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The map label for this gene is shc [H]

Identifier: 116620309

GI number: 116620309

Start: 1460354

End: 1462279

Strand: Direct

Name: shc [H]

Synonym: Acid_1186

Alternate gene names: 116620309

Gene position: 1460354-1462279 (Clockwise)

Preceding gene: 116620304

Following gene: 116620310

Centisome position: 14.65

GC content: 64.8

Gene sequence:

>1926_bases
ATGTCGTACGAATGGACCGAACCCGTCCGCCCGGGCCGCCGCCACGCGGTCAGCCCCGTGCAAAACTTTTGCCAGTCGCT
CGCCCCAGCGATCCAGAGAGCCTGTGACGCTCTCTTCAGTCAGCAGGCCGCCGACGGCTTCTGGTGCGGCGAGCTGACTG
CCGACACCACTCTCGAATCCGATTACATCCTCCTCCAGCTCTGGCTCAACCAGCCCGACGATCACGGCTGGAATCCTCCC
ACCCGCCCCCGCATAGACCGAGCCGGCCGCTCCATCCTCGAGCGCCAGTTGCCCGATGGCGGCTTTAACATCTACGCCGG
CGGCCCTTCCGAAGTCAGCGCCACCATCAAGGCTTACTGTGCCCTCAAACTCGCCGGGCTCGACCCCCATAGCCCGCCCC
TGCGCCGCGCCCGCGAACGCATCCTCGCCCTCGGCGGACTCCAGGCCGCCAATAGCTACGTCAAGATCAACCTCAGCCTC
TTCGGCCTCTACCCCCGCAAGCACGTCCCTTCCGTGCCGCCCGAAATCGTCATGCTGCCCGGCAACGTGCTTTACGAAAT
GTCCTCCTGGACGCGCTCCATCCTGGTCCCTCTCTCCATCGTCCAGGCGCGCGGCTCCAACCGCCGCGCACCGAACGGCT
TCAACCTCGACGAGCTTCTCCTCCCCGGCGTCAAACTCGCCCTGCCCAAGCGCAAGGGCCTCGCCGTCCTCTTCCACCAC
CTGGACCGCATGTTCAAGGTCTGGGAAAAACGCGGCAGCGAGCGCATTCGCGGCGCCGCCATCCGCGAGGCCGAGCGCTG
GCTCATCGCCCGCACCCATTACACCGAAGGCCTCGGCGCGATCTATCCCGCCATGATGTACTTCATCATGGCCCTCGACG
CCCTCGGTTACGCCGAGGACCACCCCGATCGCTCCGAAGCCATTCGCCACTTCGAATCCCTCCTCATCGAAACTGACGAC
CGCTTCCTCTTTCAGCCCTGCGTCTCCCCAGTATGGGATACCGCGATCTGCGCTTTCGCACTCGGTGAAGCCGGCAACAC
AGACGACCCGCGCATGACGCTCGCCGCCGATTGGCTGATCAGCAAAGAGGTTCGCCGCAAAGGCGATTGGAGCATTAAGC
GCCCCGATACCGAACCCTCCGGCTGGGCCTTCGAGTTTGCCAACGAGTTCTACCCGGATATCGACGATACCGCCATGGTG
CTGCTCGCGCTCATGCACGCCAATGGCTCCAATCCCGAGGCGCAGGCTGCCGCCGAGCGCCGCGCCGTCAACTGGCTCCT
CGCCATGCAATCGAGCGACGGCGGCTGGGCCGCGTTTGATGTCGATAACAACTGGGCCATGCTCAATCAGGTTCCCTTCG
CCGATCACAACGCCATGCTCGACCCCACCTGCCCGGATATCACCGGCCGTGTGCTCGAGTGTCTCTGCCGGCGCGGCATG
GCAGGGCATGATGCCGCGCGCCGCGGTGTCGCCTACCTGCTCCAGGCCCAGGAGAAGGACGGCAGTTGGTACGGACGCTG
GGGAGTCAATTACATCTACGGCAGCTTCCTCGCCATGCGCGGACTTACTACCAGTGGCGCTCCAGGCTCCCAGGACGCCG
TCGATCGCGCCGCCCGCTGGCTCCGCGCGATCCAGAATCCCGATGGCGGCTGGGGTGAATCCTGCGCCAGTTATGCCCGC
GATGGCTATGTTGCAGCGCCCAGTTCCGCGTCCCAGACCGCTTGGGCCCTTCTCGGCCTGTGCGCCGCCGGCGATCGCGA
TTCGGCTCAGTTCCGCCGCGGCGTTGAGTATCTACTTACTCTCCAGGCTCCCGACGGAAAATGGCCCGAAGGGGCTACCA
CCGGCACCGGCTTCCCGAACGTTTTCTATCTGACCTACGCCATGTACCGGGATTATTTCCCCCTTTTGGCGCTATCTCAG
GTGTGA

Upstream 100 bases:

>100_bases
TCGCCTCCTTCTCCATTAGTGCGCCCAGCACGCGCAGCTCCGCGGCGTCGAGTTGCCAGTCCATGTTTTCAGTGTACGTT
GTTACCATGTGATTTCAGCG

Downstream 100 bases:

>100_bases
CATCATCCAAATATTTACGATTTTGCGGGTACGCTCGTCCGAATTTTGTGACATAATCCCGCGCATGCACTCAGCCATTC
GAGTCGCCCTCGTCGGCGAT

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MSYEWTEPVRPGRRHAVSPVQNFCQSLAPAIQRACDALFSQQAADGFWCGELTADTTLESDYILLQLWLNQPDDHGWNPP
TRPRIDRAGRSILERQLPDGGFNIYAGGPSEVSATIKAYCALKLAGLDPHSPPLRRARERILALGGLQAANSYVKINLSL
FGLYPRKHVPSVPPEIVMLPGNVLYEMSSWTRSILVPLSIVQARGSNRRAPNGFNLDELLLPGVKLALPKRKGLAVLFHH
LDRMFKVWEKRGSERIRGAAIREAERWLIARTHYTEGLGAIYPAMMYFIMALDALGYAEDHPDRSEAIRHFESLLIETDD
RFLFQPCVSPVWDTAICAFALGEAGNTDDPRMTLAADWLISKEVRRKGDWSIKRPDTEPSGWAFEFANEFYPDIDDTAMV
LLALMHANGSNPEAQAAAERRAVNWLLAMQSSDGGWAAFDVDNNWAMLNQVPFADHNAMLDPTCPDITGRVLECLCRRGM
AGHDAARRGVAYLLQAQEKDGSWYGRWGVNYIYGSFLAMRGLTTSGAPGSQDAVDRAARWLRAIQNPDGGWGESCASYAR
DGYVAAPSSASQTAWALLGLCAAGDRDSAQFRRGVEYLLTLQAPDGKWPEGATTGTGFPNVFYLTYAMYRDYFPLLALSQ
V

Sequences:

>Translated_641_residues
MSYEWTEPVRPGRRHAVSPVQNFCQSLAPAIQRACDALFSQQAADGFWCGELTADTTLESDYILLQLWLNQPDDHGWNPP
TRPRIDRAGRSILERQLPDGGFNIYAGGPSEVSATIKAYCALKLAGLDPHSPPLRRARERILALGGLQAANSYVKINLSL
FGLYPRKHVPSVPPEIVMLPGNVLYEMSSWTRSILVPLSIVQARGSNRRAPNGFNLDELLLPGVKLALPKRKGLAVLFHH
LDRMFKVWEKRGSERIRGAAIREAERWLIARTHYTEGLGAIYPAMMYFIMALDALGYAEDHPDRSEAIRHFESLLIETDD
RFLFQPCVSPVWDTAICAFALGEAGNTDDPRMTLAADWLISKEVRRKGDWSIKRPDTEPSGWAFEFANEFYPDIDDTAMV
LLALMHANGSNPEAQAAAERRAVNWLLAMQSSDGGWAAFDVDNNWAMLNQVPFADHNAMLDPTCPDITGRVLECLCRRGM
AGHDAARRGVAYLLQAQEKDGSWYGRWGVNYIYGSFLAMRGLTTSGAPGSQDAVDRAARWLRAIQNPDGGWGESCASYAR
DGYVAAPSSASQTAWALLGLCAAGDRDSAQFRRGVEYLLTLQAPDGKWPEGATTGTGFPNVFYLTYAMYRDYFPLLALSQ
V
>Mature_640_residues
SYEWTEPVRPGRRHAVSPVQNFCQSLAPAIQRACDALFSQQAADGFWCGELTADTTLESDYILLQLWLNQPDDHGWNPPT
RPRIDRAGRSILERQLPDGGFNIYAGGPSEVSATIKAYCALKLAGLDPHSPPLRRARERILALGGLQAANSYVKINLSLF
GLYPRKHVPSVPPEIVMLPGNVLYEMSSWTRSILVPLSIVQARGSNRRAPNGFNLDELLLPGVKLALPKRKGLAVLFHHL
DRMFKVWEKRGSERIRGAAIREAERWLIARTHYTEGLGAIYPAMMYFIMALDALGYAEDHPDRSEAIRHFESLLIETDDR
FLFQPCVSPVWDTAICAFALGEAGNTDDPRMTLAADWLISKEVRRKGDWSIKRPDTEPSGWAFEFANEFYPDIDDTAMVL
LALMHANGSNPEAQAAAERRAVNWLLAMQSSDGGWAAFDVDNNWAMLNQVPFADHNAMLDPTCPDITGRVLECLCRRGMA
GHDAARRGVAYLLQAQEKDGSWYGRWGVNYIYGSFLAMRGLTTSGAPGSQDAVDRAARWLRAIQNPDGGWGESCASYARD
GYVAAPSSASQTAWALLGLCAAGDRDSAQFRRGVEYLLTLQAPDGKWPEGATTGTGFPNVFYLTYAMYRDYFPLLALSQV

