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The map label for this gene is ptpA [H]

Identifier: 116619305

GI number: 116619305

Start: 204502

End: 206940

Strand: Direct

Name: ptpA [H]

Synonym: Acid_0161

Alternate gene names: 116619305

Gene position: 204502-206940 (Clockwise)

Preceding gene: 116619304

Following gene: 116619306

Centisome position: 2.05

GC content: 65.11

Gene sequence:

>2439_bases
ATGCACACCTTGACCCGACTCTCCGTACTCTCGATTGCGGCGGTGGCCCTGCTTACGTGGCCCCTCGCCGCGGCCCCGAA
TAAAGTTCCGCTCTACCAACAGTTCCTCAGTCCGGCGTCGCCGCAGGAGGTGGTGTCGGCGCGCAAGGTGGACCGGGTCG
CGTGGGTGGACTATGCCGAAGGCAAGCGCAACGCGTACACGGCAGTGGCGCCCTTGTTCGCGCCGGTGCGGCTGACGAAT
TTTCTGAAGGACGACGGCATCATGATGTCCGGCATTCGAATCTCGGACGACGGCAGCACCGTCGTGTTCCTGCGCGGCGA
GGGTCCGAACCGCGACGGCTGGTCCCCCAACGCCTCGGCGGACCCCAATGGGCCGGAGCACGCCATCTGGGCGGCGCGGA
CCAGCGGCGTGGGCGGAGCGTGGCGGGTGGTGGACGCCACCAATCCGGAGTTGGCGCCGGATGGCAGCGCGATTCTCTTC
GTGAAGGCGGGACAGATTTTTCGCGCGAAAGTTACGCCGGTGAAGCCGGCCAGCGACGTGGATCGCGGCGAGAAGGCCTT
CATTACCGAGTGGGGCGTGCAGAGCGACCCGAAATGGTCTCCGGATGGGCGCAAGATCGCGTTCGTCAGTACGCGCACCG
ATCACAGCTTCATTGTCGTGTACGACGTCGCGACCCGGACCGTGAAGTACATGTCGCCGAGCGTGGATTTCGATACGATG
CCGATGTGGCTGGCGGACAGCAAGCACTTGATGTTCGTGAGGCGTCCGGGCCTGCCATTCGGATTGCAGGCGCAGCAGGG
GACGGGCGCGCTCGGACTGCCGAACGGGCCGGCGTTACCGACCTCGGCCGCGGCCACGACGGCGGCCACCGCGGGCCGGG
GCGGCGGGCGGGGCGGACGGGGAACCGCAGCTCCGGCGATCCAGGCGGCTACCACTCCGGCGGCCGCGGCTTCGGCGACT
CCGGCCGCGCCCGCAGTGGTCAATAATTCTCCGGGCCTGATGCGCGCGACATTCAAGGGCGGCTACACACTGGCTTTCTA
CAAGTCCGATGTCACGACTGGCGAGGCACAGGAGACCTGGCACAATCAGCCGAACGACACTCTTGTCGCGAATCTCGCGG
GCGCACGGATGGCCGGCGATTTCGCCATCTTTCCGTTCGTGGTGGGCGGCGGACGGGGGGGCAGAGGGGGACGGGGTAAT
GCGCCGGGTGCGGCCCCGGCCGCGGCGCCAGAAAACGAAGCGCCCGCGGCGAACCAGCCTCCGGCGGACGAATGGGACCG
CTATTACGCGCTTAACGTCATGGATGCTTCGGCTCGCCCCGTGCTGCTGACGACCACCGACGGGCTCATTGAAAATCAGA
CCTCGGTGGCGGTCTCCGCTGACGAGAAGACGTTCTATTACTGCACGAACGCCAAGGATATCGAACTGCGCCACATCTGG
GCGGTACCGGCCGGCGGCGGTGCGCCGGTACAGGTCACGACCGGCGAGGGCGTGGAGACCTACCCGGCTCCGCTCGCATC
CGGCAAGTACATGGCGACGCTAAGCGCGAGCTGGAAAATGCCGCAATCGCTCGGGATGTGGAAGTTGGGCACGGCGCCAG
CGACGCAGAAAATCGTTTTCCCCACGTCGCGGCCTGGCTTTCCGATTGAAGAGCACGTGAAGCCGGAGACGGTGATTACC
AAGGCCGCAGACGGGCTCGAGATCCACAATCAAATCTTCGTGCCGAAAGACCTGAAGCCAGGCGAGCGGCGCCCGGCGAT
CGTCTTTGTACACGGCGGGCCGGTGCGCCAGATGATGCCGGCCTATCACTATATGCAGTTCTACCACTGGGCGTACGGTA
TCAATCAGTGGCTGGCCAACCAGGGCTACATCGTGATGTCGATCAATTACCGCAGCGGCGTGGGCTATGGGCGGTCGTTC
CGCACCGCGGCGAATACGGGAGCCGCGGGCAACAGCGAGTATCAGGACGTAGTCGCGGGCGGAAAGTACCTGCAGACCAG
GGCGGATGTGGATCCAAACCGGATCGGGATCTGGGGCCTGTCGTACGGCGGCGTGCTGACGTCGCAGGCGCTGGCGCGCA
ACTCCGATATCTTCAAGGTGGGTGTGGACCTGGCTGGTGTGCACCTGTGGGGCAGTTCGCTCGACCCCGCGTCGGTCTCC
TACAAGTCTTCGACCATCGGCGCGATCGATGGCTGGAAGTCGCCGGTGCTGCTGATCCAGGGAGACGACGACCGCAACGT
CGCATTCCAGCAGATGACCGGACTGGTACAACTGCTGCGGCAGCGCGATGTGTATTATGAGCTCATCGTCTTCCCGGACG
ACGTGCACGAGTCGCTGCTGCACAGCCGGTGGATTTACACGCTGGGCCGCATGGAGACTTTCCTGCACAAGTTCCTGTCC
GAGACGCCGGTCAGCGTGAGTACGGGTCAGCACCAGTAA

Upstream 100 bases:

>100_bases
CAGCGCCGAAACGGCGCGGGACGGGGTGGGCTAACCCAAGGTTGCCCGTGTTATACTCGCGCATCGGCCGGACCGGCCGT
TGTCTCACTCAGAGGTAACC

Downstream 100 bases:

>100_bases
GGGACGTGGAAAACGCGCGGTCCAGTGCCCGGGACAGCAGGGCCGCGCGCAGTGTACGCAAACGCCGGTAAGTCTCCTTA
CACAGTAGAGGAGTTTCGCA

Product: peptidase S9 prolyl oligopeptidase

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 812; Mature: 812

Protein sequence:

>812_residues
MHTLTRLSVLSIAAVALLTWPLAAAPNKVPLYQQFLSPASPQEVVSARKVDRVAWVDYAEGKRNAYTAVAPLFAPVRLTN
FLKDDGIMMSGIRISDDGSTVVFLRGEGPNRDGWSPNASADPNGPEHAIWAARTSGVGGAWRVVDATNPELAPDGSAILF
VKAGQIFRAKVTPVKPASDVDRGEKAFITEWGVQSDPKWSPDGRKIAFVSTRTDHSFIVVYDVATRTVKYMSPSVDFDTM
PMWLADSKHLMFVRRPGLPFGLQAQQGTGALGLPNGPALPTSAAATTAATAGRGGGRGGRGTAAPAIQAATTPAAAASAT
PAAPAVVNNSPGLMRATFKGGYTLAFYKSDVTTGEAQETWHNQPNDTLVANLAGARMAGDFAIFPFVVGGGRGGRGGRGN
APGAAPAAAPENEAPAANQPPADEWDRYYALNVMDASARPVLLTTTDGLIENQTSVAVSADEKTFYYCTNAKDIELRHIW
AVPAGGGAPVQVTTGEGVETYPAPLASGKYMATLSASWKMPQSLGMWKLGTAPATQKIVFPTSRPGFPIEEHVKPETVIT
KAADGLEIHNQIFVPKDLKPGERRPAIVFVHGGPVRQMMPAYHYMQFYHWAYGINQWLANQGYIVMSINYRSGVGYGRSF
RTAANTGAAGNSEYQDVVAGGKYLQTRADVDPNRIGIWGLSYGGVLTSQALARNSDIFKVGVDLAGVHLWGSSLDPASVS
YKSSTIGAIDGWKSPVLLIQGDDDRNVAFQQMTGLVQLLRQRDVYYELIVFPDDVHESLLHSRWIYTLGRMETFLHKFLS
ETPVSVSTGQHQ

Sequences:

