Click here to switch to the map view.

The map label for this gene is ppiD [H]

Identifier: 116619198

GI number: 116619198

Start: 79904

End: 81838

Strand: Direct

Name: ppiD [H]

Synonym: Acid_0053

Alternate gene names: 116619198

Gene position: 79904-81838 (Clockwise)

Preceding gene: 116619197

Following gene: 116619199

Centisome position: 0.8

GC content: 60.36

Gene sequence:

>1935_bases
ATGTTTGACCTATTTCGTAGCCGCGACAAAATGGTGCGCATCCTTTTGGGTGCTTTGCTGGGCGTCGTGGCGCTCTCAAT
GCTGACCTACCTGGTCCCGAACTATAACACCGGCTCGTCCACTTCGGACGTGGTGGTAGCGGAGATCGGCAAAGACACGA
TTACGCTGCCGGAGATGCAGCGCGTGATTCAAGCGACCATCCGCGGCCGCCAGCTGCCCACGGAGATTCTGCCGACTTAT
ATCCCGCAGATGGTGGACCAGATGGTGACGGAGCGGGCGATGGCGATGGAAGCCGAGCGGTTGGGCTACCAGGTGAGCGA
CGCCGACGTGGCGGACAGCATCCGTCAGATGGTGCCGAGCCTTTTCCCCGATGGCAAGTTCGTCGGCAAGGAAACCTACG
CCGCGATGCTGGCACAGCAGAACATGACGATCGACCAGTTCGAAGCCGACCTGAAACGCCAGGTGGCGATCAGCCGCTTC
CGCGATATCGCAATGGAAGGTACGATCGTAACTCCGGCGGAGATCGAAGCGGCATTCAAGAAGAAGAACGAAAAGATCAA
GGTCGAGTGGGTCAAGCTGACGGCCGACAAATACAAAGGCGAGTCGCAGCCCAGCGCGCAGGAACTCCAGGATTTCTACA
AGGCCAACGTCTCGCGGTACACCGTGCCGGAGAAGCGGAACCTGACGGTGCTGACGGCTGATGAAGCCAAGATGTCCGCC
AGCCTGAACATCACGGATGCGGACCTGCAGCGCGTTTACGACCAGAACAAAGAAGCCTTCCGCACCCCGGAGCGGGTGAA
GGCGCGCCACATCCTGTTGAAGACCCAGGGCAAGCCGGCCAGCGAAGAAGCGGCGATCAAGGCCAAGGGCGAGAGCCTGC
TGAAGCAGATCAAAGCGGGCGGCGATTTCGCGAAACTGGCGAAGGAAAATTCCGAAGATCCGGGATCGGCTGTCAACGGC
GGCGACCTGGGCGATTGGATCACGCATGGACAGATGGTGGCGGAATTCGACAAGGCGATTTTCGCGTTGAAGCCGGGTGA
GGTCAGCGACCTTGTGAAGACGCAGTATGGTTATCACATTGTGCAGACGCTGGCGAAGCAGGACGCCGGAATGCGCACGT
TCGCCGAAGTAAAGGGCGATCTGGCTACCCAGTACAAGAAGCAGCGTGTCAGCGAGCTAATGCAGCAGGCGTCCGACCGG
GCGCAGGCGGCGCTGCAGAAGGATCCGCAGCATCCTGAGAAGGTGGCCGCGGAGTTGAACATGCAGTTGGCGAAGGTGCC
GAACTTTGCGCCTGGCGGCGCGATCGGCGAGTTGCCTGCAAACGCCGATTTCGACCAGTCTGTGGCGAACCTCAAAAAGG
GCGAGGTCTCGCAGCCGGTCACGGTCAACAACAAAGTTGTGGTCGCGGTGGTGGACGATGTGATTCCGGGCCATCCTTCG
ACCTTCGAGGAAGTGCAGGGCCAGATCCGCGACACGATCGTGGCCAACCGTGCGGCGGCGGCAGTCCAAAGGCACGCCAA
TGAGCTCGTGGAGAAGGCCAAGGCAATGGGCGGCGATCTGGAGAAGGCCGCCAAATCCATGGGACTGGACGTGAAGACCT
CGGGAGATGTGGACCGCAGCGGGAATATCGAAGGGCTGGGCACCGCCAGCTACATCGCGGAGGGTTTCTCGCGGCCCGAC
GGTACGGTCTATGGCCCGATCGGCACGCCGGACGGCGGCACCGTGGTGATGAAGGTGATTTCGCACACGGGCGCCGATAT
GGCGCAGCTTCCGGCGCAACGCAACGCGATTCGAGACGAAATCAAGAGCCAGCGCGCACGTGACCGCAACACGCTGTTCG
AAAACGGCGTCAAGGATATGTTGATCAAGCAGGGTAAGATCAAGATCCACCAGGATGTGATCAACCGCCTGATCGCCAAT
TACCGGACCAGCTAA

Upstream 100 bases:

>100_bases
TGGGGCCTCCGAAGGACGGGCGCAGCGTCCGACAAAGCGGTAGGGCCCGGTTTCCGATATACTGGAGTTTCCCCTTTAGA
TCACAGGAGTTCTGTCTAAC

Downstream 100 bases:

>100_bases
AAATGCTGCACGGTTTAATGCAGGTCTGGTTCGGCTGGGTCCGCGACGGAGGCTACTGGGGCGTGATCGCCCTGATGGCG
ATGGAAAGTTCGATTCTCCC

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MFDLFRSRDKMVRILLGALLGVVALSMLTYLVPNYNTGSSTSDVVVAEIGKDTITLPEMQRVIQATIRGRQLPTEILPTY
IPQMVDQMVTERAMAMEAERLGYQVSDADVADSIRQMVPSLFPDGKFVGKETYAAMLAQQNMTIDQFEADLKRQVAISRF
RDIAMEGTIVTPAEIEAAFKKKNEKIKVEWVKLTADKYKGESQPSAQELQDFYKANVSRYTVPEKRNLTVLTADEAKMSA
SLNITDADLQRVYDQNKEAFRTPERVKARHILLKTQGKPASEEAAIKAKGESLLKQIKAGGDFAKLAKENSEDPGSAVNG
GDLGDWITHGQMVAEFDKAIFALKPGEVSDLVKTQYGYHIVQTLAKQDAGMRTFAEVKGDLATQYKKQRVSELMQQASDR
AQAALQKDPQHPEKVAAELNMQLAKVPNFAPGGAIGELPANADFDQSVANLKKGEVSQPVTVNNKVVVAVVDDVIPGHPS
TFEEVQGQIRDTIVANRAAAAVQRHANELVEKAKAMGGDLEKAAKSMGLDVKTSGDVDRSGNIEGLGTASYIAEGFSRPD
GTVYGPIGTPDGGTVVMKVISHTGADMAQLPAQRNAIRDEIKSQRARDRNTLFENGVKDMLIKQGKIKIHQDVINRLIAN
YRTS

Sequences:

>Translated_644_residues
MFDLFRSRDKMVRILLGALLGVVALSMLTYLVPNYNTGSSTSDVVVAEIGKDTITLPEMQRVIQATIRGRQLPTEILPTY
IPQMVDQMVTERAMAMEAERLGYQVSDADVADSIRQMVPSLFPDGKFVGKETYAAMLAQQNMTIDQFEADLKRQVAISRF
RDIAMEGTIVTPAEIEAAFKKKNEKIKVEWVKLTADKYKGESQPSAQELQDFYKANVSRYTVPEKRNLTVLTADEAKMSA
SLNITDADLQRVYDQNKEAFRTPERVKARHILLKTQGKPASEEAAIKAKGESLLKQIKAGGDFAKLAKENSEDPGSAVNG
GDLGDWITHGQMVAEFDKAIFALKPGEVSDLVKTQYGYHIVQTLAKQDAGMRTFAEVKGDLATQYKKQRVSELMQQASDR
AQAALQKDPQHPEKVAAELNMQLAKVPNFAPGGAIGELPANADFDQSVANLKKGEVSQPVTVNNKVVVAVVDDVIPGHPS
TFEEVQGQIRDTIVANRAAAAVQRHANELVEKAKAMGGDLEKAAKSMGLDVKTSGDVDRSGNIEGLGTASYIAEGFSRPD
GTVYGPIGTPDGGTVVMKVISHTGADMAQLPAQRNAIRDEIKSQRARDRNTLFENGVKDMLIKQGKIKIHQDVINRLIAN
YRTS
>Mature_644_residues
MFDLFRSRDKMVRILLGALLGVVALSMLTYLVPNYNTGSSTSDVVVAEIGKDTITLPEMQRVIQATIRGRQLPTEILPTY
IPQMVDQMVTERAMAMEAERLGYQVSDADVADSIRQMVPSLFPDGKFVGKETYAAMLAQQNMTIDQFEADLKRQVAISRF
RDIAMEGTIVTPAEIEAAFKKKNEKIKVEWVKLTADKYKGESQPSAQELQDFYKANVSRYTVPEKRNLTVLTADEAKMSA
SLNITDADLQRVYDQNKEAFRTPERVKARHILLKTQGKPASEEAAIKAKGESLLKQIKAGGDFAKLAKENSEDPGSAVNG
GDLGDWITHGQMVAEFDKAIFALKPGEVSDLVKTQYGYHIVQTLAKQDAGMRTFAEVKGDLATQYKKQRVSELMQQASDR
AQAALQKDPQHPEKVAAELNMQLAKVPNFAPGGAIGELPANADFDQSVANLKKGEVSQPVTVNNKVVVAVVDDVIPGHPS
TFEEVQGQIRDTIVANRAAAAVQRHANELVEKAKAMGGDLEKAAKSMGLDVKTSGDVDRSGNIEGLGTASYIAEGFSRPD
GTVYGPIGTPDGGTVVMKVISHTGADMAQLPAQRNAIRDEIKSQRARDRNTLFENGVKDMLIKQGKIKIHQDVINRLIAN
YRTS

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=488, Percent_Identity=26.844262295082, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1786238, Length=100, Percent_Identity=42, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI1790211, Length=99, Percent_Identity=43.4343434343434, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17537235, Length=119, Percent_Identity=39.4957983193277, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 70482; Mature: 70482

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDLFRSRDKMVRILLGALLGVVALSMLTYLVPNYNTGSSTSDVVVAEIGKDTITLPEMQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHH
RVIQATIRGRQLPTEILPTYIPQMVDQMVTERAMAMEAERLGYQVSDADVADSIRQMVPS
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LFPDGKFVGKETYAAMLAQQNMTIDQFEADLKRQVAISRFRDIAMEGTIVTPAEIEAAFK
HCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHH
KKNEKIKVEWVKLTADKYKGESQPSAQELQDFYKANVSRYTVPEKRNLTVLTADEAKMSA
CCCCEEEEEEEEEEHHHHCCCCCCCHHHHHHHHHCCCCCEECCCCCCEEEEEECCCHHHC
SLNITDADLQRVYDQNKEAFRTPERVKARHILLKTQGKPASEEAAIKAKGESLLKQIKAG
CCCCCHHHHHHHHHCCHHHHCCHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
GDFAKLAKENSEDPGSAVNGGDLGDWITHGQMVAEFDKAIFALKPGEVSDLVKTQYGYHI
CHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHH
VQTLAKQDAGMRTFAEVKGDLATQYKKQRVSELMQQASDRAQAALQKDPQHPEKVAAELN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
MQLAKVPNFAPGGAIGELPANADFDQSVANLKKGEVSQPVTVNNKVVVAVVDDVIPGHPS
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCEEEEEECCCCCCCCC
TFEEVQGQIRDTIVANRAAAAVQRHANELVEKAKAMGGDLEKAAKSMGLDVKTSGDVDRS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
GNIEGLGTASYIAEGFSRPDGTVYGPIGTPDGGTVVMKVISHTGADMAQLPAQRNAIRDE
CCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHCCCCHHHCCHHHHHHHHH
IKSQRARDRNTLFENGVKDMLIKQGKIKIHQDVINRLIANYRTS
HHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFDLFRSRDKMVRILLGALLGVVALSMLTYLVPNYNTGSSTSDVVVAEIGKDTITLPEMQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHHH
RVIQATIRGRQLPTEILPTYIPQMVDQMVTERAMAMEAERLGYQVSDADVADSIRQMVPS
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LFPDGKFVGKETYAAMLAQQNMTIDQFEADLKRQVAISRFRDIAMEGTIVTPAEIEAAFK
HCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHH
KKNEKIKVEWVKLTADKYKGESQPSAQELQDFYKANVSRYTVPEKRNLTVLTADEAKMSA
CCCCEEEEEEEEEEHHHHCCCCCCCHHHHHHHHHCCCCCEECCCCCCEEEEEECCCHHHC
SLNITDADLQRVYDQNKEAFRTPERVKARHILLKTQGKPASEEAAIKAKGESLLKQIKAG
CCCCCHHHHHHHHHCCHHHHCCHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
GDFAKLAKENSEDPGSAVNGGDLGDWITHGQMVAEFDKAIFALKPGEVSDLVKTQYGYHI
CHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHH
VQTLAKQDAGMRTFAEVKGDLATQYKKQRVSELMQQASDRAQAALQKDPQHPEKVAAELN
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
MQLAKVPNFAPGGAIGELPANADFDQSVANLKKGEVSQPVTVNNKVVVAVVDDVIPGHPS
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCEEEEEECCCCCCCCC
TFEEVQGQIRDTIVANRAAAAVQRHANELVEKAKAMGGDLEKAAKSMGLDVKTSGDVDRS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
GNIEGLGTASYIAEGFSRPDGTVYGPIGTPDGGTVVMKVISHTGADMAQLPAQRNAIRDE
CCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHCCCCHHHCCHHHHHHHHH
IKSQRARDRNTLFENGVKDMLIKQGKIKIHQDVINRLIANYRTS
HHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]