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The map label for this gene is lpxC

Identifier: 116620276

GI number: 116620276

Start: 1419300

End: 1420187

Strand: Direct

Name: lpxC

Synonym: Acid_1153

Alternate gene names: 116620276

Gene position: 1419300-1420187 (Clockwise)

Preceding gene: 116620275

Following gene: 116620277

Centisome position: 14.24

GC content: 62.61

Gene sequence:

>888_bases
TTGCGATTTGAAACCACGGTTCAACGCCCGGTTGAAGCATCGGGTGTCGGGCTCCATTCCGGAGTCCCGGTAAAGATCCG
CATCCTGCCAGCGCCGGTTTCCACCGGAGTGGTTTTCGTGCGGACCGATTTGGACGGCTTTCAGATTCCCGCGAGCTGGC
GGCATGTGGCGCGCGTGAGCTACGCGACCAGCCTGATGAGGCAGGGCGTGCTGATCTCGACCACGGAGCATCTGTTGAGC
GTGTTCTACTCCATGGGGATCGACAACGTCTACGTGGAGATCGATAACCTCGAGGTGCCGATTCTGGATGGCAGCGGGCT
GCCATTCGTGAAGCTGATCGCGCAGGCGGGCATCCGGCAGTATCGCAGGAAGCGCCGCTACCTGCGCATCCGGCGGCCGA
TTTCGGTGGAAGACAAGGGGAAGCGCATCAGCATTCTCCCCGACGAGGCTTTCCGGTTGACGTGTGACACGGAATATCCG
GCGCCGGTGGGGCGGCAATCGCTCGAACTGGTAGTGACACCGGAGCACTACGCGTCCGAACTGGCGTTTGCACGCACTTT
CGGGTGGGAGAACGATCTGGACCAGATGCGTAACATGGGACTGATCCGCGGAGCGAGTTTGGCGAACGCCGTGTGCTTCA
CGTCTGAGGGCCCGCTGAACCCCGACGGCCTGCGCGCGGTGGACGAGTGCTGCCGGCACAAGGCGCTGGACCTGATTGGC
GACCTGGCGCTGCTGGGACGTCCGCTGCTCGGACATGTGATTGCGGAGCGCGCCGGGCACGCGATGCATGCGGCGCTGGT
GGCGCGGATCATGGGCGATCCCTCGATCTACGAGATCATCACGTTCGATCAATTAGCCTCGCGCGTGACACAAGCCTTGG
TTTCCTGA

Upstream 100 bases:

>100_bases
TTTGACCACAGTGGAACCTTAACAAGTCCTTCTGCATCAAACAGTTGACCAGCCCTATTGCGACTGGTGTAATAGGAGTT
CAAGATGCCGGAGATCCACA

Downstream 100 bases:

>100_bases
ATCAGCAAATCCCATCACGCGGGCGTCCGCTCCAATAGGCAAGGGATCGCTCCCTGACGGTCGCGGCTCTGATTGCGGGC
GTTGCGAGAGCGACGGGTGT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MRFETTVQRPVEASGVGLHSGVPVKIRILPAPVSTGVVFVRTDLDGFQIPASWRHVARVSYATSLMRQGVLISTTEHLLS
VFYSMGIDNVYVEIDNLEVPILDGSGLPFVKLIAQAGIRQYRRKRRYLRIRRPISVEDKGKRISILPDEAFRLTCDTEYP
APVGRQSLELVVTPEHYASELAFARTFGWENDLDQMRNMGLIRGASLANAVCFTSEGPLNPDGLRAVDECCRHKALDLIG
DLALLGRPLLGHVIAERAGHAMHAALVARIMGDPSIYEIITFDQLASRVTQALVS

Sequences:

>Translated_295_residues
MRFETTVQRPVEASGVGLHSGVPVKIRILPAPVSTGVVFVRTDLDGFQIPASWRHVARVSYATSLMRQGVLISTTEHLLS
VFYSMGIDNVYVEIDNLEVPILDGSGLPFVKLIAQAGIRQYRRKRRYLRIRRPISVEDKGKRISILPDEAFRLTCDTEYP
APVGRQSLELVVTPEHYASELAFARTFGWENDLDQMRNMGLIRGASLANAVCFTSEGPLNPDGLRAVDECCRHKALDLIG
DLALLGRPLLGHVIAERAGHAMHAALVARIMGDPSIYEIITFDQLASRVTQALVS
>Mature_295_residues
MRFETTVQRPVEASGVGLHSGVPVKIRILPAPVSTGVVFVRTDLDGFQIPASWRHVARVSYATSLMRQGVLISTTEHLLS
VFYSMGIDNVYVEIDNLEVPILDGSGLPFVKLIAQAGIRQYRRKRRYLRIRRPISVEDKGKRISILPDEAFRLTCDTEYP
APVGRQSLELVVTPEHYASELAFARTFGWENDLDQMRNMGLIRGASLANAVCFTSEGPLNPDGLRAVDECCRHKALDLIG
DLALLGRPLLGHVIAERAGHAMHAALVARIMGDPSIYEIITFDQLASRVTQALVS

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=284, Percent_Identity=36.2676056338028, Blast_Score=186, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_SOLUE (Q029X9)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_822432.1
- ProteinModelPortal:   Q029X9
- SMR:   Q029X9
- STRING:   Q029X9
- GeneID:   4430698
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_1153
- NMPDR:   fig|234267.9.peg.1091
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- PhylomeDB:   Q029X9
- ProtClustDB:   PRK13186
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 32615; Mature: 32615

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFETTVQRPVEASGVGLHSGVPVKIRILPAPVSTGVVFVRTDLDGFQIPASWRHVARVS
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHH
YATSLMRQGVLISTTEHLLSVFYSMGIDNVYVEIDNLEVPILDGSGLPFVKLIAQAGIRQ
HHHHHHHCCEEEEHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHHH
YRRKRRYLRIRRPISVEDKGKRISILPDEAFRLTCDTEYPAPVGRQSLELVVTPEHYASE
HHHHHHHEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCEEEEECCHHHHHH
LAFARTFGWENDLDQMRNMGLIRGASLANAVCFTSEGPLNPDGLRAVDECCRHKALDLIG
HHHHHHCCCCCCHHHHHCCCCEECCCHHCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
DLALLGRPLLGHVIAERAGHAMHAALVARIMGDPSIYEIITFDQLASRVTQALVS
HHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MRFETTVQRPVEASGVGLHSGVPVKIRILPAPVSTGVVFVRTDLDGFQIPASWRHVARVS
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHH
YATSLMRQGVLISTTEHLLSVFYSMGIDNVYVEIDNLEVPILDGSGLPFVKLIAQAGIRQ
HHHHHHHCCEEEEHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHHH
YRRKRRYLRIRRPISVEDKGKRISILPDEAFRLTCDTEYPAPVGRQSLELVVTPEHYASE
HHHHHHHEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCEEEEECCHHHHHH
LAFARTFGWENDLDQMRNMGLIRGASLANAVCFTSEGPLNPDGLRAVDECCRHKALDLIG
HHHHHHCCCCCCHHHHHCCCCEECCCHHCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
DLALLGRPLLGHVIAERAGHAMHAALVARIMGDPSIYEIITFDQLASRVTQALVS
HHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA