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The map label for this gene is lytS [H]

Identifier: 116620255

GI number: 116620255

Start: 1394539

End: 1396359

Strand: Direct

Name: lytS [H]

Synonym: Acid_1132

Alternate gene names: 116620255

Gene position: 1394539-1396359 (Clockwise)

Preceding gene: 116620251

Following gene: 116620260

Centisome position: 13.99

GC content: 63.87

Gene sequence:

>1821_bases
ATGCTGGGACTCAACCAACCCTTATTGATCAACATTCTCGGGCACGCGGCCGGAGCGTTGATCTTCGCGATTTTCCTGGT
TCTGCTTTACAGCGGCCGCGGATGGTCGGGGCTTCAGGGACGCTATCTATCGGGGCTTGCGGCGGGGCTGTCGTTGGTTT
GGAACCTCGGGTCGCTGGTTGTTCTGGCGTGGCCCGGCTTGCCGGCGCCGGTGCTGGCGCTGGTTGCGGCGACGAGTTTT
TCGGTGCTCAGCCTGCTTCCCGCCGTGCTGCTGCAAGTCTCGCTCGAGGGCACGTGGCCGGCGTTGGTGGGGGCAGGTTA
CGTGCTCAGCACGGCGGCGGTGGCGATGCACTTTTGGGAGATCCACGGCAATGGGCCGGCTCTGCATCAGACCGCGCTGA
TGGTGATCACGGTGGGATTTCTGATTCTGGCCGCGGTGGCCGTGGCCGCGCCCGCGCTGCGCCACCGGCACGGCAGAATT
CGCAGCCTCGCTTCGATGTGCCTGGCGCTGTTCGCCATGTCCTTCGTTCATTTTGGATCGGGACACGCTGGTGAGGCGTG
GTCCAGCGAACTGGTAGTGCATCACGCAGGCATTCCGCTGGCGCTCTTCGTTCTACTGCAGGATTACCGGTTCGTGCTGC
TGGACGCCTTCGTTCGGTTTTTGACGAACGCGCTGCTGGCCGCGATCCTGACGGGCCTGGTGATCGCGGTGGCATTCCGT
TTGGTGCTGGTGGAACGCATCGCGCAGCAGCAGCCGTTGCACGAAGCGATCCTGCTAATAAGCATTTGTCTTTTCCTGGT
CTTCTTCGCGTGGCTGCGCAACTGGGTGCAGGCATGGCTGACGCGAGCGATCTTCCACCGCGGCAATGTCGCCGGCCTGG
TGAGCCGCGTGAAGGATGCACCGGCATTTTCGAGTGAAGAGCAGTATGTGGAGTGGGCGGCGGCCTTAATCGCGGCGGCG
GTAGGAACCAAGGAGTGCGCCGTGGTGGCGCGGGAGGAGTTAAGCACTGCGGTCGGCCTGCATGTTCCGGTGCTTGCCGC
CGCGCTGCCGGAGAAATGGAATTGGGTAGTGGTCGTGCTGCCGGTTCGGTTCGGACAGGACGATGTGCGTTTGATCCTGC
TGGGCCGGCGTCATGGCGGACAGCGCTACTTCAGCGAGGACCTCGACACGCTGCGGCAGGCGGCGCTGGAAATTGCGGAG
CGGCTCGATACCCTGCGGCGCGAGGAGATGAATCGACTGGTCAGCCAGGCGGAACTGCGCGCGCTGCAATCGCAGATCAA
TCCGCACTTCCTGTTCAACGCACTCAATACGCTGTACGGCACGATTCCGCGCGAGGCTGCCGGGGCGCGCCGCATGGTGA
TCAACCTTGCCGAGATCTTCCGCTACTTCCTGCAATCGGACCGGACGTTCGTGCCGCTCGCGCAAGAGATGCAGATCGTG
CGCGCGTACCTTGAGGTGGAACAACTGCGGCTGGGCGAACGCTTGCGCGTGGAGTTCGAGGTGGACGACGCGGCGCTGGA
GGTCCCGGTGCCGGTGCTCTCGATCCAACCGTTGGTGGAGAACGCGATTAAGCACGGCGTCGCGCAGAGCTCCGAGCCCG
GCTACGTGCGGGTGCGAATCGAACGGCGCGGCGAGCAGTTGAACATCGTCGTGGAGAACAGCAATGAGCGGCCTTATGCG
AGTGTGACCGGCACGGGCGTGGGGCTGCAGAATGTGCGGCGCCGCCTGGAGATCTGCTACGGGCCTGGGGCGACTCTCCG
GTTGGCGCCCGACGAGCAGAGGACCATCGCCGAAATTTCCATTCCGTTAACGCCGCGATGA

