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The map label for this gene is apt [H]

Identifier: 116516257

GI number: 116516257

Start: 1426253

End: 1426783

Strand: Reverse

Name: apt [H]

Synonym: SPD_1407

Alternate gene names: 116516257

Gene position: 1426783-1426253 (Counterclockwise)

Preceding gene: 116517093

Following gene: 116516883

Centisome position: 69.73

GC content: 41.24

Gene sequence:

>531_bases
TTGAAAGAAAGAAAAAAGATGAATTTAAAAGATTACATTGCAACAATTGAAAATTATCCAAAGGAAGGCATTACCTTCCG
TGATATTAGTCCTTTGATGGCTGATGGAAATGCTTATAGCTACGCTGTTCGTGAAATCGTTCAGTATGCTACTGACAAGA
AAGTCGACATGATCGTGGGACCTGAAGCTCGTGGATTTATCGTGGGTTGTCCAGTTGCCTTTGAGTTGGGAATTGGTTTT
GCGCCTGTTCGTAAGCCAGGTAAATTGCCACGCGAAGTTATTTCTGCTGACTATGAAAAAGAGTACGGTGTCGATACCTT
GACTATGCACGCGGATGCCATTAAGCCAGGTCAACGTGTTCTTATTGTAGATGACCTTTTGGCGACAGGTGGAACTGTTA
AGGCAACTATCGAGATGATTGAAAAACTTGGTGGTGTTATGGCAGGTTGTGCCTTCCTTGTTGAATTGGATGAATTGAAC
GGCCGTGAAAAAATTGGTGACTACGACTACAAAGTTCTTATGCATTATTAA

Upstream 100 bases:

>100_bases
GATGGCTAGTTATAAATCGTCAAAACGTTAGATAATTATTGAAGTTAACTTTTCCTTTTTTCTTTCTTAAAAAATATGCT
ATAATAGAGAGTAAAAAACT

Downstream 100 bases:

>100_bases
TGAAAACAGTCCCTAGGGCTGTTTTCTCTACACTAGGATATAAAAATAGACTATAACTAGTTAGAGAAAAACTATAATTG
AAAACTATATCTTCTTGCAG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MKERKKMNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKVDMIVGPEARGFIVGCPVAFELGIGF
APVRKPGKLPREVISADYEKEYGVDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELN
GREKIGDYDYKVLMHY

Sequences:

>Translated_176_residues
MKERKKMNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKVDMIVGPEARGFIVGCPVAFELGIGF
APVRKPGKLPREVISADYEKEYGVDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELN
GREKIGDYDYKVLMHY
>Mature_176_residues
MKERKKMNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKVDMIVGPEARGFIVGCPVAFELGIGF
APVRKPGKLPREVISADYEKEYGVDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELN
GREKIGDYDYKVLMHY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=179, Percent_Identity=39.1061452513966, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=39.8496240601504, Blast_Score=100, Evalue=9e-22,
Organism=Escherichia coli, GI1786675, Length=157, Percent_Identity=52.2292993630573, Blast_Score=177, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=42.1052631578947, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=162, Percent_Identity=40.7407407407407, Blast_Score=112, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=177, Percent_Identity=32.2033898305085, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136334, Length=159, Percent_Identity=44.6540880503145, Blast_Score=134, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19530; Mature: 19530

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKERKKMNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKVDMIVG
CCCCCCCCHHHHHHHHHHCCCCCCEEECCCHHHCCCCHHHHHHHHHHHHHCCCCEEEEEC
PEARGFIVGCPVAFELGIGFAPVRKPGKLPREVISADYEKEYGVDTLTMHADAIKPGQRV
CCCCCEEEECCCCEECCCCCCCCCCCCCCCHHHHHCCCCHHCCCCEEEEECCCCCCCCEE
LIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIGDYDYKVLMHY
EEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MKERKKMNLKDYIATIENYPKEGITFRDISPLMADGNAYSYAVREIVQYATDKKVDMIVG
CCCCCCCCHHHHHHHHHHCCCCCCEEECCCHHHCCCCHHHHHHHHHHHHHCCCCEEEEEC
PEARGFIVGCPVAFELGIGFAPVRKPGKLPREVISADYEKEYGVDTLTMHADAIKPGQRV
CCCCCEEEECCCCEECCCCCCCCCCCCCCCHHHHHCCCCHHCCCCEEEEECCCCCCCCEE
LIVDDLLATGGTVKATIEMIEKLGGVMAGCAFLVELDELNGREKIGDYDYKVLMHY
EEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA