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The map label for this gene is ykcC [H]

Identifier: 116619788

GI number: 116619788

Start: 821935

End: 823890

Strand: Direct

Name: ykcC [H]

Synonym: Acid_0658

Alternate gene names: 116619788

Gene position: 821935-823890 (Clockwise)

Preceding gene: 116619787

Following gene: 116619789

Centisome position: 8.25

GC content: 55.06

Gene sequence:

>1956_bases
TTGCGAAAGATTGCTAGTTTACGCGGGCCGATCCTGGTGCTCGGAGCGAGCGGTTTTGTAGGCGCCAACCTGCTCAGAAT
GCTCCTGGAGGAGCGCTCCGACGTATATGGGACGGCCTTTGCCTTGCCAGCTTGGCGGCTTGAGGGAATCCCAAAGAAGA
ACCTCCTCAGCGTAGATTTGCTGGTTCCGCAGAGCGCCGACGCGCTGGTGAGGGAACTGGCGCCGGCTACGGTCTTCGAC
TTCGTTGCCTTTGGAGCCTACTCCTTCGAACGGGACGTGGCTAGAATTTATGAAACGAACGTGACCTTTAAGGTACGGCT
GCTGGAGTTACTGCGCGAAACCAAGGTCCACTGCTACATCCACGCCGGCAGTTCTTCGGAATATGGGAATCGGGCAGACC
GTCCAACGGAAGATACGGCTTTATTACCGAATAGCCACTACTCCGTCACCAAGTCGACAACCTCTGGTCTGATTTACTAC
GCGGGACAGAGTCTCGGTGTCCGCTGTGCGAATCTGCGCCTGTACTCCGTATACGGGCCAATGGAAGAACGTTCGCGGCT
CGTTCCTTCACTTATCGTAAAGGGCCTAAACGGAGAATATCCGCCCTTGGTGGATCCCGCCGTTTCTCGCGATTTTATCT
ACATAGACGACGCGTGTGAGGCCTTCGTCGATTGTGCGCTGAACCTGACTCCGACTTGGTACGGCGAGTCTTTCAATATC
GGAACCGGCACATCTACAACAATCGGTGAACTTGCGGAGATCGCGCGGGACTTGCTACACATCGATATCTCGCCGCCGTT
CTCGACCATGCCGAAGCGGCTGTGGGACACGACCAGCGTCTGGTGCGCCGACGCGTCTCGCGCGACTCAGCACCTGGGCT
GGAGCCCTCGCACCACCATCCGGGAAGGACTTCAACGCACGATCGAATGGTATCGGTCGCTGCCCGACAAGTCGATTTAT
GAAAGGCATGCCAAGGGCTACCAAGGCAATCCGGACGAAAGCGTTTCGGCGGTTGTTGCGTGCTACAAGGACGGCCAGGC
CATTCCGATCATGTACCAACGTCTGGTTCAAGTATTCGAGAAGCTGCACATCGATTATGAGATCATCTTCGTAAACGACG
GTAGCCCCGACAATAGTCAGGAGATCATTCAGCAGATCAGCAACCGAAACCATCGCGTTCTCGGGATCACCCACAGCCGC
AACTTCGGATCGCAATCCGCCTTCCGAAGTGGAATGGAGCTGTCCAGCAAAAGGTCGTGTGTGTTACTCGATGGAGATCT
TCAGGACCCTCCTGAGTTGATCGAGCAGTTCGTCGAAAAATGGCGGGAGGGCTACGACGTGGTTTACGGAACGCGGGTGA
AGCGCGATGCGCCTCCCCTGATGCGTACCGCTTACAGAGCCTTCTATCTATTGTTTAACAGGATGTCCTATGTTTACATG
CCTCGCGACGCCGGAGATTTTTCTCTCGTTGACAGACGCGTGGTCCGTTGGTTGCTGGAATGCAAAGAACGGGACTTGTT
CCTGCGAGGTTTGCGAGCGTTTGTCGGCTTTCGGCAGACCGGCGTCGATTACCTCAGGCCGGAACGCATGTTTGGACACA
GCACCAACAACCTCCTGAAGAATTTGGGCTGGGCAAAGAAGGGCATCCTTTCGTTTAGCAACGTCCCATTAAGCATGCTC
ACCTCTGCCGGGACCCTGCTGTTCGCAGCCGGGCTGTTATTGGGATTCCTGCAGGCTCTCGCTAGAGTCCTGTTCCCGAA
CTCAGCACCTCGAGGTATCACGACCATCGTGATTTTGATTCTAATAATGGGTGCATTGAATCTGCTGGCAATCAGCGTGG
TTGGCGAATACATTGCCAAGATTTTCGAGGAGGTGAAGCGCCGCCCCCACTTTATCCGAATGAACATCATCCAGAACGGC
GAAATTCGTCGGACTGAGATTCAAAAGGGGGAATAG

Upstream 100 bases:

>100_bases
GAGTTCCACCGGGCGGAGAGCGGAATCAGCGCCCCGAAGATTCGGCAAGCGATTTTGGAGTCCAGCGTCTTCCGGGGGGC
GGGCGTTGCACCCTGAACTC

Downstream 100 bases:

>100_bases
CCGTCCAGTGAATATTTCGCCGCACTTGAGAGAACGCAACTGCCCCCTTTGCGGCTCGGCGGACCGAACCGCTGTCCGGT
ACTCGGCGAATTTCGATGAA

Product: NAD-dependent epimerase/dehydratase

Products: GDP; dolichyl D-mannosyl phosphate

Alternate protein names: NA

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MRKIASLRGPILVLGASGFVGANLLRMLLEERSDVYGTAFALPAWRLEGIPKKNLLSVDLLVPQSADALVRELAPATVFD
FVAFGAYSFERDVARIYETNVTFKVRLLELLRETKVHCYIHAGSSSEYGNRADRPTEDTALLPNSHYSVTKSTTSGLIYY
AGQSLGVRCANLRLYSVYGPMEERSRLVPSLIVKGLNGEYPPLVDPAVSRDFIYIDDACEAFVDCALNLTPTWYGESFNI
GTGTSTTIGELAEIARDLLHIDISPPFSTMPKRLWDTTSVWCADASRATQHLGWSPRTTIREGLQRTIEWYRSLPDKSIY
ERHAKGYQGNPDESVSAVVACYKDGQAIPIMYQRLVQVFEKLHIDYEIIFVNDGSPDNSQEIIQQISNRNHRVLGITHSR
NFGSQSAFRSGMELSSKRSCVLLDGDLQDPPELIEQFVEKWREGYDVVYGTRVKRDAPPLMRTAYRAFYLLFNRMSYVYM
PRDAGDFSLVDRRVVRWLLECKERDLFLRGLRAFVGFRQTGVDYLRPERMFGHSTNNLLKNLGWAKKGILSFSNVPLSML
TSAGTLLFAAGLLLGFLQALARVLFPNSAPRGITTIVILILIMGALNLLAISVVGEYIAKIFEEVKRRPHFIRMNIIQNG
EIRRTEIQKGE

Sequences:

>Translated_651_residues
MRKIASLRGPILVLGASGFVGANLLRMLLEERSDVYGTAFALPAWRLEGIPKKNLLSVDLLVPQSADALVRELAPATVFD
FVAFGAYSFERDVARIYETNVTFKVRLLELLRETKVHCYIHAGSSSEYGNRADRPTEDTALLPNSHYSVTKSTTSGLIYY
AGQSLGVRCANLRLYSVYGPMEERSRLVPSLIVKGLNGEYPPLVDPAVSRDFIYIDDACEAFVDCALNLTPTWYGESFNI
GTGTSTTIGELAEIARDLLHIDISPPFSTMPKRLWDTTSVWCADASRATQHLGWSPRTTIREGLQRTIEWYRSLPDKSIY
ERHAKGYQGNPDESVSAVVACYKDGQAIPIMYQRLVQVFEKLHIDYEIIFVNDGSPDNSQEIIQQISNRNHRVLGITHSR
NFGSQSAFRSGMELSSKRSCVLLDGDLQDPPELIEQFVEKWREGYDVVYGTRVKRDAPPLMRTAYRAFYLLFNRMSYVYM
PRDAGDFSLVDRRVVRWLLECKERDLFLRGLRAFVGFRQTGVDYLRPERMFGHSTNNLLKNLGWAKKGILSFSNVPLSML
TSAGTLLFAAGLLLGFLQALARVLFPNSAPRGITTIVILILIMGALNLLAISVVGEYIAKIFEEVKRRPHFIRMNIIQNG
EIRRTEIQKGE
>Mature_651_residues
MRKIASLRGPILVLGASGFVGANLLRMLLEERSDVYGTAFALPAWRLEGIPKKNLLSVDLLVPQSADALVRELAPATVFD
FVAFGAYSFERDVARIYETNVTFKVRLLELLRETKVHCYIHAGSSSEYGNRADRPTEDTALLPNSHYSVTKSTTSGLIYY
AGQSLGVRCANLRLYSVYGPMEERSRLVPSLIVKGLNGEYPPLVDPAVSRDFIYIDDACEAFVDCALNLTPTWYGESFNI
GTGTSTTIGELAEIARDLLHIDISPPFSTMPKRLWDTTSVWCADASRATQHLGWSPRTTIREGLQRTIEWYRSLPDKSIY
ERHAKGYQGNPDESVSAVVACYKDGQAIPIMYQRLVQVFEKLHIDYEIIFVNDGSPDNSQEIIQQISNRNHRVLGITHSR
NFGSQSAFRSGMELSSKRSCVLLDGDLQDPPELIEQFVEKWREGYDVVYGTRVKRDAPPLMRTAYRAFYLLFNRMSYVYM
PRDAGDFSLVDRRVVRWLLECKERDLFLRGLRAFVGFRQTGVDYLRPERMFGHSTNNLLKNLGWAKKGILSFSNVPLSML
TSAGTLLFAAGLLLGFLQALARVLFPNSAPRGITTIVILILIMGALNLLAISVVGEYIAKIFEEVKRRPHFIRMNIIQNG
EIRRTEIQKGE

Specific function: Involved In O Antigen Modification. Catalyzes The Transfer Of The Glucose Residue From Udp-Glucose To A Lipid Carrier (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 2 family. GtrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503363, Length=122, Percent_Identity=31.1475409836066, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1788692, Length=300, Percent_Identity=34, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI1788588, Length=318, Percent_Identity=27.3584905660377, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1788353, Length=343, Percent_Identity=25.3644314868805, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17568069, Length=335, Percent_Identity=24.4776119402985, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17539532, Length=331, Percent_Identity=23.2628398791541, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21356223, Length=324, Percent_Identity=25, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: 2.4.1.83

Molecular weight: Translated: 73375; Mature: 73375

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIASLRGPILVLGASGFVGANLLRMLLEERSDVYGTAFALPAWRLEGIPKKNLLSVDL
CCCCHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHCCCHHHHCCCCCCCCEEEEE
LVPQSADALVRELAPATVFDFVAFGAYSFERDVARIYETNVTFKVRLLELLRETKVHCYI
ECCCCHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEHHHHHHHHHCCCEEEEE
HAGSSSEYGNRADRPTEDTALLPNSHYSVTKSTTSGLIYYAGQSLGVRCANLRLYSVYGP
ECCCCCCCCCCCCCCCCCCEECCCCCCEEECCCCCCEEEEECCCCCEEEEEEEEEEECCC
MEERSRLVPSLIVKGLNGEYPPLVDPAVSRDFIYIDDACEAFVDCALNLTPTWYGESFNI
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCEECC
GTGTSTTIGELAEIARDLLHIDISPPFSTMPKRLWDTTSVWCADASRATQHLGWSPRTTI
CCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCEEECCHHHHHHHCCCCCCHHH
REGLQRTIEWYRSLPDKSIYERHAKGYQGNPDESVSAVVACYKDGQAIPIMYQRLVQVFE
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
KLHIDYEIIFVNDGSPDNSQEIIQQISNRNHRVLGITHSRNFGSQSAFRSGMELSSKRSC
HHCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCCE
VLLDGDLQDPPELIEQFVEKWREGYDVVYGTRVKRDAPPLMRTAYRAFYLLFNRMSYVYM
EEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEE
PRDAGDFSLVDRRVVRWLLECKERDLFLRGLRAFVGFRQTGVDYLRPERMFGHSTNNLLK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCCHHHHHH
NLGWAKKGILSFSNVPLSMLTSAGTLLFAAGLLLGFLQALARVLFPNSAPRGITTIVILI
HCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LIMGALNLLAISVVGEYIAKIFEEVKRRPHFIRMNIIQNGEIRRTEIQKGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCCC
>Mature Secondary Structure
MRKIASLRGPILVLGASGFVGANLLRMLLEERSDVYGTAFALPAWRLEGIPKKNLLSVDL
CCCCHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHCCCHHHHCCCCCCCCEEEEE
LVPQSADALVRELAPATVFDFVAFGAYSFERDVARIYETNVTFKVRLLELLRETKVHCYI
ECCCCHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEHHHHHHHHHCCCEEEEE
HAGSSSEYGNRADRPTEDTALLPNSHYSVTKSTTSGLIYYAGQSLGVRCANLRLYSVYGP
ECCCCCCCCCCCCCCCCCCEECCCCCCEEECCCCCCEEEEECCCCCEEEEEEEEEEECCC
MEERSRLVPSLIVKGLNGEYPPLVDPAVSRDFIYIDDACEAFVDCALNLTPTWYGESFNI
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCEECC
GTGTSTTIGELAEIARDLLHIDISPPFSTMPKRLWDTTSVWCADASRATQHLGWSPRTTI
CCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHCCCCEEECCHHHHHHHCCCCCCHHH
REGLQRTIEWYRSLPDKSIYERHAKGYQGNPDESVSAVVACYKDGQAIPIMYQRLVQVFE
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHH
KLHIDYEIIFVNDGSPDNSQEIIQQISNRNHRVLGITHSRNFGSQSAFRSGMELSSKRSC
HHCCCEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCCCCCCCE
VLLDGDLQDPPELIEQFVEKWREGYDVVYGTRVKRDAPPLMRTAYRAFYLLFNRMSYVYM
EEEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEE
PRDAGDFSLVDRRVVRWLLECKERDLFLRGLRAFVGFRQTGVDYLRPERMFGHSTNNLLK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCCHHHHHH
NLGWAKKGILSFSNVPLSMLTSAGTLLFAAGLLLGFLQALARVLFPNSAPRGITTIVILI
HCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LIMGALNLLAISVVGEYIAKIFEEVKRRPHFIRMNIIQNGEIRRTEIQKGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDPmannose; dolichyl phosphate

Specific reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]