Upstream 100 bases:

>100_bases
CTGGTCCATTGCGTGCGATTCAGCGTCCCATACTTCCCGGTGAGCGGGCAAGTTGGTTCGCAGTACAGTAAAGGAGACGC
GCCTGCAGAGGCGGCCGGCG

Downstream 100 bases:

>100_bases
AGTCGCGGCCAACACGTTCGGTCTGGCCGGTATTGCCGCTGCGATCTCCTGGGCCACCAGCCCTGCGGCCGCCGTGATCG
ACCACGAGATGAAGAATGCG

Product: signal transduction histidine kinase LytS

Products: NA

Alternate protein names: Autolysin sensor kinase [H]

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MLGLNQPLLINILGHAAGALIFAIFLVLLYSGRGWSGLQGRYLSGLAAGLSLVWNLGSLVVLAWPGLPAPVLALVAATSF
SVLSLLPAVLLQVSLEGTWPALVGAGYVLSTAAVAMHFWEIHGNGPALHQTALMVITVGFLILAAVAVAAPALRHRHGRI
RSLASMCLALFAMSFVHFGSGHAGEAWSSELVVHHAGIPLALFVLLQDYRFVLLDAFVRFLTNALLAAILTGLVIAVAFR
LVLVERIAQQQPLHEAILLISICLFLVFFAWLRNWVQAWLTRAIFHRGNVAGLVSRVKDAPAFSSEEQYVEWAAALIAAA
VGTKECAVVAREELSTAVGLHVPVLAAALPEKWNWVVVVLPVRFGQDDVRLILLGRRHGGQRYFSEDLDTLRQAALEIAE
RLDTLRREEMNRLVSQAELRALQSQINPHFLFNALNTLYGTIPREAAGARRMVINLAEIFRYFLQSDRTFVPLAQEMQIV
RAYLEVEQLRLGERLRVEFEVDDAALEVPVPVLSIQPLVENAIKHGVAQSSEPGYVRVRIERRGEQLNIVVENSNERPYA
SVTGTGVGLQNVRRRLEICYGPGATLRLAPDEQRTIAEISIPLTPR

Sequences:

>Translated_606_residues
MLGLNQPLLINILGHAAGALIFAIFLVLLYSGRGWSGLQGRYLSGLAAGLSLVWNLGSLVVLAWPGLPAPVLALVAATSF
SVLSLLPAVLLQVSLEGTWPALVGAGYVLSTAAVAMHFWEIHGNGPALHQTALMVITVGFLILAAVAVAAPALRHRHGRI
RSLASMCLALFAMSFVHFGSGHAGEAWSSELVVHHAGIPLALFVLLQDYRFVLLDAFVRFLTNALLAAILTGLVIAVAFR
LVLVERIAQQQPLHEAILLISICLFLVFFAWLRNWVQAWLTRAIFHRGNVAGLVSRVKDAPAFSSEEQYVEWAAALIAAA
VGTKECAVVAREELSTAVGLHVPVLAAALPEKWNWVVVVLPVRFGQDDVRLILLGRRHGGQRYFSEDLDTLRQAALEIAE
RLDTLRREEMNRLVSQAELRALQSQINPHFLFNALNTLYGTIPREAAGARRMVINLAEIFRYFLQSDRTFVPLAQEMQIV
RAYLEVEQLRLGERLRVEFEVDDAALEVPVPVLSIQPLVENAIKHGVAQSSEPGYVRVRIERRGEQLNIVVENSNERPYA
SVTGTGVGLQNVRRRLEICYGPGATLRLAPDEQRTIAEISIPLTPR
>Mature_606_residues
MLGLNQPLLINILGHAAGALIFAIFLVLLYSGRGWSGLQGRYLSGLAAGLSLVWNLGSLVVLAWPGLPAPVLALVAATSF
SVLSLLPAVLLQVSLEGTWPALVGAGYVLSTAAVAMHFWEIHGNGPALHQTALMVITVGFLILAAVAVAAPALRHRHGRI
RSLASMCLALFAMSFVHFGSGHAGEAWSSELVVHHAGIPLALFVLLQDYRFVLLDAFVRFLTNALLAAILTGLVIAVAFR
LVLVERIAQQQPLHEAILLISICLFLVFFAWLRNWVQAWLTRAIFHRGNVAGLVSRVKDAPAFSSEEQYVEWAAALIAAA
VGTKECAVVAREELSTAVGLHVPVLAAALPEKWNWVVVVLPVRFGQDDVRLILLGRRHGGQRYFSEDLDTLRQAALEIAE
RLDTLRREEMNRLVSQAELRALQSQINPHFLFNALNTLYGTIPREAAGARRMVINLAEIFRYFLQSDRTFVPLAQEMQIV
RAYLEVEQLRLGERLRVEFEVDDAALEVPVPVLSIQPLVENAIKHGVAQSSEPGYVRVRIERRGEQLNIVVENSNERPYA
SVTGTGVGLQNVRRRLEICYGPGATLRLAPDEQRTIAEISIPLTPR

Specific function: Member of the two-component regulatory system lytR/lytS that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=200, Percent_Identity=35.5, Blast_Score=132, Evalue=8e-32,
Organism=Escherichia coli, GI1788446, Length=263, Percent_Identity=31.9391634980989, Blast_Score=127, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66498; Mature: 66498

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGLNQPLLINILGHAAGALIFAIFLVLLYSGRGWSGLQGRYLSGLAAGLSLVWNLGSLV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCEE
VLAWPGLPAPVLALVAATSFSVLSLLPAVLLQVSLEGTWPALVGAGYVLSTAAVAMHFWE
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHE
IHGNGPALHQTALMVITVGFLILAAVAVAAPALRHRHGRIRSLASMCLALFAMSFVHFGS
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GHAGEAWSSELVVHHAGIPLALFVLLQDYRFVLLDAFVRFLTNALLAAILTGLVIAVAFR
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLVERIAQQQPLHEAILLISICLFLVFFAWLRNWVQAWLTRAIFHRGNVAGLVSRVKDA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
PAFSSEEQYVEWAAALIAAAVGTKECAVVAREELSTAVGLHVPVLAAALPEKWNWVVVVL
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
PVRFGQDDVRLILLGRRHGGQRYFSEDLDTLRQAALEIAERLDTLRREEMNRLVSQAELR
EEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALQSQINPHFLFNALNTLYGTIPREAAGARRMVINLAEIFRYFLQSDRTFVPLAQEMQIV
HHHHHCCHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHH
RAYLEVEQLRLGERLRVEFEVDDAALEVPVPVLSIQPLVENAIKHGVAQSSEPGYVRVRI
HHHHHHHHHCCCCCEEEEEEECCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
ERRGEQLNIVVENSNERPYASVTGTGVGLQNVRRRLEICYGPGATLRLAPDEQRTIAEIS
EECCCEEEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEE
IPLTPR
CCCCCC
>Mature Secondary Structure
MLGLNQPLLINILGHAAGALIFAIFLVLLYSGRGWSGLQGRYLSGLAAGLSLVWNLGSLV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCEE
VLAWPGLPAPVLALVAATSFSVLSLLPAVLLQVSLEGTWPALVGAGYVLSTAAVAMHFWE
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHE
IHGNGPALHQTALMVITVGFLILAAVAVAAPALRHRHGRIRSLASMCLALFAMSFVHFGS
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GHAGEAWSSELVVHHAGIPLALFVLLQDYRFVLLDAFVRFLTNALLAAILTGLVIAVAFR
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLVERIAQQQPLHEAILLISICLFLVFFAWLRNWVQAWLTRAIFHRGNVAGLVSRVKDA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
PAFSSEEQYVEWAAALIAAAVGTKECAVVAREELSTAVGLHVPVLAAALPEKWNWVVVVL
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
PVRFGQDDVRLILLGRRHGGQRYFSEDLDTLRQAALEIAERLDTLRREEMNRLVSQAELR
EEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALQSQINPHFLFNALNTLYGTIPREAAGARRMVINLAEIFRYFLQSDRTFVPLAQEMQIV
HHHHHCCHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHH
RAYLEVEQLRLGERLRVEFEVDDAALEVPVPVLSIQPLVENAIKHGVAQSSEPGYVRVRI
HHHHHHHHHCCCCCEEEEEEECCCCEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
ERRGEQLNIVVENSNERPYASVTGTGVGLQNVRRRLEICYGPGATLRLAPDEQRTIAEIS
EECCCEEEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEE
IPLTPR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA