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The map label for this gene is cysK [H]

Identifier: 116516389

GI number: 116516389

Start: 2015730

End: 2016650

Strand: Direct

Name: cysK [H]

Synonym: SPD_2037

Alternate gene names: 116516389

Gene position: 2015730-2016650 (Clockwise)

Preceding gene: 116515439

Following gene: 116515378

Centisome position: 98.51

GC content: 41.15

Gene sequence:

>921_bases
ATGTCTATTTATAACAACATTACTGAATTAATCGGTCAAACACCGATTGTTAAACTTAACAACATCGTGCCAGAAGGTGC
TGCAGACGTCTATATAAAGCTTGAAGCATTTAATCCTGGTTCATCTGTAAAAGACCGTATTGCCCTTAGCATGATTGAAA
AAGCTGAACAAGATGGTATTCTGAAACTTGGTTCTACTATTGTTGAAGCAACAAGTGGAAACACCGGTATTGGACTTTCA
TGGGTAGGTGCTGCTAAAGGGTATAAAGTCGTCATCGTTATGCCTGAAACTATGAGTGTAGAACGACGTAAAATTATCCA
AGCTTATGGTGCTGAACTCGTCCTAACTCCTGGTAGCGAGGGAATGAAAGGTGCTATTGCTAAGGCTCAAGAAATCGCTG
CTGAACGTGATGGTTTCCTTCCTCTTCAATTTGACAATCCAGCTAATCCAGAAGTACACGAAAGAACAACAGGAGCTGAG
ATACTAGCTGCTTTCGGTAAAGATGGATTAGATGCCTTTGTTGCTGGAGTAGGTACTGGTGGAACGATTTCTGGTGTTTC
TCATGCACTCAAATCAGAAAATTCTAACATTCAAGTTTTTGCAGTAGAAGCAGATGAATCTGCTATTCTATCTGGTGAAA
AACCTGGTCCTCACAAAATTCAAGGTATCTCAGCTGGATTTATTCCTGATACACTTGATACTAAAGCCTATGATGGTATC
GTTCGTGTAACATCAGATGACGCTCTTGCACTCGGACGTGAAATTGGTGGAAAAGAAGGCTTCCTTGTAGGGATTTCCTC
AGCTGCAGCTATCTACGGAGCCATCGAGGTTGCCAAAAAATTAGGTACAGGTAAAAAAGTCCTTGCCCTAGCACCAGATA
ACGGTGAACGTTATCTCTCTACAGCACTTTATGAATTGTAA

Upstream 100 bases:

>100_bases
ATGATATATAGAAATCCTATCGCTTCGATAGGATTTCTATATTTTACAAATGGTATGGATAGCGTTATACTAAAGATATC
TTATACAAAGAGGTATTCAT

Downstream 100 bases:

>100_bases
CCGTCCAATAACGAAGTCTATTGAAAAATCTCCAGACTAGAGAACTCACGGATAGTTCCTAATCTGGAGATTTCTTATTT
GCACTTTTCTTGTACAACTT

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVKDRIALSMIEKAEQDGILKLGSTIVEATSGNTGIGLS
WVGAAKGYKVVIVMPETMSVERRKIIQAYGAELVLTPGSEGMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAE
ILAAFGKDGLDAFVAGVGTGGTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPHKIQGISAGFIPDTLDTKAYDGI
VRVTSDDALALGREIGGKEGFLVGISSAAAIYGAIEVAKKLGTGKKVLALAPDNGERYLSTALYEL

Sequences:

>Translated_306_residues
MSIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVKDRIALSMIEKAEQDGILKLGSTIVEATSGNTGIGLS
WVGAAKGYKVVIVMPETMSVERRKIIQAYGAELVLTPGSEGMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAE
ILAAFGKDGLDAFVAGVGTGGTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPHKIQGISAGFIPDTLDTKAYDGI
VRVTSDDALALGREIGGKEGFLVGISSAAAIYGAIEVAKKLGTGKKVLALAPDNGERYLSTALYEL
>Mature_305_residues
SIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVKDRIALSMIEKAEQDGILKLGSTIVEATSGNTGIGLSW
VGAAKGYKVVIVMPETMSVERRKIIQAYGAELVLTPGSEGMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAEI
LAAFGKDGLDAFVAGVGTGGTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPHKIQGISAGFIPDTLDTKAYDGIV
RVTSDDALALGREIGGKEGFLVGISSAAAIYGAIEVAKKLGTGKKVLALAPDNGERYLSTALYEL

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=36.741214057508, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=36.741214057508, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=36.741214057508, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI11345492, Length=198, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788754, Length=314, Percent_Identity=49.6815286624204, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI2367138, Length=300, Percent_Identity=39.3333333333333, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17535051, Length=302, Percent_Identity=45.6953642384106, Blast_Score=261, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=48.3660130718954, Blast_Score=250, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=45, Blast_Score=243, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=45.0847457627119, Blast_Score=238, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=42.4749163879599, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=43.4579439252336, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17534315, Length=318, Percent_Identity=38.0503144654088, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25147552, Length=316, Percent_Identity=35.126582278481, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=40.5172413793103, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321594, Length=318, Percent_Identity=37.4213836477987, Blast_Score=181, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=34.2342342342342, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24643623, Length=310, Percent_Identity=37.4193548387097, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI20129101, Length=310, Percent_Identity=37.4193548387097, Blast_Score=184, Evalue=9e-47,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 31874; Mature: 31742

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVKDRIALSMIEKAEQDGI
CCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
LKLGSTIVEATSGNTGIGLSWVGAAKGYKVVIVMPETMSVERRKIIQAYGAELVLTPGSE
EHHCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCCC
GMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAEILAAFGKDGLDAFVAGVGTG
CCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCHHHHHHHHHCCCCHHHHHHCCCCC
GTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPHKIQGISAGFIPDTLDTKAYDGI
CCHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCCCCEEEEEECCCCCCCCCCHHHCCE
VRVTSDDALALGREIGGKEGFLVGISSAAAIYGAIEVAKKLGTGKKVLALAPDNGERYLS
EEEECCCHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHH
TALYEL
HHHHCC
>Mature Secondary Structure 
SIYNNITELIGQTPIVKLNNIVPEGAADVYIKLEAFNPGSSVKDRIALSMIEKAEQDGI
CHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
LKLGSTIVEATSGNTGIGLSWVGAAKGYKVVIVMPETMSVERRKIIQAYGAELVLTPGSE
EHHCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCCC
GMKGAIAKAQEIAAERDGFLPLQFDNPANPEVHERTTGAEILAAFGKDGLDAFVAGVGTG
CCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCHHHHHHHHHCCCCHHHHHHCCCCC
GTISGVSHALKSENSNIQVFAVEADESAILSGEKPGPHKIQGISAGFIPDTLDTKAYDGI
CCHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCCCCEEEEEECCCCCCCCCCHHHCCE
VRVTSDDALALGREIGGKEGFLVGISSAAAIYGAIEVAKKLGTGKKVLALAPDNGERYLS
EEEECCCHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHH
TALYEL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA