLKMKLTPFETGLKETY
HHHHHCCHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
KWYVRNHKARTAGFEFDDKVLALARAGSPASV
HHHHHCCCCCCCCCCCCCHHHEEEECCCCCCC
>Mature Secondary Structure
MKVLVIGGTLFIGKALVEELLKEGHEVAVLHRKPKHDFGRRVENIMADRNNGDAMREALA
CEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHC
GRRFDVVFDNVYDWERGTTAAQVEATIRACGDRLSRYIFMSSVAAYGDGLNHKESDPLAP
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DYHPIPYTSHKATTERMLFRMHATSGLPVVTFRPPFVYGPRTNYYREQFFWDRLRAGRPI
CCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEECCCCCHHHHHHHHHHHHCCCCE
IIPGDGHRLMQFVYVNDLVTAMVKAMDEPRAVGEAFNIGDPKPVTQVELVEKLAKVANVE
EEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC
PALVRVPRDVITQAGGNVFNEPLYFGEYYDLPPITENIGKVTRVLKMKLTPFETGLKETY
HHHHHCCHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHH
KWYVRNHKARTAGFEFDDKVLALARAGSPASV
HHHHHCCCCCCCCCCCCCHHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]