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=645, Percent_Identity=26.8217054263566, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI47933397, Length=645, Percent_Identity=26.8217054263566, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI224177558, Length=645, Percent_Identity=26.8217054263566, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI224177556, Length=577, Percent_Identity=26.5164644714038, Blast_Score=128, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321863, Length=626, Percent_Identity=25.5591054313099, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 71100; Mature: 70969

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS01074 TERPENE_SYNTHASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYEWTEPVRPGRRHAVSPVQNFCQSLAPAIQRACDALFSQQAADGFWCGELTADTTLES
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
DYILLQLWLNQPDDHGWNPPTRPRIDRAGRSILERQLPDGGFNIYAGGPSEVSATIKAYC
CEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHH
ALKLAGLDPHSPPLRRARERILALGGLQAANSYVKINLSLFGLYPRKHVPSVPPEIVMLP
HEEEECCCCCCCHHHHHHHHHHHHCCHHHCCCEEEEEEEEEEECCCCCCCCCCCCEEEEC
GNVLYEMSSWTRSILVPLSIVQARGSNRRAPNGFNLDELLLPGVKLALPKRKGLAVLFHH
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEECCCCCCHHHHHHH
LDRMFKVWEKRGSERIRGAAIREAERWLIARTHYTEGLGAIYPAMMYFIMALDALGYAED
HHHHHHHHHHHCHHHHHHHHHHHHHHHHEEEHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
HPDRSEAIRHFESLLIETDDRFLFQPCVSPVWDTAICAFALGEAGNTDDPRMTLAADWLI
CCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHH
SKEVRRKGDWSIKRPDTEPSGWAFEFANEFYPDIDDTAMVLLALMHANGSNPEAQAAAER
HHHHHHCCCCCEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
RAVNWLLAMQSSDGGWAAFDVDNNWAMLNQVPFADHNAMLDPTCPDITGRVLECLCRRGM
HHHEEEEEEECCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
AGHDAARRGVAYLLQAQEKDGSWYGRWGVNYIYGSFLAMRGLTTSGAPGSQDAVDRAARW
CCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LRAIQNPDGGWGESCASYARDGYVAAPSSASQTAWALLGLCAAGDRDSAQFRRGVEYLLT
HHHHCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHCCCEEEEE
LQAPDGKWPEGATTGTGFPNVFYLTYAMYRDYFPLLALSQV
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYEWTEPVRPGRRHAVSPVQNFCQSLAPAIQRACDALFSQQAADGFWCGELTADTTLES
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCC
DYILLQLWLNQPDDHGWNPPTRPRIDRAGRSILERQLPDGGFNIYAGGPSEVSATIKAYC
CEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHH
ALKLAGLDPHSPPLRRARERILALGGLQAANSYVKINLSLFGLYPRKHVPSVPPEIVMLP
HEEEECCCCCCCHHHHHHHHHHHHCCHHHCCCEEEEEEEEEEECCCCCCCCCCCCEEEEC
GNVLYEMSSWTRSILVPLSIVQARGSNRRAPNGFNLDELLLPGVKLALPKRKGLAVLFHH
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEECCCCCCHHHHHHH
LDRMFKVWEKRGSERIRGAAIREAERWLIARTHYTEGLGAIYPAMMYFIMALDALGYAED
HHHHHHHHHHHCHHHHHHHHHHHHHHHHEEEHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
HPDRSEAIRHFESLLIETDDRFLFQPCVSPVWDTAICAFALGEAGNTDDPRMTLAADWLI
CCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHH
SKEVRRKGDWSIKRPDTEPSGWAFEFANEFYPDIDDTAMVLLALMHANGSNPEAQAAAER
HHHHHHCCCCCEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHH
RAVNWLLAMQSSDGGWAAFDVDNNWAMLNQVPFADHNAMLDPTCPDITGRVLECLCRRGM
HHHEEEEEEECCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
AGHDAARRGVAYLLQAQEKDGSWYGRWGVNYIYGSFLAMRGLTTSGAPGSQDAVDRAARW
CCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LRAIQNPDGGWGESCASYARDGYVAAPSSASQTAWALLGLCAAGDRDSAQFRRGVEYLLT
HHHHCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHCCCEEEEE
LQAPDGKWPEGATTGTGFPNVFYLTYAMYRDYFPLLALSQV
EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7894707 [H]