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The map label for this gene is strD [H]

Identifier: 116619558

GI number: 116619558

Start: 521320

End: 522012

Strand: Direct

Name: strD [H]

Synonym: Acid_0419

Alternate gene names: 116619558

Gene position: 521320-522012 (Clockwise)

Preceding gene: 116619557

Following gene: 116619559

Centisome position: 5.23

GC content: 64.94

Gene sequence:

>693_bases
ATGCTGCCGATCGCCATTCTCGCCGGCGGCCTGGCCACGCGCCTGCGTCCCATCACGGAGACGGTTCCGAAGGCGCTGAT
CGAAATCGCGGGCGAGCCGTTTCTGGCGCATCAGTTGCGCCTTCTGAAGCGCCACGGCTTTGAACGTGTGGTGCTGTGCG
TAGCGTACCTCAGCGATCAGATCCGCGATTTCGCGGGCGACGGCAGCCGCTTCGGCCTCGAGATCGACTATTCGCCCGAC
GGCCCGCAGTTGCTCGGCACCGCGGGCGCCCTTCGCCGCGCCCTGCCGCTGCTGGGCGATGCCTTTGCGGTGATCTACGG
TGATTCCTACCTGCCTTGCGATTACGCGGCCGCCCTGGCCGCCTTCTCCGAATCCGGCAAACTCGGCCTGATGACCATCT
ACCGCAATCGCGGCCTTTGGGACAGCAGCAACGTGGAGTTTACCGGAGGCCGCATCGTGGCCTACGATAAGGCGAACCGT
ACGTCTTCCATGCATCACATCGATTACGGCCTTGGCGCTTTCCATCGCACCGCGTTCGACGCCGTTCCCCCGGACCGGCC
CTACGATCTCGCCGCGGTTTATCAGGACCTGCTGCGGCGCGGCGAACTGGCTGCGTGGGAATCGCCCGACCGGTTCTACG
AGATCGGGTCGCTGGAAGGCATTCGCGACCTGACGGAGTTCCTTGCCCCATGA

Upstream 100 bases:

>100_bases
ACAAAACCCGGCTGCGCCACGCCCTCCGCGAAGCCGGATTACGCGAAGTGCGGGTGCGCTTCGATTTCGAAGGCACCACG
CTGATGGCCCGCTCCTAGCC

Downstream 100 bases:

>100_bases
CATTCACCGAGCAGTTCCTCGCCGAAGCCACGGAAATCATCAAGCAGATCGACGTCGCCGCTGTGGAGCGGGTCGCCGCG
ACTCTGGCCGCCTCTCGCGA

Product: nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MLPIAILAGGLATRLRPITETVPKALIEIAGEPFLAHQLRLLKRHGFERVVLCVAYLSDQIRDFAGDGSRFGLEIDYSPD
GPQLLGTAGALRRALPLLGDAFAVIYGDSYLPCDYAAALAAFSESGKLGLMTIYRNRGLWDSSNVEFTGGRIVAYDKANR
TSSMHHIDYGLGAFHRTAFDAVPPDRPYDLAAVYQDLLRRGELAAWESPDRFYEIGSLEGIRDLTEFLAP

Sequences:

>Translated_230_residues
MLPIAILAGGLATRLRPITETVPKALIEIAGEPFLAHQLRLLKRHGFERVVLCVAYLSDQIRDFAGDGSRFGLEIDYSPD
GPQLLGTAGALRRALPLLGDAFAVIYGDSYLPCDYAAALAAFSESGKLGLMTIYRNRGLWDSSNVEFTGGRIVAYDKANR
TSSMHHIDYGLGAFHRTAFDAVPPDRPYDLAAVYQDLLRRGELAAWESPDRFYEIGSLEGIRDLTEFLAP
>Mature_230_residues
MLPIAILAGGLATRLRPITETVPKALIEIAGEPFLAHQLRLLKRHGFERVVLCVAYLSDQIRDFAGDGSRFGLEIDYSPD
GPQLLGTAGALRRALPLLGDAFAVIYGDSYLPCDYAAALAAFSESGKLGLMTIYRNRGLWDSSNVEFTGGRIVAYDKANR
TSSMHHIDYGLGAFHRTAFDAVPPDRPYDLAAVYQDLLRRGELAAWESPDRFYEIGSLEGIRDLTEFLAP

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=218, Percent_Identity=27.0642201834862, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI11761619, Length=218, Percent_Identity=27.0642201834862, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=217, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=114, Percent_Identity=35.9649122807018, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21355443, Length=219, Percent_Identity=27.8538812785388, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644084, Length=219, Percent_Identity=27.8538812785388, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 25265; Mature: 25265

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPIAILAGGLATRLRPITETVPKALIEIAGEPFLAHQLRLLKRHGFERVVLCVAYLSDQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
IRDFAGDGSRFGLEIDYSPDGPQLLGTAGALRRALPLLGDAFAVIYGDSYLPCDYAAALA
HHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHH
AFSESGKLGLMTIYRNRGLWDSSNVEFTGGRIVAYDKANRTSSMHHIDYGLGAFHRTAFD
HHHCCCCEEEEEEEECCCCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
AVPPDRPYDLAAVYQDLLRRGELAAWESPDRFYEIGSLEGIRDLTEFLAP
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHEECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MLPIAILAGGLATRLRPITETVPKALIEIAGEPFLAHQLRLLKRHGFERVVLCVAYLSDQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHH
IRDFAGDGSRFGLEIDYSPDGPQLLGTAGALRRALPLLGDAFAVIYGDSYLPCDYAAALA
HHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHH
AFSESGKLGLMTIYRNRGLWDSSNVEFTGGRIVAYDKANRTSSMHHIDYGLGAFHRTAFD
HHHCCCCEEEEEEEECCCCCCCCCEEEECCEEEEEECCCCCCCHHHHHHHHHHHHHHHHC
AVPPDRPYDLAAVYQDLLRRGELAAWESPDRFYEIGSLEGIRDLTEFLAP
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]