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The map label for this gene is pyrH

Identifier: 116620032

GI number: 116620032

Start: 1133499

End: 1134206

Strand: Reverse

Name: pyrH

Synonym: Acid_0904

Alternate gene names: 116620032

Gene position: 1134206-1133499 (Counterclockwise)

Preceding gene: 116620033

Following gene: 116620031

Centisome position: 11.38

GC content: 60.17

Gene sequence:

>708_bases
ATGGCCGGTTATAAGCGCATCCTGCTGAAATTAAGCGGTGAAGCGTTAGCCGGAGCGGCCACCTTCGGCATCGACGCGGA
CCGTGTGCGCTCTCTGGGGCGCGAAGTAGCCGATGTCGCGGCAAGTGGCATTCAAGTGGGAGTCGTGGTCGGCGGCGGCA
ACATCTTTCGGGGTGTCGCCGCCGCTGCCCGCAGTATGGACCGTGTAACCGGCGACCACATGGGCATGCTCGCCACGGTC
ATCAATTCGCTGGCCTTGAGCGACGCGCTGGAGCAGATGGGGATTCCGACGCGGGTCATGAGCGCGATCGAAATGCACCA
GGTAGCGGAGCCGTATATCCGCCGCCGCGCCATCCGGCACCTGGAAAAGGGACGCATCGTCATCTTCGCGGCGGGCACCT
CCAATCCGTATTTCTCCACCGACACCGCGGCCACTCTGCGGGCGCTCGAAATCAAGGCCGACGTAATCGCCAAAGCGACG
CGCGTGGACGGCGTTTACGATAAGGACCCGCTCAAGCATCCGGACGCGGTCAAATTCCCCGAGATCAGCTATTTGGAAGT
CCTGTCCCGAGGCTTGGGCGTCATGGACGCGACATCCATCGCCATGTGCCGGGACAACAAGCTCCCCATTATCGTTTTCA
ATTTGAACACGATAGGAAATATAATGCGTATGTCGATGGGTGAGACTATCGGCACCGTGATTCACTAG

Upstream 100 bases:

>100_bases
CAAGCTCGGCGAGAATATCAGCGTGGCTCGGTTCGTCCGCTTCAAAGTTGGTGATGCCCAGGGTTCCGACTCCGGCAGCG
AGACTCCGGCAGCCGAATAA

Downstream 100 bases:

>100_bases
CAGCACCAGAGCACGGAGAGACTTCGCTATGAAGACAGAACAGCCTGCAGCAACCACCGGTCCTGCATTCACCTCGGTGA
AGGAAGTCGAGGCGAACCTC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MAGYKRILLKLSGEALAGAATFGIDADRVRSLGREVADVAASGIQVGVVVGGGNIFRGVAAAARSMDRVTGDHMGMLATV
INSLALSDALEQMGIPTRVMSAIEMHQVAEPYIRRRAIRHLEKGRIVIFAAGTSNPYFSTDTAATLRALEIKADVIAKAT
RVDGVYDKDPLKHPDAVKFPEISYLEVLSRGLGVMDATSIAMCRDNKLPIIVFNLNTIGNIMRMSMGETIGTVIH

Sequences:

>Translated_235_residues
MAGYKRILLKLSGEALAGAATFGIDADRVRSLGREVADVAASGIQVGVVVGGGNIFRGVAAAARSMDRVTGDHMGMLATV
INSLALSDALEQMGIPTRVMSAIEMHQVAEPYIRRRAIRHLEKGRIVIFAAGTSNPYFSTDTAATLRALEIKADVIAKAT
RVDGVYDKDPLKHPDAVKFPEISYLEVLSRGLGVMDATSIAMCRDNKLPIIVFNLNTIGNIMRMSMGETIGTVIH
>Mature_234_residues
AGYKRILLKLSGEALAGAATFGIDADRVRSLGREVADVAASGIQVGVVVGGGNIFRGVAAAARSMDRVTGDHMGMLATVI
NSLALSDALEQMGIPTRVMSAIEMHQVAEPYIRRRAIRHLEKGRIVIFAAGTSNPYFSTDTAATLRALEIKADVIAKATR
VDGVYDKDPLKHPDAVKFPEISYLEVLSRGLGVMDATSIAMCRDNKLPIIVFNLNTIGNIMRMSMGETIGTVIH

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=52.8138528138528, Blast_Score=245, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_SOLUE (Q02AL3)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_822188.1
- ProteinModelPortal:   Q02AL3
- SMR:   Q02AL3
- STRING:   Q02AL3
- GeneID:   4430973
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_0904
- NMPDR:   fig|234267.9.peg.851
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q02AL3
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25140; Mature: 25008

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: BINDING 52-52 BINDING 53-53 BINDING 57-57 BINDING 72-72 BINDING 160-160 BINDING 166-166 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGYKRILLKLSGEALAGAATFGIDADRVRSLGREVADVAASGIQVGVVVGGGNIFRGVA
CCCHHEEHHHCCCCHHHCHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHHHH
AAARSMDRVTGDHMGMLATVINSLALSDALEQMGIPTRVMSAIEMHQVAEPYIRRRAIRH
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRIVIFAAGTSNPYFSTDTAATLRALEIKADVIAKATRVDGVYDKDPLKHPDAVKFP
HHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
EISYLEVLSRGLGVMDATSIAMCRDNKLPIIVFNLNTIGNIMRMSMGETIGTVIH
CHHHHHHHHHCCCCCCHHHHHEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGYKRILLKLSGEALAGAATFGIDADRVRSLGREVADVAASGIQVGVVVGGGNIFRGVA
CCHHEEHHHCCCCHHHCHHHCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHHHH
AAARSMDRVTGDHMGMLATVINSLALSDALEQMGIPTRVMSAIEMHQVAEPYIRRRAIRH
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRIVIFAAGTSNPYFSTDTAATLRALEIKADVIAKATRVDGVYDKDPLKHPDAVKFP
HHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
EISYLEVLSRGLGVMDATSIAMCRDNKLPIIVFNLNTIGNIMRMSMGETIGTVIH
CHHHHHHHHHCCCCCCHHHHHEECCCCCCEEEEECHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA