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The map label for this gene is lpxB

Identifier: 116619899

GI number: 116619899

Start: 969285

End: 970430

Strand: Direct

Name: lpxB

Synonym: Acid_0771

Alternate gene names: 116619899

Gene position: 969285-970430 (Clockwise)

Preceding gene: 116619897

Following gene: 116619900

Centisome position: 9.73

GC content: 62.04

Gene sequence:

>1146_bases
ATGCCCAAAATTCTGGTATCGGCCGGTGAGGCGTCCGGGGACCTCTATGCCTCGCTGGTGGTCCAGGAGCTGCGGCGCAT
CATGCCCGATGCCGAGTTTTTCGGCTGTACCGGACCGCGCCTGCGCGCCGCCGGAGTGCGAACCATTGTGGATTCCGCCG
ACCTGGCGGTGGTCGGGCTGATCGAGGTGGTGGCCCACATTCCGCGGATCTACGGGGAGTTTCGAAAACTGCTGCGTGCG
GCGCGAGAGGAGCGGCCGTTGCTGGCCATCCTCACCGATTCGCCGGATTTTCACCTGCGGGTGGCGCGCAAACTCCACCG
TCAGGAAGTCCCGGTGGTCTACCTGGTAGCCCCCCAGGCATGGGCCTGGAGACGGGGCCGGGTCCGTGAGATGCGGCGCA
CTATCCGCCGTCTTTTGTGTATTTTCCCTTTCGAGGAGGAGTTTTTCCGCCGCTATGGTGTGCCTGCTACGTATATAGGG
CATCCCTTGGCCGGATTGGTGCATCCAGCGCTATCGCGGGAGGAGTTTTTTAAGAAACACAGGTTGGCCGCCGAACGTCC
CTTAGTATCAGTGCTCCCTGGGAGCCGACGCGGTGAAGCAGCGCGCCATATTCCGGCGCTGTTGGATGCCGTGGACCGGA
TCTACCGGGAGCAGGCTGTAAATGTGGTGCTTCCGGCATCGGCGACCACCGGGGTCGCCTTTTTCCAGGAGCGTATGGGG
AACTCTCCGATTCGGGTGATTGAAGGGGAAAGCTGGGACGCCATGGCACATTCCGATCTCGCGCTGGCCGCCAGCGGCAC
TGTGACCGTGGAAGCCGCCCTCCTGGGCACCCCGATGGTGACATTTTATAAGGTGACCGGCGTGAGCTGGCTGGCCGGAA
AATTTTTGGTGGATATTCCGTTCTATTCGATGGTGAACCTGATCGCAGGCCGCGCCGTTGTGCCGGAGCTGATGCAAAGT
CAGATGACGGGTGAGAATCTCGCCCGGGAAGCCCTGCGCCTGCTGCAGGGCGGCCGCGACCGCGAGGAAATGAAGGCCGG
GCTGGCCCAGGTCAAAGAGAAACTCGCGGGCCGAACCGGCGCCCCTGGAAGAGCCGCGCTGGCCATACAAGAAATCCTGG
AAGGACAAGTTACTCATGTTTCGTAA

Upstream 100 bases:

>100_bases
CCCGATCTCGGTGGACATTCTCGTGGTTCGATTGTATCAGGGCGACACGTCGCTCTCGCGGGAAGCTGAGCCCAAAATCG
CCGCGATACACTGAAGGGGA

Downstream 100 bases:

>100_bases
TCGCACGCTCGCAGCCGTTCTCACGCTGGTAGTAGGCGCATGCGCCGCCTGGTCGCAGGACCGCCGCTCGCGCATCGACG
TGGAGCAATACGTCATCGAC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MPKILVSAGEASGDLYASLVVQELRRIMPDAEFFGCTGPRLRAAGVRTIVDSADLAVVGLIEVVAHIPRIYGEFRKLLRA
AREERPLLAILTDSPDFHLRVARKLHRQEVPVVYLVAPQAWAWRRGRVREMRRTIRRLLCIFPFEEEFFRRYGVPATYIG
HPLAGLVHPALSREEFFKKHRLAAERPLVSVLPGSRRGEAARHIPALLDAVDRIYREQAVNVVLPASATTGVAFFQERMG
NSPIRVIEGESWDAMAHSDLALAASGTVTVEAALLGTPMVTFYKVTGVSWLAGKFLVDIPFYSMVNLIAGRAVVPELMQS
QMTGENLAREALRLLQGGRDREEMKAGLAQVKEKLAGRTGAPGRAALAIQEILEGQVTHVS

Sequences:

>Translated_381_residues
MPKILVSAGEASGDLYASLVVQELRRIMPDAEFFGCTGPRLRAAGVRTIVDSADLAVVGLIEVVAHIPRIYGEFRKLLRA
AREERPLLAILTDSPDFHLRVARKLHRQEVPVVYLVAPQAWAWRRGRVREMRRTIRRLLCIFPFEEEFFRRYGVPATYIG
HPLAGLVHPALSREEFFKKHRLAAERPLVSVLPGSRRGEAARHIPALLDAVDRIYREQAVNVVLPASATTGVAFFQERMG
NSPIRVIEGESWDAMAHSDLALAASGTVTVEAALLGTPMVTFYKVTGVSWLAGKFLVDIPFYSMVNLIAGRAVVPELMQS
QMTGENLAREALRLLQGGRDREEMKAGLAQVKEKLAGRTGAPGRAALAIQEILEGQVTHVS
>Mature_380_residues
PKILVSAGEASGDLYASLVVQELRRIMPDAEFFGCTGPRLRAAGVRTIVDSADLAVVGLIEVVAHIPRIYGEFRKLLRAA
REERPLLAILTDSPDFHLRVARKLHRQEVPVVYLVAPQAWAWRRGRVREMRRTIRRLLCIFPFEEEFFRRYGVPATYIGH
PLAGLVHPALSREEFFKKHRLAAERPLVSVLPGSRRGEAARHIPALLDAVDRIYREQAVNVVLPASATTGVAFFQERMGN
SPIRVIEGESWDAMAHSDLALAASGTVTVEAALLGTPMVTFYKVTGVSWLAGKFLVDIPFYSMVNLIAGRAVVPELMQSQ
MTGENLAREALRLLQGGRDREEMKAGLAQVKEKLAGRTGAPGRAALAIQEILEGQVTHVS

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=375, Percent_Identity=29.0666666666667, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_SOLUE (Q02AZ6)

Other databases:

- EMBL:   CP000473
- RefSeq:   YP_822055.1
- ProteinModelPortal:   Q02AZ6
- STRING:   Q02AZ6
- GeneID:   4431100
- GenomeReviews:   CP000473_GR
- KEGG:   sus:Acid_0771
- NMPDR:   fig|234267.9.peg.726
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- PhylomeDB:   Q02AZ6
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 42110; Mature: 41978

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKILVSAGEASGDLYASLVVQELRRIMPDAEFFGCTGPRLRAAGVRTIVDSADLAVVGL
CCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHCCCCHHHHHH
IEVVAHIPRIYGEFRKLLRAAREERPLLAILTDSPDFHLRVARKLHRQEVPVVYLVAPQA
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCH
WAWRRGRVREMRRTIRRLLCIFPFEEEFFRRYGVPATYIGHPLAGLVHPALSREEFFKKH
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHCCCHHHHHHHHCCHHHHHHHH
RLAAERPLVSVLPGSRRGEAARHIPALLDAVDRIYREQAVNVVLPASATTGVAFFQERMG
HHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHC
NSPIRVIEGESWDAMAHSDLALAASGTVTVEAALLGTPMVTFYKVTGVSWLAGKFLVDIP
CCCEEEEECCCCCCHHCCCEEEEECCCEEEEHHHHCCCHHHHHHHHCHHHHHHHHHEECC
FYSMVNLIAGRAVVPELMQSQMTGENLAREALRLLQGGRDREEMKAGLAQVKEKLAGRTG
HHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
APGRAALAIQEILEGQVTHVS
CCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PKILVSAGEASGDLYASLVVQELRRIMPDAEFFGCTGPRLRAAGVRTIVDSADLAVVGL
CCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHCCCCHHHHHH
IEVVAHIPRIYGEFRKLLRAAREERPLLAILTDSPDFHLRVARKLHRQEVPVVYLVAPQA
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCH
WAWRRGRVREMRRTIRRLLCIFPFEEEFFRRYGVPATYIGHPLAGLVHPALSREEFFKKH
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHCCCHHHHHHHHCCHHHHHHHH
RLAAERPLVSVLPGSRRGEAARHIPALLDAVDRIYREQAVNVVLPASATTGVAFFQERMG
HHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHC
NSPIRVIEGESWDAMAHSDLALAASGTVTVEAALLGTPMVTFYKVTGVSWLAGKFLVDIP
CCCEEEEECCCCCCHHCCCEEEEECCCEEEEHHHHCCCHHHHHHHHCHHHHHHHHHEECC
FYSMVNLIAGRAVVPELMQSQMTGENLAREALRLLQGGRDREEMKAGLAQVKEKLAGRTG
HHHHHHHHHCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
APGRAALAIQEILEGQVTHVS
CCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA