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The map label for this gene is kdpD [H]

Identifier: 116619222

GI number: 116619222

Start: 109048

End: 110085

Strand: Direct

Name: kdpD [H]

Synonym: Acid_0077

Alternate gene names: 116619222

Gene position: 109048-110085 (Clockwise)

Preceding gene: 116619221

Following gene: 116619223

Centisome position: 1.09

GC content: 63.78

Gene sequence:

>1038_bases
ATGAGCCGCCCCGGCCAGCTCAAGATCTACCTTGGCTATGCGGCCGGCGTCGGCAAAACCTACCGCATGCTCGAAGAGGC
ACAGGCCCTGCGCGCCAAGGATATCGACGTGGTCATCGGCTACTTCGAGCCTCACGGCCGTCAGGAAACCATCGACAAGA
CCGAAGGCCTGGAAACCGTGCCGCGCCGCGCCATCCAATACGGCGGCACGCGTTTCGAAGAGATGGACCTGGACGCGGTC
CTCCGGCGCAAGCCCGCTGTAGCCGTGGTCGATGAATTCGCGCACAGCAATATCCCCGGTAGCGGCAATGAAAAGCGCTG
GCAGGACGTGCATGCTCTGCTCGATGCCGGAATTAACGTCCTCACCACTATGAACGTGCAGCACCTGGAGAGCCTCAACG
ACCAGGTCTGGCAGGTCACTGGTGTGCGCGTGCGCGAGACCGTGCCGGACTGGGTGGTGGATGAAGCCGACGAGGTCGTG
CTCGTGGACCTCACGCCGCGCGCCCTGCGCAACCGCATCGATCGCGGCGTGGTCTATGCCTCCGAGAAGGCCCGCCGCGC
CCTCGACAACTTCTTCACCGAGGCCAACCTCACCGCCCTGCGCGAACTCGCCATTCGCCATACCGCGCACGAAGTGGAAG
ACAAGCTCCTCGACCCGCGCCGCGAAGAGCGCATTCTCATCTGTCTCACCGGCCGGCCTTCCTCCGCGAACCTGATCCGG
CGCGGCAAGCGGGTCGCCGACTATCTGCAGGGCGATTGCCTCGCCGTACATGTCGCCCCGGGGGCCGTGTGCGATGAAAA
CGTGCGGCGTCACATGAGCTTCGCGCGTAACCTGCGCATTGAGACACACGTCCTGGAAGGTGAGGATGTGCCCTCCGTGA
TCGCGGAGTTCGCGCGTTCCCACAAGATTACTCAGATCTTCATGGGCCGCTCCAGCGCGCGTCCCTGGTGGAAGCGATTC
GGGGAGACGGTGGTGCAGCGCATGGTCCGCCTGGCACGCGACATGCAAATAACAATTGTGGCGGAAAGACGCCGATAA

Upstream 100 bases:

>100_bases
TGTTCCTCGGACACTCGCAGCGTGAGCGCAGTCCCATTGAGCGGCTGATCGATGCGGCCGAGGACTTCGACATCCGGCTG
TTCCCGCATGGAGAGGGCAA

Downstream 100 bases:

>100_bases
AGGATACGATAGAGCGTCAATGCTGCGATCGTCAATGCTGCGAACCTGCGCACTAATCGCCCTATTTTGCGCGTCCGCTT
TCGGCGCTGGCGAACCGACC

Product: osmosensitive K+ channel His kinase sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSRPGQLKIYLGYAAGVGKTYRMLEEAQALRAKDIDVVIGYFEPHGRQETIDKTEGLETVPRRAIQYGGTRFEEMDLDAV
LRRKPAVAVVDEFAHSNIPGSGNEKRWQDVHALLDAGINVLTTMNVQHLESLNDQVWQVTGVRVRETVPDWVVDEADEVV
LVDLTPRALRNRIDRGVVYASEKARRALDNFFTEANLTALRELAIRHTAHEVEDKLLDPRREERILICLTGRPSSANLIR
RGKRVADYLQGDCLAVHVAPGAVCDENVRRHMSFARNLRIETHVLEGEDVPSVIAEFARSHKITQIFMGRSSARPWWKRF
GETVVQRMVRLARDMQITIVAERRR

Sequences:

>Translated_345_residues
MSRPGQLKIYLGYAAGVGKTYRMLEEAQALRAKDIDVVIGYFEPHGRQETIDKTEGLETVPRRAIQYGGTRFEEMDLDAV
LRRKPAVAVVDEFAHSNIPGSGNEKRWQDVHALLDAGINVLTTMNVQHLESLNDQVWQVTGVRVRETVPDWVVDEADEVV
LVDLTPRALRNRIDRGVVYASEKARRALDNFFTEANLTALRELAIRHTAHEVEDKLLDPRREERILICLTGRPSSANLIR
RGKRVADYLQGDCLAVHVAPGAVCDENVRRHMSFARNLRIETHVLEGEDVPSVIAEFARSHKITQIFMGRSSARPWWKRF
GETVVQRMVRLARDMQITIVAERRR
>Mature_344_residues
SRPGQLKIYLGYAAGVGKTYRMLEEAQALRAKDIDVVIGYFEPHGRQETIDKTEGLETVPRRAIQYGGTRFEEMDLDAVL
RRKPAVAVVDEFAHSNIPGSGNEKRWQDVHALLDAGINVLTTMNVQHLESLNDQVWQVTGVRVRETVPDWVVDEADEVVL
VDLTPRALRNRIDRGVVYASEKARRALDNFFTEANLTALRELAIRHTAHEVEDKLLDPRREERILICLTGRPSSANLIRR
GKRVADYLQGDCLAVHVAPGAVCDENVRRHMSFARNLRIETHVLEGEDVPSVIAEFARSHKITQIFMGRSSARPWWKRFG
ETVVQRMVRLARDMQITIVAERRR

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=353, Percent_Identity=45.042492917847, Blast_Score=277, Evalue=9e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR014729
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39290; Mature: 39159

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS00039 DEAD_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPGQLKIYLGYAAGVGKTYRMLEEAQALRAKDIDVVIGYFEPHGRQETIDKTEGLETV
CCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCHHHH
PRRAIQYGGTRFEEMDLDAVLRRKPAVAVVDEFAHSNIPGSGNEKRWQDVHALLDAGINV
HHHHHHHCCCCCHHCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCE
LTTMNVQHLESLNDQVWQVTGVRVRETVPDWVVDEADEVVLVDLTPRALRNRIDRGVVYA
EEECCHHHHHHHHHHHEEECCCCHHHCCCCHHHCCCCCEEEEECCHHHHHHHHHCCEEEE
SEKARRALDNFFTEANLTALRELAIRHTAHEVEDKLLDPRREERILICLTGRPSSANLIR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHH
RGKRVADYLQGDCLAVHVAPGAVCDENVRRHMSFARNLRIETHVLEGEDVPSVIAEFARS
HHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHC
HKITQIFMGRSSARPWWKRFGETVVQRMVRLARDMQITIVAERRR
CCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
>Mature Secondary Structure 
SRPGQLKIYLGYAAGVGKTYRMLEEAQALRAKDIDVVIGYFEPHGRQETIDKTEGLETV
CCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCHHHH
PRRAIQYGGTRFEEMDLDAVLRRKPAVAVVDEFAHSNIPGSGNEKRWQDVHALLDAGINV
HHHHHHHCCCCCHHCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCE
LTTMNVQHLESLNDQVWQVTGVRVRETVPDWVVDEADEVVLVDLTPRALRNRIDRGVVYA
EEECCHHHHHHHHHHHEEECCCCHHHCCCCHHHCCCCCEEEEECCHHHHHHHHHCCEEEE
SEKARRALDNFFTEANLTALRELAIRHTAHEVEDKLLDPRREERILICLTGRPSSANLIR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHH
RGKRVADYLQGDCLAVHVAPGAVCDENVRRHMSFARNLRIETHVLEGEDVPSVIAEFARS
HHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHC
HKITQIFMGRSSARPWWKRFGETVVQRMVRLARDMQITIVAERRR
CCHHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]