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The map label for this gene is hpt [H]

Identifier: 116619272

GI number: 116619272

Start: 169816

End: 170385

Strand: Direct

Name: hpt [H]

Synonym: Acid_0128

Alternate gene names: 116619272

Gene position: 169816-170385 (Clockwise)

Preceding gene: 116619271

Following gene: 116619273

Centisome position: 1.7

GC content: 58.6

Gene sequence:

>570_bases
ATGAGCGCGCTCCCCATCCCAGGCCTCGACCGCATCCTGTTCACTGAAGAACAGATCAAGGCCCGCATTCGTGAGGTCGC
CGCCGAAATTACCGCGCGCTACCAGGGCCGCACCGTGAAATTGATCGGCGTCCTCAAAGGCTCCGTCTTCTTCATGACCG
CCCTCGCGCGTCACATCGATCTTCCGCTCAAGATCGATTTTCTGGCCATCTCCAGCTTCTCTAACAAGAGCGGCTCTCCC
GGCGTGGTGCGGATCGCCAAAGATCTTGACGAGAGCATCGAGGGCGATGACGTAATCCTGGTCGAAGACATCGTCGATAC
CGGCTTCACCCTTCGCTATCTGCTGCAGACGCTTGCCGGCCGCGCGCCTAATTCACTTTCCGTCTGCACTTTTCTGGACC
GCAATTCGCGCCGCATTGTCCAGGTCCCGGTAGATTTCCGCTGCTTCGAAATCCCCGACCGTTTTGTCGTGGGCTTCGGC
CTCGATTCCAACCAACTCTACCGTAACCTGCCCTACGTCGCCGTCCTGATTCCCGCGAACCGTGACAATCAGAGCCGCGA
CCGTTATTAG

Upstream 100 bases:

>100_bases
TCCGCCAGCTTTATCCGCACCTAAACATCCAGGTCTTCTACCAGAAGGATTTCGAGAACCTGATCTTTAAGTACGGGCTT
GCCGAGCGGCCGGTGCAGGC

Downstream 100 bases:

>100_bases
CGAGCGATCCACCAGGCCATAGTGCGCTATCCCCCTTTCTCCCCTGCACGAGTCATTGTGCCCTCTATGCCCGAGTACTA
AAATGAAAGAAGATTAAGAA

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MSALPIPGLDRILFTEEQIKARIREVAAEITARYQGRTVKLIGVLKGSVFFMTALARHIDLPLKIDFLAISSFSNKSGSP
GVVRIAKDLDESIEGDDVILVEDIVDTGFTLRYLLQTLAGRAPNSLSVCTFLDRNSRRIVQVPVDFRCFEIPDRFVVGFG
LDSNQLYRNLPYVAVLIPANRDNQSRDRY

Sequences:

>Translated_189_residues
MSALPIPGLDRILFTEEQIKARIREVAAEITARYQGRTVKLIGVLKGSVFFMTALARHIDLPLKIDFLAISSFSNKSGSP
GVVRIAKDLDESIEGDDVILVEDIVDTGFTLRYLLQTLAGRAPNSLSVCTFLDRNSRRIVQVPVDFRCFEIPDRFVVGFG
LDSNQLYRNLPYVAVLIPANRDNQSRDRY
>Mature_188_residues
SALPIPGLDRILFTEEQIKARIREVAAEITARYQGRTVKLIGVLKGSVFFMTALARHIDLPLKIDFLAISSFSNKSGSPG
VVRIAKDLDESIEGDDVILVEDIVDTGFTLRYLLQTLAGRAPNSLSVCTFLDRNSRRIVQVPVDFRCFEIPDRFVVGFGL
DSNQLYRNLPYVAVLIPANRDNQSRDRY

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=177, Percent_Identity=32.2033898305085, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI9910262, Length=194, Percent_Identity=29.3814432989691, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI87081689, Length=168, Percent_Identity=46.4285714285714, Blast_Score=157, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17510817, Length=181, Percent_Identity=36.4640883977901, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 21205; Mature: 21074

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALPIPGLDRILFTEEQIKARIREVAAEITARYQGRTVKLIGVLKGSVFFMTALARHID
CCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCHHHHHHHHHHHCC
LPLKIDFLAISSFSNKSGSPGVVRIAKDLDESIEGDDVILVEDIVDTGFTLRYLLQTLAG
CCEEEEEEEEECCCCCCCCCCEEEEEHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHC
RAPNSLSVCTFLDRNSRRIVQVPVDFRCFEIPDRFVVGFGLDSNQLYRNLPYVAVLIPAN
CCCCCCEEEEEEECCCCEEEECCCCEEEEECCCEEEEEECCCCHHHHHCCCEEEEEEECC
RDNQSRDRY
CCCCCCCCC
>Mature Secondary Structure 
SALPIPGLDRILFTEEQIKARIREVAAEITARYQGRTVKLIGVLKGSVFFMTALARHID
CCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHCHHHHHHHHHHHCC
LPLKIDFLAISSFSNKSGSPGVVRIAKDLDESIEGDDVILVEDIVDTGFTLRYLLQTLAG
CCEEEEEEEEECCCCCCCCCCEEEEEHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHC
RAPNSLSVCTFLDRNSRRIVQVPVDFRCFEIPDRFVVGFGLDSNQLYRNLPYVAVLIPAN
CCCCCCEEEEEEECCCCEEEECCCCEEEEECCCEEEEEECCCCHHHHHCCCEEEEEEECC
RDNQSRDRY
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12354221 [H]