>Translated_812_residues
MHTLTRLSVLSIAAVALLTWPLAAAPNKVPLYQQFLSPASPQEVVSARKVDRVAWVDYAEGKRNAYTAVAPLFAPVRLTN
FLKDDGIMMSGIRISDDGSTVVFLRGEGPNRDGWSPNASADPNGPEHAIWAARTSGVGGAWRVVDATNPELAPDGSAILF
VKAGQIFRAKVTPVKPASDVDRGEKAFITEWGVQSDPKWSPDGRKIAFVSTRTDHSFIVVYDVATRTVKYMSPSVDFDTM
PMWLADSKHLMFVRRPGLPFGLQAQQGTGALGLPNGPALPTSAAATTAATAGRGGGRGGRGTAAPAIQAATTPAAAASAT
PAAPAVVNNSPGLMRATFKGGYTLAFYKSDVTTGEAQETWHNQPNDTLVANLAGARMAGDFAIFPFVVGGGRGGRGGRGN
APGAAPAAAPENEAPAANQPPADEWDRYYALNVMDASARPVLLTTTDGLIENQTSVAVSADEKTFYYCTNAKDIELRHIW
AVPAGGGAPVQVTTGEGVETYPAPLASGKYMATLSASWKMPQSLGMWKLGTAPATQKIVFPTSRPGFPIEEHVKPETVIT
KAADGLEIHNQIFVPKDLKPGERRPAIVFVHGGPVRQMMPAYHYMQFYHWAYGINQWLANQGYIVMSINYRSGVGYGRSF
RTAANTGAAGNSEYQDVVAGGKYLQTRADVDPNRIGIWGLSYGGVLTSQALARNSDIFKVGVDLAGVHLWGSSLDPASVS
YKSSTIGAIDGWKSPVLLIQGDDDRNVAFQQMTGLVQLLRQRDVYYELIVFPDDVHESLLHSRWIYTLGRMETFLHKFLS
ETPVSVSTGQHQ
>Mature_812_residues
MHTLTRLSVLSIAAVALLTWPLAAAPNKVPLYQQFLSPASPQEVVSARKVDRVAWVDYAEGKRNAYTAVAPLFAPVRLTN
FLKDDGIMMSGIRISDDGSTVVFLRGEGPNRDGWSPNASADPNGPEHAIWAARTSGVGGAWRVVDATNPELAPDGSAILF
VKAGQIFRAKVTPVKPASDVDRGEKAFITEWGVQSDPKWSPDGRKIAFVSTRTDHSFIVVYDVATRTVKYMSPSVDFDTM
PMWLADSKHLMFVRRPGLPFGLQAQQGTGALGLPNGPALPTSAAATTAATAGRGGGRGGRGTAAPAIQAATTPAAAASAT
PAAPAVVNNSPGLMRATFKGGYTLAFYKSDVTTGEAQETWHNQPNDTLVANLAGARMAGDFAIFPFVVGGGRGGRGGRGN
APGAAPAAAPENEAPAANQPPADEWDRYYALNVMDASARPVLLTTTDGLIENQTSVAVSADEKTFYYCTNAKDIELRHIW
AVPAGGGAPVQVTTGEGVETYPAPLASGKYMATLSASWKMPQSLGMWKLGTAPATQKIVFPTSRPGFPIEEHVKPETVIT
KAADGLEIHNQIFVPKDLKPGERRPAIVFVHGGPVRQMMPAYHYMQFYHWAYGINQWLANQGYIVMSINYRSGVGYGRSF
RTAANTGAAGNSEYQDVVAGGKYLQTRADVDPNRIGIWGLSYGGVLTSQALARNSDIFKVGVDLAGVHLWGSSLDPASVS
YKSSTIGAIDGWKSPVLLIQGDDDRNVAFQQMTGLVQLLRQRDVYYELIVFPDDVHESLLHSRWIYTLGRMETFLHKFLS
ETPVSVSTGQHQ

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI37577089, Length=343, Percent_Identity=26.530612244898, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI18450280, Length=343, Percent_Identity=26.530612244898, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI194394146, Length=242, Percent_Identity=26.0330578512397, Blast_Score=79, Evalue=3e-14,
Organism=Homo sapiens, GI16933540, Length=263, Percent_Identity=25.0950570342205, Blast_Score=68, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25144540, Length=258, Percent_Identity=23.6434108527132, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25144537, Length=258, Percent_Identity=23.6434108527132, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508017, Length=269, Percent_Identity=25.6505576208178, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508019, Length=269, Percent_Identity=25.6505576208178, Blast_Score=75, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17552908, Length=273, Percent_Identity=26.3736263736264, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17564634, Length=268, Percent_Identity=27.2388059701493, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17564632, Length=268, Percent_Identity=27.2388059701493, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24582257, Length=231, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 86963; Mature: 86963

