Click here to switch to the map view.

The map label for this gene is lepB [H]

Identifier: 116619927

GI number: 116619927

Start: 996619

End: 997224

Strand: Direct

Name: lepB [H]

Synonym: Acid_0799

Alternate gene names: 116619927

Gene position: 996619-997224 (Clockwise)

Preceding gene: 116619926

Following gene: 116619930

Centisome position: 10.0

GC content: 60.73

Gene sequence:

>606_bases
ATGCAAGAGAACGACCAGCCCATCTCCGGCCCCATCGAGCCTGCCGCACCCGCGGAGCCCCAGGCCCCAGGGCCTCTAGT
TCCTTCCAGCGTCTGGAACGCGCTCTCCTGGGTGCGCGACCTCGCCTTCTCGGTATTGATTGCAGTCATCCTGATCGTCT
TCATCTATCAGCCGGTCAAGGTCGAAGGCACCAGCATGATGCCGACTTTGACGGATCAGGAACGCATCTTCATCAACAAG
TTCACCTACCATTTCGGGCTCGGGAGCATTGAGCGCGGCGATATGGTGGTCTTCTGGTTTCCACTGGATCCCTCGAAGTC
CTATATCAAGCGCGTAATCGGTGTGCCCGGGGATATGGTGCGCATCGAGGCCGGTCAAGTCTTCGTGAACGGCGAGGCGC
TCTCCGAGGGCTACGTTCCAGACGAGTACCGCGACCGAGTGTCGTGGGAAGAGCACCGCGTGCCCCCCGGCAATTACTTC
GTGCTCGGCGATCATCGCAGTTCTTCCAGCGACAGCCGCACGTGGGGCTTCGTCAAGCGCGACGCCATTTACGGCAAGGC
AGTCTTCGTCTACTGGCCGCTCGAGAAGATGGGCCGGCTCCACTAG

Upstream 100 bases:

>100_bases
GGCGCCGTCCCATTTCCGGTGCTGAGTACCTTGCTGAAGTAGTTGGTACGGCAACCAAAGCAGGGGGCCGAGCGTCTATA
ATTTGTGTAGTACTAGCGGG

Downstream 100 bases:

>100_bases
CGCGACGACCGTTATCGACTACTGGCCGAACCAGAGGTAAATGATGTTGGACGGGTCCGGCCGCAGATCCAGCGTGAACG
CGAGGTTAAAGGTCGGCGGA

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MQENDQPISGPIEPAAPAEPQAPGPLVPSSVWNALSWVRDLAFSVLIAVILIVFIYQPVKVEGTSMMPTLTDQERIFINK
FTYHFGLGSIERGDMVVFWFPLDPSKSYIKRVIGVPGDMVRIEAGQVFVNGEALSEGYVPDEYRDRVSWEEHRVPPGNYF
VLGDHRSSSSDSRTWGFVKRDAIYGKAVFVYWPLEKMGRLH

Sequences:

>Translated_201_residues
MQENDQPISGPIEPAAPAEPQAPGPLVPSSVWNALSWVRDLAFSVLIAVILIVFIYQPVKVEGTSMMPTLTDQERIFINK
FTYHFGLGSIERGDMVVFWFPLDPSKSYIKRVIGVPGDMVRIEAGQVFVNGEALSEGYVPDEYRDRVSWEEHRVPPGNYF
VLGDHRSSSSDSRTWGFVKRDAIYGKAVFVYWPLEKMGRLH
>Mature_201_residues
MQENDQPISGPIEPAAPAEPQAPGPLVPSSVWNALSWVRDLAFSVLIAVILIVFIYQPVKVEGTSMMPTLTDQERIFINK
FTYHFGLGSIERGDMVVFWFPLDPSKSYIKRVIGVPGDMVRIEAGQVFVNGEALSEGYVPDEYRDRVSWEEHRVPPGNYF
VLGDHRSSSSDSRTWGFVKRDAIYGKAVFVYWPLEKMGRLH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Homo sapiens, GI21450679, Length=155, Percent_Identity=29.6774193548387, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1788921, Length=87, Percent_Identity=42.5287356321839, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323800, Length=152, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 22705; Mature: 22705

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQENDQPISGPIEPAAPAEPQAPGPLVPSSVWNALSWVRDLAFSVLIAVILIVFIYQPVK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VEGTSMMPTLTDQERIFINKFTYHFGLGSIERGDMVVFWFPLDPSKSYIKRVIGVPGDMV
ECCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCEE
RIEAGQVFVNGEALSEGYVPDEYRDRVSWEEHRVPPGNYFVLGDHRSSSSDSRTWGFVKR
EEECCEEEECCCCCCCCCCCHHHHHCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCEEEC
DAIYGKAVFVYWPLEKMGRLH
CCEECCEEEEEECHHHCCCCC
>Mature Secondary Structure
MQENDQPISGPIEPAAPAEPQAPGPLVPSSVWNALSWVRDLAFSVLIAVILIVFIYQPVK
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VEGTSMMPTLTDQERIFINKFTYHFGLGSIERGDMVVFWFPLDPSKSYIKRVIGVPGDMV
ECCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCEE
RIEAGQVFVNGEALSEGYVPDEYRDRVSWEEHRVPPGNYFVLGDHRSSSSDSRTWGFVKR
EEECCEEEECCCCCCCCCCCHHHHHCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCEEEC
DAIYGKAVFVYWPLEKMGRLH
CCEECCEEEEEECHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7865790 [H]