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The map label for this gene is ispA [C]

Identifier: 116620237

GI number: 116620237

Start: 1371494

End: 1372390

Strand: Direct

Name: ispA [C]

Synonym: Acid_1114

Alternate gene names: 116620237

Gene position: 1371494-1372390 (Clockwise)

Preceding gene: 116620236

Following gene: 116620238

Centisome position: 13.76

GC content: 66.44

Gene sequence:

>897_bases
ATGGATCTGCACCGTATGGACCTGCGCGATTACCTCGCCCAGCAGCAGCGACTGGTGGATTCGGAACTCGACCGTCTCGT
CCCCCCGGAAAGCGCCGCCCCGGAAACCATCCATCGCGCCATGCGCTACAGCCTCTTCGCCGGCGGCAAGCGCATCCGCC
CTATCCTCTGTATAGAGGCCGCCCGCACCGTCTCCGACGATTGCGCTGGCGTCGCCGCCGCCGCCTGCTCACTCGAGCTC
ATCCATACCTACTCCCTCATCCACGACGATCTCCCCGCGCTCGATAACGACGATTACCGCCGCGGCAAGCTCACCAACCA
CAAAGTCTTCGGCGACGCCATGGCCATTCTCGCCGGCGATTCGCTCCTCACCCTCGCCTTCCAGGTCCTCGCCCAGCTTG
ACGCGCCGGACGCTCGCAAGACGCGCCTCATCGCCGAGCTCGCCACTGCCAGCGGCACCGTGGGCGGAATGATCGGCGGC
CAGGTCGCCGATCTCGAAGGCGAAGGCAAACCGCCCGACGCACAGCTGCTCGAAACCATCCATCGCGCCAAGACCGGAGC
CCTCCTCCGCGCCTCCCTGCGTCTCGGCGCCATCTTCGCCGGCGCAGCCGAGCCGCAGTACGAAGCCCTCTCCTGCTACG
GCCAGCACGTCGGCCTCGCCTTTCAAATCGTGGACGATATCCTCGATGTTGAAGAGTCCTCCGAAGCCCTCGGCAAGACC
GCCGGCAAGGACGCCGCCCAGCACAAGATCACCTTTCCCGCCGTCTACGGCCTTGAACCTTCGCGCGAAATGGCCGCCCG
CGAGTGCGAACGTGCCCACGCCGTCCTCGCTCCCTTCGGCGAGCGCGCCCTGCGCCTCCACGAACTGGCCGATCTGATCG
TCCGCCGCAAATCATGA

Upstream 100 bases:

>100_bases
GCAAACAGCTCGAAGCCGCCGAGACCCGCGTCGAAACCCTCATCCGCAAAGAGGGTAAAATGACCGCGGAACCCTTCCGC
CCGGAGAAGTCCTGACCGCA

Downstream 100 bases:

>100_bases
AGACCCGGCTGGACCGCCTGATCGTGGACCGCGGTCTGGTTGAGTCGCGGGAAAAAGCCCAGGCCCTCATCATGGCCGGC
GAAGTCCGCGTCAACGGCCA

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MDLHRMDLRDYLAQQQRLVDSELDRLVPPESAAPETIHRAMRYSLFAGGKRIRPILCIEAARTVSDDCAGVAAAACSLEL
IHTYSLIHDDLPALDNDDYRRGKLTNHKVFGDAMAILAGDSLLTLAFQVLAQLDAPDARKTRLIAELATASGTVGGMIGG
QVADLEGEGKPPDAQLLETIHRAKTGALLRASLRLGAIFAGAAEPQYEALSCYGQHVGLAFQIVDDILDVEESSEALGKT
AGKDAAQHKITFPAVYGLEPSREMAARECERAHAVLAPFGERALRLHELADLIVRRKS

Sequences:

>Translated_298_residues
MDLHRMDLRDYLAQQQRLVDSELDRLVPPESAAPETIHRAMRYSLFAGGKRIRPILCIEAARTVSDDCAGVAAAACSLEL
IHTYSLIHDDLPALDNDDYRRGKLTNHKVFGDAMAILAGDSLLTLAFQVLAQLDAPDARKTRLIAELATASGTVGGMIGG
QVADLEGEGKPPDAQLLETIHRAKTGALLRASLRLGAIFAGAAEPQYEALSCYGQHVGLAFQIVDDILDVEESSEALGKT
AGKDAAQHKITFPAVYGLEPSREMAARECERAHAVLAPFGERALRLHELADLIVRRKS
>Mature_298_residues
MDLHRMDLRDYLAQQQRLVDSELDRLVPPESAAPETIHRAMRYSLFAGGKRIRPILCIEAARTVSDDCAGVAAAACSLEL
IHTYSLIHDDLPALDNDDYRRGKLTNHKVFGDAMAILAGDSLLTLAFQVLAQLDAPDARKTRLIAELATASGTVGGMIGG
QVADLEGEGKPPDAQLLETIHRAKTGALLRASLRLGAIFAGAAEPQYEALSCYGQHVGLAFQIVDDILDVEESSEALGKT
AGKDAAQHKITFPAVYGLEPSREMAARECERAHAVLAPFGERALRLHELADLIVRRKS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=233, Percent_Identity=29.6137339055794, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786623, Length=299, Percent_Identity=42.809364548495, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI1789578, Length=226, Percent_Identity=33.1858407079646, Blast_Score=120, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17505681, Length=260, Percent_Identity=28.8461538461538, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6325188, Length=258, Percent_Identity=24.4186046511628, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24651612, Length=232, Percent_Identity=27.5862068965517, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32227; Mature: 32227

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLHRMDLRDYLAQQQRLVDSELDRLVPPESAAPETIHRAMRYSLFAGGKRIRPILCIEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEHHH
ARTVSDDCAGVAAAACSLELIHTYSLIHDDLPALDNDDYRRGKLTNHKVFGDAMAILAGD
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
SLLTLAFQVLAQLDAPDARKTRLIAELATASGTVGGMIGGQVADLEGEGKPPDAQLLETI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCHHHHHHHH
HRAKTGALLRASLRLGAIFAGAAEPQYEALSCYGQHVGLAFQIVDDILDVEESSEALGKT
HHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGKDAAQHKITFPAVYGLEPSREMAARECERAHAVLAPFGERALRLHELADLIVRRKS
CCCHHHHCEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLHRMDLRDYLAQQQRLVDSELDRLVPPESAAPETIHRAMRYSLFAGGKRIRPILCIEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEHHH
ARTVSDDCAGVAAAACSLELIHTYSLIHDDLPALDNDDYRRGKLTNHKVFGDAMAILAGD
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
SLLTLAFQVLAQLDAPDARKTRLIAELATASGTVGGMIGGQVADLEGEGKPPDAQLLETI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCHHHHHHHH
HRAKTGALLRASLRLGAIFAGAAEPQYEALSCYGQHVGLAFQIVDDILDVEESSEALGKT
HHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGKDAAQHKITFPAVYGLEPSREMAARECERAHAVLAPFGERALRLHELADLIVRRKS
CCCHHHHCEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]