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTLTRLSVLSIAAVALLTWPLAAAPNKVPLYQQFLSPASPQEVVSARKVDRVAWVDYAE
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHCCEEEEEECC
GKRNAYTAVAPLFAPVRLTNFLKDDGIMMSGIRISDDGSTVVFLRGEGPNRDGWSPNASA
CCCCCEEEHHHHHHHHHHHHHHCCCCEEEECEEECCCCCEEEEEECCCCCCCCCCCCCCC
DPNGPEHAIWAARTSGVGGAWRVVDATNPELAPDGSAILFVKAGQIFRAKVTPVKPASDV
CCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCC
DRGEKAFITEWGVQSDPKWSPDGRKIAFVSTRTDHSFIVVYDVATRTVKYMSPSVDFDTM
CCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCHHEEECCCCCCCCCCC
PMWLADSKHLMFVRRPGLPFGLQAQQGTGALGLPNGPALPTSAAATTAATAGRGGGRGGR
CEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
GTAAPAIQAATTPAAAASATPAAPAVVNNSPGLMRATFKGGYTLAFYKSDVTTGEAQETW
CCCCCCEEECCCCCHHCCCCCCCCEEECCCCCEEEEEECCCEEEEEEECCCCCCCHHHHH
HNQPNDTLVANLAGARMAGDFAIFPFVVGGGRGGRGGRGNAPGAAPAAAPENEAPAANQP
CCCCCCEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PADEWDRYYALNVMDASARPVLLTTTDGLIENQTSVAVSADEKTFYYCTNAKDIELRHIW
CCCCCCCEEEEEEECCCCCCEEEEECCCCEECCCEEEEEECCCEEEEECCCCEEEEEEEE
AVPAGGGAPVQVTTGEGVETYPAPLASGKYMATLSASWKMPQSLGMWKLGTAPATQKIVF
EEECCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCHHHCCCEEECCCCCCCEEEE
PTSRPGFPIEEHVKPETVITKAADGLEIHNQIFVPKDLKPGERRPAIVFVHGGPVRQMMP
CCCCCCCCHHHCCCCCCEEEECCCCEEECCEEEECCCCCCCCCCCEEEEECCCCHHHHHH
AYHYMQFYHWAYGINQWLANQGYIVMSINYRSGVGYGRSFRTAANTGAAGNSEYQDVVAG
HHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCC
GKYLQTRADVDPNRIGIWGLSYGGVLTSQALARNSDIFKVGVDLAGVHLWGSSLDPASVS
CCEEEEECCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEECCEEEEEEEECCCCCCCCEE
YKSSTIGAIDGWKSPVLLIQGDDDRNVAFQQMTGLVQLLRQRDVYYELIVFPDDVHESLL
ECCCCEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHH
HSRWIYTLGRMETFLHKFLSETPVSVSTGQHQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MHTLTRLSVLSIAAVALLTWPLAAAPNKVPLYQQFLSPASPQEVVSARKVDRVAWVDYAE
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHCCEEEEEECC
GKRNAYTAVAPLFAPVRLTNFLKDDGIMMSGIRISDDGSTVVFLRGEGPNRDGWSPNASA
CCCCCEEEHHHHHHHHHHHHHHCCCCEEEECEEECCCCCEEEEEECCCCCCCCCCCCCCC
DPNGPEHAIWAARTSGVGGAWRVVDATNPELAPDGSAILFVKAGQIFRAKVTPVKPASDV
CCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCC
DRGEKAFITEWGVQSDPKWSPDGRKIAFVSTRTDHSFIVVYDVATRTVKYMSPSVDFDTM
CCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCHHEEECCCCCCCCCCC
PMWLADSKHLMFVRRPGLPFGLQAQQGTGALGLPNGPALPTSAAATTAATAGRGGGRGGR
CEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCC
GTAAPAIQAATTPAAAASATPAAPAVVNNSPGLMRATFKGGYTLAFYKSDVTTGEAQETW
CCCCCCEEECCCCCHHCCCCCCCCEEECCCCCEEEEEECCCEEEEEEECCCCCCCHHHHH
HNQPNDTLVANLAGARMAGDFAIFPFVVGGGRGGRGGRGNAPGAAPAAAPENEAPAANQP
CCCCCCEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PADEWDRYYALNVMDASARPVLLTTTDGLIENQTSVAVSADEKTFYYCTNAKDIELRHIW
CCCCCCCEEEEEEECCCCCCEEEEECCCCEECCCEEEEEECCCEEEEECCCCEEEEEEEE
AVPAGGGAPVQVTTGEGVETYPAPLASGKYMATLSASWKMPQSLGMWKLGTAPATQKIVF
EEECCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCHHHCCCEEECCCCCCCEEEE
PTSRPGFPIEEHVKPETVITKAADGLEIHNQIFVPKDLKPGERRPAIVFVHGGPVRQMMP
CCCCCCCCHHHCCCCCCEEEECCCCEEECCEEEECCCCCCCCCCCEEEEECCCCHHHHHH
AYHYMQFYHWAYGINQWLANQGYIVMSINYRSGVGYGRSFRTAANTGAAGNSEYQDVVAG
HHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHCC
GKYLQTRADVDPNRIGIWGLSYGGVLTSQALARNSDIFKVGVDLAGVHLWGSSLDPASVS
CCEEEEECCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEECCEEEEEEEECCCCCCCCEE
YKSSTIGAIDGWKSPVLLIQGDDDRNVAFQQMTGLVQLLRQRDVYYELIVFPDDVHESLL
ECCCCEECCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHH
HSRWIYTLGRMETFLHKFLSETPVSVSTGQHQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA