Click here to switch to the map view.

The map label for this gene is bfmBAB [H]

Identifier: 116619494

GI number: 116619494

Start: 452098

End: 453069

Strand: Direct

Name: bfmBAB [H]

Synonym: Acid_0353

Alternate gene names: 116619494

Gene position: 452098-453069 (Clockwise)

Preceding gene: 116619493

Following gene: 116619495

Centisome position: 4.54

GC content: 62.14

Gene sequence:

>972_bases
ATGTCCACCACGTACCTCGAAGCAATCCGCGAAGGCCTCTGGGAAGAGATGGAGCGCGATCCCAACGTCTTCTGCATCGG
TGAGGACATCGGCGAATACGGCGGCGCCTTTAAAGTCACCGCCGGTTTCCTGGAGCACTTCGGCGCCAGGCGCATCGTCG
ATACTCCCATCTCCGAGGCCGCCATCGCCGGCGCGTCCATCGGCGCCGGACTCATGGGCCTCCGCCCCGTCGCTGAAATG
CAGTTCGCCGATTTCATCTCCTGCGGCTTCGATCAAATCGTCAACTTCGCCGCCAAGTGCCGCTATCGCTGGAATGCCTC
CGTTCCCATGGTCGTGCGTTCGCCTTCCGGCGGTGGCATTCACGGCGGACCCTTCCACTCCCAGAATCCCGAAATGTGGT
TCGTCCGCACCCCCGGTCTTAAGGTCGTCTGCCCCGCCACCGCCTACGATGCCAAGGGCCTGATCAAATCCGCCATCCGC
GATAACGACCCCGTCCTTTTCTTCGAGCACAAGGCCCTCTACCGCCGCATCAAGGAAGATCTGCCCGCCGGAGACTTCAC
CGTCCCCATCGGTAAGGCCCGAGTCATCCGCGAAGGCCGCGATCTCAGCATCATCACCTACGGCGCCATGGTCTGGACCG
CCTTGGAAGCCGCCGACAAACTCGCGCCCGAAGGCATCAGCGTCGAGGTCGTTGACCTCCGCACCCTCGTCCCCCTCGAT
CGCGATACCGTCTGCGAAAGCGTTCGCAAAACCTCCAAGGTTCTGCTCCTCCATGAGGACACCCGCACCGGCGGCATGGC
CGGCGAACTCGCCGCCACCATCACCGAAAATGTCTTCGAGTATCTCGATGGCCCCATCGTGCGCGTCACTGCTCCCGATA
CTCCGGTCCCTTACAGTCCCCCGTTGGAAGAGGCATTCCTGCCCAATGCGGATAAGGTCGTCGAAAAGGCTCGCTGGCTG
TATCGCTATTGA

Upstream 100 bases:

>100_bases
CGTCATCCGCGAAGTGGATGACGCTGTCGCCTGGGCCGAGCAGAGTCCCTACCCCGACGCCGCCAGCCTGCTTGACGACG
TTTACGAGAACCAATAGCCC

Downstream 100 bases:

>100_bases
GCTCGCGCTGCTCGCCGCGGTCGCCCGGCCGGCCGATTTTCGCGCCGGCGCGGCCACCGCTGCCACCACCCGCGCGCTCG
TGCTCGAAGATGCGCGCGGC

Product: branched-chain alpha-keto acid dehydrogenase E1 component

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSTTYLEAIREGLWEEMERDPNVFCIGEDIGEYGGAFKVTAGFLEHFGARRIVDTPISEAAIAGASIGAGLMGLRPVAEM
QFADFISCGFDQIVNFAAKCRYRWNASVPMVVRSPSGGGIHGGPFHSQNPEMWFVRTPGLKVVCPATAYDAKGLIKSAIR
DNDPVLFFEHKALYRRIKEDLPAGDFTVPIGKARVIREGRDLSIITYGAMVWTALEAADKLAPEGISVEVVDLRTLVPLD
RDTVCESVRKTSKVLLLHEDTRTGGMAGELAATITENVFEYLDGPIVRVTAPDTPVPYSPPLEEAFLPNADKVVEKARWL
YRY

Sequences:

>Translated_323_residues
MSTTYLEAIREGLWEEMERDPNVFCIGEDIGEYGGAFKVTAGFLEHFGARRIVDTPISEAAIAGASIGAGLMGLRPVAEM
QFADFISCGFDQIVNFAAKCRYRWNASVPMVVRSPSGGGIHGGPFHSQNPEMWFVRTPGLKVVCPATAYDAKGLIKSAIR
DNDPVLFFEHKALYRRIKEDLPAGDFTVPIGKARVIREGRDLSIITYGAMVWTALEAADKLAPEGISVEVVDLRTLVPLD
RDTVCESVRKTSKVLLLHEDTRTGGMAGELAATITENVFEYLDGPIVRVTAPDTPVPYSPPLEEAFLPNADKVVEKARWL
YRY
>Mature_322_residues
STTYLEAIREGLWEEMERDPNVFCIGEDIGEYGGAFKVTAGFLEHFGARRIVDTPISEAAIAGASIGAGLMGLRPVAEMQ
FADFISCGFDQIVNFAAKCRYRWNASVPMVVRSPSGGGIHGGPFHSQNPEMWFVRTPGLKVVCPATAYDAKGLIKSAIRD
NDPVLFFEHKALYRRIKEDLPAGDFTVPIGKARVIREGRDLSIITYGAMVWTALEAADKLAPEGISVEVVDLRTLVPLDR
DTVCESVRKTSKVLLLHEDTRTGGMAGELAATITENVFEYLDGPIVRVTAPDTPVPYSPPLEEAFLPNADKVVEKARWLY
RY

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=324, Percent_Identity=40.4320987654321, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI34101272, Length=324, Percent_Identity=40.4320987654321, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI156564403, Length=320, Percent_Identity=40.3125, Blast_Score=243, Evalue=1e-64,
Organism=Homo sapiens, GI291084858, Length=318, Percent_Identity=38.6792452830189, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17538422, Length=323, Percent_Identity=40.8668730650155, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17506935, Length=323, Percent_Identity=40.5572755417957, Blast_Score=226, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6319698, Length=324, Percent_Identity=40.4320987654321, Blast_Score=250, Evalue=2e-67,
Organism=Drosophila melanogaster, GI21358145, Length=318, Percent_Identity=40.251572327044, Blast_Score=238, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24650940, Length=318, Percent_Identity=40.251572327044, Blast_Score=238, Evalue=3e-63,
Organism=Drosophila melanogaster, GI160714828, Length=314, Percent_Identity=38.5350318471338, Blast_Score=227, Evalue=8e-60,
Organism=Drosophila melanogaster, GI160714832, Length=314, Percent_Identity=38.5350318471338, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24650943, Length=89, Percent_Identity=39.3258426966292, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24650945, Length=89, Percent_Identity=39.3258426966292, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 35516; Mature: 35385

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTYLEAIREGLWEEMERDPNVFCIGEDIGEYGGAFKVTAGFLEHFGARRIVDTPISEA
CCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHCCEEEHHHHHHHHCCCCCEECCCCHHH
AIAGASIGAGLMGLRPVAEMQFADFISCGFDQIVNFAAKCRYRWNASVPMVVRSPSGGGI
HHCCCHHCCCHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCEEEECCCCCEEEECCCCCCC
HGGPFHSQNPEMWFVRTPGLKVVCPATAYDAKGLIKSAIRDNDPVLFFEHKALYRRIKED
CCCCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHH
LPAGDFTVPIGKARVIREGRDLSIITYGAMVWTALEAADKLAPEGISVEVVDLRTLVPLD
CCCCCEEECCCCHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCC
RDTVCESVRKTSKVLLLHEDTRTGGMAGELAATITENVFEYLDGPIVRVTAPDTPVPYSP
HHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCC
PLEEAFLPNADKVVEKARWLYRY
CHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
STTYLEAIREGLWEEMERDPNVFCIGEDIGEYGGAFKVTAGFLEHFGARRIVDTPISEA
CHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHCCEEEHHHHHHHHCCCCCEECCCCHHH
AIAGASIGAGLMGLRPVAEMQFADFISCGFDQIVNFAAKCRYRWNASVPMVVRSPSGGGI
HHCCCHHCCCHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCEEEECCCCCEEEECCCCCCC
HGGPFHSQNPEMWFVRTPGLKVVCPATAYDAKGLIKSAIRDNDPVLFFEHKALYRRIKED
CCCCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHH
LPAGDFTVPIGKARVIREGRDLSIITYGAMVWTALEAADKLAPEGISVEVVDLRTLVPLD
CCCCCEEECCCCHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHCCCC
RDTVCESVRKTSKVLLLHEDTRTGGMAGELAATITENVFEYLDGPIVRVTAPDTPVPYSP
HHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCC
PLEEAFLPNADKVVEKARWLYRY
CHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]