Click here to switch to the map view.

The map label for this gene is thrB

Identifier: 116620030

GI number: 116620030

Start: 1131872

End: 1132786

Strand: Reverse

Name: thrB

Synonym: Acid_0902

Alternate gene names: 116620030

Gene position: 1132786-1131872 (Counterclockwise)

Preceding gene: 116620031

Following gene: 116620025

Centisome position: 11.37

GC content: 66.12

Gene sequence:

>915_bases
ATGAGTGCGTCCAATTCATGGTTTCACCTCAAGGTGCCGGCTTCCAGCGCCAACCTGGGGCCGGGCTTCGACGCGCTGGG
GCTGGCGCTGGGAGTGTACCTGACCTGCCGCTTCCGGCATAGTGCAACGCTCTCGATTACCGCCGCTGGCCGCGACGCTT
GCGGCATTCCAGCGAGCCCCGATAACCTGATCTGGCAGACCGCACTCACGGTGGCGCGCAATCAGCGCATGACCATGCCG
CCCATCGAGCTCGAAATCCACAACGAAATCCCGCTAGGCAAGGGCATGGGGTCGAGCGCCGCGGCACTGACGGCGGGCGT
GGTGATCGCAGACGAGCTTCTGGACTTAGGTTGGAAACCGCTCCGCATCCTCGACGAAGCGGCGCGTCTCGAAGGCCATC
CCGATAACGTCGCGCCCTGCACCCTGGGCTCGATCGTGGCCAGCGCGATCGATTCGGGCGGAGTCACGCGCGCCGTCCGG
CTTCCCCTGCCGAAGAGCTTCGACCTGGCCATCGTGGTGCCGGATTTCGACCTCCCGACCGCGAAGGCGCGCGCCGTGCT
CCCCTCCGGCTACAGCCGCGAGGACGCTGTCTTCAACGTGCAGCGCGCGGCCCTCTTGATCGCGGCGCTGGCCACCGGGA
CCACCAACGTCTTTCCCGCCGCCATCGAAGACCGCTTCCACCAACCCTACCGGGAAGCCCTGGTGCCCGGCCTGCACGAA
ATTCTGCGGCTGCGCGCCCCTGGGCTGCTTGGCTGCGCGTTGAGCGGCGCCGGTCCCTCGATTCTGGTCTTCTTCGAGCG
CGGCTACGAAAGCGTGTGCGAACTGGTGGAGCAGATCTTCCGGTTAAACGGCCACGCTTCGGAGACACTCCATTGCAGTA
TTCCGGAACGCGGCTTCGAGCTAACGCGGGCGTGA

Upstream 100 bases:

>100_bases
AGAGATCATGGAAATCCGCTAGCCGCGAGGCCCGGAGATCCATCTTGGGATTCGTTGATCGCTCGTTCGCCCCGCCGGCG
CGAGCCGCAGCCGACCCGTT

Downstream 100 bases:

>100_bases
CTCCGGTCACTGCGGAGTTCTCCTTTCTCGCAAAGCCGCAGAGCCGCAAAGAACCGCCAAGAAAACAGCCTTCTTCTCTG
CGTTAACTCTGTGTCTCTGC

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSASNSWFHLKVPASSANLGPGFDALGLALGVYLTCRFRHSATLSITAAGRDACGIPASPDNLIWQTALTVARNQRMTMP
PIELEIHNEIPLGKGMGSSAAALTAGVVIADELLDLGWKPLRILDEAARLEGHPDNVAPCTLGSIVASAIDSGGVTRAVR
LPLPKSFDLAIVVPDFDLPTAKARAVLPSGYSREDAVFNVQRAALLIAALATGTTNVFPAAIEDRFHQPYREALVPGLHE
ILRLRAPGLLGCALSGAGPSILVFFERGYESVCELVEQIFRLNGHASETLHCSIPERGFELTRA

Sequences:

>Translated_304_residues
MSASNSWFHLKVPASSANLGPGFDALGLALGVYLTCRFRHSATLSITAAGRDACGIPASPDNLIWQTALTVARNQRMTMP
PIELEIHNEIPLGKGMGSSAAALTAGVVIADELLDLGWKPLRILDEAARLEGHPDNVAPCTLGSIVASAIDSGGVTRAVR
LPLPKSFDLAIVVPDFDLPTAKARAVLPSGYSREDAVFNVQRAALLIAALATGTTNVFPAAIEDRFHQPYREALVPGLHE
ILRLRAPGLLGCALSGAGPSILVFFERGYESVCELVEQIFRLNGHASETLHCSIPERGFELTRA
>Mature_303_residues
SASNSWFHLKVPASSANLGPGFDALGLALGVYLTCRFRHSATLSITAAGRDACGIPASPDNLIWQTALTVARNQRMTMPP
IELEIHNEIPLGKGMGSSAAALTAGVVIADELLDLGWKPLRILDEAARLEGHPDNVAPCTLGSIVASAIDSGGVTRAVRL
PLPKSFDLAIVVPDFDLPTAKARAVLPSGYSREDAVFNVQRAALLIAALATGTTNVFPAAIEDRFHQPYREALVPGLHEI
LRLRAPGLLGCALSGAGPSILVFFERGYESVCELVEQIFRLNGHASETLHCSIPERGFELTRA

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily

Homologues:

Organism=Escherichia coli, GI1786184, Length=271, Percent_Identity=28.7822878228782, Blast_Score=104, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6321814, Length=334, Percent_Identity=36.5269461077844, Blast_Score=181, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_SOLUE (Q02AL5)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_822186.1
- ProteinModelPortal:   Q02AL5
- SMR:   Q02AL5
- STRING:   Q02AL5
- GeneID:   4430971
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_0902
- NMPDR:   fig|234267.9.peg.849
- eggNOG:   COG0083
- HOGENOM:   HBG646290
- OMA:   FDCLGAA
- PhylomeDB:   Q02AL5
- GO:   GO:0005737
- HAMAP:   MF_00384
- InterPro:   IPR006204
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PIRSF:   PIRSF000676
- PRINTS:   PR00958
- TIGRFAMs:   TIGR00191

Pfam domain/function: PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.39

Molecular weight: Translated: 32305; Mature: 32174

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASNSWFHLKVPASSANLGPGFDALGLALGVYLTCRFRHSATLSITAAGRDACGIPASP
CCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCCCCCCC
DNLIWQTALTVARNQRMTMPPIELEIHNEIPLGKGMGSSAAALTAGVVIADELLDLGWKP
CCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCH
LRILDEAARLEGHPDNVAPCTLGSIVASAIDSGGVTRAVRLPLPKSFDLAIVVPDFDLPT
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCC
AKARAVLPSGYSREDAVFNVQRAALLIAALATGTTNVFPAAIEDRFHQPYREALVPGLHE
CHHHEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHH
ILRLRAPGLLGCALSGAGPSILVFFERGYESVCELVEQIFRLNGHASETLHCSIPERGFE
HHHHCCCCEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCE
LTRA
ECCC
>Mature Secondary Structure 
SASNSWFHLKVPASSANLGPGFDALGLALGVYLTCRFRHSATLSITAAGRDACGIPASP
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHEEEEECCCEEEEEEECCCCCCCCCCCC
DNLIWQTALTVARNQRMTMPPIELEIHNEIPLGKGMGSSAAALTAGVVIADELLDLGWKP
CCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCH
LRILDEAARLEGHPDNVAPCTLGSIVASAIDSGGVTRAVRLPLPKSFDLAIVVPDFDLPT
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCC
AKARAVLPSGYSREDAVFNVQRAALLIAALATGTTNVFPAAIEDRFHQPYREALVPGLHE
CHHHEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHH
ILRLRAPGLLGCALSGAGPSILVFFERGYESVCELVEQIFRLNGHASETLHCSIPERGFE
HHHHCCCCEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCE
LTRA
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA