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The map label for this gene is ctaD [H]

Identifier: 116619637

GI number: 116619637

Start: 609318

End: 610943

Strand: Direct

Name: ctaD [H]

Synonym: Acid_0498

Alternate gene names: 116619637

Gene position: 609318-610943 (Clockwise)

Preceding gene: 116619636

Following gene: 116619638

Centisome position: 6.11

GC content: 59.72

Gene sequence:

>1626_bases
ATGATTACCGAAGCCGCTGTAGAACGCGAGCATTACCTGAACGCCAGTTACGGCCTGAAGTCCTGGCTGCTGACCAAGGA
CCACAAGCGCATCGGCCTGCTTTACCTCGCCACCATCACGCTTTTCTTCTTCATCGGAGGCGCCTTCGCCACCCTGATCC
GCATCGAACTCCTCACGCCGCAGGGCGATCTGGTGAGCTCGGAGACGTACAACAAACTTTTCACCATGCACGCGGTGGCG
ATGATCTTCTTCTTCCTCATCCCATCCATTCCAGCCGTGCTGGGCAATTTCTTCTTGCCCATCATGATCGGCGCCCGCGA
CTTGGCCTTTCCCAGGATTAACCTGCTGAGCTGGTACCTGCTGGTGTTCGGCGGGGCCTTCAGCCTCTTCGCCATGATTG
CCGGCGGCGTCGATACCGGCTGGACGTTTTACACGCCGTACAGTACGTCGTACTCCAATACCTGGGTGATCGCGACCGCG
CTCGGCATTTTCATTGCGGGCTTCTCGTCGATTCTCACCGGACTTAATTTCATTGTCACCGTACACCGCATGCGCGCCCC
CGGGATGACCTGGTTCCGCATGCCGCTGTTCGTGTGGGCCAACTACGCCACCAGCCTGATCCAGGTGCTCGGCACCCCGG
TGCTGGCCGTCACCATCGTGCTGCTCTTCGTGGAGCGCGTCTTCCATCTCGGCATCTTCGACCCGGCGCGCGGCGGCGAT
CCCGTTCTGTTCCAGCACCTCTTCTGGTTCTATTCGCATCCCGCCGTGTACATTATGATTCTGCCCTCGATGGGCGTGAT
CAGCGAACTCATCAGCACCTTCTCCCGCAAAGCGCCCTTCGGCTATGGGTTCATCGCTTTCTCCAGCGTCGCGATCGCCG
TACTCGGCTTTCTGGTCTGGGGCCACCATCTCTTCGTCAGCGGCATGTCGCTCTATGCCGGCATGGTGTTCAGCTTCCTC
AGCTACTTCGTGGCAATCCCCTCCGCGATCAAAGTCTTCAACTGGACCGCGACCCTGTATCGAGGTTCGATATCCTTCCA
GACGCCGATGCTCTACGCGTTCGGCTTCATCGGCCTCTTCACCGTCGGCGGCCTCACCGGCCTGTTCCTGGCCGCGCTCG
GCATGGACATCCACGTCACCGACACCTACTTCGTGATCGCGCACTTTCACTACATCATGGTGGGCGGCGCCCTTATGGGT
TATCTCGGCGGCATGCACTTCTGGTGGCCCAAGATGACCGGGCGCATGTATCCCGAGGGATGGGCCAAGCTTTCCGCGCT
GATCATTTTCCTCGGCTTCAACCTGACCTTCTTCCCGCAGTTCATCCTAGGCTACCTCGGGATGCCGCGCCGCTACCATG
CGTACCCGGAAGAGTTCCAGGTGCTTAACGTGCTCTCTACCGCGGGCGCCAGCGTGCTGGCTGTCGGCTACCTGATTCCC
ATGATCTATTTCATCTGGTCGCTGCGTTACGGCCAGATGGCGCCCGCCAACCCGTGGGGCGCTACCGGATTGGAGTGGAA
GACTTCTTCGCCGCCGCCGGTTCACAATTTTGACGAGACCCCAATCGTGACCCACGACGCGTACGATTACACCACCGTCA
TGGGAGAGGAGATCGAAGTTGGCTGA

Upstream 100 bases:

>100_bases
GTGAAATCCATCGGTCCCAAACCGGCCGCAGGTCCGGTGAATAGCGGGACCACTCCAGCCGCGGGGACTGTGACCACTCC
GGCAAAACGTTGAGAACCAT

Downstream 100 bases:

>100_bases
TCACGGCACAGAGACGCTCGCGCTGCGAGTGCAGTTCGATTCCGCCGAGCAGCAGAAGGACGCATCCCAGCTTGGGATGT
GGATCTTCCTGATCACGGAA

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MITEAAVEREHYLNASYGLKSWLLTKDHKRIGLLYLATITLFFFIGGAFATLIRIELLTPQGDLVSSETYNKLFTMHAVA
MIFFFLIPSIPAVLGNFFLPIMIGARDLAFPRINLLSWYLLVFGGAFSLFAMIAGGVDTGWTFYTPYSTSYSNTWVIATA
LGIFIAGFSSILTGLNFIVTVHRMRAPGMTWFRMPLFVWANYATSLIQVLGTPVLAVTIVLLFVERVFHLGIFDPARGGD
PVLFQHLFWFYSHPAVYIMILPSMGVISELISTFSRKAPFGYGFIAFSSVAIAVLGFLVWGHHLFVSGMSLYAGMVFSFL
SYFVAIPSAIKVFNWTATLYRGSISFQTPMLYAFGFIGLFTVGGLTGLFLAALGMDIHVTDTYFVIAHFHYIMVGGALMG
YLGGMHFWWPKMTGRMYPEGWAKLSALIIFLGFNLTFFPQFILGYLGMPRRYHAYPEEFQVLNVLSTAGASVLAVGYLIP
MIYFIWSLRYGQMAPANPWGATGLEWKTSSPPPVHNFDETPIVTHDAYDYTTVMGEEIEVG

Sequences:

>Translated_541_residues
MITEAAVEREHYLNASYGLKSWLLTKDHKRIGLLYLATITLFFFIGGAFATLIRIELLTPQGDLVSSETYNKLFTMHAVA
MIFFFLIPSIPAVLGNFFLPIMIGARDLAFPRINLLSWYLLVFGGAFSLFAMIAGGVDTGWTFYTPYSTSYSNTWVIATA
LGIFIAGFSSILTGLNFIVTVHRMRAPGMTWFRMPLFVWANYATSLIQVLGTPVLAVTIVLLFVERVFHLGIFDPARGGD
PVLFQHLFWFYSHPAVYIMILPSMGVISELISTFSRKAPFGYGFIAFSSVAIAVLGFLVWGHHLFVSGMSLYAGMVFSFL
SYFVAIPSAIKVFNWTATLYRGSISFQTPMLYAFGFIGLFTVGGLTGLFLAALGMDIHVTDTYFVIAHFHYIMVGGALMG
YLGGMHFWWPKMTGRMYPEGWAKLSALIIFLGFNLTFFPQFILGYLGMPRRYHAYPEEFQVLNVLSTAGASVLAVGYLIP
MIYFIWSLRYGQMAPANPWGATGLEWKTSSPPPVHNFDETPIVTHDAYDYTTVMGEEIEVG
>Mature_541_residues
MITEAAVEREHYLNASYGLKSWLLTKDHKRIGLLYLATITLFFFIGGAFATLIRIELLTPQGDLVSSETYNKLFTMHAVA
MIFFFLIPSIPAVLGNFFLPIMIGARDLAFPRINLLSWYLLVFGGAFSLFAMIAGGVDTGWTFYTPYSTSYSNTWVIATA
LGIFIAGFSSILTGLNFIVTVHRMRAPGMTWFRMPLFVWANYATSLIQVLGTPVLAVTIVLLFVERVFHLGIFDPARGGD
PVLFQHLFWFYSHPAVYIMILPSMGVISELISTFSRKAPFGYGFIAFSSVAIAVLGFLVWGHHLFVSGMSLYAGMVFSFL
SYFVAIPSAIKVFNWTATLYRGSISFQTPMLYAFGFIGLFTVGGLTGLFLAALGMDIHVTDTYFVIAHFHYIMVGGALMG
YLGGMHFWWPKMTGRMYPEGWAKLSALIIFLGFNLTFFPQFILGYLGMPRRYHAYPEEFQVLNVLSTAGASVLAVGYLIP
MIYFIWSLRYGQMAPANPWGATGLEWKTSSPPPVHNFDETPIVTHDAYDYTTVMGEEIEVG

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=506, Percent_Identity=42.4901185770751, Blast_Score=374, Evalue=1e-103,
Organism=Escherichia coli, GI1786634, Length=536, Percent_Identity=37.6865671641791, Blast_Score=346, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6226519, Length=526, Percent_Identity=37.4524714828897, Blast_Score=342, Evalue=7e-95,
Organism=Saccharomyces cerevisiae, GI6226524, Length=322, Percent_Identity=38.1987577639752, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6226523, Length=247, Percent_Identity=34.0080971659919, Blast_Score=133, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 60416; Mature: 60416

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITEAAVEREHYLNASYGLKSWLLTKDHKRIGLLYLATITLFFFIGGAFATLIRIELLTP
CCCHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
QGDLVSSETYNKLFTMHAVAMIFFFLIPSIPAVLGNFFLPIMIGARDLAFPRINLLSWYL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHH
LVFGGAFSLFAMIAGGVDTGWTFYTPYSTSYSNTWVIATALGIFIAGFSSILTGLNFIVT
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VHRMRAPGMTWFRMPLFVWANYATSLIQVLGTPVLAVTIVLLFVERVFHLGIFDPARGGD
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PVLFQHLFWFYSHPAVYIMILPSMGVISELISTFSRKAPFGYGFIAFSSVAIAVLGFLVW
HHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GHHLFVSGMSLYAGMVFSFLSYFVAIPSAIKVFNWTATLYRGSISFQTPMLYAFGFIGLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHEECCCCCCCHHHHHHHHHHHH
TVGGLTGLFLAALGMDIHVTDTYFVIAHFHYIMVGGALMGYLGGMHFWWPKMTGRMYPEG
HHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHCCCCCCHH
WAKLSALIIFLGFNLTFFPQFILGYLGMPRRYHAYPEEFQVLNVLSTAGASVLAVGYLIP
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHH
MIYFIWSLRYGQMAPANPWGATGLEWKTSSPPPVHNFDETPIVTHDAYDYTTVMGEEIEV
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCC
G
C
>Mature Secondary Structure
MITEAAVEREHYLNASYGLKSWLLTKDHKRIGLLYLATITLFFFIGGAFATLIRIELLTP
CCCHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
QGDLVSSETYNKLFTMHAVAMIFFFLIPSIPAVLGNFFLPIMIGARDLAFPRINLLSWYL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHH
LVFGGAFSLFAMIAGGVDTGWTFYTPYSTSYSNTWVIATALGIFIAGFSSILTGLNFIVT
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VHRMRAPGMTWFRMPLFVWANYATSLIQVLGTPVLAVTIVLLFVERVFHLGIFDPARGGD
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PVLFQHLFWFYSHPAVYIMILPSMGVISELISTFSRKAPFGYGFIAFSSVAIAVLGFLVW
HHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GHHLFVSGMSLYAGMVFSFLSYFVAIPSAIKVFNWTATLYRGSISFQTPMLYAFGFIGLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHEECCCCCCCHHHHHHHHHHHH
TVGGLTGLFLAALGMDIHVTDTYFVIAHFHYIMVGGALMGYLGGMHFWWPKMTGRMYPEG
HHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHCCCCCCHH
WAKLSALIIFLGFNLTFFPQFILGYLGMPRRYHAYPEEFQVLNVLSTAGASVLAVGYLIP
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCCHHHHHHHHHHH
MIYFIWSLRYGQMAPANPWGATGLEWKTSSPPPVHNFDETPIVTHDAYDYTTVMGEEIEV
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8387368; 8905231 [H]