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The map label for this gene is msrB [H]

Identifier: 116619312

GI number: 116619312

Start: 217455

End: 217997

Strand: Direct

Name: msrB [H]

Synonym: Acid_0169

Alternate gene names: 116619312

Gene position: 217455-217997 (Clockwise)

Preceding gene: 116619311

Following gene: 116619313

Centisome position: 2.18

GC content: 61.88

Gene sequence:

>543_bases
ATGCCGGTGGCGTTTGCCGGACTGATGGCGCTATGGTACCGGCGCGAACGTCCGCTGCCCAATCCGCGGCAACCGGGTAG
CGGGCGCCCAATCAGGGTCGTGCTGTTCCTGGATAATGGGAAGAGAGGGGAGACCATCCAAGTGAACAAGATTGCCAAGA
CCGATGCCGACTGGCAGAAGGAACTCACGCCGGAAGAGTTCGCCGTGACGCGCAAGAAGGGCACGGAGCGGGCATTTACC
GGCCGCTACTGGGACAATCACGAGCCGGGCCTCTATCGCTGCACGTGTTGCGGGACAACCCTGTTTCGCGCCAACGAAAA
GTTCGATTCCGGGACAGGGTGGCCGAGTTTCTACGCTCCGGCGGCAGAGGAGAATGTGGCTACGGAGACGGACAGCAGCC
TCTTCATGAAACGCACTGAGGTGCTGTGCAGCAAGTGCGACGCGCATCTGGGGCACGTGTTCGACGACGGACCCGCGCCC
ACCGGACTGCGCTACTGCATCAACTCGGCGGCCCTGAAGTTTACCCCGGAGAAAGAGAAGTAG

Upstream 100 bases:

>100_bases
GTGTACAAACGGTGGTGATCGGCGGTCTGGCATCGGCGGCCGCATTCGGGTTGGCAAGGTGGATCAGCTAGAAGGTACGC
CACGTCGCGCGTTCCTGATC

Downstream 100 bases:

>100_bases
GAAGCCTCCCACGCCGGGCTGTTGTACGCTAGTCTCATGTGGATGCGAGTGGCACTGCTGGGACTGCTGCCGCTGCTTTG
CGGGGCGGCGACAGCGCCCG

Product: methionine-R-sulfoxide reductase

Products: NA

Alternate protein names: Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MPVAFAGLMALWYRRERPLPNPRQPGSGRPIRVVLFLDNGKRGETIQVNKIAKTDADWQKELTPEEFAVTRKKGTERAFT
GRYWDNHEPGLYRCTCCGTTLFRANEKFDSGTGWPSFYAPAAEENVATETDSSLFMKRTEVLCSKCDAHLGHVFDDGPAP
TGLRYCINSAALKFTPEKEK

Sequences:

>Translated_180_residues
MPVAFAGLMALWYRRERPLPNPRQPGSGRPIRVVLFLDNGKRGETIQVNKIAKTDADWQKELTPEEFAVTRKKGTERAFT
GRYWDNHEPGLYRCTCCGTTLFRANEKFDSGTGWPSFYAPAAEENVATETDSSLFMKRTEVLCSKCDAHLGHVFDDGPAP
TGLRYCINSAALKFTPEKEK
>Mature_179_residues
PVAFAGLMALWYRRERPLPNPRQPGSGRPIRVVLFLDNGKRGETIQVNKIAKTDADWQKELTPEEFAVTRKKGTERAFTG
RYWDNHEPGLYRCTCCGTTLFRANEKFDSGTGWPSFYAPAAEENVATETDSSLFMKRTEVLCSKCDAHLGHVFDDGPAPT
GLRYCINSAALKFTPEKEK

Specific function: Unknown

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=127, Percent_Identity=53.5433070866142, Blast_Score=150, Evalue=4e-37,
Organism=Homo sapiens, GI301336162, Length=127, Percent_Identity=53.5433070866142, Blast_Score=150, Evalue=4e-37,
Organism=Homo sapiens, GI73089054, Length=127, Percent_Identity=53.5433070866142, Blast_Score=150, Evalue=4e-37,
Organism=Homo sapiens, GI37620216, Length=127, Percent_Identity=53.5433070866142, Blast_Score=150, Evalue=6e-37,
Organism=Homo sapiens, GI117606353, Length=142, Percent_Identity=47.887323943662, Blast_Score=145, Evalue=2e-35,
Organism=Homo sapiens, GI7706511, Length=104, Percent_Identity=38.4615384615385, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1788077, Length=119, Percent_Identity=52.1008403361345, Blast_Score=136, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17553450, Length=120, Percent_Identity=47.5, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI115532676, Length=120, Percent_Identity=47.5, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319816, Length=130, Percent_Identity=36.9230769230769, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221378664, Length=140, Percent_Identity=45.7142857142857, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24645799, Length=140, Percent_Identity=45, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI45553335, Length=140, Percent_Identity=45, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI21356369, Length=140, Percent_Identity=45, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI221378662, Length=154, Percent_Identity=44.1558441558442, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24645801, Length=151, Percent_Identity=42.3841059602649, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24645804, Length=151, Percent_Identity=42.3841059602649, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057 [H]

Pfam domain/function: PF01641 SelR [H]

EC number: =1.8.4.12 [H]

Molecular weight: Translated: 20267; Mature: 20136

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVAFAGLMALWYRRERPLPNPRQPGSGRPIRVVLFLDNGKRGETIQVNKIAKTDADWQK
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCHHH
ELTPEEFAVTRKKGTERAFTGRYWDNHEPGLYRCTCCGTTLFRANEKFDSGTGWPSFYAP
CCCHHHHHHHHCCCCCCCEECCCCCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCCCC
AAEENVATETDSSLFMKRTEVLCSKCDAHLGHVFDDGPAPTGLRYCINSAALKFTPEKEK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure 
PVAFAGLMALWYRRERPLPNPRQPGSGRPIRVVLFLDNGKRGETIQVNKIAKTDADWQK
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCCHHH
ELTPEEFAVTRKKGTERAFTGRYWDNHEPGLYRCTCCGTTLFRANEKFDSGTGWPSFYAP
CCCHHHHHHHHCCCCCCCEECCCCCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCCCC
AAEENVATETDSSLFMKRTEVLCSKCDAHLGHVFDDGPAPTGLRYCINSAALKFTPEKEK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]